Stimulants Amphetamine and methylphenidate comparaison and a copule of questions

[Dextro .45]

Ritalin (Methylphenidate) is approximately 2X more potent than Cocaine at inhibiting the DAT / monoamine increase & release….both are “Inverse Agonists” and both compete for the same binding sites in the CNS pleasure centres

Ritalin is VERY euphoric & pleasurable…….VERY…..and it’s the safest dopaminergic stimulant regarding it’s cardiovascular effects

Ritalin & Oxycodone……only 2 drugs to EVER give me true euphoria in my 43 years on this planet

d-Desoxyephedrine (Methamphetamine/Desoxyn/Methedrine)
Benzphetamine (pro-drug to d-Meth then into d-Amph)
Biphetamine 20mg “Black Beauty” …..todays Adderall
Phenmetrazine (Preludin)
Methylphenidate (Ritalin)
Cocaine
d-Amphetamine (Dexedrine)
Dexamyl & Desbutal (Methamphetamine + Amytal Barbiturate)

Valium, Xanax, Lorazepam, Klonopin
Etizolam
Avizafone (Pro-Diazepam )
Diclazepam (2-Chloro Diazepam) BEST Benzodiazepines ever synthesized

Oxycodone, Hydromorphone, Diacetylmorphine, Methadone

LSD-25

Ethanol & Cigarettes

 

[Keif' Richards]

@KurtAurelius thanks for all of the numbers. That really helps put some of the more abstract qualities of the substance into perspective. You hit the nail on the head regarding the shitty nature of the comedown. This was my experience. When you described that it jogged memories loose. I really only used Methylphenidate back in High School and to a lesser extent in College. I distinctly remember the beginning of the experience to be pretty good. The comedowns were sometimes so bad I would literally end up crying. The comedown was truly terrible.

I can totally see why people would inject it and analogs of it. That absolutely makes sense now, as you´re generally chasing a rush anyway.

 

[Halif2]

Yes it won’t agree with everyone fair enough, but on paper it is quite good.

Ah, so you're supposed to just read about it, and that's where the good high is? Novel!

d-Desoxyephedrine (Methamphetamine/Desoxyn/Methedrine)
Benzphetamine (pro-drug to d-Meth then into d-Amph)
Biphetamine 20mg “Black Beauty” …..todays Adderall
Phenmetrazine (Preludin)
Methylphenidate (Ritalin)
Cocaine
d-Amphetamine (Dexedrine)
Dexamyl & Desbutal (Methamphetamine + Amytal Barbiturate)

Valium, Xanax, Lorazepam, Klonopin
Etizolam
Avizafone (Pro-Diazepam )
Diclazepam (2-Chloro Diazepam) BEST Benzodiazepines ever synthesized

Oxycodone, Hydromorphone, Diacetylmorphine, Methadone

LSD-25

Ethanol & Cigarettes

What is all this, Dextro? Just a list of drugs you like?

I feel a bit sorry for OP right now. It seems like they had a traumatic experience with an ADHD med and is perhaps seeking some reassurance from people who have similar experiences, but instead they got people rating levels of euphoria from different stims, and discussing crack cocaine, and such.

Unfortunately, I am not equipped to help here as I know little about ADHD, its meds, and associated neurological complications which can come from use and abuse of said meds. Hopefully someone will come in and just nail the answer and OP will feel better and have some hope.

 

[fuckabout89]

Ah, so you're supposed to just read about it, and that's where the good high is? Novel!



What is all this, Dextro? Just a list of drugs you like?

I feel a bit sorry for OP right now. It seems like they had a traumatic experience with an ADHD med and is perhaps seeking some reassurance from people who have similar experiences, but instead they got people rating levels of euphoria from different stims, and discussing crack cocaine, and such.

Unfortunately, I am not equipped to help here as I know little about ADHD, its meds, and associated neurological complications which can come from use and abuse of said meds. Hopefully someone will come in and just nail the answer and OP will feel better and have some hope.

Those papers mean jack shit vs trying a substance. Yeah everyone is gonna respond different to each substance some people hate the weed high so much they domt consider it a high or stims. As I come too learn they really mean nothing, some people get higher from cocaine then meth.


Sometimes you can try it over and over until you like it thats what happened to me with weed. Now I absolutely love greening out if im lucky enough to experience it.

 

[MedicinalUser247]

Meth and Speed have their own feeling that I don't care too much for. On the other hand I Love Cocaine and Methylphenidate. The euphoria you get off either of them just hits the spot.

 

[TheLightBringer]

@KurtAurelius thanks for all of the numbers. That really helps put some of the more abstract qualities of the substance into perspective. You hit the nail on the head regarding the shitty nature of the comedown. This was my experience. When you described that it jogged memories loose. I really only used Methylphenidate back in High School and to a lesser extent in College. I distinctly remember the beginning of the experience to be pretty good. The comedowns were sometimes so bad I would literally end up crying. The comedown was truly terrible.

I can totally see why people would inject it and analogs of it. That absolutely makes sense now, as you´re generally chasing a rush anyway.

Oh yeah the comedown is horrid, worst cognitive comedown out of any drug ive ever experienced. For some odd reason when I built tolerance to stimulants I stopped feeling the methylphenidate comedown

I had a friend who described it in a non scientific way I can relate to though. He said ”Its like once youre fully addicted to stimulants you stop getting the comedown because you feel so shit all the time that your sober state of mind is worse than a comedown”

I found that to be true with most stimulants tbh, even amphetamine didnt have that bad of a cognitive depression moreso than the ”comedown” just being the sensation of the extreme stress I had put my body through after a binge. A sickly exhausted type feeling accompanied by anxiety.

 

[paranoid android]

Fun fact about myself. I don´t really like Methylphenidate and I don´t really like Cocaine either, honestly. I´ve had Crack put in front of me and of course have smoked several hundred dollars worth a handful of times, but I didn´t Like it. I´m sure there are other folks on here who can relate. Cocaine and Methylphenidate both had a tendency to produce what felt like a disproportionate degree of physical/psychological tension. This is in comparison to Amphetamine, which causes 1/10th the anxiety for me of Cocaine.

I´d be interested to hear from other people regarding their experiences. I never understood Methylphenidate to be that desired by anyone. I was always under the impression that people only took it when they couldn´t get a hold of Amphetamine. I´m definitely keen to hear from other people though. Isn´t learning fun?

I actually quite like ritalin its great at waking you up. Took one last week when had to get a really early morning blood test and it woke me right up. I still like dexedrine more but i havent tried ritalin at high doses yet.I used to quite like coke back in the day to especially IV coke. That seizure i had made me nervous about coke though

 

[Keif' Richards]

@TheLightBringer that quotation regarding stimulant addiction is poetic. I´ve never lived that life personally. In my line of work, I encounter Methamphetamine intoxication on a daily basis, sometimes severe, sometimes just inconvenient. I only knew my personal experience with stimulants, which typically involved feeling wicked high and loving it. I never understood what was going on in the heads of these people. They were so prone to crying, breaking down, etc. They clearly were not enjoying any part of it. Thanks for that,

 

[Greed420]

I am an addicted to rotalin, took almost a whole gram of methylphenidate through boofing and snorting in less than 48h. Not proud of that. Of course did with a SKYROCKET tolerance. But man... snorting MPH feels like good coke but try plug the sweet spot dosage and you'll feel an amazing auphoria for 30minutes, almost like an opiate-like high followed by a stim effect. Ultimate speedball pharma drug in a single med.

 

[TheLightBringer]

I am an addicted to rotalin, took almost a whole gram of methylphenidate through boofing and snorting in less than 48h. Not proud of that. Of course did with a SKYROCKET tolerance. But man... snorting MPH feels like good coke but try plug the sweet spot dosage and you'll feel an amazing auphoria for 30minutes, almost like an opiate-like high followed by a stim effect. Ultimate speedball pharma drug in a single med.

Do you find that most stims give you that relaxation at high dosages? Idk if its just ADHD but I used to love ”overamping” on whatever stim because of the couch locked relaxing effect that would ensue for 30 - 60 minutes before stimulation and tweakiness took over, which of course I enjoyed too.

But i relate greatly to the statement that boofing or snorting a massive dose of MPH yields a like you said almost ”opiate-like” (or at least relaxing) feeling at first. With MPH it dissipated with tolerance though and never came back even when dosing 300mg at once.

The craziest case of MPH use ive seen is a friend of mine who once did 3600mg MPH in less than 24 hours. Consumed sixty 60mg pills, said it was her favorite stimulant even over speed, which I cannot relate to…

 

[crazyotter87]

Do you find that most stims give you that relaxation at high dosages? Idk if its just ADHD but I used to love ”overamping” on whatever stim because of the couch locked relaxing effect that would ensue for 30 - 60 minutes before stimulation and tweakiness took over, which of course I enjoyed too.

But i relate greatly to the statement that boofing or snorting a massive dose of MPH yields a like you said almost ”opiate-like” (or at least relaxing) feeling at first. With MPH it dissipated with tolerance though and never came back even when dosing 300mg at once.

The craziest case of MPH use ive seen is a friend of mine who once did 3600mg MPH in less than 24 hours. Consumed sixty 60mg pills, said it was her favorite stimulant even over speed, which I cannot relate to…

3,600mg? Wtf... I think I could take over a small country if I were that high. Or just do something very productively unproductive, either or.

 

[TheLightBringer]

3,600mg? Wtf... I think I could take over a small country if I were that high. Or just do something very productively unproductive, either or.

Its quite literally insane, luckily shes clean now but how it was even nice at that point I cannot comprehend. Think I would just go psychotic from that amount or collapse due to the overwhelming cardiac effects

 

[crazyotter87]

Its quite literally insane, luckily shes clean now but how it was even nice at that point I cannot comprehend. Think I would just go psychotic from that amount or collapse due to the overwhelming cardiac effects

Good for her, it's insane. 3,600 mg of methylphenidate would probably last me well over 2 years. I don't know how some people can handle that...

 

[Halif2]

I had a friend who described it in a non scientific way I can relate to though. He said ”Its like once youre fully addicted to stimulants you stop getting the comedown because you feel so shit all the time that your sober state of mind is worse than a comedown”

Now that's a ringing endorsement of methylphenidate if I've ever heard one. Really makes me want to get out there and get some right now!

One of the most interesting parts of this thread is just reading about how wildly different people's subjective experiences are. I think we all know that different people have different experiences and preferences; however, it's kind of fascinating just how different they can be.

If you ever want to spark a lively discussion amongst a group of drug users, just ask them to rate their top two and bottom two benzos. Out of all the substances around, the variation of responses to benzos seems to be especially random. You'll frequently get people having perfectly inverted lists (top 5, worst 5, and such) and perfectly opposite experiences.

Man... I'm still spinning after reading that quote about how to "defeat" MPH comedowns. Holy shit. Fortunately, I don't use MPH - too scary and rollercoaster-y. I prefer to stick with the safety and reliability of meth

 

[Cheradenine]

Actually I find MPH more addictive than AMP. With AMP I have never had the urge to go for another round the day after. I had fun, and my body makes it clear that it’s time to recover. But with MPH I’m never fully satisfied, and I know there is a chance that it will give me more tomorrow. Totally unpredictable. These are therapeutic doses prescribed by a psychiatrist, and exceeding these doses by any significant margin is simply unpleasant. I honestly think MPH does more damage to my body than AMP. Then again if I took AMP on a daily basis it would perhaps quickly turn into ‘the drug you learn to hate’.

 

[ageingpartyfiend]

3 years ago i was a stupid kid that decided to abuse his ritalin script it gave me a nice pleasurable feeling thats feels way better than amphetamine for like 3 weeks and then it just hacked my brain and i ended up abusing it daily for like 5 months it was horrible this shit complthy rotted my brain i wasnt even abusing it
to be honest.. snorting 20-40 mg daily cant be called abuse if people take 54 mg concertas or whatever the withdrawal of this shit is he worst hell ever and it lasted super long for 2.5 years i felt it i felt noticable cognitive imparirement drug induced asexuality?? like for a year
my libido was 0 and i wasnt attracted to women anymore in the beginning of my withdrawal i couldnt even form sentences writing on my keyboard was difficult cuz my memory etc was so slow i felt retarded like thats shit you would expect from abusing grams of meth daily not from stupid adhd pills i lost all childhood memories and was living "in the moment" but in a bad way for 1.5 yr i couldnt remember whan happened yesterday to this day i cant fully recall what i was doing during the week before abusing this shit i could do it flawlesly i also remeber how mph made every stimulant fuckign useless back in the day i was offered meth to snort i snorted it like 25mg and only felt anxiety and paranoia and brainfog .now i started to take dexroamphetamine for my adhd cuz it jsut came to my country i learned from
my mistakes and now i am scared to take it tbh i take it liek once a week to make my shit done and its great when you have to do something that you dont want to but it doesent do nothign for focus i still cannot focus no matter what for example when a dude on the internet was explaining some math related shit i still was wandering into my mind unvolountarily and had to repeat the same setgment of the video also i when i am on them i sitll sometimes switch tabs on my pc to watch brainrot for example instead of studying i thought meds were suppsoed to fix that i mean i couldve fucked my brain up premanently and its just residual tolerance that stayed from ritalin abuse i am taking like 30mg of elvanse rn .like what am i supposed to so ritalin hasnt worked for my focus too i am scared thats its fucking over and i will never be able to focus

OP I'm not what you're asking but I'll chime in anyway

If I'm understanding, you took ritalin daily for 6 months then had a 2.5 year bad time. You also occasionally mixed other stims with the ritalin. You then went on dex and found it not to help with 'focus' but it WAS "great when you have to do something that you dont want to" - which tbh does make it sound good for focus, or application anyway. You're now on 30mg elvanse (so approx 9mg dex daily when converted) but this isn't helping due to tolerance and you feel like your brain is broken - yeah?

From what you've said the outcome doesn't surprise me. There's no magic fix for focus (although meds can help tons, especially when combined with other non-drug techniques). If you can have some time when you don't need to get much done a month completely off all stimulants sounds like a good option. Restarting with a low dose (30mg elvanse fine, rising to 50/60 after a few weeks IF NEED be. Hold yourself accountable and only take therapeutic doses - do not use to get high. And then you may find the meds helpful. Use sparingly (like it sounds you do?) Once a week for a day of mega-focus and get tons shit done that day that you would usually struggle with is the way forward

Was gonna provide my own personal stim history / recommends for different scenarios here but tired so maybe tomorrow. One thing for sure though - same with all drugs stims hit people differently. Tons of variables, with age / health / amount of previous use / tolerance / intention/ dose etc etc are all huge factors. Cocaine/crack/cathinones are not in any way productive drugs for the vast, vast majority of people. Meth can be productive for a very small percentage of people - it's problematic at best for most and a total disaster for plenty.

 

[KurtAurelius]

Stimulants can only be used chronically with a anal amount of factors, it’s essentially a full time job,

If you fucked your tolerance up, you have to take a long break, and really sort out lifestyle, exercise, sleep, nutrition all that stuff,

Then you can only slowly start using infrequently before using more often.

I’ve tried up to 108mg of Methylphenidate a day as I love to experiment with different things and methods.

The drug works best as prescribed as obvious as that sounds, when I use to much Methylphenidate it really fucks up my mood and the crashes are so debilitating, I would sleep 12 hours a day.

This is me, but a 10mg Instant with a 54mg ER 3 hours later keeps my ADHD subdued from 7am to about 7-8pm.

If I am very careful with my sleep, and I eat 3 whole food meals a day, walk about 10km a day, lift weights everday or other day, take my laundry’s list of supplements

Creatine
Vitamin D
Magnesium
Thiamine
Choline
Taurine
Agmatine
Decaff Black Tea (Theanine protects tolerance and up regulates dopamine)

My tolerance is relatively steady and protected and Methylphenidate will work for a long time before a break is needed.

This is my experience with using Methylphenidate for a year or so now,

Using chronically
Using periodically
Using more than prescribed
Using as prescribed.

 

[Greed420]

Do you find that most stims give you that relaxation at high dosages? Idk if its just ADHD but I used to love ”overamping” on whatever stim because of the couch locked relaxing effect that would ensue for 30 - 60 minutes before stimulation and tweakiness took over, which of course I enjoyed too.

But i relate greatly to the statement that boofing or snorting a massive dose of MPH yields a like you said almost ”opiate-like” (or at least relaxing) feeling at first. With MPH it dissipated with tolerance though and never came back even when dosing 300mg at once.

The craziest case of MPH use ive seen is a friend of mine who once did 3600mg MPH in less than 24 hours. Consumed sixty 60mg pills, said it was her favorite stimulant even over speed, which I cannot relate to…

Damn 3600mg?! That's insanely high. I tought to be rock bottom having almost a gram in 48h but your friend makes me feel less worried about my addiction. Sorry to say that, hope he's doing fine rn.

Anyway yes, most of the stim gave that couch-lock euphoria where I can do a 12h straight gaming session, just keep taking lines. Happen with amphetamines, cathinones, pyrovalerones (they're caths I know but better specify) and phenidates. Cokes makes me chatty af but still a pleasant chill euphoria. Different from a low dose opiates like oxys, but methylphenidate boofed reminds me opiates for the forst 30 minutes it's absurd.

 

[Greed420]

Stimulants can only be used chronically with a anal amount of factors, it’s essentially a full time job,

If you fucked your tolerance up, you have to take a long break, and really sort out lifestyle, exercise, sleep, nutrition all that stuff,

Then you can only slowly start using infrequently before using more often.

I’ve tried up to 108mg of Methylphenidate a day as I love to experiment with different things and methods.

The drug works best as prescribed as obvious as that sounds, when I use to much Methylphenidate it really fucks up my mood and the crashes are so debilitating, I would sleep 12 hours a day.

This is me, but a 10mg Instant with a 54mg ER 3 hours later keeps my ADHD subdued from 7am to about 7-8pm.

If I am very careful with my sleep, and I eat 3 whole food meals a day, walk about 10km a day, lift weights everday or other day, take my laundry’s list of supplements

Creatine
Vitamin D
Magnesium
Thiamine
Choline
Taurine
Agmatine
Decaff Black Tea (Theanine protects tolerance and up regulates dopamine)

My tolerance is relatively steady and protected and Methylphenidate will work for a long time before a break is needed.

This is my experience with using Methylphenidate for a year or so now,

Using chronically
Using periodically
Using more than prescribed
Using as prescribed.

I was a bit into nootropics and supplements so I have taken with my methylphenidate this stack:
Magnesium glycinate
Vitamin C
NAC
ALCAR
L-Theanine
Citicoline/Alpha-GPC
Tyrosine
Vitamin D3+K2
Vitamin B complex methylated
Omega 3

Of course there were the day stack and the nioght stack when the effects was over to cope the possible side effects.

I don't use caffeine but I was a Tea-Nerd and prepare the tea oriental style with Gaiwans and clays teapots. Did you say Theanine in the tea helps to keep tolerance in check? Is it like NMDA antagonist?

 

[KurtAurelius]

I was a bit into nootropics and supplements so I have taken with my methylphenidate this stack:
Magnesium glycinate
Vitamin C
NAC
ALCAR
L-Theanine
Citicoline/Alpha-GPC
Tyrosine
Vitamin D3+K2
Vitamin B complex methylated
Omega 3

Of course there were the day stack and the nioght stack when the effects was over to cope the possible side effects.

I don't use caffeine but I was a Tea-Nerd and prepare the tea oriental style with Gaiwans and clays teapots. Did you say Theanine in the tea helps to keep tolerance in check? Is it like NMDA antagonist?

I am relying on my terrible memory, but there is a process of metabolism regarding theanine and in the latter stages it up regulates dopamine

The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent - PubMed

L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green tea. L-theanine has been historically reported as a relaxing agent, prompting scientific research on its pharmacology. Animal neurochemistry studies suggest that L-theanine increases brain serotonin...

pubmed.ncbi.nlm.nih.gov

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l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes - PMC

l-Theanine (γ-glutamylethylamide), a component of green tea, is considered to have regulatory and neuroprotective roles in the brain. The present study was designed to determine the effect of l-theanine on excess dopamine-induced neurotoxicity in ...

pmc.ncbi.nlm.nih.gov

I am too poor to afford supplement form theanine so I drink 4-5 cups of very strong Decaff tea a day.