Opioids Plugging Opiates

[4DQSAR]

ODD BUT TRUE - Paracetamol (acetaminophen) can demonstrate far lower rectal biovailability than oral bioavailability BUT I note a note suggesting that the figure is highly dependent on the formulation of the pill.

Even if you only occassionally consume a compound medication containing paracetamol, it's worth the money to buy and consume methionine (sold in health food shops) as it's the body running out of methionine that makes paracetamol hepatotoxic.

In the UK we had paracetamol/methionine compound tablets with 500/250 i.e. it seems half the mass of methionine is sufficient to prevent the mis-metabolism that yields the toxin.

The liver is amazing but it's so cheap that I would consider taking a methionine just in case your diet means you don't have a large store of that amino acid. Every month or so someone in the UK will wind up dead from taking too much paracetamol. I don't mean ten times the maximum (4g/24 hours) but just twice that dose. A TI of ONE seems very narrow to me.

 

[Yunai]

what about liquid morphine? it is already in liquid form at 20mg/ml, so i am wondering if this will irritate my bowels since it isnt a pill dissolved in water, it’s a chemical mixture. I think its Morphine HCl (i would assume) but i have a 30ml bottle of it along with 20 2mg dillys and a crap ton of oxy IR 10s and 30s.

Have any of you had experience boofing morphine that is already in liquid form? I have also never boofed a drug in my life, so i am kinda worried about the effect, safety, and constipation.

Hey, I just made a new more in depth post about this (Guide for boofing). You might want to check it out. In it you’ll get to know everything what you need for boofing! It won’t irritate your bowels. Boofing never will. It’s only inserted into the outmost part of the rectum where huge anal column veins absorb the drug and skip first pass metabolism). Except if you mean constipation which is a common side effect from opiates but that has nothing to do with the ROA. It doesn’t matter if it’s HCL it can be sulfate too (different brands use either HCL or sulfate)

Absolutely not! I would recommend you boof the Morphine. If it’s already liquid you skip the hustles of crushing the pills, mixing it with water, etc.

boofing is a big harm reduction and the next safest thing to oral. It’s much better than snorting and smoking and much much much better than IV.

Idk about your tolerance so be careful about that (don’t take all your opiates at once). Morphine rectal has a much higher BA than oral and MUCH MUCH higher than nasal. If you have no tolerance 20mg rectal will not kill you but it will be a rather strong rush (you might nod)
For Oxy take that orally since its oral BA is already exceptionally high especially if you have IR already.
Dilaudid 2mg is standard dose for people with no tolerance. You can take that different ways too depending on in which form you got it.

But please check PsychonautWiki for each substance dosage first, depending on your tolerance this can vary IMMENSELY but assuming you have no tolerance it’s accurate.

Ps sorry for the late response. One of my bros died from fake percs (fuck fentanyl) on the 2nd of October so I was and still am very depressed and stayed away from social media.

 

[Yunai]

ODD BUT TRUE - Paracetamol (acetaminophen) can demonstrate far lower rectal biovailability than oral bioavailability BUT I note a note suggesting that the figure is highly dependent on the formulation of the pill.

Even if you only occassionally consume a compound medication containing paracetamol, it's worth the money to buy and consume methionine (sold in health food shops) as it's the body running out of methionine that makes paracetamol hepatotoxic.

In the UK we had paracetamol/methionine compound tablets with 500/250 i.e. it seems half the mass of methionine is sufficient to prevent the mis-metabolism that yields the toxin.

The liver is amazing but it's so cheap that I would consider taking a methionine just in case your diet means you don't have a large store of that amino acid. Every month or so someone in the UK will wind up dead from taking too much paracetamol. I don't mean ten times the maximum (4g/24 hours) but just twice that dose. A TI of ONE seems very narrow to me.

I didn’t know that about Paracetamol, since I do not take it, thanks for letting us know.
Rectal bypasses first pass metabolism though.

 

[db7132]

Hey, I just made a new more in depth post about this (Guide for boofing). You might want to check it out. In it you’ll get to know everything what you need for boofing! It won’t irritate your bowels. Boofing never will. It’s only inserted into the outmost part of the rectum where huge anal column veins absorb the drug and skip first pass metabolism). Except if you mean constipation which is a common side effect from opiates but that has nothing to do with the ROA. It doesn’t matter if it’s HCL it can be sulfate too (different brands use either HCL or sulfate)

Absolutely not! I would recommend you boof the Morphine. If it’s already liquid you skip the hustles of crushing the pills, mixing it with water, etc.

boofing is a big harm reduction and the next safest thing to oral. It’s much better than snorting and smoking and much much much better than IV.

Idk about your tolerance so be careful about that (don’t take all your opiates at once). Morphine rectal has a much higher BA than oral and MUCH MUCH higher than nasal. If you have no tolerance 20mg rectal will not kill you but it will be a rather strong rush (you might nod)
For Oxy take that orally since its oral BA is already exceptionally high especially if you have IR already.
Dilaudid 2mg is standard dose for people with no tolerance. You can take that different ways too depending on in which form you got it.

But please check PsychonautWiki for each substance dosage first, depending on your tolerance this can vary IMMENSELY but assuming you have no tolerance it’s accurate.

Ps sorry for the late response. One of my bros died from fake percs (fuck fentanyl) on the 2nd of October so I was and still am very depressed and stayed away from social media.

thank you for the reply! i did 10mg (0.5ml) rectally and 35mg orally over the course of 30 min (i put it in soda and drank it with a meal). it hit pretty nicely in the legs but i honestly orefer oxycodone still. i also have 2mg dilaudid pills but i cant seem to find any euphoric feeling, besides a slight happy feeling, when taking orally and nasally (tried 7mg orally and then a different time i did 2mg nasally just to try but nothing really).

I am very sorry for your loss, i have had a couple of buddies pass away from the fake percs as well. Fuck fentanyl!