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Açaí Berry Juice as an Opiate Potentiator

dunwich

dunwich

Bluelighter
Joined
Jul 22, 2006
Messages
706
Location
in the fade
(Im aware that there are many potentiation threads as well as a megathread, but since nothing in relation to potentiation came up in a serach for Acai i thought it deserved its own thread. Merge if you must)

Last night at 9pm i took 20mg extended release morphine. I have no tolerance. At T+13:00 (10am this morning) i awoke and immediately ate breakfast, which included a bottle of Açaí juice. While eating i noticed i was still very, very slightly buzzed. After about 45 minutes i noticed i was pretty high. It is now T+17:00 and i am faded. I feel higher than i did last night! I was friggin nodding in class today.


Açaí berries contain COX-1 and COX-2 enzyme inhibitors. Online i was able to find some information that stated that COX-2 inhibitors can potentiate/"reduce the need for" opiates. Im surprised I havent seen anything here on bluelight about it. I have never gotten such a strong effect from grapefruit juice.

SO, i ask you bluelighters, have any of you had any success with Açaí berry juice as an opiate potentiator?

If youve never tried it, i think its worth a shot!
 
wow. i am very glad you made this post. I am an opiohead and I love that shit. I also noticed that it is becoming much more common in local grocery stores not just the organic hippy stores. Its benefits and antioxidant power (and taste) is just starting to be realized. this is very interesting. thank you for the info. If anyone else could comment on this it would be great. stay safe! -Spaz-
 
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I noticed a big difference in tramadol's effect after I drank an acai mix. Seemed to noticeable to be placebo.
 
okay you have my attention.
I've never had acai juice. How is the taste? What would you compare it to? If it didn't potentate anything, would you still drink it?

This may be something better handled in ADD. The folks over there seem to know a lot more when it comes to this stuff. They have all kinds of smart journals and such.

Finally, what juices (brands) could I find this in? are they pretty heavily marketed or can I pick some up at, say, my local superstore?
 
Wow yea, I'm definitely interested in this. Luckily I work right next to a giant grocery store so I'll have to go see if they carry any kind of acai juice. I wanna try this out ASAP.
 
oh man, I really envy you for this. I love finding little consumable thrills to potent. my oxy. sadly, however, i just started my first dose of subox today and cannot get high (and will hopefully never again, ironically enough). guess i missed out on this one, but very interesting none the less, would love to see more literature and personal results on it.
 
Açaí berries contain COX-1 and COX-2 enzyme inhibitors. Online i was able to find some information that stated that COX-2 inhibitors can potentiate/"reduce the need for" opiates. Im surprised I havent seen anything here on bluelight about it. I have never gotten such a strong effect from grapefruit juice.
Click to expand...

Ibuprofen is a commonly utilised analgesic in a clinical setting, and it's action is primarily via COX-1enzyme inhibition (a common pathway for NSAIDs). I can't see how this juice would prove to be any more effective than ibuprofen or aspirin, in the framework of opioid potentiation. It's simple synergistic analgesia, just like the APAP in Vicodin.

I don't doubt the report though, so I'm interested to see if perhaps there is another pathway which may be more promising (ie CYP450 inhibition such as how cimetidine works)

EDIT: I would also think that a thinning of the stomach lining due to decreased prostaglandin synthesis (downstream effect of COX enzyme inhibition) would speed up absorption.
The more I think about this, the more I am leaning towards the notion that this juice may have compounds of a similar class to grapefruit, with the COX inhibition being just an added bonus
 
djsim said:
The more I think about this, the more I am leaning towards the notion that this juice may have compounds of a similar class to grapefruit, with the COX inhibition being just an added bonus
Click to expand...

That's what I was thinking as well; Did that report or any other mention any findings regarding CYP2D6 inhibition? I don't know anything about the Acai berry or it's juice, but this is indeed an interesting topic. Maybe I'll pick some up next time I'm out.
 
I was on a bit of a bender this weekend and drank a shitload of acai juice then I did a smallish shot and I was fucking wrecked...

It all makes sense.
 
I'm always very skeptical of these things, hell I'm not even sure if I believe that Grapefruit juice can be used to potentiate poppy tea. I mean I know the evidence, but it's hard to say if I honestly feel a difference.

However I don't completely shun these things, I still drink GFJ sometimes with my tea so maybe if I were feeling adventerous I'll grab a bottle of this Acai berry juice from work and give it a shot.
 
^
Grapefruit juice doesn't seem to work for me either (with pod tea). I just drank some acai with my pod tea an hour ago. Will report back later.
 
grabbed a bottle of the juice today and I just wanted to give a heads up to everyone that every bottle I found was at least double the cost of other juices.
For an 8 oz bottle, I paid over $3.00

(I know that I'm not allowed to discuss prices on BL but it's a juice, not drug! That's acceptable, right?)

Tastes pretty good. I'd drink the stuff because I generally prefer juices over carbonated coke or pepsi products.

Has everyone else paid around the same or is my co-op overcharging me?
 
I've read a lot about opioid-sparing agents and that is exactly what they mean about cox-1 and cox-2 inhibitors affect the analgesia from opioids. When you combines an NSAID* with an opioid it reduces the amount of opioid needed for the same level of analgesia. I can tell you from both experience and reading the literature that adding cyclooxygenase inhibitors to opioids WILL NOT affect the high... sedation, euphoria, etc... at all.

The reason they use opioid sparing agents (NSAIDS, muscle relaxers, acetaminophen, recently dextromethorphan, etc.) with opioids is so that they can get more pain relief with LESS of the side effects (the side effects being the negative ones like nausea and itchiness but also the pleasant ones as well like euphoria and nodding).

If the acai juice has effect on the enzymes like grapefruit juice does then I could see it potentiating but I've never heard of it doing that; the cox inhibition will not potentiate the high whatsoever. I am always skeptical about people extrapolating based on their own experience(s) because its difficult for anybody to be able to decipher in their bodies exactly what is causing what.


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*most Non-Steroidal Anti-inflammatory Drugs (NSAIDs) inhibit cox-1 and 2, the former controls stomach lining, the later prostaglandin synthesis therefore reducing inflammation and pain. Celebrex only inhibits cox-2 so it is far less likely to produce/exacerbate ulcers, lead to stomach bleeding, acid reflux, etc. Other NSAIDs like aspirin, naproxen/aleve, ibuprofin/motrin, etc. inhibit cox-1 and 2 which helps with inflammation but can be harmful to your GI tract, especially your stomach.
 
I drank an acai blueberry vitamin water a few minutes ago and I'm about eat some hydro. There probably isn't enough acai in the vitamin water to do anything but we'll see.
 
If acai does indeed have flavinoids or whatever else that causes enzyme inhibition, it'll be the same procedure as taking grapefruit juice.

That is, store bought kind generally won't work well, and you need fresh squeezed juice (as in you do it yourself) or ideally just eat the fruit.

Don't know this for sure, but that would be my instinct with this one.
 
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