💂‍♂️ UK 💂‍♂️ Pharma Connoisseurs - What are the best brands available in the UK

[Zopiclone bandit]

2. Pregabalin - always generic indian, but a few suppliers now are shipping "UK" pharma supplied brands, are they better?

IMHO & direct lived experience Indian Pregabalin has a kick to it the UK stuff lacks.

I have no idea how they cook that stuff up in India but I would shake their "Chef" by the hand, in my experience & I've done a few Indian Pregabalin kicks in in 30 mins unlike UK stuff that takes 90 mins & It'll take your legs right from under you.

 

[placebonaut]

IMHO & direct lived experience Indian Pregabalin has a kick to it the UK stuff lacks.

I have no idea how they cook that stuff up in India but I would shake their "Chef" by the hand, in my experience & I've done a few Indian Pregabalin kicks in in 30 mins unlike UK stuff that takes 90 mins & It'll take your legs right from under you.

hmm that's interesting

I've only ever had the HAB stuff and that takes 90 mins to kick in if swallowed, have you tried?

this metamed is from a newish pharma, been around since 2022, they're only doing pretty basic stuff and acting as a 3rd party manufacturer. I'm not holding my hopes up for anything spectacular but thought it was worth a try for a change.

 

[placebonaut]

Woukdnt touch SSRI-SNRIs ever again, ive tried must of what the doctors prescribe. The are poison and a SHIT nedication, ive just been on the phone and to the GP, they can offer SSRIS for my anxiety.... What sort of bull shit is that! FOR ONE - they take 6-8 weeks to starts properly working... Who can but up with crippling anxiety for that long - no wonder theres so many suicides. Whats wrong with Lorazepam on top on the SSRIs just until they 'start working' but taper off the lorazepam. Easy! It will be more comfortable aswell but no.

yeah, SSRI was no use to me, I had a short term issue and good reasons not to take them given the downsides.

just needed instant help

 

[4DQSAR]

I absolutely do not recommend ANY CNS depressant as time and time again clinicians are fed the same line 'non-addictive' and guess what?

https://michaellinnell.org.uk/michael_linnell_archive/mc_dermotts_guides/pdf/M6%20MCDERMOTT.pdf

The original 1993 edition was in truth out of date even when published (Palfium was a strictly 80s thing) but it got updated in 2010. It never contained chlormezanone simply because not even McDermott (or ML) had ever come across the stuff but my 1984 BNF certainly lists it as a sedative/muscle relaxant. I even asked my GP in the 80s and noted that they had never had cause to even consider prescribing the stuff. Had to look it up!

A quick Google will tell you that chlormezanone has a rare but particularly nasty side-effect. Now I sense that this MAY be due to sensitization but I say only MAY as I couldn't find case-studies that either supported or equally disputed my hypothesis.

But just like clomethazole (Heminevrin), for some reason chlormezanone has never been listed in the MoDA which is proof of nothing, given that LSD and heroin are both class A drugs. So it isn't safety!

The fact that it binds at the same site as the benzodiazepines thus is an allosteric modulator is no proof of inherent safety. In fact, especially given the typical prescription doses and the little I was able to infer suggests the chlormezanone acts in a manner similar to the barbiturates but is in fact LESS selective.

I hope you all take the time to read the booklet as I know ML does put in a tremendous amount of work to get it right, just as Dr. Nuke (RIP) did. They were always paranoid that they would get something wrong but in fact, I couldn't find fault in their works. That proves nothing - I am fallable; likely more than most.

 

[BadBoy377]

Woukdnt touch SSRI-SNRIs ever again, ive tried must of what the doctors prescribe. The are poison and a SHIT nedication, ive just been on the phone and to the GP, they can offer SSRIS for my anxiety.... What sort of bull shit is that! FOR ONE - they take 6-8 weeks to starts properly working... Who can but up with crippling anxiety for that long - no wonder theres so many suicides. Whats wrong with Lorazepam on top on the SSRIs just until they 'start working' but taper off the lorazepam. Easy! It will be more comfortable aswell but no.

Apparently anxiety can worsen with some SSRI's. I think there was a prescribing regime where docs would give low dose benzo at start SSRI to compensate for this.

 

[Zopiclone bandit]

I've only ever had the HAB stuff and that takes 90 mins to kick in if swallowed, have you tried?

What does HAB mean?
Yeah all my Pregab experiences they have taken 90 mins to start, only once when I was so hungry & had not eaten anything in 20 hours I took 2X 300mg in one go, that kicked in STRONG by 30 mins, by 45 mins I was "fackin moshed" on 'em.

 

[placebonaut]

What does HAB mean?
Yeah all my Pregab experiences they have taken 90 mins to start, only once when I was so hungry & had not eaten anything in 20 hours I took 2X 300mg in one go, that kicked in STRONG by 30 mins, by 45 mins I was "fackin moshed" on 'em.

HAB are an Indian pharma company

Hab Pharma

Hab Pharma

habpharma.com

 

[Zopiclone bandit]

HAB are an Indian pharma company

Hab Pharma

Hab Pharma

habpharma.com

You are well versed in Pregab abuse, I am still at Primary School compared to you.

Ever had RLS (Restless Leg Syndrome) from doing to much Pregab?
If you ever had an Opiate issue it's the same feeling you get in your legs, they twitch & feel like you have ants inside your skin, you CANNOT get away from the feeling inside them & it's a horrible thing to have.

I am starting to see the Darkside to Pregabs & it's not a nice picture.

 

[placebonaut]

thankfully I've managed to avoid abusing them too hard, managed to keep it to once a week.

yes I get RLS, not too bad that other people notice it though, I don't find it a big issue, pregab clear effects me in a different way to you, the RLS is much more a function of have loads of energy when I take pregab, shit I can clean the entire house and make a 3 course dinner for 10 people when I'm on it if I don't have a bit of diazapam to calm me down.

 

[Zopiclone bandit]

pregab clear effects me in a different way to you

I was just about to say that, is that normal in having such a huge gap in the effect it has on me compared to you?

a function of have loads of energy when I take pregab, shit I can clean the entire house and make a 3 course dinner for 10 people when I'm on it if I don't have a bit of diazapam to calm me down.

My God, for me it's hard to even stand up to take a piss.
The first thing I know they are working is they make my vision go a little weird, it's hard to express in words but it's like what I am viewing is a second behind the words being spoken.
The next thing I know is I feel my legs go "loose" if you ever had a Heroin or Opiate issue it's 100% the same feeling when you are dopesick & you have that 2nd line of Heroin, blow it out & you feel your legs go loose & you give praises to your dealer & God the Heroin is good quality.

You ever mixed Pregab with Opiates?
IMHO & Direct Lived Experience you let pregab kick in very well, say give it 2.5 hours after eating them then you smoke some good smack your head will be in your knees very soon & the whole day passes by in a blink, it's 11am & the sun is up, the next thing you know it's 4pm & then it's all of a sudden 11pm at night

 

[placebonaut]

I was just about to say that, is that normal in having such a huge gap in the effect it has on me compared to you?

IIRC I think pregab is 1 of those drugs known for producing a range of different effects in people.

even ignoring other tolerance/GABA you're taking/CNS differences.

something to do with difference in calcium channels between people I think, but will need someone with more knowledge than me to explain it!

My God, for me it's hard to even stand up to take a piss.
The first thing I know they are working is they make my vision go a little weird, it's hard to express in words but it's like what I am viewing is a second behind the words being spoken.

sounds a bit like the SOMA shuffle.

maybe I should give them a try with some mogadon!

The next thing I know is I feel my legs go "loose" if you ever had a Heroin or Opiate issue it's 100% the same feeling when you are dopesick & you have that 2nd line of Heroin, blow it out & you feel your legs go loose & you give praises to your dealer & God the Heroin is good quality.

You ever mixed Pregab with Opiates?
IMHO & Direct Lived Experience you let pregab kick in very well, say give it 2.5 hours after eating them then you smoke some good smack your head will be in your knees very soon & the whole day passes by in a blink, it's 11am & the sun is up, the next thing you know it's 4pm & then it's all of a sudden 11pm at night

never been an opiate user, I know I will like it too much!

saving it for a rainy day

 

[Zopiclone bandit]

maybe I should give them a try with some mogadon!

LMAO
My God that stuff sounds quite a Benzo.

I only found out a few days ago Mogadon is nitrazepam, it's been on my "bucket list" of drugs to try before I die since my mid teenage years. I had N,N DMT & 5-MeO-DMT on there too but I got to cross those both off a few years ago & the only one left was Mogadon. A random dog I spoke to a few days ago helped me out & I have access to a whole shop of Benzo type drugs now, it ranges from A-Z (alprazolam to zopiclone) so next payment off the sate I get 30 Mogadon at 5mg each. @Bleaney who seems to really know their stuff when it comes to Benzo drugs said about Mogadon a few days ago in reply to me & I saw a few posts made by @Shambles about that stuff too, he said it has some real length to the effects & from what he said the word "Mogadon" sounds 100% fitting, you can just see a guy totally "monged out" on that stuff.

never been an opiate user

My advice is if you never got into it DON'T try it.
I am so jealous of people who can eat 240mg of DHC & get fackin moshed, I can wash 240mg of DHC down with 40mg Oral Moprhine & start to sneeze, yawn, have RLS syndrome etc in less than 6 hours.
I have actually done that dose with the DHC & Morphine before a few times, all it did was stop me from being sick for a few hours.
I had 250mcg of NHS Fent I.V. when in hospital, the nurses were all shocked when I said I was in pain again after 3 hours of that dose, they gave me oral morphine too right after the I.V. shot of Fent, the one nurse said "anybody else would be sleeping yet this man is wide awake saying his in more pain after he has taken Fentanyl. It was at that moment I think they all twigged I have a huge tolerance for Heroin & they were quite shy about giving my more medicine "to help with the pain"

 

[Bleaney]

Thanks @Zopiclone bandit for your kind words. I'm no 'authority on the subject' but I'm often reading or listening to what other people have to say about various aspects and angles of the subject, and there's always something new to be learnt.

The best way I could describe things really, imho, is that Nitrazepam is to benzos, as whisky is to alcohol.

It's not just that they are often regarded as having the most powerful effects of their type, but imo Nitrazepam actually has a similar kind of kick and buzz to whisky imo. It's hard to put into words any further, but it definitely works much better as a 'once in a blue moon' thing, as it then seems to capture your GABA receptors by surprise, as if they have forgotten how to deal with it, and the buzz hits all the sweeter.

Same for whisky too tbh. Take those things too often though, and that magic quickly disappears.

You'd know about the risks of combining benzos with opiates. Especially if you don't have a benzo tolerance, I'd be wary about taking the Nitraz at the peak of any heroin dose. It'd probably be better and safer as a 'booster' when the peak of the heroin has subsided. Ideally totally seperately if possible, but then if you're in heroin W/D, the nitraz would probably do nothing but knock you out cold for several hours, depending on the dose.

@ everyone / anyone else reading; since this thread is about brands, has anyone found a good alternative brand of Nitrazepam, now that those huge, ever reliable, Arnite pills no longer seem to be available? For about 10 years they seemed to be the ONLY brand you could get, which was no problem as they were always great. But suddenly over the last year or so, not one vendor that I know of has the Arnites any more.

 

[BadBoy377]

Thanks @Zopiclone bandit for your kind words. I'm no 'authority on the subject' but I'm often reading or listening to what other people have to say about various aspects and angles of the subject, and there's always something new to be learnt.

The best way I could describe things really, imho, is that Nitrazepam is to benzos, as whisky is to alcohol.

It's not just that they are often regarded as having the most powerful effects of their type, but imo Nitrazepam actually has a similar kind of kick and buzz to whisky imo. It's hard to put into words any further, but it definitely works much better as a 'once in a blue moon' thing, as it then seems to capture your GABA receptors by surprise, as if they have forgotten how to deal with it, and the buzz hits all the sweeter.

Same for whisky too tbh. Take those things too often though, and that magic quickly disappears.

You'd know about the risks of combining benzos with opiates. Especially if you don't have a benzo tolerance, I'd be wary about taking the Nitraz at the peak of any heroin dose. It'd probably be better and safer as a 'booster' when the peak of the heroin has subsided. Ideally totally seperately if possible, but then if you're in heroin W/D, the nitraz would probably do nothing but knock you out cold for several hours, depending on the dose.

@ everyone / anyone else reading; since this thread is about brands, has anyone found a good alternative brand of Nitrazepam, now that those huge, ever reliable, Arnite pills no longer seem to be available? For about 10 years they seemed to be the ONLY brand you could get, which was no problem as they were always great. But suddenly over the last year or so, not one vendor that I know of has the Arnites any more.

I like Accord the best but can only get 5mg. They're decent.

The cheap Indian Elza 10mg and 5mg Noctin are alright. But given the chance I'd pay a little extra and get the Accord.

 

[placebonaut]

time to restock and have been doing a bit of AI research which I thought I'd share.

I'm just trying to figure out what the best quality is and frankly there's not enough trip reports/discussion/consensus and opinions are subjective.

so I asked AI what are the reg standards, how are they measured and what brands have reg approval.

here's the results for a few things, if there's no public data (lots missing from diazepam for example) then provided they have reg approval they must fall within certain specs to get a license, so you should know it's "about as good" as the OG

AUC = “How much you get overall”
Cmax = “How high it peaks”

Spoiler: Pregabalin

Manufacturer / product	AUC GMR	90% CI AUC	Cmax GMR	90% CI Cmax	UK reg status	EU reg status	USA reg status
Drugtech-Recalcine / Pregobin	~101%*	~98–104%	~98%*	~97–113%	Not established	Not established	Not established
Zentiva	101.84%	98.51–105.28%	98.00%	91.94–104.46%	Yes / national product	Yes	Not established
PT Dexa Medica / Leptica	101.54%	98.75–104.41%	104.19%	98.75–109.93%	Not established	Not established	Not established
Tecnimede / Sociedade Técnico Medicinal	101.54%	100.13–102.98%	99.29%	93.29–105.67%	EU/UK evidence; exact current UK product status product-dependent	Yes / national	Not established
Viatris / Mylan	99.54%	97.45–101.67%	98.13%	89.49–107.61%	Yes	Yes	Yes
Prelexa	99.57%	97.85–101.32%	100.56%	95.51–105.88%	European-market evidence	Yes / national	Not established
Pfizer / Lyrica †	100%	—	100%	—	Yes — originator	Yes — originator	Yes — originator
Pharmathen	Not numerically reported	Within 80–125%	Not numerically reported	Within 80–125%	European evidence	Yes / national	Not established
Pharmaline / Neurexal	Not numerically reported	Within 80–125%	Not numerically reported	Within 80–125%	Not established	National EU evidence	Not established
MSN / Pregabalin MSN	Not publicly located	Regulatory criterion	Not publicly located	Regulatory criterion	Yes — current UK product	European manufacturing evidence; exact EU product status product-dependent	Yes — MSN pregabalin products/history
Teva	Not publicly located	Regulatory criterion	Not publicly located	Regulatory criterion	Yes / product-dependent	Yes / national	Yes — FDA generic approval
Accord	Not publicly located	Regulatory criterion	Not publicly located	Regulatory criterion	Yes	Yes — EU generic	Yes / generic approvals
Sandoz	Not publicly located	Regulatory criterion	Not publicly located	Regulatory criterion	Yes / product-dependent	Yes, but product-specific status varies	Yes / US generics
Krka	Not publicly located	Regulatory criterion	Not publicly located	Regulatory criterion	Yes / national	Yes / national	Not established

Spoiler: Diazepam/Valium

UK 10 mg diazepam tablets​

Manufacturer / product	AUC GMR	90% CI AUC	Cmax GMR	90% CI Cmax	UK reg status	EU reg status	USA reg status
Valium — Roche/Pfizer	100%†	—	100%†	—	Reference/originator	Reference/originator	Reference/originator
Milpharm Ltd	Not publicly located	—	Not publicly located	—	Approved — PL 16336/0840	Not established	Not established
Accord-UK Ltd	Not publicly located	—	Not publicly located	—	UK-approved/current supplier	Not established	Not established
Teva UK Ltd	Not publicly located	—	Not publicly located	—	Approved — PL 00287/0166	Not established	Yes — US generic
Sovereign Medical / Waymade	Not publicly located	—	Not publicly located	—	Approved — PL 06464/1402	Not established	Not established
A A H Pharmaceuticals Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Alliance Healthcare (Distribution) Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Almus Pharmaceuticals Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Phoenix Healthcare Distribution Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
DE Pharmaceuticals	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Crescent Pharma Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Sigma Pharmaceuticals Plc	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Medihealth (Northern) Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
IVAX Pharmaceuticals UK Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Yes — US/Teva history
Viatris UK Healthcare Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Yes — US generic presence
Kent Pharma (UK) Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Sun Pharma UK Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Yes — US generic presence
DDSA Pharmaceuticals / Tensium	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Arrow Generics Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established
Dr Reddy's Laboratories (UK) Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Yes — US generic presence
Wockhardt UK Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Yes — US presence
Mawdsley-Brooks & Company Ltd	Not publicly located	—	Not publicly located	—	UK product/supplier	Not established	Not established

Spoiler: Clonazepam

Clonazepam — UK-approved tablet products

Manufacturer / product	Strength	AUC GMR	90% CI AUC	Cmax GMR	90% CI Cmax	UK reg status	EU reg status	USA reg status
Sanofi-Aventis de Colombia — generic clonazepam	2 mg	102.50%	99.87–105.19%	103.28%	98.10–108.64%	Not established	Not established	Not established
Rivotril — Roche †	2 mg	100%†	—	100%†	—	Reference/originator	Reference/originator	Reference/originator
Aristo Pharma — Clonazepam Aristo	0.5 / 2 mg	Not publicly located	—	Not publicly located	—	Approved — PL 40546/0234, /0235	Product-dependent	Not established
Celix Pharma — Clonazepam Celix	0.5 / 2 mg	Not publicly located	—	Not publicly located	—	Approved — PL 53835/0025, /0026	Product-dependent	Not established
Neuraxpharm UK — Clonazepam Neuraxpharm	0.5 / 1 / 2 mg	Not publicly located	—	Not publicly located	—	Approved — PL 49718/0062, /0061, /0060	Product-dependent	Not established
Roma Pharmaceuticals — Clonazepam Roma	0.5 / 2 mg	Not publicly located	—	Not publicly located	—	UK-approved/current	Product-dependent	Not established

Spoiler: Xanax/Alprazolam

Alprazolam — published manufacturer / regulatory evidence​

Manufacturer / product	Formulation	Strength(s) documented	AUC GMR / ratio	Cmax GMR / ratio	UK reg status	EU/EEA reg status	USA reg status
Xanax — Upjohn / Pfizer / Viatris	IR tablet	0.25, 0.5, 1, 2 mg*	100% reference	100% reference	Approved — current UK Xanax 0.25 & 0.5 mg	Approved/reference product in multiple EU states	Approved/reference
Alprazolam Hexal — Hexal AG / Sandoz	IR tablet	0.25, 0.5, 1 mg	96% (90% CI 92–99.6%)	103% (95–112%)	Not currently identified	Approved — EU DCP; Netherlands/Ireland etc.	Not established
TEVA-ALPRAZOLAM — Teva	IR tablet	0.5 mg documented	101%	100%	Not currently identified	National approvals documented, including Canada/EU-linked products	Generic alprazolam approvals exist, manufacturer-specific status varies by ANDA
NTP-ALPRAZOLAM — Teva Canada / Nu-Pharm lineage	IR tablet	0.5 mg	101%	100%	—	—	—
Alprazolam — Geneva Pharmaceuticals / Sandoz	IR tablet	1 mg	BE study vs Xanax	BE study vs Xanax	—	—	FDA generic development/approval history documented
Alprazolam — Geneva Pharmaceuticals / Sandoz	IR tablet	2 mg	BE study vs Xanax	BE study vs Xanax	—	—	FDA generic development/approval history documented
Alprazolam Orion — Orion Corporation	IR tablet	0.25, 0.5, 1 mg	BE study vs Xanax; numerical results not publicly posted in registry	Same	—	Approved — e.g. Sweden; MR/DCP history	—
Niravam — Schwarz Pharma	ODT	0.25, 0.5, 1, 2 mg	BE vs Xanax; within 80–125% CI	BE vs Xanax; within 80–125% CI	—	—	FDA approved NDA
Alprazolam ODT — Kali Laboratories	ODT	0.25, 0.5, 1, 2 mg	BE vs Niravam/Xanax pathway	BE vs Niravam/Xanax pathway	—	—	FDA ANDA documented
Actavis Elizabeth	XR tablet	0.5, 1, 2, 3 mg	FDA BE/TE approval	FDA BE/TE approval	—	—	FDA approved generic Xanax XR
Amneal Pharmaceuticals NY	XR tablet	0.5, 1, 2, 3 mg	FDA BE/TE approval	FDA BE/TE approval	—	—	FDA approved generic Xanax XR
Aurobindo Pharma	XR tablet	0.5, 1, 2, 3 mg	FDA BE/TE approval	FDA BE/TE approval	—	—	FDA approved generic Xanax XR
Anchen Pharmaceuticals	XR tablet	0.5, 1, 2, 3 mg	FDA BE/TE approval	FDA BE/TE approval	—	—	FDA approved generic Xanax XR
Apotex	XR tablet	0.5, 1, 2, 3 mg	FDA BE/TE approval	FDA BE/TE approval	—	—	FDA approved generic Xanax XR
Upjohn / Pfizer — Xanax XR	XR tablet	0.5, 1, 2, 3 mg	100% reference	100% reference	—	EU national approvals historically documented	FDA reference listed drug

Spoiler: Zolpidem

Manufacturer / product	Formulation	Strength(s)	AUC GMR / ratio	Cmax GMR / ratio	UK reg status	EU/EEA reg status	USA reg status
Ambien — Sanofi	IR tablet	5, 10 mg	100% reference	100% reference	Not UK reference product	National products	FDA reference product
Torrent Pharmaceuticals	IR tablet	10 mg	BE study vs Ambien; numerical GMR not located	BE study vs Ambien; numerical GMR not located	—	—	FDA generic development/approval evidence
Zolpidem generic — multiple manufacturers	IR tablet	5, 10 mg	Manufacturer-specific	Manufacturer-specific	Generic zolpidem products approved	Multiple national approvals	Multiple FDA ANDAs
Zolpidem ER — multiple manufacturers	ER tablet	6.25, 12.5 mg	Partial-AUC BE required	Partial-AUC BE required	Market-dependent	National approvals	FDA-approved generics
Brazilian 5 mg ODT formulation	ODT	5 mg	97.44% (91.85–103.37%)	99.73% (93.69–106.16%)	Not established	Not established	Not established
Patz SL reference	Sublingual	5 mg	100% reference	100% reference	—	—	Reference in Brazilian study

Spoiler: Gabapentin

Manufacturer / product	Formulation	All documented strengths	AUC GMR / ratio	Cmax GMR / ratio	UK reg status	EU/EEA reg status	USA reg status
Neurontin — Pfizer/Parke-Davis	Capsules/tablets/solution	100, 300, 400, 600, 800 mg; 250 mg/5 mL solution	100% reference	100% reference	Approved	Approved	FDA reference
Aurobindo / Milpharm	Capsules/tablets	100, 300, 400, 600, 800 mg	Not publicly located by manufacturer	Not publicly located	Approved	Approved in European markets	FDA generic products
Morningside Healthcare	Capsules	100, 300 mg	Not publicly located	Not publicly located	Approved	—	—
Strides Pharma UK	Capsules	100 mg	Not publicly located	Not publicly located	Approved	—	—
Amarox	Capsules	100, 300 mg	Not publicly located	Not publicly located	Approved	—	—
Tecnimede	Capsules	400 mg study	~101–106% depending parameter	~102%	—	Approved/national products	—
Biosintética	Capsule	300 mg	AUC 101.7%*	100.0%*	—	—	—
Sandoz — Gabasandoz	Tablet	800 mg	BE to Neurontin demonstrated	BE demonstrated	—	Approved	—
Sun Pharma — Gabantin GRS	ER tablet	600 mg	91.71% (82.60–101.83%)	91.35% (83.24–100.26%)	—	—	ER product/regulatory development documented

Spoiler: Ritalin

Manufacturer / product	Formulation	All documented strengths	AUC GMR / ratio	Cmax GMR / ratio	UK reg status	EU/EEA reg status	USA reg status
Ritalin — Novartis	IR tablet	5, 10, 20 mg	100% reference	100% reference	Approved	Approved	Reference/history
Concerta — Janssen	ER tablet	18, 27, 36, 54 mg	100% reference	100% reference	Approved	Approved	FDA reference
Concerta/generic ER — multiple manufacturers	ER tablet	18, 27, 36, 54, 72 mg	Manufacturer-specific	Manufacturer-specific	Approved generics	Multiple approvals	FDA generics
Adium — Consiv	Multiphasic ER	54 mg study; marketed strengths vary	BE demonstrated	BE demonstrated	—	—	—
Generic IR methylphenidate	IR tablet	5, 10, 20 mg	BE demonstrated in individual studies	BE demonstrated	Approved	Multiple national approvals	Multiple ANDAs
Ritalin LA — Novartis	Modified-release capsule	10, 20, 30, 40 mg	Formulation-specific	Formulation-specific	Approved	Approved	Approved/reference

Spoiler: Adderall

Manufacturer / product	Formulation	All documented strengths	AUC GMR / ratio	Cmax GMR / ratio	UK reg status	EU/EEA reg status	USA reg status
Adderall — Teva/Shire	IR mixed amphetamine salts	5, 7.5, 10, 12.5, 15, 20, 30 mg	100% reference	100% reference	Not currently UK-marketed	Limited/national	FDA approved
Adderall XR — Shire/Takeda	ER mixed amphetamine salts	5, 10, 15, 20, 25, 30 mg	100% reference	100% reference	Not currently UK-marketed	Limited/national	FDA reference
Generic mixed amphetamine salts ER — multiple manufacturers	ER	5, 10, 15, 20, 25, 30 mg	Manufacturer-specific	Manufacturer-specific	—	—	FDA-approved generics
Pharmascience pms-AMPHETAMINES XR	ER mixed amphetamine salts	30 mg BE study	99.9% AUC∞ for L-amphetamine	108.2% L-amphetamine	—	—	Canadian approval
AR19 / Tris Pharma	ER amphetamine sulfate	5–30 mg studied	BE demonstrated	BE demonstrated	—	—	Development/US regulatory evidence
Amphetamine sulfate generics	IR	5, 10, 15, 20, 30 mg	Manufacturer-specific	Manufacturer-specific	—	—	FDA-approved

Spoiler: Soma/Carisoprodol

Manufacturer / product	Formulation	All documented strengths	AUC GMR / ratio	Cmax GMR / ratio	UK reg status	EU/EEA reg status	USA reg status
Soma — Wallace/MedPointe	IR tablet	250, 350 mg	100% reference	100% reference	Not approved/currently marketed	Not generally authorised	US reference/history
Qualitest / Vintage	IR tablet	350 mg	BE data not publicly located	Not publicly located	—	—	FDA generic
Dispensing Solutions	IR tablet	350 mg	Not publicly located	Not publicly located	—	—	FDA generic
Granulation Technology	IR tablet	350 mg	Not publicly located	Not publicly located	—	—	FDA generic
Other US generic manufacturers	IR tablet	250, 350 mg	Manufacturer-specific	Manufacturer-specific	—	—	FDA-approved products

Spoiler: Explanation of AUC and cMax

* For Drugtech-Recalcine, the published paperreports the 90% CIs but does not explicitly give the geometric meanratios in the abstract; the approximate values are inferred fromreported means, so they should not be treated as directly reportedGMRs.
† Lyrica is the reference/originator, so 100%is shown only as the mathematical Test/Reference baseline. It is nota bioequivalence result, hence no CI.

What do AUC and Cmax mean?​

AUC — Area Under the Curve
AUC represents the total amount of pregabalin exposure inthe bloodstream over time.
Think of it as the overall “exposure” to the drug:

• Higher AUC →greater overall systemic exposure.
• Lower AUC →lower overall systemic exposure.
• In a bioequivalence study, AUC primarily assesses theextent of absorption.

For example, an AUC GMR of 101.54% means the testproduct's estimated exposure was about 1.54% higher than thereference on a geometric-mean basis.
Cmax — Maximum Concentration
Cmax is the highest measured concentration of pregabalinin the blood after the dose.
It mainly reflects the rate of absorption:

• Higher Cmax → drug reaches ahigher peak concentration.
• Lower Cmax → lower peakconcentration.
• Cmax generally occurs around the Tmax (timeto maximum concentration).

So, for the PT Dexa Medica example:

• AUC GMR = 101.54%→ overall exposure was very close to Lyrica.
• Cmax GMR = 104.19%→ peak concentration was about 4.2% higher.
• Most importantly, the 90% CIs for both remainedcomfortably inside 80–125%, which is what supportsbioequivalence.

The key point about the 80–125% rule​

The 80–125% range applies to the 90% confidenceinterval, not simply to the observed GMR.
For example:

AUC GMR = 101.54%
90% CI = 98.75–104.41%

This is an especially tight result because the entire confidenceinterval is very close to 100%.
Likewise, Cmax = 98.13%, CI 89.49–107.61% forViatris/Mylan still passes comfortably: although Cmax has morevariability than AUC, its entire 90% CI remains within the regulatoryacceptance interval.

 

[Ismene2]

I hve tried adormorfinal - one tablet of an indian generic kept me from sleeping for 48 hours and gave me the most painful headache ive ever felt. On the instructions booklet it says "One of our chemists slipped over and lost both of his sandals into the vat where they instantly melted in a cloud of bubbles. They were a present from his mother so we left them in the final concoction. The leather may cause extra stimulation and headaches"

 

[placebonaut]

more digging and here's a very useful resource

AUC and Cmax for uk authorised drugs can be searched directly on the .gov site, just select Public Assessment Reports (PAR) when you search for a specific drug and manufacturer

Diazepam from accord as an example

MHRA Products | Search results

gives this data

https://mhraproducts4853.blob.core.windows.net/docs/fb30ecf712531226770179990678677d1166a0dd

AUC is 103.2% and Cmax 100.5% against Valium as a baseline, Accord's a good one!

 

[Perkins : Reborn]

All I'm trying to say that is if you're looking for visuals, you're probably dosing too high.

 

[placebonaut]

All I'm trying to say that is if you're looking for visuals, you're probably dosing too high.

did you mean this for the preg thread?

if you are talking about preg visuals, sometimes it's good to push it that hard, it's fun, OEV with practically no headspace, is it too high a dose? hmm, maybe, I don't know, but it feels fine and within my limits from my experience

 

[Perkins : Reborn]

did you mean this for the preg thread?

if you are talking about preg visuals, sometimes it's good to push it that hard, it's fun, OEV with practically no headspace, is it too high a dose? hmm, maybe, I don't know, but it feels fine and within my limits from my experience

I just find it a bit boring.