Stimulants Is this a good way to split 2g dextroamphetamine into 5mg capsules?

[Deleted member 594230]

Hey, I want to make 400 capsules each containing 5 mg dextroamphetamine powder (±0.5 mg desired) using microcrystalline cellulose as filler.

Equipment:

• 0.01 g digital scale (200 g capacity)
• Capsule filling stand for 100 capsules (with tamper, frame plate, etc.)
• Size 0 or size 2/3 empty gelatine capsules
• MCC filler
• Small mixing bottle

1. Determine fill weight per capsule
   • Fill around 10 empty capsules with MCC only using the stand and scraping method.
   • Weigh the total MCC that went into those 10 capsules.
   • Divide by 10, average fill weight per capsule (e.g., 0.400 g = 400 mg).
2. Calculate batch quantities (per 100 capsules)
   • Active per 100 caps = 0.5 g dextroamphetamine (100 × 5 mg).
   • Total mix weight per 100 caps = 100 × fill weight (e.g., 40 g if fill weight = 0.4 g).
   • MCC needed = total mix weight − 0.5 g = e.g., 39.5 g.
3. Mixing
   • Weigh 0.5 g dextroamphetamine on scale
   • Weigh 39.5 g MCC
   • Combine both in a clean, dry bottle
   • Close tightly and shake strongly for 30+ seconds
4. Filling capsules
   • Place 100 empty capsule bottoms in the stand.
   • Pour mixed powder from bottle onto frame plate
   • Spread evenly with scraper
   • Remove frame, cap capsules using capping plate.
5. Repeat
   • Make 4 batches of 100 capsules each (total 400 caps)
6. Verification plan
   • Weigh 10 finished capsules from different batches; weights should be very close (e.g., within 0.015 g of each other)
   • Acceptable dose variation set at 4.5–5.5 mg per capsule

Question:

1. Does this sound like a reliable method to achieve consistent dosing?
2. Which capsule size do you think is better for this case: size 0 (more fill volume) or size 2/3 (less fill volume)?
3. Should I mix each 100‑capsule batch separately or mix the entire 400‑capsule batch at once?
4. When measuring the total fill volume of capsules with filler, should I tamp the powder (to see how much really fits when packed) or leave it loose (scrape‑only method)?

 

[Vastness]

You're gonna try to mix 2 dry powders in a bottle just by shaking it for 30 seconds?!

I guess the general principle otherwise sounds sensible, I haven't checked your calculations or anything but it sounds fairly well planned. However that one step intuitively just sounds like it's never gonna work properly and you're gonna have a crazy unpredictable range of doses from 0 to even quite close to 0.4g, quite honestly, depending on your "shaking" technique. I could be wrong about this, I don't actually know but I'm pretty sure you need better equipment than an empty, dry bottle, or you'd need to shake it and otherwise agitate it for far longer than 30 seconds, possibly too long to do practically... if there's some reason I am wrong about this would love to know where you got the idea for this so that I can revise my incorrect intuitive assumptions about reality and the ease of evenly mixing dry powders... but, intuitively, again, it just sounds like it's never gonna work... doesn't it?

 

[shreddedlettuce]

Acceptable dose variation set at 4.5–5.5 mg per capsule

IMO, NO variation should be acceptable.
If you have all that detail and equipment etc. , why can't it be 100% accurate?

Not being a dick, just interested in why you put that quoted section in?

Be careful and stay safe

EDIT - There are a few unnecessary steps IMO, that could cause inaccuracy and IMO, feel are not necessary, but if I missed something and made an idiot of myself, let me know too.

 

[Helpmeescapethis]

IMO, NO variation should be acceptable.
If you have all that detail and equipment etc. , why can't it be 100% accurate?

Not being a dick, just interested in why you put that quoted section in?

Be careful and stay safe

EDIT - There are a few unnecessary steps IMO, that could cause inaccuracy and IMO, feel are not necessary, but if I missed something and made an idiot of myself, let me know too.

They have no equipment except a scale lmao. They planned on mixing it by shaking a bottle for 30 seconds.

OP, this will not work in the slightest. You’ll have to figure out how to dissolve all of your active ingredient and cut into a solvent, throughly mix for a significant amount of time, then evaporate that liquid into a solid. Only then will you have a chance of even distribution.

Your current method is hopeless, sorry.

You’d genuinely be better off weighing 25mg piles, and attempting to split those into 4ths/5ths.

 

[F.U.B.A.R.]

Why even bother with the filler? Can't you just put the dex into the capsules, no mixing required?

Also, I'd put 30mg in each capsule. Easier to weigh out.

 

[shreddedlettuce]

Why even bother with the filler? Can't you just put the dex into the capsules, no mixing required?

Also, I'd put 30mg in each capsule. Easier to weigh out.

my point exactly. a scale is all you need.
again am i missing something?

 

[PenguinWithNapalm]

Where the shit did you get 2 Gs of 100% pure dextroamphetamine powder is my question lol

 

[yoyoman]

If you don't NEED it to be in capsules, but you just want accurate dosing, hard to beat just dissolving it in water/liquid.. like 0.1ml=1mg or something like that then just measure doses with a little syringe.

Maybe look for documents related to compounding pharmacies and how they do it. I have read lots of stuff about how even big pharmaceutical companies get things way wrong, way more often than we would think. Liquid dosing will be crazy accurate.

 

[Shinji Ikari]

Where the shit did you get 2 Gs of 100% pure dextroamphetamine powder is my question lol

Seconded. Sure it isn't just racemic?

 

[Deleted member 594230]

They have no equipment except a scale lmao. They planned on mixing it by shaking a bottle for 30 seconds.

OP, this will not work in the slightest. You’ll have to figure out how to dissolve all of your active ingredient and cut into a solvent, throughly mix for a significant amount of time, then evaporate that liquid into a solid. Only then will you have a chance of even distribution.

Your current method is hopeless, sorry.

You’d genuinely be better off weighing 25mg piles, and attempting to split those into 4ths/5ths.

Thanks for your advice earlier. I’ve never dissolved my powder in a liquid and I’m not sure I could do it safely or reliably at home.
I thought about using a 0.001 g scale, but I’m not sure if a $10 scale could actually measure 5 mg accurately. Thats why i thoughts measuring with volume makes more sense. Also I got this guide from someone online who said he has been doing it like this for years, Ive got no idea how to reliably mix active ingredients with filler.

I researched a bit and most people suggest geometric dilution
Would geometric dilution with a glass mortar and pestle, like in this video, work for evenly spreading 2 g active in filler to get consistent 5 mg capsules?

Why even bother with the filler? Can't you just put the dex into the capsules, no mixing required?

Also, I'd put 30mg in each capsule. Easier to weigh out.

my point exactly. a scale is all you need.
again am i missing something?

This was my original idea but I dont know if a cheap scale can accurately measure 5mg. I take it for adhd and i mostly take 10mg twice a day so 30mg would be too much for me.

Where the shit did you get 2 Gs of 100% pure dextroamphetamine powder is my question lol

If you don't NEED it to be in capsules, but you just want accurate dosing, hard to beat just dissolving it in water/liquid.. like 0.1ml=1mg or something like that then just measure doses with a little syringe.

Maybe look for documents related to compounding pharmacies and how they do it. I have read lots of stuff about how even big pharmaceutical companies get things way wrong, way more often than we would think. Liquid dosing will be crazy accurate.

I really dont know dissolving in liquid seems a lot more complicate to me than just mixing with filler, but I could be wrong as I never did this before

Seconded. Sure it isn't just racemic?

I hope not but I read mostly good things about the vendor

Also it was $ per gram so it better be pure d amph

 

[Deleted member 576750]

dissolving in liquid is actually the far simpler solution here. 1mL of water weighs 1 gram, if you dissolve 2 grams into 400ml water that is 5mg per mL. then all you need to do is consume 1 gram of water and it's guaranteed to be the right concentration. distributing powders equally is far more difficult and usually requires special machinery. dissolving in water distributes it evenly on its own with no effort

 

[PenguinWithNapalm]

Thanks for your advice earlier. I’ve never dissolved my powder in a liquid and I’m not sure I could do it safely or reliably at home.
I thought about using a 0.001 g scale, but I’m not sure if a $10 scale could actually measure 5 mg accurately. Thats why i thoughts measuring with volume makes more sense. Also I got this guide from someone online who said he has been doing it like this for years, Ive got no idea how to reliably mix active ingredients with filler.

I researched a bit and most people suggest geometric dilution
Would geometric dilution with a glass mortar and pestle, like in this video, work for evenly spreading 2 g active in filler to get consistent 5 mg capsules?





This was my original idea but I dont know if a cheap scale can accurately measure 5mg. I take it for adhd and i mostly take 10mg twice a day so 30mg would be too much for me.





I really dont know dissolving in liquid seems a lot more complicate to me than just mixing with filler, but I could be wrong as I never did this before


I hope not but I read mostly good things about the vendor

Also it was $ per gram so it better be pure d amph

I highly doubt that it’s going to be pure d amp. I don’t wanna rain on your parade but that I’m extremely skeptical. Even 100% pure racemic would be insane outside of a literal pharmaceutical manufacturing setting.

 

[Helpmeescapethis]

I highly doubt that it’s going to be pure d amp. I don’t wanna rain on your parade but that I’m extremely skeptical. Even 100% pure racemic would be insane outside of a literal pharmaceutical manufacturing setting.

Nah mate, you’d be very surprised at the state of the current amp market. Extremely good product easily available, cheaper than ever.

I know for a fact a very small run of D-amp JUST got produced and sold out. So this checks out entirely.

 

[PenguinWithNapalm]

Nah mate, you’d be very surprised at the state of the current amp market. Extremely good product easily available, cheaper than ever.

I know for a fact a very small run of D-amp JUST got produced and sold out. So this checks out entirely.

Holy crap really? I had no idea

 

[F.U.B.A.R.]

If the OP has ADHD, surely he has a script and doesn't need to be sourcing stuff from the darkweb?

Also, making up 400 capsules sounds like a commercial operation to me...

 

[Helpmeescapethis]

If the OP has ADHD, surely he has a script and doesn't need to be sourcing stuff from the darkweb?

Also, making up 400 capsules sounds like a commercial operation to me...

While I agree this was obviously an attempt at producing a mass quantity to distribute for cash, even someone with extremely well documented and verified ADD will be refused stimulant medications these days.

The catch-all term “narcotic” has poisoned the well of treatment beyond repair.

 

[PenguinWithNapalm]

While I agree this was obviously an attempt at producing a mass quantity to distribute for cash, even someone with extremely well documented and verified ADD will be refused stimulant medications these days.

The catch-all term “narcotic” has poisoned the well of treatment beyond repair.

In the US? Dude you can get a script for adderall so easily. If you don’t have any kind of drug abuse history on your record then you literally can go to basically any psychiatrist and say you can’t concentrate and they are gonna throw adderall at you. My medical chart is littered with drug abuse and I still easily found a psychiatrist to prescribe me vyvanse. Granted I had to do the song and dance of being in recovery and trying out Strattera first but still. There are even private psychs that “specialize in ADHD.” They are like 400$ a session which in my mind just makes them a legal (extremely expensive) speed dealer. I believe there are even some telehealth psychs that will do it (that one I’m not 100% sure that they do anymore but a few years ago there were)

 

[Deleted member 594230]

If the OP has ADHD, surely he has a script and doesn't need to be sourcing stuff from the darkweb?

Also, making up 400 capsules sounds like a commercial operation to me...

in my country theres only elvanse, no tentin. I dont like elvanse as I dont want elevated dopamin levels when I dont need it. I currently buy tentin pharma (tentin is 100% pure d amph) from the dark web, but it costs too much (I even wanted to switch to d meth as it would be cheaper, you can look at my old post). But i found a source for d amph powder so no need for d meth.

400 capsules with 5mg each would last me 5-6 months.

While I agree this was obviously an attempt at producing a mass quantity to distribute for cash, even someone with extremely well documented and verified ADD will be refused stimulant medications these days.

The catch-all term “narcotic” has poisoned the well of treatment beyond repair.

Lol you guys are so funny
I dont give a fuck you can think of what you want

 

[yoyoman]

dissolving in liquid is actually the far simpler solution here. 1mL of water weighs 1 gram, if you dissolve 2 grams into 400ml water that is 5mg per mL. then all you need to do is consume 1 gram of water and it's guaranteed to be the right concentration. distributing powders equally is far more difficult and usually requires special machinery. dissolving in water distributes it evenly on its own with no effort

Actually you are making it way too complicated, there is no need for a scale at all with liquid measurement. You only need the scale for measuring the amount of amphetamine/substance at the beginning to put in the liquid.

I think its called volumetric measurement, and it is this easy:
Lets say you have 1g/1000mg d-amphetamine. You can use exactly 1000mL of water, measured with something bought at a store that will accurately measure 1 liter which is 1000mL. Find a bottle with a screw on top like pop bottle or something and put 1000mL water and the 1000mg d-amphetamine in there and let it dissolve, shake etc. Once it is fully dissolved (let it sit for a while just to be sure) it will stay that way, and then just use a medicine syringe that measures in mL... 1 mL = 1mg.

This is a lot of liquid and you probably would rather it be a lot less liquid to deal with so you can make the ratio whatever you want. If you put 1000mg d-amphetamine in 100mL water instead, then each mL will be 10mg. This is actually a good ratio because those little syringes with 100 units to 1mL.. 10 units or 0.1mL = 1mg. This is exactly what I do, and the dosing will ALWAYS be waaaaaay more accurate than any type of powder measuring you try to do. You really cannot get more accurate. You don't even need the scale after you do this, and you can just dose it using a tiny syringe til its gone and you have to make a new batch. You could dissolve much larger amount like 5g in 500mL, 50g in 5000mL etc. and the dosing is the same.

I would put food coloring and put a label on it like "danger, name-of-something-toxic" so random people won't accidently drink it.

 

[Deleted member 576750]

Actually you are making it way too complicated, there is no need for a scale at all with liquid measurement. You only need the scale for measuring the amount of amphetamine/substance at the beginning to put in the liquid.

I think its called volumetric measurement, and it is this easy:
Lets say you have 1g/1000mg d-amphetamine. You can use exactly 1000mL of water, measured with something bought at a store that will accurately measure 1 liter which is 1000mL. Find a bottle with a screw on top like pop bottle or something and put 1000mL water and the 1000mg d-amphetamine in there and let it dissolve, shake etc. Once it is fully dissolved (let it sit for a while just to be sure) it will stay that way, and then just use a medicine syringe that measures in mL... 1 mL = 1mg.

This is a lot of liquid and you probably would rather it be a lot less liquid to deal with so you can make the ratio whatever you want. If you put 1000mg d-amphetamine in 100mL water instead, then each mL will be 10mg. This is actually a good ratio because those little syringes with 100 units to 1mL.. 10 units or 0.1mL = 1mg. This is exactly what I do, and the dosing will ALWAYS be waaaaaay more accurate than any type of powder measuring you try to do. You really cannot get more accurate. You don't even need the scale after you do this, and you can just dose it using a tiny syringe til its gone and you have to make a new batch. You could dissolve much larger amount like 5g in 500mL, 50g in 5000mL etc. and the dosing is the same.

I would put food coloring and put a label on it like "danger, name-of-something-toxic" so random people won't accidently drink it.

I went with a scale because that was listed in the available materials, not everyone has the ability to easily measure mL so mass is a good surrogate