Stimulants Bupropion, what a drug!

[Smuck_Hey_Dee_Hewitt]

Bupropion (Wellbutrin; Zyban) is a pretty fucked up drug man.

If a person has been diagnosed with depression and has been through the gamut of Psychiatry, they will likely be prescribed Bupropion at one point or another. It's a central nervous stimulant related to Amphetamines, but more closely related to Cathinones, although both the latter and former are very similar in their effects.

I've never been addicted to stimulants. I've used plenty of different stimulants, but they were never more than 5% of my total drug usage at most. This is relevant as I've tried insufflating Bupropion on a one-off, let me see what this is all about basis, only to find myself sniffing more and more compulsively until finally having a tonic-clonic seizure. I was pretty stunned by how my willpower was completely non-existent throughout the experience. I knew enough about Bupropion to know that something terrible was going to happen if I didn't stop, yet I didn't.

As anyone will tell you, Bupropion is the bottom-barrel of stimulant experiences, proabably on par with Propylhexedrine (Benzedrex). It's a shitty high, yet both myself and apparently tons of other people report similar compulsive issues surrounding the use of Bupropion.

I know everyone is going to say I'm full of shit, but there is a junkie known in my area for the complications resulting from his addiction to Bupropion. I don't know the guy, but I understand that he's a lifelong crack head who ended up with no crack but months' worth of Bupropion. He destroyed all of the veins on both of his arms in a matter of days injecting Bupropion. He had a ton of open sores on his arms from injecting. He went from arms to hands to feet, destroying his body in the process. This run ended when he injected some Bupropion into a vein on his penis. The injection site then became gangrenous, as he continued binging on Bupropion for several days after the missed shot.

They basically had to cut half of his dick off. He now basically has an opening that they have refashioned into a new dick of sorts, but I here he still has to use catheters to urinate and will never have sex again in any normal context. I didn't believe the story at first, but I've talked to several people who have seen the damage. This guy was such a sad, sad character that after the whole debacle, he was charging people money to look at it so he could have money for drugs. The same guy now lives downtown, permanently outside in a wheelchair (he lives in the wheelchair. use your imagination for that picture). I don't know if he has had his legs fucked with or what, but this guy now is sans-penis, unable to walk on his own and this was all the result of Bupropion injecting. This guy was a crackhead for decades, but a few short binges with Bupropion was enough to perma-fuck him. Every time I see him, I no lie pray to God that he will overdose and die so he might have some sweet relief from the nightmare of what his life has become.

So yea, Bupropion has become a pretty nefarious character in the world of addiction. It's caused a lot of serious damage to a lot of people. The compulsive nature of the drug shows how someone can start out sniffing a pill on a Friday only to be injecting them compulsively by Sunday with only half a penis by Wednesday. Fucked up.

Holy sh*t (It´s close to dinner here, bruv ) ! Just as some Euro geezer asked the other day : " What kind of drugs do you get in the USA ?Or maybe sth in the water ,perhaps ? " . This being his reaction ,all shocked at the effect reported by some American lad to drug X ( name evades me now ) .
Then there´s the " different folk, different strokes" ( no pun intended ) factor, of course .

The hideous picture you just painted would be justifiable if we would be discussing sth such as MDPV in here ...it is truly incredible how compulsive, more -ish, insidious that substance can be once you decide to use IV (or even plain old foil) as your ROA.
Having said that ... Bupoprion (w t f )? I do believe you ,of course. Why would you bother to type what you just did ( well, unless under the influence of PeeVee and no other source of focus/entertainment available ) otherwise ?
Whether I believe you or not is hardly the question here: basically, I feel , based on personal experience ,that Wellbutrin can be EXTREMELY beneficial if not abused in any way, shape or form . Just take your 150mgs/300mgs ( orally/once per day ) and chances are you will get very positive results from it ( and no, not getting sponsored by GSK pharms here ) .
When I say beneficial let me explain what it did for me 15 years ago or so :
- Only anti depressant which had instant ( by this I mean in 45 minutes after taking my 1st 150 mgs pill orally ) effect on the way I was feeling - increased motivation, happiness, joy ( all synonyms but just to reinforce its benefits ). Fog dissipated to a large extent, sth which never had happened with any other prescribed anti depressant ...not even close . Again ,another instant effect. I could also see things brighter as you do in ,say, some molly come up.
- Perhaps the most important benefit was the following: within less than 24 hours I went from 2 - 3 packs of cigs a day to Zero -it was simply impossible to smoke since it tasked rank ,like I was smoking fake Pall Mall or sth along those lines ...worse actually, no words to how smoking feel while on Wellbutrin. No cravings for it either ...it basically cured me of tabagism - again instantly.
- Related to the 1st one ( and then I´ll quit this rather tedious rambling ) :I was again able to pursue things I used to love -it gave my social life back , back to doing sports , hobbies too, lost weight while on it ... 1 year later i was basically drug free and relying on the many joys of life without any chemical .
MDPV , a stimulant like that definitely , took me down the dark path you describe, fortunately , even though I´m an idiot ,I soon became aware where I was heading ...again ...with MDPV came Heroin back into my life again.
Are you old enough to remember when these things were sold in the internet by the grams ?As if you had ordered Aspirin from Amazon ? You do ? Alright ,so the following will not sound far fetched to you .
I just had the good sense to go and get rid of one of those big 10g(s) bags I had just ordered cause my behaviour was bordering plain Lunacy . A drug like THAT , yeah, I can see how you can loose your penis over it ( not from IVing it though ) ,but Bupropion ?
As I said above, we are all different ...the only time I crushed and snorted it with my partner att ( we had run out of coke and were fiending hard in the middle of the night ), having snorted it felt revolting to both of us -as I said , like smoking crack for the anxiety and paranoia with a few seconds of stimulation a couple minutes after inhaling it (if memory serves ) .
Impressive story up there ...may your post and mine even things out for anybody who is considering getting on Wellbutrin for depression ...distilling both our posts we have Common sense :" Orally as prescribed, no addict behaviours ...trust your GP) .
Over Wellbutrin ...over Wellbutrin ...and here I was ,convinced that I had seen some of the most horrific things addiction can cause in an individual .
Thanks for typing that! As out there and surreal as it may sound it is dissuasive to people who may be about to start abusing that "drug"/med in such way(s) .

 

[Jabberwocky]

Snorted bupropion almost destroyed my sense of smell completely. My nose was bleeding blood almost a month every day. And bupropion destroyed my veins, most of them. Shitty drug, great medicine.

 

[packjamNL]

I will get Bupropion for my nicotine addiction, I am tired of it, I get patches 21mg, chewing gum 2mg, I can take 4 gums, but I eat the whole 12 strip in a day. The patches have a succes rate of 26%, quiting with Bupropion it's 50%, I haven't read all the posts, but does anybody have a good experience with Bupropion when it comes to quit smoking?

 

[Jabberwocky]

I will get Bupropion for my nicotine addiction, I am tired of it, I get patches 21mg, chewing gum 2mg, I can take 4 gums, but I eat the whole 12 strip in a day. The patches have a succes rate of 26%, quiting with Bupropion it's 50%, I haven't read all the posts, but does anybody have a good experience with Bupropion when it comes to quit smoking?

I have a good experience with bupropion and quitting cigarettes few years ago. It really helps with The cravings and it actually makes you want to smoke less and less.

 

[Smuck_Hey_Dee_Hewitt]

Speak of Bupropion ,I´ve came across an expired (still sealed though ) bottle of Wellbutrin. Says It´s expired in mid 2021 ,I´m thinking of taking it instead of the Bupre I´m currently on , and about to jump off entirely altogether, yet, am afraid and anxious about the Bupropion being off or sth wrong with its time release mechanism etc ...
Would appreciate if any of you could share their knowledge on the subject .

 

[kiz]

I was prescribed bupropion for depression (started at 50mg went to 150mg) and was on it for about 2 months before stopping by myself (no WD I could notice) since I couldn't feel any emotions...like at all. Other negative symptoms included lack of regard for consequences (I say this as a generally very risk averse person), killed my appetite, shaky hands, lightheadedness with any abrupt movement... personally cannot imagine ever using it for enjoyment/entertainment

 

[SpiralusSancti]

I think bupropion is ok as ad or for stopping smoking and rather shitty as recreational drug.

 

[Smuck_Hey_Dee_Hewitt]

I will get Bupropion for my nicotine addiction, I am tired of it, I get patches 21mg, chewing gum 2mg, I can take 4 gums, but I eat the whole 12 strip in a day. The patches have a succes rate of 26%, quiting with Bupropion it's 50%, I haven't read all the posts, but does anybody have a good experience with Bupropion when it comes to quit smoking?

From a 20+ years , 2 -3 packs/daily ( later stages ) habit to 0 in less than a week . That is my experience with it ,and the irony is I wasn´t prescribed Wellbutrin with that purpose in mind (PAWs induced Depression rather ) .
10+ years have passed ,the odd drunken drag here and there -all dizzy and same repulsion as when you 1st tried smoking as a child out of peer pressure .
Others state they manage to smoke on Wellbutrin -"inconceivable " would be the perfect word for that ...

 

[plumbus-nine]

Never used bupropion for the reason of stopping cigarettes but dextromethorphan and memantine which both antagonize the same nicotinic acetylcholine receptor indeed stop any pleasure from smoking, suddenly I'd realize how stupid and stinky it was to smoke and had no more desire to do it. I think one needs to stay on the drug until the habituation goes or one will start again though.

 

[Kimock Is Da Mon]

What withdrawal symptoms do you get?

Bupropion wasn't that addictive for me, had no problems kicking it, but it was quite compulsive when snorted. And an entirely different drug when combined with dextromethorphan (just 100mg XR/d and 150mg XR bupropion). More stimulating than amphetamine even, but more chilled. It's a "real" drug for sure, but on itself boring.

FYI I just learned that buproprion combined with DXM and marketed under the name Auvelity is a new miracle treatment for depression. Heard it from a pysch nurse, and was looking to get it prescribed, but it cost more than $1,000 a month. According to the nurse, it works within 1-2 weeks, and is a total game changer. Was wondering what a good dosage might be, and saw your post.

Can you pretty please elaborate on how you combined the two, your dosage, and ROA? Thanks, and you may have unlocked a work- around to the latest new med for intractable depression!

 

[drewbocop]

FYI I just learned that buproprion combined with DXM and marketed under the name Auvelity is a new miracle treatment for depression. Heard it from a pysch nurse, and was looking to get it prescribed, but it cost more than $1,000 a month. According to the nurse, it works within 1-2 weeks, and is a total game changer. Was wondering what a good dosage might be, and saw your post.

Can you pretty please elaborate on how you combined the two, your dosage, and ROA? Thanks, and you may have unlocked a work- around to the latest new med for intractable depression!

Sorry for the ancient bump, but I was searching for another thread and saw this. They are shilling that drug on "TV" like mad now. And by TV, I of course mean the ads that are run on cheap streaming services. I find it so hilarious they are taking two drugs, one of which is OTC and the other which has been available for practically free in generic form for decades, mix them together, and charge 1000 bucks for a name brand "new" drug... What a world.

 

[TheGyattDamnRizzler]

I love that people are raw dogging buporion its so wild.

 

[ksi]

I've never been addicted to stimulants. I've used plenty of different stimulants, but they were never more than 5% of my total drug usage at most. This is relevant as I've tried insufflating Bupropion on a one-off, let me see what this is all about basis, only to find myself sniffing more and more compulsively until finally having a tonic-clonic seizure. I was pretty stunned by how my willpower was completely non-existent throughout the experience. I knew enough about Bupropion to know that something terrible was going to happen if I didn't stop, yet I didn't.

That’s interesting and also counts as a warning to snort the same dosage as you take orally.
Ow and thanks for bumping haha.

As I understand bupropion undergoes extensive first pass metabolism. Snorting will give you an overdose really quickly. If you take this orally it works slower and less intense (obviously). The blood levels of bupropion are way lower that way.

 

[chippermonk]

Bupropion inhibts afaik 2D6 and 3A4. This will interfere with codeine and tramadol but not e.g. morphine or methadone.

Off topic, but kratom also inhibits cyp2D6 cyp3A4, which affects the actions of many drugs

 

[headshrinker89]

What is going with all these bupropion threads? Is there a bupropion epidemic?
I started experimenting with it out of curiosity—big mistake. Luckily, I never had a seizure, but I think I came close. I also believe that bupropion-induced seizures are pretty nasty, and sometimes you can have multiple ones.

 

[notsmokeymcpot42088]

I love that people are raw dogging buporion its so wild.

I DO NOT LOVE IT and wish people just had access to something decent that didnt tear they body and mind up

 

[notsmokeymcpot42088]

What is going with all these bupropion threads? Is there a bupropion epidemic?
I started experimenting with it out of curiosity—big mistake. Luckily, I never had a seizure, but I think I came close. I also believe that bupropion-induced seizures are pretty nasty, and sometimes you can have multiple ones.

FR do we need a buproprion mega thread that eventually goes to the hall of shame?

ps I have never had a seizure either despite TREMENDOUS benzo addiction, opiate addiction, smoking a shite ton of pot and hash and hypothetically fuxxing with almost the circa 2010 RC's -- the kind of benzo #'s even BL said "Go to the ER you gunna die" (Told you guys id be fine, have I mentioned I told ya so enough times yet...) --- oh fuck ya Im fine; before anyone gets a good one in.

My point is that this drug does not feel like peak harm reduction to me --- "Dont do it" is all I can say -- if ppl use it recreationally does it therefor now have a street value, trade that shit for something decent?

 

[Dextro .45]

Any walk-in clinic will script Bupropion for smoking cessation…..150mg XR or 300mg XR Wellbutrin

It isn’t a controlled substance or drug of abuse (per se) …..now go try to get a script of Ritalin (Methylphenidate) of Adderall / Dexedrine (Amphetamine)….good luck with that

Bupropion 150-300mg XR ……DOES have its places, I’ve used it for years. A decent stimulant & antidepressant, but it’s DAT affinity is low, and doesn’t inhibit 50% of DAT at therapeutic doses, not even close (20-30% Max in Massive doses) Methylphenidate inhibits DAT was past the 50% mark, 60-75% inhibition, and VERY Euphoric

Bupropion also had its seizure B.S. blown way outta proportion btw, but the word got around and damage done

a Beta-Ketone Amphetamine skelatal structure, and a substituted Cathinone…….in Cathinone it’s basically Khat or 4-MMC that have euphoric mood-boosting properties……Khat & 4-MMC.

Bupropion was pleasant in the sense that I was alert and enhanced vigilance with a mild uppity feeling that could be misunderstood for euphoria…when initiating treatment, which subsided in a week or two……Ritalin (Methylphenidate) is REAL euphoria at 60-70% DAT inhibition…..not 25% with Bupropion

PLUS Bupropion has robust anti-cholinergic properties, which is Very bad….Very. The coined “smart dumb drug” as AcetylCholine is an essential neurotransmitter for Memory & information retention, processing speed, and work recollection. I DID notice this….problems finding the right word, speaking issues that shouldn’t be happening, forgetting shit…..2-3 years of Bupropion took its toll……fuck that. Done.

Enter a real dopaminergic stimulant, Ritalin (Methylphenidate) for 20 years approximately now

Please don’t abuse Bupropion….. it’s a useful compound in the vault for days my real Amphetamines, Ritalin, Cocaine are finished and I require a subtle CNS stimulant to give me the necessary drive to get the day over with at work

 

[headshrinker89]

FR do we need a buproprion mega thread that eventually goes to the hall of shame?

ps I have never had a seizure either despite TREMENDOUS benzo addiction, opiate addiction, smoking a shite ton of pot and hash and hypothetically fuxxing with almost the circa 2010 RC's -- the kind of benzo #'s even BL said "Go to the ER you gunna die" (Told you guys id be fine, have I mentioned I told ya so enough times yet...) --- oh fuck ya Im fine; before anyone gets a good one in.

My point is that this drug does not feel like peak harm reduction to me --- "Dont do it" is all I can say -- if ppl use it recreationally does it therefor now have a street value, trade that shit for something decent?

I had two seizures from tramadol, but—curiously enough—never from bupropion. The tramadol seizuees were actually pretty stupid on my part, because I had just quit benzodiazepines cold turkey after taking them for a few months, and I didn't know that tramadol lowers the seizure threshold.
Yeah, please don't abuse this drug; it works quite well as an oral antidepressant, and it’s not worth wrecking your nose or veins for a five-minute high. I think a lot of us who have abused it did so out of curiosity and a lack of money or access to better stimulants. Where I live, you can't find Ritalin on the street and coke is more expensive, but I can buy bupropion at drugstores without a prescription for under $10.

 

[headshrinker89]

Any walk-in clinic will script Bupropion for smoking cessation…..150mg XR or 300mg XR Wellbutrin

It isn’t a controlled substance or drug of abuse (per se) …..now go try to get a script of Ritalin (Methylphenidate) of Adderall / Dexedrine (Amphetamine)….good luck with that

Bupropion 150-300mg XR ……DOES have its places, I’ve used it for years. A decent stimulant & antidepressant, but it’s DAT affinity is low, and doesn’t inhibit 50% of DAT at therapeutic doses, not even close (20-30% Max in Massive doses) Methylphenidate inhibits DAT was past the 50% mark, 60-75% inhibition, and VERY Euphoric

Bupropion also had its seizure B.S. blown way outta proportion btw, but the word got around and damage done

a Beta-Ketone Amphetamine skelatal structure, and a substituted Cathinone…….in Cathinone it’s basically Khat or 4-MMC that have euphoric mood-boosting properties……Khat & 4-MMC.

Bupropion was pleasant in the sense that I was alert and enhanced vigilance with a mild uppity feeling that could be misunderstood for euphoria…when initiating treatment, which subsided in a week or two……Ritalin (Methylphenidate) is REAL euphoria at 60-70% DAT inhibition…..not 25% with Bupropion

PLUS Bupropion has robust anti-cholinergic properties, which is Very bad….Very. The coined “smart dumb drug” as AcetylCholine is an essential neurotransmitter for Memory & information retention, processing speed, and work recollection. I DID notice this….problems finding the right word, speaking issues that shouldn’t be happening, forgetting shit…..2-3 years of Bupropion took its toll……fuck that. Done.

Enter a real dopaminergic stimulant, Ritalin (Methylphenidate) for 20 years approximately now

Please don’t abuse Bupropion….. it’s a useful compound in the vault for days my real Amphetamines, Ritalin, Cocaine are finished and I require a subtle CNS stimulant to give me the necessary drive to get the day over with at work

Well, the anticholinergic properties would explain why I would forget things when I was snorting large amounts. Also, I often ended up with slurred speech.
I don't think high DAT occupancy is necessarily required for reinforcing effects. DAT occupancy is only one variable; the rate of CNS exposure and the resulting rate of change in DAT occupancy/dopaminergic signaling may also matter. A relatively modest peak occupancy reached rapidly could theoretically produce a different behavioral effect than the same occupancy reached gradually. This could potentially help explain why changing the route of administration can alter the reinforcing properties of a drug without requiring extremely high DAT occupancy. In the case of bupropion, however, this remains a mechanistic hypothesis rather than evidence that intranasal administration produces a specific percentage of DAT occupancy.
Low affinity does not mean zero pharmacological effect; it means that higher concentrations are required to achieve a given receptor/transporter occupancy. The relevant question is therefore not only affinity, but also the concentration-time profile at the site of action.