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Opioids bypass hydromorphone 16mg extended release?

Time2Fly120 said:
Smart and Congratulations. Got any Stregth, Experience, or Hope your willing to share with us all. Are you saying you did Hydromorphone when you were 15-16 yrs old or in 2015-2016? Thank God you stopped when you did.

That same time I knew I would be asked for a divorce if I had told her I need rehab. She still didn't know something was up as I was functunal on Oxy. Well when you stopped I was getting blues and one day I heard a customer of the same source was turning blue on the floor of the convince store and the ambulance was called. I'm here in Miami Fl. It was my dealers fault for actually hanging a bad UA sample and could have just gone the next week as she didn't take them. Anyways I crushed one then went to her and said wtf is this shit. "I don't know its new" I got em from my pos brother. Playing dumb with literal death in her pocket. So I did what seemed resonable research drug bust Miami Dea and sure enough, 10,000 m30 fentpills. Range of dose from non to enough to kill 8 people. I over sniffed and thought a half would be fine I was doing 3 at a time (fucking hole in pocket). It didn't stop me. I woke up and did it again. Same result od. Woke up bent over face first into my center console, I thought I was cleaning and woke up soaking wet way after I would had I been on real oxy. It was hard to judge. I can't prove this but it seemed to have hot spots and from pill to pill would vary. I sniffed at the time. There was no good way to do street dope from the moment it hit the street and that was before Iso, Zylazine, Tranc, god only knows that was 3-5 yrs ago. I made it but I was only God that saved me. I had a bolt with an opening that I would tie around my waist because I was od'ing on almost any dose. I'll never forget when I got it I was warned "It hasn't been cut yet" I figured a 1/3rd my usual was fine nope less nope ever time the fucking floor till the last time, I believe around 8 hours.

Woke up like a pretzel took me 2 hours to get myself sitting on the floor. I feel face first off the toilet in a small space the my head must had hit the wall then the floor. I knew something wasn't right. The feeling in my legs was not coming back I could not move them. I got compartment syndrom from loss of circulation. They had to remove the dead tissue and I barley have but a bone below the knee and my foot that is stuck. Have not been able to move it for 5 years. Its not even so the presure hits right behind my pinky toe the size of a nickle instead of evenly dispersed. Its really bad out there. During covid the Cartels were putting Fent into Meth which was crazy fucking cheap. I could buy a qp for 800 about the same price for weed in Austin if you don't know anyone. I had a friend that didn't know what was wrong and I told him months before when it wasn't crystalizing the same it would be clumpy and milky and fuck your pipe up. Sometimes it would turn black it was ovious shit changed well didn't stop him. I had to break it to him and told him if he wants to see if im right I'll give him just a few grains and see if his ovious W/D's would stop. I was careful it took a f few time but each time he would get a bit better. Yeah he was fucking livid pissed as he hated opiods and was a complete sex addict that loved getting his bird sucked fucked you name it if he was on meth which was always he was trying to stick his dick in the closest girl to him and to him he would pull it off. Not quality but he was having his version of fun where mine was suicidal looking back.

Be safe out there guys and girls. God Bless us all especially our USA Military, the people of Israel, Citizens feel victim to an evil dictatorship with extream Islamic views and vowed to Kill us ALL. There are plenty of good people over there I don't hear anyone talking about them except for "they need to raise up". This whole ops Is a Win Win for US and Iran. God Bless us all ><>
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2015 2016 -- that is when the US got -- well it was more than just a "Fent batch" they were ALL fent batches.

Yup I blue lipped off a half a pack under 24 hours after 4mgs suboxone --- (That is how I "quit" no magic bullet there)

I was lucky and woke up before they got to the narcan -- but very disturbing experience none the less.

God bless every human of every religion --- every soldier fighting to defend there country.

"Wrote it for the thousands who have died, thinking that we all were on their side, wrote for the 100's thousands that have died, thinkin that the lord was on their side" Johnny Cash (Now thats good americana mama mia -- i mean damnit)
 
Purdue Pharma Canada 🇨🇦

Dilaudid 2/4/8mg IR tablets

Hydromorph-Contin 3/6/9/12/18/24/30mg XR capsules with beads inside

The coveted Dilaudid 4 & 8mg IR tablets …..and the Gold Standard Hydromorph-Contin 30mg XR big red capsules….the infamous “ Red Rockets” 30mg beads pulverized into IR HM and Dilaudid 8mg IR
 
In Canada 🇨🇦….sadly….specifically B.C. Canada where Fentanyl is a chemical weapon/warfar killing THOUSANDS & THOUSANDS of people daily

The government actually has a “safe supply program” were it provides 100% PURE pharmaceutical grade Hydromorphone (Dilaudid 8mg IR tablets) and Hydromorph-Contin XR capsules 18/24/30mg capsules

In Canada there is also injectable Diamorphine (Heroin) & injectable Hydromorphone for serious users who repeatedly failed oral Methadone treatment.

I personally due to medical condition re chronic pain due to RA I received 160 Metadol 25mg tablets in sealed factory bottle every 30 days (daily dose Methadone 100-125mg + Ritalin (Methylphenidate) a safe & potent dopaminergic stimulant causing minimal if no increase in HR or BP ……an “Inverse Agonists “ IDENTICAL in its MOA to Cocaine HCL as they both compete for the same binding sites at the DAT/NET (Cocaine being a Tropaine Alkaloid and a Potent Triple Reuptake Inhibitor with a hi affinity for the Dopamine transporter and all monoamine levels…as an “Inverse Agonists” their unique MOA (Ritalin & Cocaine) the prevent the reuptake of these monoamines while indirectly causing the significant release & increase of Dopamine > Serotonin >> Norepinephrine

Hence providing an insanely EUPHORIC RUSH + natural endorphins ……THEN you add the most euphoric non-sedating, slightly stimulating opioid analgesic medicine on planet earth. Oxycodone Hydrochloride

And HOLY FUCK…….the mammalian CNS centre responsible for “pleasure & reward” just CUMMED Soooooooo Fcking hard you’ll never have a sexual climax that spiritually mind blowing EVER AGAIN IN UR ENTIRE NATURAL LIFE.

That’s oral Oxycodone IR & Ritalin (Methylphenidate) a euphoric dopaminergic stimulant paired with Eukadol (Oxycodone) to ME PERSONALLY……THE ONLY 2 compounds to EVER enduce TRUE overpowering Euphoric ecstasy that made my CNS cum like a dirty little high school whore finger fucking her @$$hole with lub
 
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in the us all I ever seen was IR hydromorphone usually the malinkrodkt m/4 m/8's --- but sometimes the cool old shaped ones (think they were yellow)

Than again I havent bought a pill off the streets in like 10yrs and I know Opana brought TimeRX and they were saying they were about to add it to everything. Did that happen?
 
4DQSAR said:
I believe diacetyldihydromorphine is only around M in terms of potency. My guess would be that the 6 acetyl will be hydrolized at a different rate because the olefinic double-bond in the C ring isn't present.

I've mused on the fact that isocodine and isomorphine are reckoned to be around x4 the potency of their epimers. But I don't know if acetylation would then further alter the potency. I know in places like New Zealand that if a 'cook' cannot access an appropriate agent to esterify morphine, morphine hydrochloride is reckoned by some to feel akin to around half way between MS and diamorphine. Lower MW would explain some of that, but it seems so niche that it's impossible to really know from reading.

BUT if isomorphine is four times more potent that morphine, finding an easier way to invert that stereocenter WOULD be interesting. It appears they were initially developed in Germany but US Patent 2774762 'DHYDROSOCODENE' might offer interesting prospects for the determined researcher. Aluminium isopropoxide isn't the friendliest reagent but compared with DEAD and Ph3P, it may be simpler. As long as unreacted material is the only impurity, it's not such a problem.
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Well thankfully most opioids have no dose ceiling (tolerance is your ceiling)

Eukadol (Oxycodone HCL) ……ULTIMATE EUPHORIC non-sedating potent opioid EVER synthesized
PF Oxy-IR 5/10/20mg tablets
PF OxyContin 20/40/80/160mg

Sandoz Hydromorphone HP FORT 10ml glass vial
1,000mg / 10ml (100mg / ml)

100kg (220 lbs) blue plastic drum of Methadone HCL USP API compounding powder


Ritalin (Methylphenidate) 20mg IR tablets
Foquest XR (Methylphenidate) 100mg capsules

Dexedrine Spansule 15mg capsules
Dexedrine 5mg IR tablets
Desoxyn (d-Methamphetamine) 5mg tablets

Valium (Diazepam) 10mg
Xanax (Alprazolam) 2mg bars

Lyrica (Pregabalin) 300mg capsules

LSD-25 - 100ug tabs
Psilocybin mushrooms- raw mushrooms

Premium Belmont cigarettes
Ethanol- Gin etc

These compounds would be properly securely stored in my temperature controlled walk in vault…..next to my other vault stocked with Firearms, Ammunition, accessories, H20, MRE’s , non perishable food, sat phones, generators, gold bullion, liquid currency …..ammunition would be just as valuable as water in bartering

Over 100,000 rounds of quality factory ammunition, 5.56mm, 7.62mm, 9mm, .45 ACP, .357 Mag, .44 Mag, 300 Win Mag, .50 BMG etc, etc, etc

Barrett M82-A1 .50 Caliber semi-auto, 10-round magazine, 3k Leupold Tactical Mil-Dot scope with premium Hornady 750 grain A-Max Silver Tip boat tail hi ballistic coefficient projectile…..with its “wind bucking performance” 1,000 yard hits for breakfast

Canadian JTF-2 (our version of SEAL Team 6) still holds record for longest confirmed kill with a McMillian TAC-50 using Hornady 750 grain A-Max ammunition……it’s like a 5-7 second flight time 2,750 yards (approx)

That’s 30 Fcking football fields length wise back to back ……with a .50 BMG that sent some taliban to Allah with ammunition stamped PROUDLY MADE IN THE U.S.A. ha ha

Fucking A …..my younger brother is on ———Police Force Tactical Team and goes to Base Borden where they train with the JTF on clearing rooms, special weapons training, explosives to breach doors where other civilians are at the next unit in complex ……countless dogs get shot in the head with the Colt M4 Commando 5.56mm (pretty sad actually) fuckers with a 64 grain bonded jacketed soft point so it doesn’t blow through 3 walls potentially injuring an innocent person

By age 20 I legally owned over $30,000 dollars worth of hi-end precision weapon systems, member at 2 ranges, 50 yard indoor and a 100-200 yard outdoor range, 5 massive vaults, each dedicated to a class, long guns, pistols, ammunition, currency/controlled substances (all legally prescribed) my meds, etc, spare parts, etc LOTS of premium factory LE ammunition (Military LC NATO for the M4 Carbine 5.56mm) hollow points for pistol ammunition, and precision rifle ammunition for bolt action scoped Remington M40A1 .308 Win

My meds just kicked in…….rambling listening to music while cleaning and oiling some fun toys

It’s my weekend ritual (no live ammunition present while cleaning & oiling my toys)

Happy Sunny Sunday :)
 
Dextro .45 said:
100kg (220 lbs) blue plastic drum of Methadone HCL USP API compounding powder
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Dangerous. Drop that on peoples heads from 10m above them and I bet the fatality rate would be close to 100%.

I'm far too physically disabled to operate a firearm and TBH, I've never even held one nor wanted to.

BUT I think given the time I could figure out how to bypass the 2-man rule and operate a Pershing II TRBM.


Someone a thousand miles away threatens me, I could 'stand my ground'. I find it bizarre that the US constitution simply says 'arms', yet people mistakenly argue the toss about which types of guns should or should not be sold to the public. From here in the UK it does seem that this confusion is constantly being propagated, likely so nobody asks 'where is MY thermonuclear weapon?'.

But getting back on topic, there has been considerable research into improvements in the epimerization of secondary hydroxyl moieties. None specifically deal with the cases I've outlined, but I assume that's because none of the medicines remained in use thus there is no specific need to test those cases.


The above are decent index papers i.e. one can read them then look at what earlier papers/patents they cite and what later paper/patents cite them.

Oxidation and chiral reduction is probably a practical alternative in many cases and as I mentioned, in formal chemistry, especially when medicines are the product, isolation of that product is required. But if a reaction yields 66% isocodine but the remaining 34% is simply unreacted material, it's not such an issue.

Long, long ago when the options for instrumental analysis were severely limited, quite often the yield would be given along with the acronym BRSM. In fact, it's almost become a sort of in-joke as given instrumental analysis was so limited, calculating yield based on BRSM was often totally wrong. I first encountered this issue in 1995 when I read an old patent on the rearrangement of codeine into hydrocodone. The stated yield BRSM was >90% but it transpired that the majority of the yield was actually hydrocodeinone...
 
I was working at a pharmaceutical factory in the API division….no CII Substances

But….I dropped a pallet holding 4 100kg blue plastic drums from top level, and the 4 barrels exploded white powder evenrwhere

It was Pregabalin HCL (Lyrica) haha …fuuuck…..I tried to help clean up and fill a large garbage bag full of Pregabalin for personal use lol, the manager (we go to the same range) was like, sorry bud I have to follow listed steps in cleanup

The only interesting compounds I saw were Pregabalin and Gabapentin

The other side of the warehouse heavy gates, security badges, cameras, etc,etc……GARANTEED they had many many CII compounds, Opipids, Benzodiazepines, Dopaminergic Stimulants

Purdue Pharma plant in Pickering Canada has trailers departing escorted by security vehicle behind trailer truck and another in front….guaranteed GPS tracking and security alert which dispatches Law Enforcement ASAP as there are MILLIONS of $$$$ and tablets of extremely potent Opioid Narcotics

When I’m at my pharmacy I notice a truck by curb filled with brown plastic bins full of meds with their route 20+ stops/pharmacies etc……im sure there are LOTS of desirable compounds on that large cargo truck
 
I have no idea what protocols are followed for cleanup of CII Substances at that scale,

Does CCTV evidence have to be supplied or something? Because with smaller quantities, there is (or was) simply a two signature system i.e. one person destroys the spilt/dropped/otherwise unusable medicine in front of someone else and then the CD (controlled drug) register is updated to show where it went.

BTW the acronym BRSM means 'by recovered starting material' and I'm talking of times when melting point and similar physical properties were used to identify unreacted start material but when two compounds differ by just a single olefinic bond, limits of the technology couldn't tell the difference. Sorry people, I wasn't showing off - I'm just an idiot and forgot to say what it meant.
 
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