Why does the same substance affect different people differently?

[inlilisimage]

Two people can describe completely different experiences with the same substance. How much do you think individual biology, sleep, mental state, medications, environment, and expectations contribute?

I'd especially like to hear about the science behind those differences.

 

[M!$TER-ED]

Excellent question, i cannot tolerate weed THC, back in the day I smoked a ton of weed, it was the social thing to do. if you didn't puff and pass you might be labeled a NARC. I cannot tolerate hard liquor, I pass out and wake up in strange places.
I don't know why

 

[thomaslucas]

I love 420 dude

 

[Cheshire_Kat]

Humans are similar but not identical. Due to genetic expression each individual has different reactions due to differences in construction of the body, chemistry and distribution of receptors; as well as other factors. This can not only be different between individuals; but also may vary in any given individual due to age, health diet and other environmental variables.

 

[Docta]

Certainly, paradoxical psychoactive effect & paradoxical reactions are very real and occur across a wide band of drug and biological pathways. Sedatives and Simulants are the most common but even Antihistamines has been observed to have paradoxical effects, especially in children. These underlying causes are quite varied, genetic and structural differences within receptors alter drug binding and signal transmission. Body-mass, age and overall neurological health have strange outcomes with Sedatives and Simulants. Intermittent and chronic substance abuse fool GABA pathways leading to unanticipated brain responses. Errant dosage and drug tolerance setup feedback loops and interactions with other medications.

We humans evolve and adapted through our subtle differences; it’s a feature not a bug.

 

[placebonaut]

agree with everything already said, also depending on which drug's being taken the batch or even pills in the same batch might be different as well - that's not just illicit production, the indian generics can be all over the place too

When did you last eat, what was the ROA, what else is still in your system (people underestimate how long drugs and metabolites hand around for), iterations with other drugs or food

hormone levels, your sex, ethnicity, mood, type of meal you ate...

there's so many variables....

 

[new2drugs]

Two people can describe completely different experiences with the same substance. How much do you think individual biology, sleep, mental state, medications, environment, and expectations contribute?

I'd especially like to hear about the science behind those differences.

Happens with me and coke all the time, seems its rubbish stuff but others saying its good