Stimulants Amphetamine and methylphenidate comparaison and a copule of questions

[xXTheGrimOneXx]

I’m the exact opposite. Amphetamines do nothing but calm me down. No rush, no euphoria. 15mg nasal bumps from a snuff bullet.

If I do Coke the rush and euphoria I get is what other people tell amphetamines produce for them.

Was on vyvanse 50mg. Lost my insurance. Between 30 pill costing over 300$.

I found a steady source of e or resolved d isomer meth.

I wash every single bag. Reagent test every bag.

Between the. Wash and mechanical loss from recrystallizing. I loose about .3g from a 1/4 oz.

No problems with it so far. When I obtain insurance I’m going to
Seek. Dexosyn or prescription MA. Comes in 5mg increments that are on par with my current consumption.

I am also type 1 bipolar so I have to restrict my usage. Or manic episode can happen. Seems to be after the 72 hour mark of no sleep. With or without amphetamines.

I also have pretty gnarly ADHD. I’ve been on meds since I was in 4th or 5th grade so age 10 if I’m correct.

I with the dosage. I have focus. I can complete a task from start to finish. Reduced depression, no racing thoughts. No intrusive thoughts or feelings.
Just calm and. Collected.

I’ve noticed my mood has been more stable since dosing amphetamines again.

I also eat a minimum of 2 balanced meals a day. Drink around a gallon of water every day.

Take my seroquel to sleep. Also read thy seroquel helps meth cravings. Which I don’t have.

Yet I do coke and what I tell people I’m feeling they say meth does for them. Regarding the Rush and euphoric feelings.

Idk. Im wired wrong.

Also noticed my nicotine and THC intake is substantially lower than the days I don’t dose.

Only thing I can imagine is between the dopamine release my brain isn’t constantly trying to get dopamine.
Also would say the focus and productive all day distracts me from it.

 

[xXTheGrimOneXx]

Not sure about 40mg IR I don’t think those are a thing, unless you mean 40mg Long Acting,

Splitting these will fuck up the delivery of the drug, if they are in fact say a Medikinet LA you will get about 10 hours.

Just one is sufficient.

If you mean 40mg of Instant release Ritalin (multiple pills)

For 10 hours of stimulation appropriate for studying,

I’d do 10mg every 2 hours, IR Methylphenidate works for 3 hours, 4 if sensestive.

You can skip after the 3rd dose to not be stimulated past your 10 hour window.

Anything more than 10mg a pop in a non tolerant user will likely be too stimulating and mood boosting to aid studying.

If it’s Ritalin it’s IR. If it’s concerta it’s an osmotic ER. Unless they’ve got an ER Ritalin. I’m unaware of that. So could he wrong.

 

[xXTheGrimOneXx]

Methylphenidate (Ritalin) has always been the less-desired relative to Amphetamine, at least in my travels. I always felt that Methylphenidate was like an Amphetamine with weaker central action (euphoria; desired effect) and greater peripheral action (tachycardia, tension). I always looked at stimulants as existing on a spectrum. On one end you have Caffeine and on the other end you have something like DextroMethamphetamine.

Caffeine -> Ephedrine -> Propylhexedrine -> Methylphenidate -> Cathinone -> Amphetamine -> Methamphetamine

I leave Cocaine out of this specifically as it is significantly different in action than the stimulants I´ve listed above. Even with these stimulants having differing mechanisms of action, I still feel Cocaine is different enough that it is difficult to include in this continuum.

Most people I have ever spoken to would absolutely prefer Amphetamine to Methylphenidate. However, because we all have this unique chemistry going on in our respective bodies, it is not out of the ordinary for there to be some people who prefer the reverse.

I personally do not like Methylphenidate at all. I felt like it had a rapid come up, a short peak and a pretty uncomfortable comedown for what I would get out of the drug. I´ve generally used stimulants in the name of productivity, even if that´ś not always what happened, so I really prefer the smoother feeling that I get from Amphetamine. Different strokes for different folks.

Definitely put coke in its own catagory of stims. Isn’t then psychoactive compound benzoylmethylecgonine. I know it’s a tropane alkaloid.

 

[Dada5000]

Well methylphenidate is basically XR cocaine. While dextroamphetamine is a carbon and a few hydrogen ions away from meth. That’s the only difference between amphetamines and meth is the methyl amine group attached to it. That’s what lets it pass the blood brain barrier so
Fast and dump dopamine, norepinephrine, and seretonin in the amount of measurable units that it does. Unlike any other substance. That’s why you can get addicted to it so fast.

And hell. Vyvanse is lisdexamphetamine. It has to be converted by the acid in your stomach then processed by the liver into the amphetamine. They came out with vyvanse because people were abusing the IR adderall.

IMO some pure D isomer meth and adderall/vyvanse feel damn near identical. You could give meth and I couldn’t tell you if it was meth or addy/vyvanse until I try to go to sleep.

I’m severely ADHD. I don’t function without stimulants. Lost my insurance too when I started the new job. My adddy script went up to over 350$ USD the vyvanse is over 400$ dollars a month without the insurance and the goodrx only takes off like 35$.

Been taking the meth at about 60mg a day and there’s no difference in how I function. Use a snuff bullet. 1-2 bumps a day. One when I get up after I eat. Then one after lunch time. If I do too much ill
Stay up for days. Nd that’s not good for me. Got the bipolar and I’m manic mostly so that’s type 1 I believe.

I get pure D isomer meth wash it with acetone and recrystallize it with methanol. Bumps the purity up. Gets any precursors and cuts out. Especially since when it recrystallizes it pushes any impurities and it’s to the outer layer of the shards. Makes it less edgy and white knuckle feeling.

Basically taking dexosyn. Which is purely D isomer meth for ADHD that doesn’t respond to amphetamines or if you’re severely obese and have to loose the weight. Comes in 5mg increments up to I think 25mg. That’s about equivalent to a 50mg addy or vyvanse.

Meth to adregenic for me, I'm not made for stimulants I guess.

 

[TheLightBringer]

Methylphenidate (Ritalin) has always been the less-desired relative to Amphetamine, at least in my travels. I always felt that Methylphenidate was like an Amphetamine with weaker central action (euphoria; desired effect) and greater peripheral action (tachycardia, tension). I always looked at stimulants as existing on a spectrum. On one end you have Caffeine and on the other end you have something like DextroMethamphetamine.

Caffeine -> Ephedrine -> Propylhexedrine -> Methylphenidate -> Cathinone -> Amphetamine -> Methamphetamine

I leave Cocaine out of this specifically as it is significantly different in action than the stimulants I´ve listed above. Even with these stimulants having differing mechanisms of action, I still feel Cocaine is different enough that it is difficult to include in this continuum.

Most people I have ever spoken to would absolutely prefer Amphetamine to Methylphenidate. However, because we all have this unique chemistry going on in our respective bodies, it is not out of the ordinary for there to be some people who prefer the reverse.

I personally do not like Methylphenidate at all. I felt like it had a rapid come up, a short peak and a pretty uncomfortable comedown for what I would get out of the drug. I´ve generally used stimulants in the name of productivity, even if that´ś not always what happened, so I really prefer the smoother feeling that I get from Amphetamine. Different strokes for different folks.

Pretty much agree, altough I view cocaine as quite an overrated compound when significantly more euphoric NDRIs exist. I used to love methylphenidate though, its great without tolerance but looses 90% of its appeal after ~2 months of daily use whereas amphetamines remain enjoyable for like 12 months of daily use.

Overall id rate Methylphenidate a 4 regarding euphoria and amphetamine as a 10
Yes amphetamine is like 2,5x more euphoric than MPH for me at equivalent doses

 

[TheLightBringer]

Id say pyros are the only NDRIs that can rival meth/amphetamines for me in terms of euphoria but theyre mostly enjoyable during the ”rush” when vaporized or IVd

 

[Dada5000]

Id say pyros are the only NDRIs that can rival meth/amphetamines for me in terms of euphoria but theyre mostly enjoyable during the ”rush” when vaporized or IVd

Did you try crack ? How does it compare.

 

[xXTheGrimOneXx]

I was taking addy 40mg ER capsules, switched to vyvanse during the stimulant shortage from the pandemic.

Lost my insurance and they want over 300$ for a month of vyvanse. If it’s in stock.

Got the link on a source of resolved D isomer meth.

Cut the amount in half for the meth dosage.

Wash and recrystallize every bag.

End up loosing around .3g out of 1/4oz.

Probably due to mechanical loss from
The filter papers.

Use a snuff bullet to
Dose 2 15mg doses.

 

[xXTheGrimOneXx]

Amphetamines give me no rush, no sex drive, no euphoria.

Coke on the other hand blows me away. I’ve explained how I feel on coke and had a meth user fell me that’s how amphetamines make him feel. Just for waaaY longer and cheaper.

Ritalin and concerta do the same thing as Coke.

 

[TheLightBringer]

Did you try crack ? How does it compare.

Unfortunately I never tries crack. I bet it would be pretty on par with pyrovalerones though just shorter lasting.

I did try vaporizing methylphenidate though, that is quite a rush compared to just snorting it. Hexen is pretty good vaporized too but is a larger amount of powder

 

[Dada5000]

Unfortunately I never tries crack. I bet it would be pretty on par with pyrovalerones though just shorter lasting.

I did try vaporizing methylphenidate though, that is quite a rush compared to just snorting it. Hexen is pretty good vaporized too but is a larger amount of powder

How to vaporize Methylphenidate, I was always interested in it.

 

[TheLightBringer]

How to vaporize Methylphenidate, I was always interested in it.

When I did it I always extracted it with isopropanol 400 - 1000mg at a time, dried and scraped it up. Then freebased with Sodium Carbonate and vaporized in a light bulb or on foil

Dont just smoke the pills straight up it destroys your lungs. My friend smoked straight MPH pills with baking soda for 2 weeks and lost his voice for almost a week

 

[Dextro .45]

thats bs 500% dopamine no way it didnt feel like this much id say 900% serotonin is possible but the dopamine is like 200-250%

Well that’s a professional medical journal study posting its results from in-vivo research

Like I said…..if…..IF you MANAGED to acquire 100% pure pharmaceutical grade synthesized 4-MMC it DID result in a 500% increase in Dopamine and 900% in Serotonin

God only knows what trash people receive from which half ass RC chemical producer

Some hick doing a shake & bake with ephedrine to make racemic Methamphetamine …….or Ovation Pharmaceuticals DESOXYN (d-Desoxyephedrine Hydrochloride) / Methedrine (d-Methamphetamine) 5mg tablets of 20 & 30mg vials of Methedrine for IV/IM/SC injection (100% PURE dextro Methamphetamine HCL USP )

Massive difference ……indeed

 

[Dextro .45]

Methylphenidate (Ritalin) has always been the less-desired relative to Amphetamine, at least in my travels. I always felt that Methylphenidate was like an Amphetamine with weaker central action (euphoria; desired effect) and greater peripheral action (tachycardia, tension). I always looked at stimulants as existing on a spectrum. On one end you have Caffeine and on the other end you have something like DextroMethamphetamine.

Caffeine -> Ephedrine -> Propylhexedrine -> Methylphenidate -> Cathinone -> Amphetamine -> Methamphetamine

I leave Cocaine out of this specifically as it is significantly different in action than the stimulants I´ve listed above. Even with these stimulants having differing mechanisms of action, I still feel Cocaine is different enough that it is difficult to include in this continuum.

Most people I have ever spoken to would absolutely prefer Amphetamine to Methylphenidate. However, because we all have this unique chemistry going on in our respective bodies, it is not out of the ordinary for there to be some people who prefer the reverse.

I personally do not like Methylphenidate at all. I felt like it had a rapid come up, a short peak and a pretty uncomfortable comedown for what I would get out of the drug. I´ve generally used stimulants in the name of productivity, even if that´ś not always what happened, so I really prefer the smoother feeling that I get from Amphetamine. Different strokes for different folks.

Solid fact……

Ritalin (Methylphenidate) is a “Classic Amphetamine” and it’s pure 100% API compounding powder was/is HIGHLY DESIRABLE along with Phenmetrazine (Preludin) …even more than IV Methamphetamine, Phenmetrazine & Methylphenidate were used in high dose injection users

Ritalin (Methylphenidate) and Cocaine were both administered to Cocaine abusers and many had difficulty differentiating which drug they received…….same with IV Diacetylmorphine (Heroin) and Hydromorphone (Dilaudid) in another medical journal study with long term users

Cocaine & Ritalin actually compete for the same binding sites inside the CNS specifically the DAT …. both being “Inverse Agonists” causing the release & increase in dopamine and monoamines & indirectly endorphins

Cocaine DAT>SERT>>NET
Ritalin DAT>NET

RITALIN is nearly 2X more potent than Cocaine at the DAT BTW……..Ritalin & Oxycodone only two drugs to ever give me TRUE powerful Euphoria ……ultimate oral Speedball. Oxycodone & Ritalin + Ethanol

 

[Keif' Richards]

Fun fact about myself. I don´t really like Methylphenidate and I don´t really like Cocaine either, honestly. I´ve had Crack put in front of me and of course have smoked several hundred dollars worth a handful of times, but I didn´t Like it. I´m sure there are other folks on here who can relate. Cocaine and Methylphenidate both had a tendency to produce what felt like a disproportionate degree of physical/psychological tension. This is in comparison to Amphetamine, which causes 1/10th the anxiety for me of Cocaine.

I´d be interested to hear from other people regarding their experiences. I never understood Methylphenidate to be that desired by anyone. I was always under the impression that people only took it when they couldn´t get a hold of Amphetamine. I´m definitely keen to hear from other people though. Isn´t learning fun?

 

[TheLightBringer]

Fun fact about myself. I don´t really like Methylphenidate and I don´t really like Cocaine either, honestly. I´ve had Crack put in front of me and of course have smoked several hundred dollars worth a handful of times, but I didn´t Like it. I´m sure there are other folks on here who can relate. Cocaine and Methylphenidate both had a tendency to produce what felt like a disproportionate degree of physical/psychological tension. This is in comparison to Amphetamine, which causes 1/10th the anxiety for me of Cocaine.

I´d be interested to hear from other people regarding their experiences. I never understood Methylphenidate to be that desired by anyone. I was always under the impression that people only took it when they couldn´t get a hold of Amphetamine. I´m definitely keen to hear from other people though. Isn´t learning fun?

Fully agree, if I had to compare methylphenidate and amphetamine in terms of euphoria and anxiogenic effects id say for me subjectively

MPH:
Euphoria 4/10
Anxiogenic effects 8/10

Amphetamine:
Euphoria 10/10
Anxiogenic effects 4/10

So 2,5x more euphoria with half the anxiety is how I would measure up amphetamine to MPH. Objectively though methylphenidate is less taxing on the body and less neurotoxic and causes less downregulation than amphetamine. Was a worthy trade off in active addiction though. Once I built tolerance to stimulants 80% of the MPH euphoria vanished regardless of dosage (I found the same to be true with 90% of NDRIs) while amphetamine and othe releasing agents remained euphoric as long as I matched the dose to my tolerance…

 

[Leprechaun]

Methylphenidate (Ritalin) has always been the less-desired relative to Amphetamine, at least in my travels. I always felt that Methylphenidate was like an Amphetamine with weaker central action (euphoria; desired effect) and greater peripheral action (tachycardia, tension). I always looked at stimulants as existing on a spectrum. On one end you have Caffeine and on the other end you have something like DextroMethamphetamine.

Caffeine -> Ephedrine -> Propylhexedrine -> Methylphenidate -> Cathinone -> Amphetamine -> Methamphetamine

I leave Cocaine out of this specifically as it is significantly different in action than the stimulants I´ve listed above. Even with these stimulants having differing mechanisms of action, I still feel Cocaine is different enough that it is difficult to include in this continuum.

Most people I have ever spoken to would absolutely prefer Amphetamine to Methylphenidate. However, because we all have this unique chemistry going on in our respective bodies, it is not out of the ordinary for there to be some people who prefer the reverse.

I personally do not like Methylphenidate at all. I felt like it had a rapid come up, a short peak and a pretty uncomfortable comedown for what I would get out of the drug. I´ve generally used stimulants in the name of productivity, even if that´ś not always what happened, so I really prefer the smoother feeling that I get from Amphetamine. Different strokes for different folks.

Have you seen people on a cocaine drip. It's quite interesting, people are yawning, relaxed and smiling. More like MDMA effects...

 

[fuckabout89]

I’ve have Mephedrone 4-MMC several time , 3 different batches, same supplier……1st was amazing quality other 2 were trash…..who the Fck knows who is synthesizing these molecules, if it’s 100% Pharma grade, proper isomer or racemate etc

900% increase is SERT
500% increase in DAT

Pleasant but pharmaceutical Cocaine would blow it outta the water
Methylphenidate & Amphetamines are far more effective as they’re 100% pure

Man did you ever try Focalin thats like pure bliss lol? My eyes turned into huge black saucers.

 

[fuckabout89]

Also with the meth you did. Do you know what they synthesized it with? If it was ephedrine or pseudo that’s the good shit. Pure D Isomer. Not the birch/nazi P2P synthesis that produces a racemic mixture of Levo and dextro meth. The Levo is what spazzes out your sympathetic nervous system makes you’re heart race and makes ya tweak out. Especially if you’re on a run. Every time I get racemic bags of meth. I get hella nervous and paranoid.

Usually. The racemic isomer combination makes big shards that are clear. D isomer meth though be opaque whitish and hard as fuck to break. If your shards crumble it’s racemic and or cut with MSM and or N-iso. Those are very similar in density, melting points, and even the crystalline structures are very similar to Meths isomers so it’s hard Get those cuts out. Acetone won’t wash it out. Almost have to do a conversion back to freebase and gas it with HCL gas to get the salt that’s the crystal. Usually have to use water to dissolve that then acidify it with sulfuric acid or muriatic acid. Or base it with NaOH or lye.

No bro the Nazi birch method and P2P are two different methods. P2P produces more Levo than dextro. Nazi method is the OG route.

 

[KurtAurelius]

Methylphenidate is in the region of 2x binding of dopamine versus norepinephrine but the half life is extremely short.

300% rise in dopamine but with 2-3 hour half life?

That makes sense why it suddenly can feel so crap.

I find it’s only the comedown is when I feel nasty, but I suspect due to an abrupt comedown it can be so drastic.

My experiments lend to needing to maintain a steady level and to ensure a peak that crashes in line with bed, and still needing cannabis and Agmatine to avoid all the mental effects.

With recreational use, I believe that tolerance causes the dopamine to not match the peripheral release due to how short the half life is, and so you feel the sides so much worse, as dopamine release will smooth out the sides.

But tolerance will negate this, and as we know tolerance means drugs can progressively make it so you only have negative effects.

Cocaine is just no good because of all its other activity, the calcium channel stuff or whatever, absolutely shocking for your heart. It perplexes me that people use cocaine, I think it’s honestly silly.
I understand it still feels good but it is such an inferior choice.

Never tried amphetamines and don’t want to.

They cause far to much downstream effects on other receptors and they have a much dirtier pharmacological profile.

I understand methylphenidate doesn’t feel as good, but it is the superior stimulant in terms of targeted effect. Yes it won’t agree with everyone fair enough, but on paper it is quite good.

The issue is only tolerance imo and like most drugs it has to be used sparingly.