I prefer LSD.
And oranges.
I have no problem comparing apples to oranges.
Apples and oranges are both popular edible fruits commonly used in juice production. The sizes vary but the two fruits are relatively similar in that regard. When eaten in their natural forms, the peel or rind of the orange is removed and discarded, while more commonly the skin of the apple is eaten, while only the seeds and core are discarded.
Comparing LSD and MDMA is a little trickier, but certainly not undoable.
LSD is, along with psilocybin mushrooms, the best-known psychedelic tryptamine. Most people are familiar with the sometimes-exaggerated visual (and other sensory) hallucinations. MDMA is a stimulant/psychedelic phenethylamine, re-discovered by the chemist Shulgin and made popular first in Texas and California, then spreading across North America, Europe, Asia and Australia. MDMA is better known as a party, or rave drug, instilling more euphoria than altered sensory illusions.
I can even compare things that are much, much more different from one another than the two above sets of examples. Just ask me.
I'm not bragging or anything. I just feel that it may be time for us to rethink the "apples to oranges" thing. It seems to me to be a meaningless cop-out response.