What's the strongest 5-HT2a Inverse Agonist ?

[MedicinalUser247]

I was just thinking about something. What's the strongest 5-HT2a Inverse Agonist ?

 

[Rectify]

Maybe Risperdal, Thorazine, Haldol, Zyprexa, Seroquel, Geodon?

 

[paranoid android]

Maybe Risperdal, Thorazine, Haldol, Zyprexa, Seroquel, Geodon?

Risperdal likely binds the tightest to that receptor. Zyprexa doesent bind that tightly in my expeience or atleast i can stll trip on it if i take a day or 2 off

 

[MedicinalUser247]

What about Nuplazid ? https://en.wikipedia.org/wiki/Pimavanserin

 

[MedicinalUser247]

"Pimavanserin, sold under the brand name Nuplazid, is an atypical antipsychotic which is approved for the treatment of Parkinson's disease psychosis. It is taken by mouth.

Side effects of pimavanserin include peripheral edema and confusion. Unlike other antipsychotics, pimavanserin is not a dopamine receptor antagonist, but rather is a selective antagonist or inverse agonist of the serotonin 5-HT2A receptor and to a lesser extent of the serotonin 5-HT2C receptor

Pimavanserin was first approved for medical use in 2016. It was approved as a generic medication in 2024."

Quoted from Wikipedia.

 

[MedicinalUser247]

I want to ask my Doctor about prescribing Nuplazid to me off label sense I have Schizophrenia.

 

[AlphaMethylPhenyl]

inverse agonists are not antagonists