I'm going to try to summarize my relationship to the three substances you mentioned, DXM, ketamine and 3-MeO-PCP. I've used a tremendous amount of all three, and keep in mind that I am virtually immune to drug induced nausea for some peculiar reason, so if one is more nauseating than the other, I'll likely not have noticed.
3-MeO-PCP is probably my all time favorite dissociative. It lasts 3-4 hours, can be eaten, insufflated or smoked, and it has unironically saved my life through its positive impacts on my mental health. I almost always coadministered it with psychedelics like miprocin, DOM, LSD, 2C-B or other dissociatives like 2F-DCK and nitrous. The specific variety of mania induced by 3-MeO-PCP is one of the most intensely effective destroyers of depression I've ever come across, my first encounter with it had my fiance and I videocalling everybody we knew at some time like 3AM or 4AM just because we were so manic, we forgot that most of these folks were asleep and we just wanted to check in. It's an exceptionally empathogenic compound in a way that I rarely hear discussed. It's also pretty easy to hole out on this, I personally call holes induced by PCP (and PCP analogs) "the urethra", since saying "P-hole" (as a variant of K-hole) sounds foolish. Besides, it's kind of funny to say "Oh ignore him, he's stuck in the urethra" instead of "Oh he's stuck in a k-hole". The street lingo for it is just "stuck", I just find the aforementioned verbiage to be sort of comical. I wish there was a less alphabet-soup name for 3-MeO-PCP too, but the most obvious ones like "metamethoxyphencyclidine" are still an absolute mouthful. Breaking through and getting stuck on 3-MeO-PCP can be exceptionally intense, intense in a way that salvia and DMT do not even come close to. In lower doses, this drug is absolutely beyond useful, it's capable of replacing 5 separate antidepressants in people who have lost access to their meds back when covid fuckd up the supply chain, and I'd have them substitute with 3-MeO-PCP, and it worked every time. 2C-B also worked though, strangely enough. I prefer eating PCP the most, then insufflating it second, and smoking it third.
Ketamine is kind of the prototypical arylcyclohexylamine to most folks, and while it may be one of the only other dissociatives I can credit with genuinely saving my life through a cloud of seemingly insurmountable mental health issues, I prefer most other dissociatives over this one. Ketamine has a colder, less empathogenic, more drunken sort of vibe to it. It excels in lower doses, and the tolerance seems to form much faster than it does with other dissociatives. I could use a PCP analog daily for a few weeks before noticing even a tiny amount of tolerance, I can build a severe ketamine tolerance in a single night though. Ketamine also requires pretty monstrous doses, fitting enough ketamine in your nose to get to where you're trying to be can be quite challenging sometimes. Ketamine is a much more lowkey, calm sort of drug that I'd say is better for recreational applications when compared to PCP analogs. Ketamine also seemed more prone to inducing delusions that I actually acted upon, whereas PCP analogs more consistently rooted me back to objective reality in a way that kept me from doing things like waking my fiance up and telling him (while on 1.5 tenstrips of LSD and ~2/3 of a gram of ketamine) that a vision of my celtic ancestors told me that if somebody were to flick a ball bearing at the Queen of England's head (on the temple, specifically) with juuuuuust enough accuracy, she would essentially turn into a cloud of vapor, a fat W for Celts worldwide. By time I had said this, she had passed away months ago. That's the strange kind of delirium that ketamine can induce, whereas PCP analogs will just have me playing upright bass in a somewhat sloppy manner and trying to write code that when I look back at it sober, appears to have been written by a fucking gray alien or something. I have only ever used ketamine via intranasal administration.
DXM is one of the most fascinating drugs I've touched in my entire life, of any class at all. I consider it a dissociative first, a psychedelic second, and an empathogen third, and exceptionally few drugs can cover all three of those bases in a noticeable fashion. Most people get pretty nauseous off of DXM, only slightly off of ketamine, and not at all off of PCP analogs. DXM with nitrous is also one hell of a combo, but the asphyxiation risk is something to be seriously worried about given the possibility of choking on vomit while unconscious from the whippets. LSD or psychedelics alongside DXM are fascinating, though serotonin releasers (MDMA, MDA, 25X-NBXX, etc.) can easily be fatal alongside DXM, so be careful with those specific drugs in combination. MAOIs (harmaline, 5-MeO-DiPT, AMT, etc.) can also be dangerous given that DXM on its own is a serotonin releaser. Combining DXM with bupropion leads to a difference in metabolism which can make for quite an interesting experience, though I prefer DXM without bupropion, the combination is currently an antidepressant sold by big pharma under the name Auvelity. DXM can induce a mystical quality that no other dissociative outside of 3-HO-PCE or 3-MeO-PCP can in my opinion, and it's absolutely worth getting to know at least plateaus 1-3, the 4th can be a bit much for most and can lead to some truly outlandish and damaging behavior while blacked out, though if you have a safe environment and a tripsitter, 4th plateau DXM doses have the potential to be quite therapeutic in my opinion. I've only ever eaten DXM, though I am curious about whether or not extracted crystal DXM could be vaporized or insufflated.
If you have any further questions, feel free to ask! My apologies if the descriptions here are a little bit scattered, I just took some stimulants so my mind's racing around like crazy, and most of my experiences with 3-MeO-PCP and DXM were 3-5 years ago.