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RCs Is there actually a stimulant out there more potent and euphoric than pure MDPV? Is that even possible?

SealSlapper

Bluelighter
Joined
Jan 30, 2025
Messages
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Location
United States
Listen, I don't think anybody who likes stims really needs anything more potent than MDPV. MDPV is basically the Godzilla of stimulants, but I'm asking out of pure curiosity. Some people say MDPV is more Euphoric and addictive than even meth, which is already an ultra potent drug. To me that is pretty bonkers, but also deeply interesting. Is there any stimulant out there that is actually more potent than MDPV. I don't really need to try anything more potent, as it would probably kill you or fry your brain, but I'm asking out of curiosity. Just let me know. I'm a huge nerd when it comes to drug shit so...
 
Have you tried it? It it massively addicting, causing compulsive redoing after the first hit, and it lasts a long time, and it doesn’t have the euphoric rush of something like methamphetamine.
I had the misfortune of having a large amount of it pre-ban, and I could never find the punch-line no matter how long I chased the high. When I started to inject it, I became psychotic and delusional. I still think methamphetamine, preferably IV, is a really good rush. Cocaine is better, but doesn’t last as long. Alpha PVP also have a good rush, as does NEP and NEB. MDPV has no rush, no matter what the route. It is, however, unique in its creepiness. It made me feel like I was possessed, moreso than any drug I ever took. It was like there was some malevolent, hedonistic entity pushing me to smoke a little more, and then banging at the door, walking around in the hall adjacent to my room, and making me feel like any second, someone was going to burst in, guns blazing. I spent more time fearing the shadow-people than actually enjoying the high. It really has no redeeming qualities.
 
i think any of the unmethylated MDA and its analogies are more euphoric. MDA. 6adpb, 6 apb.

and then there is crack. most intense rush by far.
 
i think any of the unmethylated MDA and its analogies are more euphoric. MDA. 6adpb, 6 apb.

and then there is crack. most intense rush by far.
Are you 100% sure about that? I thought MDPV would be more intense than crack given its dopamine agonist effect that elevates your dopamine 1400% over the baseline. Which is fucking unreal btw.
 
Have you tried it? It it massively addicting, causing compulsive redoing after the first hit, and it lasts a long time, and it doesn’t have the euphoric rush of something like methamphetamine.
I had the misfortune of having a large amount of it pre-ban, and I could never find the punch-line no matter how long I chased the high. When I started to inject it, I became psychotic and delusional. I still think methamphetamine, preferably IV, is a really good rush. Cocaine is better, but doesn’t last as long. Alpha PVP also have a good rush, as does NEP and NEB. MDPV has no rush, no matter what the route. It is, however, unique in its creepiness. It made me feel like I was possessed, moreso than any drug I ever took. It was like there was some malevolent, hedonistic entity pushing me to smoke a little more, and then banging at the door, walking around in the hall adjacent to my room, and making me feel like any second, someone was going to burst in, guns blazing. I spent more time fearing the shadow-people than actually enjoying the high. It really has no redeeming qualities.
This is an interesting take. I might try it some day just to see what it feels like as I am a psychonaut druggie who would like to experience every single drug (with some exceptions like Xylazine or Krokodil or Carfentanyl) so I can know how they feel and write a book or journal about it maybe.
 
General Alcazar's whole post is gold. It made me laugh and brought back memories. I did some MDPV back in the day but personally preferred a-PVP and did a boatload of it. I think much of what the General said is applicable to a-PVP as well.

I could never find the punch-line no matter how long I chased the high.

This is such a great way of putting it. Succinct and relatable. I think you the user becomes the punchline in a binge of MDPV/a-PVP.

I spent more time fearing the shadow-people than actually enjoying the high.

This is so true. The epic a-PVP binges I had were some of the worst experiences of my life. It was hideously uncomfortable but also the most compulsive thing I've ever done. Even when meta-cognition was intact and I was aware that I was just destroying my mind and body, I could not stop lighting up the glass pipe every 4 to 5 minutes. It was pure compulsion. I was the rat in the experiment, pushing the reward button over and over even though the 'reward' system was broken, overloaded.

I haven't smoked a-PVP for about 15 years, yet I still have dreams about it sometimes and even the dreams are characterised by frustration. The dreams usually start with a surprise finding of some a-PVP at the back of a cupboard or in a shoe or somewhere (probably because I used to hide it everywhere). Then I'll find myself loading a glass pipe and there's an overwhelming sense of anticipation. However, when it's time to fire that thing up, the lighter won't work or there will be continuous gusts of wind making it impossible to light up. And that's how the dreams go!

I might try it some day just to see what it feels like

I wouldn't recommend it to anyone, but if you have to do it I would suggest only buying 100-200mg. And have heavy duty benzos to hand for the big ol' crash when you run out.
 
Is there any stimulant out there that is actually more potent than MDPV.
One man's meat is another man's poison. There is no "most addictive/euphoric/whatever" drug. Even the drugs that are typically considered "most addictive" are hardly universally so.

It's not even particularly helpful to think of drugs as *causing* addiction. And before people come at me, I was quite the enthusiastic little junkster in my day lol--nothing exceptional, but definitely enough! lol
I took wads of cash out my dad's fire safe to go to get bricks entirely for personal use from, err, I'll call him "Flaco". At my worst I was shooting a bundle at a time. I would take atenolol and some Klonopin so that I could eat Adderall until my vision whited out--yes, you can do that with dextroamphetamine. Doing a bundle per shot (NY/NJ in early 2000s) was no problem.

Now, fast forward to around 2012-2013 Some idiot moved into the flophouse I was living in, and he didn't have a mattress. Unbeknownst to us, he dragged some random thing in off the street. Well, he brought scabies and bedbugs into the damn house. I got bitten on one of my nuts, and it got infected. It was the most pain I have ever experienced. I was crying like a little child, begging "please help me". The resident looked me in the eyes and said "Don't worry, I GOT U." He made a gesture with his hand, and a nurse hung a bag of morphine, programmed the pump, and hooked it up to my catheter. The. dose was *HIGH*. I was nodding out all over the place at first lol. It was so bad that they actually convened a meeting of all the doctors on staff in that unit in some room (I saw them file in and out). Then he told me that they were discussing whether they should have me airlifted to a trauma center, because although they could do the surgery at that hospital if they had to, they didn't want to risk f-ing anything up because ... testicles. So he told me that they were just gonna keep me blitzed on morphine for 24 hours. blast me with as much vancomycin and some other IV antibiotic as they could, and "cross their fingers" that I wouldn't need surgery. I thought that seemed like a pretty good plan, cuz getting my nutsack cut open is something I've never been in a hurry to have happen, even under anesthesia. Well, it worked. I literally cried the next day thanking him, it was like 70%+ better.

So the reason I'm telling you this is because at that time, it had already been a year or two at least since I last used dope. See, I have treatment-resistant depression and really bad ADHD. There was a doctor in the public health system here who was also a psychopharmacology professor at the state medical school, and he actually cared enough to put me on 90mg/day of Nardil + 60mg/day of Dexedrine (it took 1.5 years to titrate the dose up that high because, you know, MAOI lol). That is oldschool shit that almost noone does anymore. Now he knew my drug history. But his deal with me was this:

"OK, I don't treat addicts. Its not that I have anything against them. It's that there are a lot of people out there who need someone who is gonna really TREAT them, and that is why I am in this business. So if you wanna use all these drugs, that's your choice. Just go take up one of the mediocre doctors' time, because I don't have it."

Of course, all I could do was thank him and say "I'll do whatever you want". And I meant it. So this is what he wanted: "OK. The licensing board is gonna wanna fry me when they see that I am prescribing the maximum off-label dose of dexedrine plus a fairly high dose of an irreversible MAOI TO a drug addict. I. would rather not deal with the deluge of phone calls that I'm about to get about this, but I know you need it and that there is no one else would ever touch this with a 10-foot pole. Therefore, this is what I am offering you:

-- You are no longer a drug addict in my book. I am wiping the slate clean. Whatever you did in the past will not influence what I prescribe you, how I view you, or anything.
-- Prepare to be drug tested. And I'm telling you right now, if you use, I WILL find out. You are a bad liar, but I'm also gonna request the absolute lowest cutoffs I can on these tests. You aren't just taking an ordinary GC/MS drug screen now. These are MY urine drug screens. I am going to call you at random times during the week, and tell you to come in. If you miss one without a good reason, we're done. I will NOT give you a second chance, because this IS your second chance. You are going to be drug tested as often as I feel I need to to be sure there's nothing in that plasma of yours that shouldn't be. It could be up to three times a week, but plan on twice for the forseeable future. This will continue until I am satisfied.
-- I'm sure you've been able to skirt drug tests before, because I know you know some pharmacology and how to manipulate people. I don't think you're stupid enough to REALLY think you can do that with me, but we'll see. Ball's in your court now. Good luck.

And that was the end of my junkie career. Done. Passed every single drug test. Never failed a drug since then. The prospect of never having access to the only meds that ever worked was so frightening it wasn't even difficult. So years later when I was in the hospital and HAD to have morphine, I was kinda nervous. And what happened stunned me:

I just didn't like it. I was wrecked on morphine (which is the same thing as being wrecked on heroin, really), and I didn't like it. I felt the same buzz, everything--it felt good. But it just didn't do it for me the way it used to. I actually was annoyed I was all spaced out and couldn't hit on the radiologist lol. When I was in my hospital bed, it was pleasant, to say thje least, but I would have felt better not being on it. Seriously. I was mindblown. I didn't even think that was a thing for me.

I know I'm long-winded, so I'll stop. This is my point: don't forget that the notion of "addiction" is meaningless without an environment, a life, etc. It is not something that happens to you. It is something you DO. It is, in effect, a choice. And talking about it as if it's like irreligious demon possession or something misses the mark because there is so much more involved. This isn't to say that it isn't ever a fight, or easy, or anything like that. What I'm saying is that it is all too easy to abstract away the real life, human aspect of this and get lost in the world of receptors and ligands and allosteric modulators and downregulation and cAMP and .. That is not he world we LIVE in.

I have *no* doubt that part of the reason I was able to do that is because I decided that there is absolutely no way I am gonna spit in the face of someone who was literally bending over backwards to help me in such a consequential way. It helped so much to know that he believed in me enough to go there. This was a clinic that took charity care and medicaid. His schedule was always 100% booked. He had no obligation to see me whatsoever. In fact, his schedule was technically completely booked according to the computer, but he overrode it.
 
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Are you 100% sure about that? I thought MDPV would be more intense than crack given its dopamine agonist effect that elevates your dopamine 1400% over the baseline. Which is fucking unreal btw.
crack is a dopamine and serotonin reuptake inhibitor so it’s a little different in terms of pharmacology.

i also think a rush is how fast you go from 0 to X value of dopamine (ie IV or smoking vs oral). this is why IV or smoking of any drugs is far more addictive than slower absorbing ROAs.

i couldn’t tell you too much about dopamine agonism by mdpv vs drugs that release dopamine. but you’re saying mdpv is a dopamine agonist - and also elevates your endogenous dopamine. those are two totally different things. in one case mdpv is binding to the dopamine receptor mimicking dopamine, in the other case it is releasing dopamine into the synapse by way of opening up DAT. so i’m a little confused about dopamine agonism by a drug increasing dopamine levels. there must be a dual mode of action for that to be true.

admittedly i never smoked or IVed mdpv so couldn’t tell you if its capable of producing a rush on cracks level
 
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Few things equate to the rush from free base or iv cocaine, shame it lasts so little time.
IV MDPV has no rush, but precipitates psychosis very rapidly. Not recommended.
 
Desoxypipradol is apparently very potent at the 1mg range, and has a very long duration.

Pipradol (Marketed like Ritalin) 4-6h
Desoxypipradol (researched by CIBA pharma but never brought to market) 16-24h
Methylphenidate (Ritalin) 3-4h

Methylphenidate was decided to be the superior drug by CIBA pharmaceuticals and marketed under the trade name Ritalin. There are several medical journal reviews comparing all three drugs

But ya…Ive heard by many that MDPV is very nice. Id rather try Methamphetamine any day, without a second thought I’d take a Desoxyn 5mg tablet, and take the adult dose of 5-25mg daily if need be. Apparently the cleanest, most pleasurable drug with very little to no cardiovascular payload in low therapeutic doses @ 5-25mg of pharmaceutical pure d-Desoxyephedrine HCL

I find Ritalin to be effective for general use, and is both pleasurable & safe for daily use
 
And that was the end of my junkie career.

Thanks for telling that story. That doctor was a gift and you were ready and willing to take the offer of help. This is a really interesting case and I feel like things would be so different if that opportunity you had was afforded to more people.

I'm glad it worked out and that you had the mental fortitude to take the offer of help and meet the challenge to turn things around.
 
Are you 100% sure about that? I thought MDPV would be more intense than crack given its dopamine agonist effect that elevates your dopamine 1400% over the baseline. Which is fucking unreal btw.
Everyone has a different reaction to these drugs one person might hate it the other might find it the most potent. Some people think cocaine is more potent than meth everyone's different the only way to be sure is too take it yourself
 
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