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  • BDD Moderators: Keif’ Richards

Opioids 10-325 Hydrocodone Acetaminophen Advice

Mr.805

Greenlighter
Joined
May 8, 2026
Messages
7
Hey all,

I am new here so if i am breaking any rules please let me know in terms of posting .

Recently i was bumped up from Tramadol to Hydros with Acetaminophen for various health issues which have resulted in quite a few surgeries . I take between 4-8 a day . Instead of spreading them out i tough it out and take them all at once for various reasons . With my tramadol it was no big deal but now that i recently started taking something with Acetaminophen i have been a bit more worried about my liver . I know if this was once or twice a month it would be no big deal . However, daily Acetaminophen at that level and at once to boot has to be rough on the liver over time .

I have been considering CWE method to help my liver out but i have heard it may be a bit of a waste since i wouldnt be CWE a ton of pills at once . Is there a CWE method for a lower amount of pills ? If so can anyone recommend anything to me ? Or is there maybe another method i could consider to separate the Acetaminophen out thats simple like CWE . I obviously can have some Acetaminophen i just dont think 2600 at once a day is a good idea .

I dont have a ton of other options for pain due to other meds i take . I have a PM doctor who is a nice lady but since i have pretty bad ADHD i am on Adderall XR as well so I cannot take Tramadol anymore or any other pain med that interacts poorly with ADHD meds. They were worried about increased risk of seizure .
Would love some advice on what to do in terms of keeping my liver healthy .

One last mention ... I have NAC supplement which i started taking just in case ? Maybe this cancels some of the Acetaminophen worries out ? But maybe thats not how that works .

Thanks in advance for the advice
 
You can take 2600mg acetaminophen daily for a long time but it will slowly damage your liver and colon. Spred it into 2 doses at least. 1300 is only 300 above max.single therapeutic dose.
 
Unless you already have issues with your liver taking that much paracetamol at once at weekly intervals shouldn't really cause any problems. As long as you're not exceeding 4g in a 24 hour period.

I don't really know about NAC but if you want to mitigate paracetamols effects on it you could take a methionine supplement the days you're taking the paracetamol. For liver protection from drugs and alcohol Milk Thistle is also a good option you could add in as well. Good for reducing the severity of hangovers too.

Obviously you could CWE extract too but you will lose a bit of product and it will probably get tiresome if you're doing it weekly.

It's also worth noting that Milk Thistle can affect the metabolism of some medications. So maybe worth checking it against any other meds you're on.

Assuming no liver issues though, if I were you, I'd just eat the pills as is. It shouldn't cause any issues once a week.
 
Unless you already have issues with your liver taking that much paracetamol at once at weekly intervals shouldn't really cause any problems. As long as you're not exceeding 4g in a 24 hour period.

I don't really know about NAC but if you want to mitigate paracetamols effects on it you could take a methionine supplement the days you're taking the paracetamol. For liver protection from drugs and alcohol Milk Thistle is also a good option you could add in as well. Good for reducing the severity of hangovers too.

Obviously you could CWE extract too but you will lose a bit of product and it will probably get tiresome if you're doing it weekly.

It's also worth noting that Milk Thistle can affect the metabolism of some medications. So maybe worth checking it against any other meds you're on.

Assuming no liver issues though, if I were you, I'd just eat the pills as is. It shouldn't cause any issues once a week.
THanks for the replies you guys ! It isn't once a week . It is every day . Would you recommend just eating them if it was every day ? I am definitely not exceeding 4g a day but i am getting over 2g at once pretty often . The guy above said this probably over time wouldn't be amazing . He recommended doing two doses a day which i could do . But i am trying to find a way to take all 8 of the pills at once so i can take them on an empty stomach . Seems to last longer and work better when i do it like that.

I am fine with the tedium of CWE every day . Just never done it before and didnt know if it was possible with only 8 pills and dont want to lose a ton .
 
Unless you already have issues with your liver taking that much paracetamol at once at weekly intervals shouldn't really cause any problems. As long as you're not exceeding 4g in a 24 hour period.

I don't really know about NAC but if you want to mitigate paracetamols effects on it you could take a methionine supplement the days you're taking the paracetamol. For liver protection from drugs and alcohol Milk Thistle is also a good option you could add in as well. Good for reducing the severity of hangovers too.

Obviously you could CWE extract too but you will lose a bit of product and it will probably get tiresome if you're doing it weekly.

It's also worth noting that Milk Thistle can affect the metabolism of some medications. So maybe worth checking it against any other meds you're on.

Assuming no liver issues though, if I were you, I'd just eat the pills as is. It shouldn't cause any issues once a week.
Also thanks for the Milk Thistle idea ! Will check it out .
 
You can take 2600mg acetaminophen daily for a long time but it will slowly damage your liver and colon. Spred it into 2 doses at least. 1300 is only 300 above max.single therapeutic dose.
Okay ! Thanks for the APAP info . I will either split in two or find a way to extract and lose a little . THanks man !
 
1300mg is in fact great for pain and potentiation of opioid analgesia but you want to use it for getting comfortable so extraction is good idea
 
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