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Opioids MGM 15 Megathread

^Anyone have any idea what solvents/impurities are left? (likely to be left using the most likely synth - lot of qualifiers).

edit--nvm that was this thread.
 
@notsmokeymcpot42088 - well, Oxone™ (2KHSO5·KHSO4·K2SO4 AKA potassium peroxymonosulfate) was apparently how 'cooks' oxidizing mitragynine to 7-OHM. A single-electron transfer oxidation.

But I would bet that mitragynine can undergo acid-catalyzed electrophilic addition (hydration) to MGM15. I have two papers in front of me that describe this telescoped down to a 1-pot reaction.
 
^Highly corrrosive that is never good -- prolly not great on the stomach.

I would not want to ingest it regularly lol --- wait were you saying that oxone is likely in there AFTER snyth -- in any small capacity? Looks pretty bad if you ingest any
 
I'm sure it's the dubious case with manufactured derivatives like MGM15 and 7oh that you can't trust any claims by sellers. But I have been wondering about the kratom powder itself of late. I don't mean whether the tests for salmonella or heavy metals derived from the soil it is grown in are accurate. I'm thinking more in terms of, is it ever spiked with other drug I know there was a past history of people adding tramadol, I believe, but you never hear about that anymore.
I'm just wondering because it would do wonders for a sellers business model just to add little bit of something to give their product a bit of a kick over the competition. Could promote brand loyalty. I'm thinking it being added here in the US by a seller because my understanding that only a few international suppliers supply all these many, many brands with product.
I'm partly wondering because I recently got a batch of kratom that really seemed to have a bigger kick, with a bit different quality to it. But the kratom experience is so variable and subjective that I really have no idea. It IS a plant, so not manufactured to specific standards, so one can expect some natural variation of naturally occurring alkaloids, unlike with a specific legal pharmaceutical. ( black market manufacturing being more dubious)
Anyhow, I would be very interested to know if any cases have come up or studies down. I'm actually considering trying to see if I can find a lab to do testing, for curiosity. But I don't know if there are any who do it for kratom and it's not like I feel like it is some big dose of fentanyl or nitazines or wherever. I was thinking more like they could add a sprinkle of mitragynine or 7oh just to bump it up
You can always have your kratom batch independently tested, and as far as added Desmethyl Tramadol that was over a decade ago, so many people are wise to that sort of a thing nowadays.
 
@notsmokeymcpot42088 - well, Oxone™ (2KHSO5·KHSO4·K2SO4 AKA potassium peroxymonosulfate) was apparently how 'cooks' oxidizing mitragynine to 7-OHM. A single-electron transfer oxidation.

But I would bet that mitragynine can undergo acid-catalyzed electrophilic addition (hydration) to MGM15. I have two papers in front of me that describe this telescoped down to a 1-pot reaction.
Can you share these papers pls? Thx
 
BL user agreement forbids discussion of syntheses.

But I found them in 10 minutes, so if I can, so can anyone else.

But would a 'batch test' REALLY detect the absence of a double-bond? Sure, NMR would plainly spot that the sole aromatic was a benzene but do such tests actually employ NMR? Because the MW and physical properities are so close that it would take an eagle-eyed chemist to note a MW 414.518 compound also had a much smaller 416.518 peak if GC-MS was relied on.

THAT is what makes it the inevitable end product. It's no more difficult to make, hard to spot and given that all the vendors pretend that they extract 7OHM rather than oxidizing mitragynine (an item of commerce). Likewike do we KNOW that MGM15 isn't found in kratom - even in vanishingly small quantities? Because isn't not a CD so no criminal case could succeed and how many end users care so much that they would take a vendor to court - even a civil action would likely fail because you can be sure that a (paid) expert defence-witness would claim MGM15 IS natural.

I would expect someone thinking long-term would selectively breed the plant so it produces MGM15. That said, do these people think for longer periods than the next payout. They KNOW it will be banned - so right now, it's all about short-term profits.
 
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^Highly corrrosive that is never good -- prolly not great on the stomach.

I would not want to ingest it regularly lol --- wait were you saying that oxone is likely in there AFTER snyth -- in any small capacity? Looks pretty bad if you ingest any

No, workup would remove it. But I hear whispers such as yield is 63-70% and THAT is being misrepresented as 'pure' 7OHM. So if someone DOES isolate just the 7OHM, the product could be 40% more potent than stated - so end-users are harmed.

If THAT is acceptable, 'cooks' wouldn't even break a sweat if their product is a mixture. In fact, being a mixture makes analysis harder, so maybe it's been thought through. If so, Impure MGM15 would also offer that obstification?

Who knows. Makers know it destroys lives, so making even MORE money would blind them to end users who buy what is a mixture just pay more for another (more potent) mixure. But hey, it's natural, right 😉
 
You can always have your kratom batch independently tested, and as far as added Desmethyl Tramadol that was over a decade ago, so many people are wise to that sort of a thing nowadays.
Well, that's what I am actually wondering about. I'd kind of like to get it tested, not just for my own sake but because people ought to know if kratom is being adulterated. Of course it's quite possible it isn't, maybe that's most likely as you never hear about it since tramadol 10 years ago. Still, I hear nothing about tests done for drug contamination. All I hear is salmonella, heavy metals. Not even much about testing it for natural alkaloid concentrations. To my mind, there are a lot of ways it could be spiked. But is there truly a financial incentive considering how cheap leaf powder is ? ( derivatives like extracts and 7oh are different)
I looked into testing companies recently but it didn't seem like any of them were offering the sort of test I would be interested in. I'm not sure what I would ask for. I also suspect the cost would be high. So I guess idle talk...
 
I am no expert but that sounds like the kind of thing that could be dangerous at low purity and high dosage.

Speculations on what that impurity may be?
If we're talking solvent contamination, I doubt there's enough for it to be noticeable, looking at the known synthetic route to MGM-15 there aren't many solvents used that wouldn't come out with ease, and even if there were residual solvents, there's maybe 5-10mg of active constituent in the whole pressie, if it's 10% solvent that's only 500 to 1,000 micrograms, you're going to have a worse time eating RSO as far as solvent exposure. If we're talking about alkaloids that get leftover though, there is certainly a plethora of minor alks that get brought along for the ride with mitragynine as it's converted into MGM-15, and how those may influence nausea I have no idea but I'm sure we'll isolate them and figure it out at some point in the future.
I'm sure it's the dubious case with manufactured derivatives like MGM15 and 7oh that you can't trust any claims by sellers. But I have been wondering about the kratom powder itself of late. I don't mean whether the tests for salmonella or heavy metals derived from the soil it is grown in are accurate. I'm thinking more in terms of, is it ever spiked with other drug I know there was a past history of people adding tramadol, I believe, but you never hear about that anymore.
I'm just wondering because it would do wonders for a sellers business model just to add little bit of something to give their product a bit of a kick over the competition. Could promote brand loyalty. I'm thinking it being added here in the US by a seller because my understanding that only a few international suppliers supply all these many, many brands with product.
I'm partly wondering because I recently got a batch of kratom that really seemed to have a bigger kick, with a bit different quality to it. But the kratom experience is so variable and subjective that I really have no idea. It IS a plant, so not manufactured to specific standards, so one can expect some natural variation of naturally occurring alkaloids, unlike with a specific legal pharmaceutical. ( black market manufacturing being more dubious)
Anyhow, I would be very interested to know if any cases have come up or studies down. I'm actually considering trying to see if I can find a lab to do testing, for curiosity. But I don't know if there are any who do it for kratom and it's not like I feel like it is some big dose of fentanyl or nitazines or wherever. I was thinking more like they could add a sprinkle of mitragynine or 7oh just to bump it up
Here in Florida something like this went down, the "Septavex" mix for example is one of a multitude of proprietary mixtures of mitragyna alks (and sometimes cat's claw alks) to form this alkaloid soup that people suspect to be 7-OH or adjacent. I guess it is, idk. I've spoken with many local smoke shop/gas station employees about it and they all hate MGM-15 because people hooked on it buy less and buy with less frequency, whereas when they were using 7-OH they were in there spending more money with a higher frequency.
I'm pretty positive the nausea is caused by the left over solvents, the highest quality mgm I've found has yet to push 90% highest has been 88.1% but I noticed the one day the lower purity powders give me far more nausea. The neausea it gives feels nothing like classic opioid overdose type nausea it feels more akin to being actually poisoned. With normal opioida if I take a dose too high I'll puke and it'll be gravy after the vomiting fit but with mgm it hits and I'll be good but a couple hours later the nausea starts hitting after
As somebody who has foolishly consumed a variety of solvents for recreational effect, I would disagree just based on subjective experience, the feeling of MGM-15 nausea is almost identical to when I take too much Dilaudid or oxycodone, but it does not resemble morphine/codeine/hyperpotent opioid nausea for sure. Just my personal take on it, but I've also had uh, I think 17 central incisions from my sternum to below my ribs, so my mesenteric nervous system is all fucked up anyways, I have to use ondansetron or promethazine virtually daily to not be vomiting randomly.
 
If we're talking solvent contamination, I doubt there's enough for it to be noticeable, looking at the known synthetic route to MGM-15 there aren't many solvents used that wouldn't come out with ease, and even if there were residual solvents, there's maybe 5-10mg of active constituent in the whole pressie, if it's 10% solvent that's only 500 to 1,000 micrograms, you're going to have a worse time eating RSO as far as solvent exposure. If we're talking about alkaloids that get leftover though, there is certainly a plethora of minor alks that get brought along for the ride with mitragynine as it's converted into MGM-15, and how those may influence nausea I have no idea but I'm sure we'll isolate them and figure it out at some point in the future.

Here in Florida something like this went down, the "Septavex" mix for example is one of a multitude of proprietary mixtures of mitragyna alks (and sometimes cat's claw alks) to form this alkaloid soup that people suspect to be 7-OH or adjacent. I guess it is, idk. I've spoken with many local smoke shop/gas station employees about it and they all hate MGM-15 because people hooked on it buy less and buy with less frequency, whereas when they were using 7-OH they were in there spending more money with a higher frequency.

As somebody who has foolishly consumed a variety of solvents for recreational effect, I would disagree just based on subjective experience, the feeling of MGM-15 nausea is almost identical to when I take too much Dilaudid or oxycodone, but it does not resemble morphine/codeine/hyperpotent opioid nausea for sure. Just my personal take on it, but I've also had uh, I think 17 central incisions from my sternum to below my ribs, so my mesenteric nervous system is all fucked up anyways, I have to use ondansetron or promethazine virtually daily to not be vomiting randomly.
I thought kratom/MIT/7oh constipation was bad until I developed a strange anxiety/nausea combination upon waking every day when I started my new job. Ondansetron constipation was NO JOKE for me. My God. Sure does its job, though. Made me able to work for that time. Either way, glad I dodged the MGM15 train and got out of the deep end with 7oh just in time. Now to rid myself of this fucking MIT dependence...
 
idk. I've spoken with many local smoke shop/gas station employees about it and they all hate MGM-15 because people hooked on it buy less and buy with less frequency, whereas when they were using 7-OH they were in there spending more money with a higher frequency.


That speaks great volumes of the products effectiveness alone.

Unless they know you looking to quit or they selling it as "kratom-off" or some shit. (Emoji this in some way if neither of those things are true) or reply idk why im doing that exactly lol
 
No, workup would remove it. But I hear whispers such as yield is 63-70% and THAT is being misrepresented as 'pure' 7OHM. So if someone DOES isolate just the 7OHM, the product could be 40% more potent than stated - so end-users are harmed.

If THAT is acceptable, 'cooks' wouldn't even break a sweat if their product is a mixture. In fact, being a mixture makes analysis harder, so maybe it's been thought through. If so, Impure MGM15 would also offer that obstification?

Who knows. Makers know it destroys lives, so making even MORE money would blind them to end users who buy what is a mixture just pay more for another (more potent) mixure. But hey, it's natural, right 😉

absolutely makes more sense than what I was asking! Thank you

thank you @Esperighanto too who I believe answered that as well.
 
That speaks great volumes of the products effectiveness alone.

Unless they know you looking to quit or they selling it as "kratom-off" or some shit. (Emoji this in some way if neither of those things are true) or reply idk why im doing that exactly lol
MGM-15 met widespread sale in Florida due to a proposed (and I believe failed) 7-OH ban that sort of shook the Mitragyna alkaloid market up here, and Florida has a fucking exceptional culture of kratom usage for some reason. I first began using kratom due to running into it at kratom/kava bars in St. Petersburg (Florida), it was just a thing kept in the back of smokeshops in New England for some reason.
I dont mean to kill anyones buzz but I dont think synth discussion is allowed --- im not a mod or anything, think I just saw this problem in anther thread though
Yeah, at least not on a public-facing thread but if you guys want to DM and share the DOI of the paper or whatever there's no issue with that.
 
Bewilders me there is a drug that can get you off opiates without serious withdrawals. Kind of like those USB vape pens.
(off topic I saw a too short high times interview today where he was talkin about smokin on planes and how you had to light up take a toke than change where your located --- than the young woman mentioned vape pens and you could almost see his head explode)

No opposite and equal reaction to all of my actions drug? --- yes please, all of that in all contexts.

ConseQuanceline (Tm) coming to a gas station near you
 
Bewilders me there is a drug that can get you off opiates without serious withdrawals.
I would argue that while you could go from a hyperpotent -> MGM-15 -> Mitragynine -> Free from addiction, an even better route is found in the usage of SR-17018. Tragically, as a benzimidazole it has been grouped up in a structural class that is widely banned due to other benzimidazoles being the hyperpotent opioids that have put us in the position of needing a tool like this in the first place. The snake is eating its own tail on that one, it seems.
 
^Oh shite ive been thinking of the wrong abc-123 chemical

Thank you for that reminder --- DOH! Noone listen to my last post. I do like Consequanceline though still for SR-17018 -- (17, 18, like six seven -- sorry note to self)
 
Did you guys see the latest news today in the USA? We finally did it! Ibogaine and other psychedelic drugs will soon be FDA approved for the treatment of drug dependency, PTSD, depression, etc. This is revolutionary:

BREAKING NEWS:

An executive order has been signed today in order to give Ibogaine FDA approval to treat opioid addiction. There are over five million people in the USA today who are habitually dependent to opioids. Research shows with a single dose of Ibogaine more than 80% of people are free of that addiction, and with two consecutive doses the figure is above 90% successful in addicts. Ibogaine is also effective in treating other drug dependencies as well such as: alcohol, stimulant abuse, etc (basically any dependency you can think of). These drugs are illegal not because they’re harmful instead they’re illegal due to the 1970 Controlled Substance Act that was passed by then president Richard Nixon, and they did it to target the Civil Rights movement, and the Anti-War movement. It’s not because these drugs harm people. Arbitrarily lumping all psychedelic substances into Schedule I has only prevented scientific and medical research into these near-miracle drugs while creating a huge stigma towards those pioneers who know better. Watch the full video straight through for more information, or feel free to PM me if you wish to discuss this more.

For more unbiased science based information on Ibogaine and nearly any other psychoactive substance please visit and support Erowid.org

 
Ibogaine is wild shite. Vastly experienced with psychedelics, and that one still scares me.

BTW ^ was not trying to call you out -- just saw someone get bitched at for it in the 'mdma isnt what it used to be' or w/e thread.

To be 100 I was kind of fishing to see if you could discuss synth is PM's. (Cuz one day ill learn chemistry lol)
 
Ibogaine is wild shite. Vastly experienced with psychedelics, and that one still scares me.

BTW ^ was not trying to call you out -- just saw someone get bitched at for it in the 'mdma isnt what it used to be' or w/e thread.

To be 100 I was kind of fishing to see if you could discuss synth is PM's. (Cuz one day ill learn chemistry lol)
Yeah man! I’m very well versed in psychedelics too, but I never tried Ibogaine even though I had a guy who could get me the whole root bark over ten years ago, but I didn’t bite. I read up on it on Erowid.org and after reading about it and learning that it can cause heart arrhythmias followed by death without supervision I was put off at the time; however, I’m still interested in trying it the proper way one day. I also learned that in West Africa the Bwiti tribe use Ibogaine as an initiation ceremony, and they say that if you don’t survive the trip then you were chosen to be taken by the spirit of Iboga (I forgot her name). Wild shite indeed, but still very interesting lol!
 
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