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D-Amphetamine salt combo - very different results by generic manufacturer?

A

aspena

Greenlighter
Joined
Feb 23, 2009
Messages
29
I was at Walgreens and they changed my generic prescription for D-Amphetamine salt combo - 30mg (Adderall) from an orange, football pill to a pink, diamond pill.

The pink pills seem to make me very jittery, have poor concentration, anxious, stomach pains, etc. Not the 'drive' and fantastic concentration from my previous orange pills.

I've researched a bit online and it looks that others have experienced something similar. But I trust bluelight, so is this all in my head or have others experienced something?

Thinking about returning the script and filling elsewhere.
 
I'm not positive, but I don't believe they will or can take drugs back. You'd probably need to talk to the doctor, rather than the pharmacist.

And, yeah, on addforums and some other boards (/stim/ on 420chan) I've seen enough people complain that I do believe something's up. Someone's probably going to tell you that generics are the exact same thing, just with different binders, but even my old Veterinary Science teacher brought up some studies with human and animal generics. Analysis showed that they're not really always the same. I don't have the handouts anymore, but Google Scholar might turn something up.

FDA or whoever regulates them only requires generics come within 80% of the original's content. Less active ingredient shouldn't cause the problems people seem to have on these, so I can't figure it out, but I definitely believe something's up.
 
you can't return a prescription, but you can give it to the pharmacy to dispose. it'd be something i'd discuss with your doc. people react differently to different generics. i do believe the jitters are caused from the l- isomer of amphetamine.

i'm on vyvanse, and that has no l-isomer in it, and i never get jittery off of it. i have seen the generics being mentioned as affecting people differently with adderall, on a lot of different boards too. enough for me to think that its not in your head.

http://wiki.answers.com/Q/What_is_levoamphetamine:
Levoamphetamine causes sweating, racing/irregular heartbeat (tachycardia), "jumpiness" or "jitters", and cotton mouth in some users. Although levoamphetamine has not been proven to have any therapeutic potential, it is still prescribed heavily by doctors for the treatment of ADD/ADHD in the form of Adderall, which is a preparation of four amphetamine salts, two of them being pure dextroamphetamine and the others being racemic (meaning they contain about equal amounts of both dextro- and levo-amphetamine). Dexedrine and its different brand-name equivalents (dextrostat, vyvnase, etc.), are the only amphetamine-based medications that contain only pure dextroamphetamine sulfate and are generally more well-tolerated than other stimulants largely due to the absence of levoamphetamine.
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People seem to report annoyances with the CorePharma brand of generic equivalent "Adderall blend," which comes as a pink, scored tablet. I have no idea why this would be, however.

I just can't understand what underlies the negative reviews of the CorePharma generic: a chemical is a chemical is a chemical and any clone of Adderall should have exactly the same enantiomeric ratio of d- and l-amphetamine. Unlike many other compounds, the bioavailablity and absorption of dl-amphetmaine should be quite uniform, regardless of binders and excipients. Nevertheless, I had a friend in college who took Adderall and paradoxically responded extremely well to the brand-name IR formulation, but quite poorly to the generic. I have never noticed a difference between different generic brands for Dextroamphetamine XR (Dexedrine), nor did I ever notice a difference between the brand and the Barr pharma clone back (a long time ago) when I was on Adderall.
 
you're not the only one who hates the new pink generics- i know a drug is a drug is a drug, but i'd been on addie for 3 years before the switch and something in this formulation is definitely different. whatever it is it does have an effect and a lot of people have noticed.

after taking the shitty ass pink 30's for 12 months i did a search for "corepharma" to research the company, and quickly found a blog post dedicated to how shitty and different the new generics are- with hundreds of comments from other users who agree that there's something wrong with this brand.

i've discovered in the past couple months that the old orange tabs from Barr are still available at Target and Wal-Mart, but all Walgreens as far as i've found have switched to the dark side. prices are lower if your insurance doesn't cover it, too (~$60 vs $80-90 for 60 30mg pills). o and i love that they taste like candy again so i don't need to drink anything to swallow 'em. i've switched back & forth a couple times to see if i could still tell a difference between brands, and i can, but not as obvious as it used to be to me. since i know both are available i'll stick with Barr from now on.
 
You'd think that with so much of our legacy being built on modernization and industry, that "ought to" and "is" should at least be equal with regards to medicine.

But, whatever, I guess capitalism always plays a big role and maybe dropping a couple milligrams of d-amp saved a few jobs. I doubt it, but hopefully that's way more likely than active impurities.
 
aspena said:
What's better about dexedrine?
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its pure dextroamphetamine, its not a salt combo,therefore its stronger but only by 5 mgs....its hard to find, atleast around here...i remember my doc prescribed it to me and when i called pharmacies for it some of them told me how bad it is and nobody had it so i had to wait like a week to get my prescription filled.there seems to be a big social stigma around dexedrine but not adderall. its weird its only like 5 mgs. stronger than adderall.
 
aspena said:
What's better about dexedrine?
Click to expand...

it has no l-amp, when i switched over I lost about 90% of the negative amphetamine side effects like jitters, muscle aches, etc. yes, it is less common but once a pharmacist knows you have a monthly script for it they will stock it for you. its cheaper than adderall too. and for me as far as effects go, 15mg of dexedrine = 15mg of adderall. I didn't find it to be any stronger, just cleaner feeling.
 
I know, it's so ridiculous how they want to curb abuse just by sticking to the one that has more side effects, so you don't feel like you can take as much.

It makes sense in a way, but you're also making it rougher the bodies of everyone who takes as prescribed. It's why I'm actually thankful Vyvanse came out, because my university psych was wary of Dex, and claimed it gave his patients a "caffeinated" feeling, which is exactly opposite of everything I've ever heard about it. Dude was okay with Vyvanse and Adderall IR, but got a very cautious look on his face when I mentioned Dexedrine.
 
fortunately dextroamphetamine costs me half the copay of generic adderall on my insurance so it was an easy conversation with my doc. I brought him the printout and said "can i try this it will save me 50%'
 
I also found the Corepharma generic not as effective. I called Walgreens and they said they would order the brand name (although if I remember correctly, this is now also made by Barr). We'll see if they have it when I go in for my next script.
 
I think the generic adderall works better for me because I LIKE TO EAT and I dont wan't to be anorexic and malnourished which is was the brand name caused me to be. It also won't keep my up and night and it really treats the ADD.
 
sarsXdave said:
FDA or whoever regulates them only requires generics come within 80% of the original's content. Less active ingredient shouldn't cause the problems people seem to have on these, so I can't figure it out, but I definitely believe something's up.
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Wrong, The FDA mandates the exact same amount of active ingredient in each generic. Within 80% is a sham, Think about that....what would stop a company from putting less ingredient in each tablet just because they could....or for that matter putting more in to get thier customers addicted. Again FDA mandates that a generic must contain the same active ingredient at the same dosage as it's original.
 
SteeleyJ said:
Wrong, The FDA mandates the exact same amount of active ingredient in each generic. Within 80% is a sham, Think about that....what would stop a company from putting less ingredient in each tablet just because they could....or for that matter putting more in to get thier customers addicted. Again FDA mandates that a generic must contain the same active ingredient at the same dosage as it's original.
Click to expand...

I was just about to say the same thing. Where this 80% figure comes from is beyond me. It seems that people believe just because they know something, it must be true. Well in the absence of proof, I will take the word of a pharmaceutical company making billions of dollars, and the regulating body of these billion dollar companies (the FDA), over "hundreds of posts" from anonymous bloggers saying the generic is weaker.
The burden of proof is on the naysayers, and I have yet to see a study showing that generic formulations are not bioequivalent to their brand name counterparts. So dig thru Google Scholar by all means and prove me wrong, but I have yet to see anything even remotely suggesting what alot of people are suggesting

I think the generic adderall works better for me because I LIKE TO EAT and I dont wan't to be anorexic and malnourished which is was the brand name caused me to be. It also won't keep my up and night and it really treats the ADD.
Click to expand...

This is what I'm talking about. You are talking about amphetamine. A generic version of amphetamine is still amphetamine. It's not some cheaper version of amphetamine. In fact, the formulation is the same in the case Adderall (salt ratios identical), so the only difference is the inert ingredients in the pill. Perhaps these inert substances are delaying absorption, but it's a real stretch saying generic amphetamine is good because you can eat and sleep on it, whereas brandname amphetamine is horrible as it stunts hunger and keeps you awake. Um, that's amphetamine for you.
I'm not saying YOU don't believe there's a difference, but there isn't. So take that as an assurance of just how powerful the human brain's power to direct beliefs can be
I'll bet $1000 you started off on brand name Aderall and couldn't eat or sleep at first, so eventually you switched to generic when you had been on the meds for a month or two... now tolerance is rising at this stage, so when you start on the generic version, your perception is that it's different. You reason that because you can eat and sleep better now, the generic must be different. If it was the other way around (you started on generic meds and switched to brand name) your belief would be reversed. As I said, its all in your head
 
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djsim said:
I was just about to say the same thing. Where this 80% figure comes from is beyond me. It seems that people believe just because they know something, it must be true. Well in the absence of proof, I will take the word of a pharmaceutical company making billions of dollars, and the regulating body of these billion dollar companies (the FDA), over "hundreds of posts" from anonymous bloggers saying the generic is weaker.
The burden of proof is on the naysayers, and I have yet to see a study showing that generic formulations are not bioequivalent to their brand name counterparts. So dig thru Google Scholar by all means and prove me wrong, but I have yet to see anything even remotely suggesting what alot of people are suggesting



This is what I'm talking about. You are talking about amphetamine. A generic version of amphetamine is still amphetamine. It's not some cheaper version of amphetamine. In fact, the formulation is the same in the case Adderall (salt ratios identical), so the only difference is the inert ingredients in the pill. Perhaps these inert substances are delaying absorption, but it's a real stretch saying generic amphetamine is good because you can eat and sleep on it, whereas brandname amphetamine is horrible as it stunts hunger and keeps you awake. Um, that's amphetamine for you.
I'm not saying YOU don't believe there's a difference, but there isn't. So take that as an assurance of just how powerful the human brain's power to direct beliefs can be
I'll bet $1000 you started off on brand name Aderall and couldn't eat or sleep at first, so eventually you switched to generic when you had been on the meds for a month or two... now tolerance is rising at this stage, so when you start on the generic version, your perception is that it's different. You reason that because you can eat and sleep better now, the generic must be different. If it was the other way around (you started on generic meds and switched to brand name) your belief would be reversed. As I said, its all in your head
Click to expand...

I find this kind of ignorance coming from a moderator here at BL to be somewhat chilling. You of all people should know better. Just do a little research and the answers are right here in other threads as well as posted elsewhere on the net. Just check under generic bioequivalency tests - the testing process has been posted more than once, and it isn't 20% - it is 20% either way from baseline.
 
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