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Trigger Warning Sertraline made me go nuts

Axemancometh

Axemancometh

Bluelighter
Joined
Mar 12, 2026
Messages
65
Location
Canada
I was prescribed Sertraline (25mg daily) for a rather intense spell of depression and anxiety that definitely stemmed from my MDMA abuse a few months ago, and it gave me the craziest and most concerning side effects from anything a doctor has ever prescribed me.

I would take my dose in the morning - sometimes one pill, sometimes two. (it was super energetic and warm that's why) I loved the stimulating energy it was giving me, almost like I was on molly.
things would be groovy until about 4pm, when no matter what dose I took, I would crash HARD. The best I could describe it was a mixture of hypomanic and suicidal. I was reckless - saying/doing stupid bullshit that pissed other people off, but at the same time I swore that I had everything figured out and that I was really doing swell. Like a fucked up enlightenment. I would also feel overwhelmed at the same time, wishing I was dead. Repeat that every day for three weeks, until I eventually threw away all my pills in hypomanic rage and rode out the withdrawal until my mood stabilized.

Thank God I didn't decide to keep going with that stuff. Doing psychedelics for years before SSRIs proved to me which is the better helper (may not apply to everyone) and smacked my chemical head into taking a proper drug break so I don't lose it entirely and have to take risperidone.

Moral of the story: always listen when people say 'take a x-week/month long break from the last time you used' NO MATTER HOW much you wanna get high; and - drugs are also not the answer to everything.

Peace.
 
Axemancometh said:
I was prescribed Sertraline (25mg daily) for a rather intense spell of depression and anxiety that definitely stemmed from my MDMA abuse a few months ago, and it gave me the craziest and most concerning side effects from anything a doctor has ever prescribed me.

I would take my dose in the morning - sometimes one pill, sometimes two. (it was super energetic and warm that's why) I loved the stimulating energy it was giving me, almost like I was on molly.
things would be groovy until about 4pm, when no matter what dose I took, I would crash HARD. The best I could describe it was a mixture of hypomanic and suicidal. I was reckless - saying/doing stupid bullshit that pissed other people off, but at the same time I swore that I had everything figured out and that I was really doing swell. Like a fucked up enlightenment. I would also feel overwhelmed at the same time, wishing I was dead. Repeat that every day for three weeks, until I eventually threw away all my pills in hypomanic rage and rode out the withdrawal until my mood stabilized.

Thank God I didn't decide to keep going with that stuff. Doing psychedelics for years before SSRIs proved to me which is the better helper (may not apply to everyone) and smacked my chemical head into taking a proper drug break so I don't lose it entirely and have to take risperidone.

Moral of the story: always listen when people say 'take a x-week/month long break from the last time you used' NO MATTER HOW much you wanna get high; and - drugs are also not the answer to everything.

Peace.
Click to expand...
Paxil and Prozac coulda got me thrown in prison.
 
i've heard of people abusing wellbutrin and sometimes rarely a srni or two like venlafaxin, i never ever heard of someone getting high of a basic fucking ssri like setraline thats fucking crazy dude, might have to do with the mdma abuse before but even then, you got some rare genetics
 
Axemancometh said:
I was prescribed Sertraline (25mg daily) for a rather intense spell of depression and anxiety that definitely stemmed from my MDMA abuse a few months ago, and it gave me the craziest and most concerning side effects from anything a doctor has ever prescribed me.

I would take my dose in the morning - sometimes one pill, sometimes two. (it was super energetic and warm that's why) I loved the stimulating energy it was giving me, almost like I was on molly.
things would be groovy until about 4pm, when no matter what dose I took, I would crash HARD. The best I could describe it was a mixture of hypomanic and suicidal. I was reckless - saying/doing stupid bullshit that pissed other people off, but at the same time I swore that I had everything figured out and that I was really doing swell. Like a fucked up enlightenment. I would also feel overwhelmed at the same time, wishing I was dead. Repeat that every day for three weeks, until I eventually threw away all my pills in hypomanic rage and rode out the withdrawal until my mood stabilized.

Thank God I didn't decide to keep going with that stuff. Doing psychedelics for years before SSRIs proved to me which is the better helper (may not apply to everyone) and smacked my chemical head into taking a proper drug break so I don't lose it entirely and have to take risperidone.

Moral of the story: always listen when people say 'take a x-week/month long break from the last time you used' NO MATTER HOW much you wanna get high; and - drugs are also not the answer to everything.

Peace.
Click to expand...

Glad you learned from that. Good moral for the story.

Just so you don't feel crazy, i snorted lithium in a psych ward. Did nothing, gave me a nose bleed. Just so you know you're not alone.
 
Featherfall said:
i've heard of people abusing wellbutrin and sometimes rarely a srni or two like venlafaxin, i never ever heard of someone getting high of a basic fucking ssri like setraline thats fucking crazy dude, might have to do with the mdma abuse before but even then, you got some rare genetics
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Hes getting manic from it.
 
I didn't like Sertraline hcl either and for similar reasons (but not for MDMA abuse). It made me feel manic and I didn't really register any emotions most of the time (good or bad). I didn't feel like myself at all. It felt like I was wearing a mask.

With that said, I found out the hard way that mixing Sertraline hcl with alcohol resulted in me being ultra-sensitive and not in control of my emotions at all. I was trying to quit cigarettes and told the girl I was seeing that I wouldn't smoke cigarettes; broke that agreement, confessed that to her at the house party we were at, crying hysterically while doing so. That combo really made me a hot mess. I avoid SSRIs at all costs personally.

EDIT: It also made it basically impossible to orgasm, which sucked too.
 
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Featherfall said:
still rather rare, not to accidently imply its cool, might have worded it wrong, i m just amazed someone felt something like that to the degree of redosing
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Getting manic from SSRIS I dont think its that rare. I known a lot people who had to go off them because there mania made them do stupid shit.
 
fuckabout89 said:
Getting manic from SSRIS I dont think its that rare. I known a lot people who had to go off them because there mania made them do stupid shit.
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ig the redosing part just threw me for a loop, mania alone from it is probably not rare then
 
The term mania has lost meaning over time but it is pretty well documented that SSRIs can induce bipolar mania.
 
Featherfall said:
ig the redosing part just threw me for a loop, mania alone from it is probably not rare then
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Yeah thats what they say the moment I go off them I no longer have Bipolar. Never experienced a manic episode since I stopped them. I dont think I ever was Bipolar as kid. Then the dumbasses had me medicated on antipsychotics all due to reaction from a med and all of it started over OCD.
 
I have repeatedly stated that the SOLE advantage of SSRIs/SDRIs/SNDRIs is their safety in overdose.

But not for nothing are all new antidepressants still compared to a tricyclic (amitriptyline most often).

I read all of the information that GPs were given and NOT ONCE did one of them ever claim to be superior to amitriptyline. They used the slippery term 'of comparible effaciacy', Comparible in which way? That is such an opaque definition.
 
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fuckabout89 said:
Yeah thats what they say the moment I go off them I no longer have Bipolar. Never experienced a manic episode since I stopped them. I dont think I ever was Bipolar as kid. Then the dumbasses had me medicated on antipsychotics all due to reaction from a med and all of it started over OCD.
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It kinda shocks me how fucked up some of these prescribed medications can be - just the other day even I was reading on one anti-seizure med that can cause aggressive behaviour. wtf??
 
4DQSAR said:
compared to a tricyclic (amitriptyline most often).
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Amitriptyline 150mg in the afternoon is helpful for me and it does not require a "warm-up phase" like Zoloft taking 3-4 weeks for it to start working. I take the Amitriptyline every 3 days. I was worried about Serotonin Syndrome taking Amitriptyline, Zoloft, Busbar, and some of my other medications. No issues with that.

Daily -- Zoloft 100mg with Busbar 30mg to treat the symptoms of "chronic pain syndrome"

I just started taking Valium 5mg 3 times per day for stress and pain.
 
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