• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Omega-3's Block Opiate

Valentine4

Valentine4

Bluelighter
Joined
Oct 26, 2007
Messages
76
Someone was taking a high H dose after a large purchase. This person then obtained some omega three supplements and consumed them. His pupil size began to increase and he began to have chills and intense lethargy an hour after consuming the Omega-3 fish oil. Re-dosing on the H did not improve the situation.

The first time this had happened to him, he had taken multiple vitamins so he could not determine the source. But this time only fish oil was taken.

This inspired research of scholarly sources. None relating Omega-3's or 6's to opiate antagonism could be found. BUT articles discussing the potential of Omega-3s to INCREASE nerve pain were discovered.

Now the researchers hypothesized different reasons as to why this might be happening, but understandably, none of them concluded anything about the opiate receptors, as the opiate system is not currently associated with omega-3s.

I must conclude then, that they may b e mistaken on the mechanism which omega-3s increase nerve pain; that it is actually some form of opiate antagonism.

Then again, this is anecdotal self-study and could be the result of a unique biochemistry...But I'd love other peoples opinions.

Dietary Omega-3 Fatty Acids May Be Associated with Increased Neuropathic Pain in Nerve-Injured Rats
Jordi Pérez, MD*{dagger}, Mark A. Ware, MBBS{dagger}{ddagger}, Stephanie Chevalier, PhD§, Rejeanne Gougeon, PhD§, and Yoram Shir, MD*
Click to expand...
 
Last edited:
As a note: omega-3s have also been shown to reduce pain in many studies. But the pain in these studies are the results of inflammation, and omega-3s may indeed be good at reducing inflmmatory problems: the source of much chronic pain.

But the opiate system is involved not in inflammation (much), but is very much so inviolved in neuropathic pain.
 
omega-3's are really pretty unpredictable effect-wise in all my readings on them. they can help or hurt or both who knows, thats why i take 6 grams a day =]
 
saveyour said:
omega-3's are really pretty unpredictable effect-wise in all my readings on them. they can help or hurt or both who knows, thats why i take 6 grams a day =]
Click to expand...

Uhhhhh..... Aren't exceptionally large doses like that fairly strongly correlated with risk of haemorrhagic strokes? Maybe you should go a bit easier on those omega 3's...



I have consistently had difficultly in eliciting information about the precise pharmacology of omega 3's (in particular DHA). I always notice a flattening of emotions and libido after taking it, but I've never been able to find out why that is so that I can counter these effects. (Probably because it increases serotonin levels?)
 
I have no problem with reduced libido from fish oil/multi oils. If anything it is increased because of the soft skin effects.

Additionally unsaturated fatty acids are indirect steroid precursors, so I don't see them causing losses in this important hormone either. Perhaps you should try exercising more after taking the fish oil/omega supplements to induce your body into utilizing them in different ways?

I also don't think there's much of a problem in taking multiple grams of a fish oil-type supplement per day. I prefer a multi-oil which contains 6-7 different unsaturated fatty acids and take around 10-15 per day as long as I have the money to keep up the habit. They do wonders for allowing intense workout regimens week-in-week-out and for keeping pot tolerance low. Plus numerous cognitive benefits just keep appearing in research the more people study them. There are people that take much more than 10 g/day as well. Some persons buy their oils in non-capsule form and just eat it with a spoon... blah...

Finally to address the original question, molecules such as DHA have many, many roles in your body, especially in the CNS. Hence it is probably hard to pin down exactly what is going on. I would suspect less of an opioid receptor antagonism hypothesis rather than an opioid receptor allosteric modulator hypothesis, whereby increased presence of DHA or EPA in the membrane structures surrounding your opioid receptors could influence their function and response to other ligands. This idea is similar to what is being proposed in the ranks of cannabinoid receptors where people still really are not sure how many of the fatty acids that bind and/or influence receptor activity truly work. Additionally there could be another molecule that the DHA/EPA is metabolized into that is serving as the primary modulator of these effects.
 
Has your friend repeated this experience? Has he been able to replicate it with other preparations and brands. I would be interested if it is all Omega 3's, or even something beyond coincidence and placebo. I find it hard to believe that a few caps of fish oil can antagonize a fat shot of dope like a narcan injection. I think this warrants more research.
 
http://www.umm.edu/altmed/articles/omega-3-000316.htm

University of Maryland Medical Center said:
Omega-3 fatty acids should be used cautiously by people who bruise easily, have a bleeding disorder, or take blood-thinning medications, including warfarin (Coumadin) or clopidogrel (Plavix), because excessive amounts of omega-3 fatty acids may lead to bleeding. In fact, people who eat more than three grams of omega-3 fatty acids per day (equivalent to 3 servings of fish per day) may be at an increased risk for hemorrhagic stroke, a potentially fatal condition in which an artery in the brain leaks or ruptures.
Click to expand...
 
Just to include my personal experience:

I take fish oil most days. The amount fluctuates and i run out for months at a time. I have been addicted to opiates, most often dope, for years and never noticed any type of effect or interaction.

I would wager that there's another cause. Damned if i know what. Aldulterants? Perhaps a big shot like that contained enough adulterants to cross a threshold and cause a toxicity from whatever it was cut with.

That would be my best guess
 
the more i think the more i sink.
the more i sink the more i drink

i'm here all weeks folks
 
Werd, it might have been cut with buprenorphine or something else that can block heroin. If he's the only one, and it's from the same batch of stuff, then theirs not enough evidence to assume that omega-3's block opiates.
 
i use 2 use omega as part of a lifting routine but havent the last half year.
Someone was taking a high H dose after a large purchase.
Click to expand...
"Someone" sounds like ah HardXcore bad apple.
 
You must log in or register to reply here.
Top