Coming off Invega/Xeplion (paliperidone) injections v 12

Most psychiatrists are focused on pharmacology, and some don’t even fully understand how antipsychotics work. When I spoke to my previous doctor and explained that low dopamine can lead to increased acetylcholine activity, he looked at me strangely, even though this information is publicly available. Excess acetylcholine in the brain is often associated with symptoms of depression and anxiety. There appears to be a correlation. Sometimes, after antipsychotics, doctors prescribe centrally acting anticholinergic drugs to help balance acetylcholine levels. These drugs (like biperiden or trihexyphenidyl) are often used to reduce muscle rigidity and other physical symptoms that can persist after antipsychotics

What you really need is a doctor who won’t just reach for another antipsychotic — someone who will listen to you and consider prescribing a corrective medication (like trihexyphenidyl or biperiden) or another form of supportive therapy instead
I searched for 21 months this kind of doctor but never found one that belived me. I’am just delusional and crazy and i have to be put on other antipsychotics.

They ended me and i’am slowling accepting my fate that my life is gone, today i won’t even play games or hear music in order to kill the time, i already killed 21 months, nothing changed.

I will spent the whole day on the bed, i don’t have anymore the will to fight this damage, doctors won’t help me and my body won’t heal by his own, so I don’t have any other options that fading on my bed for the rest of my life.
 
I searched for 21 months this kind of doctor but never found one that belived me. I’am just delusional and crazy and i have to be put on other antipsychotics.

They ended me and i’am slowling accepting my fate that my life is gone, today i won’t even play games or hear music in order to kill the time, i already killed 21 months, nothing changed.

I will spent the whole day on the bed, i don’t have anymore the will to fight this damage, doctors won’t help me and my body won’t heal by his own, so I don’t have any other options that fading on my bed for the rest of my life.
What’s it like for you in this moment — is there anything, even tiny, that still reaches you at all?
 
Everything seems to come back other than lack of libido and stimulation.

I got new gf few days ago and am very nervous because my sexual ability is not as before.

I hope hormone test for prolactin and testosterone level become the solution...
I'm going to the doctor for a consultation on Monday, and on Tuesday I'm hoping to get my prolactin, testosterone, and estradiol tested. I'll share the results here
 
Im told people with Brilliant minds arnt supposed to be put on Antipsychotic drugs. There is a law about it. For example, Doctors/PHD people are legally not allowed to be put on Antipsychotics.

MAybe you guys can argue in court they werent supposed to put you on antipsychotics because you have a brilliant mind?

This is something John Nash, the person the movie The Beautiful Mind is based off had influence and put a bit of work to make it illegal.
 
Hello everyone! How are you doing?

I'm at 4 months since the injection and not really a lot of improvement. Still can't feel. Now I'm in bed like a lot of the time.

A doctor wants to put me on prozac and vraylar but I'm afraid of the akathisia so I didn't take them :(
He wants to put you on another antipsychotic
 
Hello I feel better at day 25 of my 150mg injection. I can listen to music without actually caring about how much time passes. I enjoyed the whole day and had somewhat of my imagination back . I used to be a heavy maladaptive daydreamer and it has partially returned . I was able to return into the novel in my head and have the characters make some decisions that released dopamine for me .
 
It has been a long time since I've posted on this forum.
I want to tell you most of you will recover.
For those that struggle give it time and push yourself.
And I know it is hard because you dont have the will to.
But the brain is constanrly rewiring. You have to stimulate it.
The main thing is to surround yourself with intelligent and good people.
Its hard to conversate but just listen and smile. Whatever they
Talk about will stimulate your brain in a safe environment.
Do NOT isolate. Second is windows will come.
All of a sudden you feel a will to do something, do it now. This rewires
Your dopamine reward system.
3rd is play puzzle games even if its some really basic low level stuff,
Kindergarten level even if you were brilliant. Your goal is to reconnect.
You are back at square one. You have to relearn how to think. But just know
For most of you it will end. 6 to 8 months off you will feel biggest difference.
One year and you almost back to normal. But i warn you you will then face
What got you there in the first place. Antipsychotics, some people have to have them
psychosis is hell on earth. But there are things that can cause it.

We live in a society that rewards selfish behavior and punishes altruism.
We live in a society full of chemicals. Full of contradiction in "truths" where
If you dont pick a side you are "with us or against us". Any brilliant mind
And loving heart will Collapse with the constant cognitive dissonance
we are fed.

Know this... whatever they say, you are not a number. You are not a machine
Or piece of paper to be processed. You are a beautiful creation who
Desires love. Give the gift you never got. Give the love freely and ask nothing in return. Accept that
This world is fallen and may never get better. Only a higher power can
save this terrible and rotten place coming from the biggest skeptic of all.

You must see that love is the only good thing in this world. And its not from
this world. Capture it in your soul like you did with fireflies as a child.
And give it away to all. God is Love. The world, your body, your mind will be dust
One day, but your love will last forever. And it will stand against the evil of this world
And it will set your mind, heart, and spirit free.
 
Also try asking for dopamine agonist and stimulants after it. They can help
I know you’re just trying to help, but I think you should stop recommending that people should ask for stimulants. You haven’t even taken them yourself it’s not as simple as you think. A lot of doctors are already biased against stimulants and are very wary of prescribing them because they are already so well known for being addictive and widely abused. Pushing doctors for a stimulant script will come off as “drug seeking behavior” and it can be noted down on your medical records and make it hard for you to get medicines in general.
Vyvanse is the stimulant that is talked about more here, but it metabolizes into dextroamphetamine, which is the same thing as adderall. If it’s your first time taking stimulants it can be very intense, and there are so many negative side effects like tachycardia, high blood pressure, anxiety, irritability, insomnia, and most importantly psychosis!! Not to mention that the come down can make you feel worse than when you started!
Even if you manage to get a prescription, in the United States at least, stimulants are controlled substances and legally you aren’t allowed to get more than 30 days worth of your prescription at a time. Brand name vyvanse is usually not covered by insurance, and costs around 10 dollars a pill. Generic vyvanse wasn’t allowed to be produced until 2023, and because of that it’s not much cheaper than brand name and without insurance you’re still looking at minimum 100 a month. If your insurance actually covers Vyvanse this isn’t an issue, but a lot of providers don’t, usually because they cover other stimulants and would prefer you take those.
More people take Adderall than Vyvanse, and it’s much cheaper with generics being on average 20 dollars for 30 pills. But there’s been a shortage since 2023 and it can be hard to even get your script filled, especially if you’re on a common dosage. And even though Adderall and Vyvanse are both dextroamphetamines, Adderall is also 25% levoamphetamine and people can be sensitive to that.
If people aren’t able to get a prescription for stimulants, they might turn to getting pills second hand or off a dealer. If you go that route you’re already running the risk of not knowing if your meds are 100% safe or not, but you’re also at a higher risk of all those negative side effects because you're more likely to have taken too high of a dose since you weren’t properly started on them by a doctor. And these stimulants can stay active in your system all day, or even longer.
Personally, Vyvanse does not help with my anhedonia. It helps with focus and only somewhat energy, but after time your body builds tolerance and it won’t make you feel amazing like it might have when you first started it. Like the drug will still motivate you, but it won’t make you want to deep clean the entire house twice. If you’re looking into stimulants because of the mood changes and intense focus from when you first start, and not the intended use of managing ADHD symptoms, you’re going to end up with an addiction. We have to remember that amphetamines aren’t a joke, meth used to be commonly prescribed for ADHD too, the real difference is just the average dose people take of the two. I just don’t think you should tell people to try stimulants as their first move, while not even telling them the risks or having experienced taking them yourself.
 
He wants to put you on another antipsychotic
I'm thinking of trying it if he agrees to start with the minimal dose. Vraylar is a bit different from old generation antipsychotics. It levels dopamine by increasing/decreasing it where it's needed. That's just what I understood, it might be wrong. But it comes with akathisia as well.
If I ever try it, I'll let you know about the outcome.

Edit: I keep on hesitating but I guess I'll just wait and not try anything for now. I'm almost at 4 months since the injection.
 
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I can’t even take a hot shower because i can’t feel pleasure and i can’t feel comfort, it’s like my brain it’s on high alert h24 and i just can’t relax a little bit in the shower or make a nap in the couch, it’s a fucking torture.

I can’t “wake up” as i’am locked into this 20% disfunctional state, but i can’t neither just let it happen and relax because my brain has lost the faculty to feel comfort and safety.

I can barely distract myself for short time playing videogames but what I need is to fucking take a break and just relax, but I can’t. It’s impossible.
 
It has been a long time since I've posted on this forum.
I want to tell you most of you will recover.
For those that struggle give it time and push yourself.
And I know it is hard because you dont have the will to.
But the brain is constanrly rewiring. You have to stimulate it.
The main thing is to surround yourself with intelligent and good people.
Its hard to conversate but just listen and smile. Whatever they
Talk about will stimulate your brain in a safe environment.
Do NOT isolate. Second is windows will come.
All of a sudden you feel a will to do something, do it now. This rewires
Your dopamine reward system.
3rd is play puzzle games even if its some really basic low level stuff,
Kindergarten level even if you were brilliant. Your goal is to reconnect.
You are back at square one. You have to relearn how to think. But just know
For most of you it will end. 6 to 8 months off you will feel biggest difference.
One year and you almost back to normal. But i warn you you will then face
What got you there in the first place. Antipsychotics, some people have to have them
psychosis is hell on earth. But there are things that can cause it.

We live in a society that rewards selfish behavior and punishes altruism.
We live in a society full of chemicals. Full of contradiction in "truths" where
If you dont pick a side you are "with us or against us". Any brilliant mind
And loving heart will Collapse with the constant cognitive dissonance
we are fed.

Know this... whatever they say, you are not a number. You are not a machine
Or piece of paper to be processed. You are a beautiful creation who
Desires love. Give the gift you never got. Give the love freely and ask nothing in return. Accept that
This world is fallen and may never get better. Only a higher power can
save this terrible and rotten place coming from the biggest skeptic of all.

You must see that love is the only good thing in this world. And its not from
this world. Capture it in your soul like you did with fireflies as a child.
And give it away to all. God is Love. The world, your body, your mind will be dust
One day, but your love will last forever. And it will stand against the evil of this world
And it will set your mind, heart, and spirit free.
“Don’t isolate” literally my “family” is angry against me when i try to reach them and they say “we have to live our lifes, we cannot stop living our lifes only because you are suffering”.

I can’t even relax into the shower, how can I “enjoy” to be around people if I feel this discomfort feeling of being inside a lucid dream that my brain feel like danger h24?

I think some people react way more worse than other people and some people can float on their sympthoms but some people just drown into them because they are stronger or differents..
 
I can’t even take a hot shower because i can’t feel pleasure and i can’t feel comfort, it’s like my brain it’s on high alert h24 and i just can’t relax a little bit in the shower or make a nap in the couch, it’s a fucking torture.

I can’t “wake up” as i’am locked into this 20% disfunctional state, but i can’t neither just let it happen and relax because my brain has lost the faculty to feel comfort and safety.

I can barely distract myself for short time playing videogames but what I need is to fucking take a break and just relax, but I can’t. It’s impossible.
Our brains have been tortured right :( I pray that you can recover with time, don't rush please and keep the smile even though it's hard, let's just fake that it's not that bad...
Personally, even things like supplements mess slightly with me giving me insomnia or even more sedation... I decided not to try new things and just wait and pray... in the meantime, hold on to those things that used to make you happy even though it feels like nothing anymore... don't think about what's missing, think about what you have, no matter how little it is, may God help us
 
I'm thinking of trying it if he agrees to start with the minimal dose. Vraylar is a bit different from old generation antipsychotics. It levels dopamine by increasing/decreasing it where it's needed. That's just what I understood, it might be wrong. But it comes with akathisia as well.
If I ever try it, I'll let you know about the outcome.

Edit: I keep on hesitating but I guess I'll just wait and not try anything for now. I'm almost at 4 months since the injection.
I take vraylar in the morning and risperidone at night time
 
I'm going to the doctor for a consultation on Monday, and on Tuesday I'm hoping to get my prolactin, testosterone, and estradiol tested. I'll share the results here

TRT is fucking great man. I managed to put on a good 25lbs of muscle on it. I upped my scripted dose abit from 150mg's every 2 weeks to 200mg's a week. But am going back to my reg dose for a few weeks to get some clean blood work so my doc dont freak out lol
 
How does one get TRT? How does one get truly tested for low T? I thought there were two different tests for checking T levels, and one test is bunk as it doesn't test for free T, only bound T, which doesn't mean much.

I've got a problem where I cannot function, and it could be due to low T.
 
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