Opioids Why did Codeine had no effect on me?

[KJ7]

So I took 60mg of codeine yesterday for the first time in my life ever. I expected some kind of high and everyone claims its super addictive but even after several hours I felt absolutely nothing. Does this mean I for sure have a low cyp2d6 activity and can't convert codeine to morphine in my liver. I'm just confused.

 

[DeathIndustrial88]

So I took 60mg of codeine yesterday for the first time in my life ever. I expected some kind of high and everyone claims its super addictive but even after several hours I felt absolutely nothing. Does this mean I for sure have a low cyp2d6 activity and can't convert codeine to morphine in my liver. I'm just confused.

Not necessarily.

Codeine is a weird drug honestly. I use to be heavily addicted to tramadol for 10 years, which also requires the cyp2d6 enzyme, yet I never felt anything from codeine really. Tramadol is a codeine analog & it use to make it nod out, itch, feel totally euphoric, etc.. So clearly there was no issues with my liver enzymes, yet I just could not get any enjoyment out of codeine the same way I could from tramadol & I never understood why either.

I think codeine is just an incredibly mild opiate to be honest, unless your dose is incredibly high. It could be that it just doesn't impact you like a different opioid would. It's not very potent, so maybe 60mg just wasn't enough for you?

Also, depending on your drug use history, you might be expecting too much from it. For example if you've used things like stimulants or harder opioids & then try codeine, you're going to probably be disappointed.

I'm not totally sure why codeine was never a great experience for me either. So I can't totally answer that. But you're not the only one who seems to get almost no effect from codeine. I had some tylenol 3's over the summer & I did feel them, but the effects were so mild & short lasting, that you almost don't even recognize that you felt them. That;'s why I asked about your past or current drug use history cause anyone use to different drugs might be expecting a big euphoric experience from codeine & that's just doesn't happen for everybody.

 

[KJ7]

Not necessarily.

Codeine is a weird drug honestly. I use to be heavily addicted to tramadol for 10 years, which also requires the cyp2d6 enzyme, yet I never felt anything from codeine really. Tramadol is a codeine analog & it use to make it nod out, itch, feel totally euphoric, etc.. So clearly there was no issues with my liver enzymes, yet I just could not get any enjoyment out of codeine the same way I could from tramadol & I never understood why either.

I think codeine is just an incredibly mild opiate to be honest, unless your dose is incredibly high. It could be that it just doesn't impact you like a different opioid would. It's not very potent, so maybe 60mg just wasn't enough for you?

Also, depending on your drug use history, you might be expecting too much from it. For example if you've used things like stimulants or harder opioids & then try codeine, you're going to probably be disappointed.

I'm not totally sure why codeine was never a great experience for me either. So I can't totally answer that. But you're not the only one who seems to get almost no effect from codeine. I had some tylenol 3's over the summer & I did feel them, but the effects were so mild & short lasting, that you almost don't even recognize that you felt them. That;'s why I asked about your past or current drug use history cause anyone use to different drugs might be expecting a big euphoric experience from codeine & that's just doesn't happen for everybody.

I do use stimulants frequently but nothing especially hard or high dosage and this was the first time I'd ever taken any opiods. Good to know that others have had similar experiences with codeine.

 

[WellTram]

Strange. Try 90mg. Loong time ago it always produced relaxing, nice short lasting feeling. If it won't have any effects, u can't metabolise it into morphine.

 

[ledbyher]

60mg is a small dosage i wouldn't feel it either.

i would dose 150mg, wait a week then 300mg next if needed.

 

[Okiv99]

So I took 60mg of codeine yesterday for the first time in my life ever. I expected some kind of high and everyone claims its super addictive but even after several hours I felt absolutely nothing. Does this mean I for sure have a low cyp2d6 activity and can't convert codeine to morphine in my liver. I'm just confused.

60mg is a nothing dosage. Took me 280mg with no tolerance to get full effect (on empty stomach), with pinpoint pupils etc.

My grandma and her friend both prescribed two 30mg codeine/500mg paracetamol tabs taken up to 4 times a day.

 

[lost weekend]

So I took 60mg of codeine yesterday for the first time in my life ever. I expected some kind of high and everyone claims its super addictive but even after several hours I felt absolutely nothing. Does this mean I for sure have a low cyp2d6 activity and can't convert codeine to morphine in my liver. I'm just confused.

I used to feel the same about codeine and much prefered dihdrocodine but I was prescribed codeine a while ago (100 x 30mg) and 120mg really hit the spot ,the only trouble is the same amount 2 or three days in a row was barely felt.

 

[WellTram]

I used to feel the same about codeine and much prefered dihdrocodine but I was prescribed codeine a while ago (100 x 30mg) and 120mg really hit the spot ,the only trouble is the same amount 2 or three days in a row was barely felt.

I will add something that really proves cyp2d6 influence codeine, tramadol BUT not dihydrocodeine.
Once i was on combination of meds that changed me from ultrametabolizer to unable to metabolize anything by cyp2d6 enzyme. Codeine stopped working after 1 day, tramadol too and i still couldn't feel them +- 30 days after stoping use of cyp2d6 inhibitors but dihydrocodeine worked perfectly fine.

 

[lost weekend]

I find dihydrocodeine much more energetic and certainly stronger ,made me want to get things done ,put me In a more socialble mood and made an excellent combination with alcohol, makes me want to dislocate my shoulder again lol.
I could swallow 240mg at a time easy although oral biovility isn't so great I here

 

[Satori446]

I remember long ago I bought several boxes of codeine pills from Australia. Prob was they had Tylenol so I did cold water extract. Im not sure how many codeine I put in first batch. Maybe 4. They were 30mg. I didn't feel a thing. I had been on 5mg roxis not to long before sobi figured my tolerance was still up. Only time I felt codeine is when I was prescribed cough medicine with it in there. Had to go to mom and pop pharmacy to get. I cant be sure of the dosage but I took it as prescribed and felt great. I don't think its your liver enzymes I just think overall, codeine is one of the weakest opiates. It is one of the three naturally occurring opiates. I remember a lecture in rehab about opiates vs. opioid. Anyway, if you wanna feel it more then like others have said bump up the dose. I don't think your occasional stimulant use woukd matter but it might. Human body is a tricky thing. Always remember that

 

[Okiv99]

I used to feel the same about codeine and much prefered dihdrocodine but I was prescribed codeine a while ago (100 x 30mg) and 120mg really hit the spot ,the only trouble is the same amount 2 or three days in a row was barely felt.

Yeah and redosing in the same day also doesnt work. Think since its a prodrug your liver can only convert so much to morphine over a certain period maybe.

 

[SpaceCampGreenOne]

Not necessarily.

Codeine is a weird drug honestly. I use to be heavily addicted to tramadol for 10 years, which also requires the cyp2d6 enzyme, yet I never felt anything from codeine really. Tramadol is a codeine analog & it use to make it nod out, itch, feel totally euphoric, etc.. So clearly there was no issues with my liver enzymes, yet I just could not get any enjoyment out of codeine the same way I could from tramadol & I never understood why either.

I think codeine is just an incredibly mild opiate to be honest, unless your dose is incredibly high. It could be that it just doesn't impact you like a different opioid would. It's not very potent, so maybe 60mg just wasn't enough for you?

Also, depending on your drug use history, you might be expecting too much from it. For example if you've used things like stimulants or harder opioids & then try codeine, you're going to probably be disappointed.

I'm not totally sure why codeine was never a great experience for me either. So I can't totally answer that. But you're not the only one who seems to get almost no effect from codeine. I had some tylenol 3's over the summer & I did feel them, but the effects were so mild & short lasting, that you almost don't even recognize that you felt them. That;'s why I asked about your past or current drug use history cause anyone use to different drugs might be expecting a big euphoric experience from codeine & that's just doesn't happen for everybody.

I’ve also noticed that kratom has a super strong binding affinity to the mu receptor site- it took 3 goes with diacetyl (tar) before breaking through to euphoria. I just the other day, got a script for 30x Tylenol 3’s and I started with x2 and felt nothing, went up to 3 and still feel nothing. I’m sitting here contemplating taking x4 ( which would be 120mg) hoping 1.2g of acetominophen is ok. I don’t have much experience with high doses of Tylenol…
Anyhow, I believe it’s my evening dose of kratom to get enough pain relief to sleep at night, that is blocking my receptors from codeine even eventually making it to my cyp2d6.
I dunno tho, had a buddy synthesize a few lbs of tramadol for me in the early 2000’s and enjoyed it immensely for almost 10 years - so I’m sure my cyp’s are 6in’ it right…

 

[evo4ever]

So I took 60mg of codeine yesterday for the first time in my life ever. I expected some kind of high and everyone claims its super addictive but even after several hours I felt absolutely nothing. Does this mean I for sure have a low cyp2d6 activity and can't convert codeine to morphine in my liver. I'm just confused.

60mg is a low dose. Try taking around 200mg.

 

[Halif2]

makes me want to dislocate my shoulder again

That is a very specific feeling. Way back when I used to enjoy codeine it generally just made me want to get comfortable and listen to some tunes.

Funny how differently these things affect us all

 

[lost weekend]

That is a very specific feeling. Way back when I used to enjoy codeine it generally just made me want to get comfortable and listen to some tunes.

Funny how differently these things affect us all

Yeh codeine makes me feel that way ,just want relax and watch TV or listen to pink Floyd but dihydrocodeine almost has the opposite affect, in doses up to 120- 150 mg I can sometimes go into a mania of fixing things round the house lol .it seems to bring more confidence as well while to much codeine can make my voice sound slowed and I guess like a strong opoide addict

 

[DeathIndustrial88]

I’ve also noticed that kratom has a super strong binding affinity to the mu receptor site- it took 3 goes with diacetyl (tar) before breaking through to euphoria. I just the other day, got a script for 30x Tylenol 3’s and I started with x2 and felt nothing, went up to 3 and still feel nothing. I’m sitting here contemplating taking x4 ( which would be 120mg) hoping 1.2g of acetominophen is ok. I don’t have much experience with high doses of Tylenol…
Anyhow, I believe it’s my evening dose of kratom to get enough pain relief to sleep at night, that is blocking my receptors from codeine even eventually making it to my cyp2d6.
I dunno tho, had a buddy synthesize a few lbs of tramadol for me in the early 2000’s and enjoyed it immensely for almost 10 years - so I’m sure my cyp’s are 6in’ it right…

Yeah it's weird. Stuff like codeine, poppy seed tea & even hydrocodone all kinda just feel "blah" to me. I don't hate them & wouldn't say no to them, but there was just something about tramadol & diacetylmorphine (heroin) that made me wanna get up & clean & get shit done versus other opioids and I dunno why. And then I could lay down & nod out if I truly wanted or keep being physically active if I wanted (long walks, exercising, cleaning the shit out of stuff). And there's always a sharp euphoria & "content" feeling accompanying it. Where as opiates/opioids like codeine & hydrocodone, I have to like, really focus on the euphoria or I some times don't even notice it.

Tramadol also gave me insane music euphoria, where I could listen to the same song over & over 100+ times for the whole "buzz" and just absolutely enjoy it every single time until I peacefully nod off. lol Can't really say codeine has ever given me effects that great honestly.

Buprenorphine use to feel like tramadol-lite / diet tramadol when I had no tolerance & first tried it, which I liked, but tramadol was wore effective when used in the long term for depression & pain than bupe is. Once I get use to buprenorphine, it just makes me feel incredibly heavy & tired when I take it. Low dose bupe + a couple 50mg tramadol is pretty nice too for whatever reason. Better than either buprenorphine or tramadol on their own.

 

[KJ7]

I remember long ago I bought several boxes of codeine pills from Australia. Prob was they had Tylenol so I did cold water extract. Im not sure how many codeine I put in first batch. Maybe 4. They were 30mg. I didn't feel a thing. I had been on 5mg roxis not to long before sobi figured my tolerance was still up. Only time I felt codeine is when I was prescribed cough medicine with it in there. Had to go to mom and pop pharmacy to get. I cant be sure of the dosage but I took it as prescribed and felt great. I don't think its your liver enzymes I just think overall, codeine is one of the weakest opiates. It is one of the three naturally occurring opiates. I remember a lecture in rehab about opiates vs. opioid. Anyway, if you wanna feel it more then like others have said bump up the dose. I don't think your occasional stimulant use woukd matter but it might. Human body is a tricky thing. Always remember that

The ones I have also contain paracetamol. I didn't think that would make much of a difference but you say you did a cold water extraction because yours had tylenol?

 

[paranoid android]

60mg is a low dose. Try taking around 200mg.

200mg's is to much for someone without tolerance imo. At that dose the histamine release can be pretty bad sometimes so at that dose id recommend having a antihistamine on hand. Taking promethazine with the codeine or hydroyzine will boost the high nicely to

 

[lost weekend]

I'm not a fan of cwe .I've obviously not done it right because it does take due diligence, there are methods which describe just using a t shirt which seems like rushing for the sake of it.
Everytime I've done it I've felt nauseous and had to go to bed ,absolutely nothing like pure codine tablets 15mg or 30mg .maybe some one can tell me if there is other ingredients like caffeine in co codamol and such products.
Actual codiene pills give me such a clean warm feeling nothing like a cwe .

 

[lost weekend]

Just to clarify I am in no way interested in cwe ,there's hundreds of posts and a mega thread about it .