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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Mephedrone Megathread

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One of my mates has bought some and considering the massive good MDMA shortage here I'm half-up for trying it. I haven't done anything apart from weed for a good 6 months now so I've been a good boy.

Having said that, I am still on mirtazapine and valproate. Is this a terrible, terrible idea considering I'm on medication in terms of interactions or is it just no-one knows yet.
 
I'm planning on doing MDMA for the first time in a year tommorow night? Will the magic be back or will it be a epic fail?
 
dandandan said:
One of my mates has bought some and considering the massive good MDMA shortage here I'm half-up for trying it. I haven't done anything apart from weed for a good 6 months now so I've been a good boy.

Having said that, I am still on mirtazapine and valproate. Is this a terrible, terrible idea considering I'm on medication in terms of interactions or is it just no-one knows yet.
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Mirtazapine/MDMA interactions

Soudium valproate/MDMA interactions

Looks reasonably safe to mix from a very brief skim.
 
DS_ said:
I'm planning on doing MDMA for the first time in a year tommorow night? Will the magic be back or will it be a epic fail?
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I took around a year off once, it was an epic fail. No magic returned. The pills were decent enough by all accounts yet I still ended up taking 7 of them to try and get to that special place but nae joy. :(
 
Shambles said:
Mirtazapine/MDMA interactions

Soudium valproate/MDMA interactions

Looks reasonably safe to mix from a very brief skim.
Click to expand...

Well like the responsible drug user I am I didn't bother and decided to go for it anyway.

I started very small (50mg) and it hit me surprisingly hard. Redosing was ok. Probably had 300-400mg over the course of the night and quite good fun. Will go for some serious doses next time I try it.

No bad effects yet but I wasn't as fucked as my girlfriend on the same amount but obviously we're not an exact comparison but it's likely mirtazapine does a similar thing to mdma in increasing the dose requirement.

Anyway, for all the other manic depressives out there that shouldn't be doing this stuff in the first place, it didn't leave me dead after mixing it with mirtazapine (30mg), sodium valproate (2000mg) and some zyprexa (stopped taking it 3 days ago. Wonder where these urges to do drugs are coming from ha.).

Good fun though and way better than the crap cut mdma I get for 3-4x the price. Will try to stick to occassional uses only.
 
When I was on mirtazapine, I took MDMA a few times. Apart from missing some of the 'depth', it was fine.
 
I've taken mdma countless times while on mirtazapine, along with many many other drugs and have experienced no problems.

Always wise to check up though, I usually do a bit of research before taking anything new like meph
 
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TheSpade said:
I took around a year off once, it was an epic fail. No magic returned. The pills were decent enough by all accounts yet I still ended up taking 7 of them to try and get to that special place but nae joy. :(
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This is about my experience (had about 1 year, 3 months off), although I had MDMA crystals and just felt shit. But then I've never much liked MDMA, so I still hold out hope that if I can get some decent MDA pills one day, the magic will return :)
 
mdma kind of lost its magic for me too, i found methylone much more rewarding though less potent untill, I mixed it with mephedrone, wow, what a combination. lots of empathy, insight, wonderfull combo and easy to adjust it to suit ... ie, more methylone = more seratonin, more mephedrone = more dopamine
 
Well I feel very shit today. Probably from the lack of sleep (no benzos and I'm coming off olanzapine) and the complete lack of food more than the drug, my mood isn't particularly lower but I just feel a bit braindead and very weak.
 
I found that I could still suffer the same kind of comedowns although I would generally say I think I'd be more prone to depression some other people I know.
 
My heart still feels weird over a week after taking mephedrone. I have had no other issues to do with my heart in my lifetime, and i'm only 19, so it's sketching me out a bit. Something definitely feels different, I don't think i'm just being paranoid. I've stopped smoking and i'm going to cut down drinking for a few weeks, and do some proper exercise as well as go to the doctors.

I don't regret taking the stuff, cos it was a fucking fun night, but i'm almost certain this heart weirdness is because of it. I just feel a lot more "aware" of the pressure of my heart in my chest, and my pulse speeding up and slowing down, as well as missing beats a bit. Maybe this is no big deal for some, but it is for me. I feel a bit dumb cos I knew the risks when I took this stuff, but hey.

Just a wee warning out there. I seem to be in the minority in terms of these effects, but play safe y'all. :)
 
forestxfaerie said:
cardiac element?
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Yes cardiac element... ever since this appeared on the market I've had serious misgivings about it's effect on the heart (something just says "dodgy interaction with 5HT2B receptor" to me because of it's structure & pharmacology). In case the above means fuck all to you - ie utter gobbledegook - look up pulmonary hypertension & fenfluramine; it's a serious condition & resulted in the slimming tablet fenfluramine (& it's d isomer dexfenfluramine) being withdrawn worldwide as it caused a lot of cases of the aforementioned pulmonary hypertension.

I know people might think me a tad irresponsible as in my time I've consumed a shitload of weird & wonderful compounds with very little toxicology data on them, but before I do, I always thouroughly research them. This means that sometimes I simply never actually experience the drug because of what I've found (eg never have & never will choose to consume any phenylpiperazine after a bit of research). Until confirmed one way or another re: pathological changes in cardiac function, this is another compound that I'll just have to take other people's word on

just dont go over 500mg-1000mg in a night and you should be fine.
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You most probably will not end up in hospital or worse the night you take it, but this in no way indicates that you'll be fine in the long run, esp if you go on to use it multiple times. I may be wrong & it might turn out to be perfectly safe, but I think the anecdotal evidence that's appearing on BL etc. indicates otherwise
 
fastandbulbous said:
Yes cardiac element... ever since this appeared on the market I've had serious misgivings about it's effect on the heart (something just says "dodgy interaction with 5HT2B receptor" to me because of it's structure & pharmacology). In case the above means fuck all to you - ie utter gobbledegook - look up pulmonary hypertension & fenfluramine; it's a serious condition & resulted in the slimming tablet fenfluramine (& it's d isomer dexfenfluramine) being withdrawn worldwide as it caused a lot of cases of the aforementioned pulmonary hypertension.
Click to expand...

Thanks for the heads-up F&B. :)

A quick search on Wiki for Fenfluramine explains that: "These receptors [5-HT] are plentiful in human cardiac valves and appear to be essential for normal cardiac development. Roth suggested that the mechanism by which fenfluramine causes damage is through inappropriately stimulating the valve cells to divide. This valve damage is found in other drugs that act on 5-HT2B receptors."

I take it Methedrone also acts on these receptors? Am I right in saying that the damage, if caused by Mephedrone, is permanent and irreversible?
 
Riklet said:
My heart still feels weird over a week after taking mephedrone. I have had no other issues to do with my heart in my lifetime, and i'm only 19, so it's sketching me out a bit. Something definitely feels different, I don't think i'm just being paranoid. I've stopped smoking and i'm going to cut down drinking for a few weeks, and do some proper exercise as well as go to the doctors.

I don't regret taking the stuff, cos it was a fucking fun night, but i'm almost certain this heart weirdness is because of it. I just feel a lot more "aware" of the pressure of my heart in my chest, and my pulse speeding up and slowing down, as well as missing beats a bit. Maybe this is no big deal for some, but it is for me. I feel a bit dumb cos I knew the risks when I took this stuff, but hey.

Just a wee warning out there. I seem to be in the minority in terms of these effects, but play safe y'all. :)
Click to expand...

I felt like that for months after a night of way too much coke+pills. Turns out it was all in my head, had my cardio checked out multiple times and its 100% normal. Go to the doctors and get them to do a check, its probably nothing but it helps a great deal to put you at ease. Its amazing what the mind can conjur up in times of panic.

Since that night I can't take drugs which speed my heart up too much otherwise I get really uncomfortable and panicky. Stimulants are a no-no, MDMA I can handle but amp or coke I simply can't do anymore. From what I've read this mephedrone does make one more aware of heartrate so I shan't be going anywhere near it. Does sound like a mighty interesting experience though.
 
I'm going to the GP and to get some checks done anyway, something like my heart, i'd rather be safe than sorry. A few friends think i'm just being paranoid, but tbh they're not me, and I know what I feel. I really hope it's just in my head, but i've felt a little dizzy and weird for days now, and my pulse feels weak compared to how i remember it before, whilst my heart area feels more "pressurised". It kinda took a few days before I really started feeling this though, it wasn't the morning after...

Exercise doesn't seem that big a deal though, i've been doing some, and having a great diet. Quit smoking and i'm gona drink less this month. On the third day atm, and I feel crap to be honest, so i've been out doing stuff and getting involved in things which is cheering me up. I'm definitely never taking mephdrone again, it just feels too dodgy for me personally, even if it's a perfect wonder drug for others. Blah I feel right low to be honest.... :( :(
 
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