Opioids Why did Codeine had no effect on me?

[lost weekend]

200mg's is to much for someone without tolerance imo. At that dose the histamine release can be pretty bad sometimes so at that dose id recommend having a antihistamine on hand. Taking promethazine with the codeine or hydroyzine will boost the high nicely to

Yeh 120 seems to hit the spot ,and if you don't mind a scratching now and again I'd say a safe dose without tollarance

 

[paranoid android]

Yeh 120 seems to hit the spot ,and if you don't mind a scratching now and again I'd say a safe dose without tollarance

Without a tolerance i used to go with about 150mg's usually. Hydroxyzine is the best antihistamine for the opiate itch and also to potentiate any opiate imo. But not over the counter here like promethazine is and for some reason docs here think hard of scripting it. Ive only had it when my mom gets a script for her hives

 

[DeathIndustrial88]

I'm an anomaly & actually enjoy the opiate-itch.
If I get it, it just means I'm feeling pretty damn good.

Where as, if I don't get it, it usually means my tolerance is too high or I'm dealing with an opioid that doesn't cause as much histamine release. And IMO/IME, the best ones all cause histamine release. It's part of the experience to me.

I've never understood why codeine/promethazine is so popular. Promethazine also has anti-dopaminergic properties, sort of like an antipsychotic, which can be counter intuitive if your goal is euphoria. The one time I tried codeine/prometh syrup, it pretty much knocked me out & made me feel heavy & braindead, most likely due to all the added interactions caused by promethazines pharmacology. I was not a fan. Tramadol was much more enjoyable at the time for me.

Histamine release also helps keep you awake if you're some one who enjoys opioids for their motivation/creativity enhancing properties.

 

[lost weekend]

Without a tolerance i used to go with about 150mg's usually. Hydroxyzine is the best antihistamine for the opiate itch and also to potentiate any opiate imo. But not over the counter here like promethazine is and for some reason docs here think hard of scripting it. Ive only had it when my mom gets a script for her hives

I don't actually mind a slight itch .yeh on the times I've been lucky enough to be prescribed it I normally waste a whole months supply within a week ,I know there not going to give a repeat prescription so I think what the hell,when it's gone it's gone
Once I'm on the last stripp I could eat them all and not feel very much atol

 

[paranoid android]

I don't actually mind a slight itch .yeh on the times I've been lucky enough to be prescribed it I normally waste a whole months supply within a week ,I know there not going to give a repeat prescription so I think what the hell,when it's gone it's gone
Once I'm on the last stripp I could eat them all and not feel very much atol

One tme when i was in severe morphine wthdrawal i crushed up a 300mg codeine contin and ate the entire thing. It realy helped the wd but i got hives on my goddamn leg from itching so much lol

 

[lost weekend]

Nothing like morphine withdrawl but I've seen me drive around supermarkets during kratom wd and buying poppy seeds and belive it or not it has worked on a few occasions but left me zombified the next day almost unable to speak.i think it's a lottery whether you manage to pick up an unwashed bag .I tried a few months ago and got zero affect.

 

[cnnka]

Kratom is kinda shitty to use with other opies if I had dose kratom the day I dosed opies I couldn’t feel the opies at all

 

[lost weekend]

Kratom is kinda shitty to use with other opies if I had dose kratom the day I dosed opies I couldn’t feel the opies at all

Yeh you only ever get a nice feeling if your tolerance is down to pretty much zero which means avoiding kratom itself for at least 3 to four days but longer the better.mostly its just to feel normal. I've never had anything stronger than dhc so I can't compare .I did try tapentadol once and instantly regretted it seemed to make me very anxious

 

[evo4ever]

200mg's is to much for someone without tolerance imo. At that dose the histamine release can be pretty bad sometimes so at that dose id recommend having a antihistamine on hand. Taking promethazine with the codeine or hydroyzine will boost the high nicely to

Oh yeah I forgot Codeine provokes a strong histamine release at high dosages. Would an antihistamine work? or would that just add to the sedation?

 

[paranoid android]

Oh yeah I forgot Codeine provokes a strong histamine release at high dosages. Would an antihistamine work? or would that just add to the sedation?

Antihistamines can prevent stuff like hives if you take them before taking a opiate. I used to take promethazine or benadryl before shooting up morphine to prevent a kinda hives reaction at the injection ssite. They do add to the sedation and imo hydroxyzine is the best for this. However as thats script only here its harder to get. Ive not had any luck tryig to get it scripted

 

[daturetard]

6% of the Caucasian population has clinically significant deficiency in 2d6, but thats probably been mentioned

 

[Satori446]

The ones I have also contain paracetamol. I didn't think that would make much of a difference but you say you did a cold water extraction because yours had tylenol?

Yeah. It was a long time ago. I looked it up and found out how one way is to do it. Can't say it didn't work but it wasbt worth the effort honestly. But luke has been said there are threads for cwe

 

[JackDick]

I have no tolerance to opiates at all. I took 300mg of codeine last week and felt mild, but really pleasant high for like 4 hours.
I also had a little afterglow the next day I think. I think I will try 450mg + eating a grapefruit before this sunday. Should be good now.

 

[HeadphonesandLSD]

Oh yeah I forgot Codeine provokes a strong histamine release at high dosages. Would an antihistamine work? or would that just add to the sedation?

It works fine. I'm mildly allergic to codeine and get a very bad histamine release from it. I usually love histamine release it's one of my favorite things about morphine. But with codeine it'll get really bad even if I only take 100mg or so. I'll break out in hives and my skin will turn red. If I don't take an anti-histamine I'll end up scratching myself until I draw blood.

As for OP: As others have said this was a really low dose and you shouldn't expect that much from it. But if you're totally opioid naive you should know that opioids are very subtle when you start out. A lot of people don't like them at first and don't see the big deal. Then on their 3rd-4th attempt they'll typically obtain their first nod. At that point opioids click with you and you'll quickly be hooked on them for life if you don't stop.

Opioids don't really reduce pain either. It's more like they make it so you don't care about pain. They take away your ability to feel emotions like joy just as much as they take away your ability to feel pain.

Also you guys going much over 120-150mg should know you're wasting most of the codeine. Codeine has a ceiling and once you reach it adding more will not make the desired effects stronger. It will only increase the side effects.

 

[AutoTripper]

From what I remember and this could be one potential explanation- Codeine requires fully accurate literacy in order to work.

Otherwise it simply refuses to cooperate (from what I hear, again)

 

[SoCalShordie]

Interesting, because when I was a baby stripper, a friend of mine who had never tried any drugs in her life, not even marijuana, took 2 of my percocets and NOTHING happened. Nothing at all. While I’m all nodding out to oblivion and itching like crazy.

 

[peace seeker 76]

So I've developed a tolerance for codeine; I did 250 mg 4 days ago and only got a very slight buzz. Thinking of going to 350 mg. Does anyone know the max dose someone, even with a high tolerance, should take? Plus, has anyone taken codeine and thrown in a few dihydrocodeine?

thanks

 

[opiatekrzy]

So I took 60mg of codeine yesterday for the first time in my life ever. I expected some kind of high and everyone claims its super addictive but even after several hours I felt absolutely nothing. Does this mean I for sure have a low cyp2d6 activity and can't convert codeine to morphine in my liver. I'm just confused.

Some people just have a naturally high tolerance after all codeine is fairly weak to begin with. Also another thing is are you on any medication? I was on an SSRI when I was 15 years old and I remember when I was abusing codeine I hit a diminished effect from it because of the medication I was on

 

[Keif' Richards]

There is a specific reason that some people are unaffected by Codeine.

Codeine (3-Methylmorphine) produces insignificant effects on its own, if any. It must first be demethylated in the body. This process renders the Codeine into Morphine, the latter of which is responsible for essentially all effects produced by Codeine.

There is an enzyme CYP2D6 that is responsible for metabolizing Codeine into Morphine. Like all enzymatic activity, heredity/genetics plays a major role in how effective this enzyme is at converting. Individuals with multiple copies of said enzyme can metabolize significantly more Morphine from the same given dose of Codeine. An individual with a weak or absent CYP2D6 function will thus not receive much effect from the use of Codeine.

For the vast majority of people on this planet, Codeine is pegged at 10% the strength of Morphine. So, 100mg Codeine = 10mg Morphine and so on. Individuals with more copies of CYP2D6 will thus have a higher ratio of conversion.

I am one of those people for whom Codeine is ineffective. I´ve never gotten tested or anything, but I´ve taken 10g of Codeine down the hatch in a single sitting following half a day of CWE hundreds of little pills. I was in Iraq at the time. It was my first day there and I was unable to find any Opioids stronger than Codeine. I knew I had had little reaction in the past and had already suspected enzymes to be the culprit. I took that huge dose as I was already dependent on Heroin and I wanted to know if I should ever fuck with Codeine again. I believe I felt a small twinge of relief from withdrawal following the ~10g dose, but I´d be lying if I said I was certain.

I´m not positive, but I believe it´s 10% of Caucasians will have an issue with their CYP2D6. As already implied, race/ethnicity is a huge predictor of potential enzymatic mutations.