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Coming off Invega/Xeplion (paliperidone) injections v11

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deathbypsychiatry said:
An update on partial agonists:

I didn't understand what partial agonist meant. It has "deleterious effect on normal brain function". Dopamine is a full agonist meaning when it binds to the receptor it produces a maximal response of %100. Abilify is a partial agonist meaning when it binds to the receptor it produces only a sub-optimal response, estimated to be 20-30%. An antagonist produces 0% response. So it won't boost dopamine and rather be like dropping it 70-80%. Abilify has a very high binding affinity for d2 receptors (Ki = 0.34 nM) meaning it readily attaches to the receptors, filling sites and stopping dopamine or anything else from being able to bind. D2 occupancy is dose dependent ranging between 40 – 95% with 0.5mg-30mg. even at the lowest dose of 2mg is still 65% and 10mg reaching 80-95% occupancy. It also has an extremely long half life of 75-156 hours. If you are a CYP2D6 poor metabolizer your dose is effectively doubled & if you cease the drug it will take twice as long to eliminate it from your system (Maybe 2.5 months for oral tablets). One of its metabolites "dehydroaripiprazole" is also active & works much like aripiprizole and an even longer half-life. 94 hours or 211 hours for CYP2D6 poor metabolizers.

Mathew is straight up wrong about dopamine agonists. They do not work like he thinks they do.

Neuroplasticity:
-Abilify causes changes in brain network topology - significant decrease in global efficiency & significant increase in clustering which is the opposite of the "normal" healthy brain state. This effect correlated with worse performance on working memory tasks. This effect is dramatic & consistent on healthy individuals lowering cognition and the impact on patients with schizophrenia is more variable with only a small and variable increase in clustering in one study. 51% of schizophrenia diagnoses are incorrect & this drug is forced involuntarily & is overperscribed for other conditions.
-Cortical thinning in some areas (prefrontal, temporal, parietal) and volume changes in the stratium (putamen, caudate)
-Abilify has been linked to increased volume in the right putamen and caudate with these changes sometimes reversing after drug withdrawal.
-Grey Matter Volume: Decreased grey matter volume in the precentral gyrus, caudate and lateral frontal regions.
These changes happen fast and may not ever reverse.

It's also harmful in other ways to the body.

Abilify is a hardcore drug & the phrases "dopamine modulator" or "partial agonist" are misdirection. It's not just about blocking receptors, it's about restructuring the brain. Chemical lobotomy, castration & straitjacket rolled into one marketable pill.
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The doctors want to give him dopamine agonists. They wanted to give partial agonists and I said because those are bad. Dopamine agonists are the right choice
 
invega011024 said:
So instead of whining, has anyone else found good information about whether we should use st johns wort? If you look through my post history at one point I did find a european agency using it to cure someones invega poisoning.
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It is inducer of g-pg, so it's suppose to get rid of it faster in the blood, the problem that it's keep realesing from the fat.
I've ordered it from China, and also I'm getting mondafinil it's also help to clear it a bit.
 
Feeling small window/wave that i feel a bit better.
Bought tickets to a movie to new Avatar movie in 3d, walked around, bought food, didn't feel like zombie 100 precent.
Also I'm feeling like i can feel the effects of Vyvanse for 1 precent, before there were 0 effects, so i feel my dopamine is starting very slowly to wake up.
4 months and 9 days.
 
RisperdalConsta50mg said:
I swear if I fully heal i will become a lawyer and sue the shit out of these big pharma
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Or become rich and hire a lawyer. I dont think big pharma is as evil as the narcissists working in the mental health system. The drugs themselves are not evil but people forcefully using these drugs on victims and destroying their lives are pure evil. They are just opportunistic narcissists. I really want the psychiatrist and one mental health worker injected by the same drug and i assure you, they would never want the same for themselves or their loved ones.

They made us pay a price for who we are, we paid a price for what these idiots thought about us, we paid a price for their narcissistic envy. We did not do anything wrong, we just paid a price for what went on in their unevolved idiotic brains about us.
 
Just found out Georgia sell over the counter, the strongest inducer of invega. It reduce blood level of invega in 50-70 precent.
 
Trueart2 said:
They don’t want to give him dopamine agonists then, they want to give him antipsychotics dressed up as dopamine agonists
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No they want to help him. Other doctors ignored and these ones are offering a PET scan for him. That why he needs full dopamine agonists
 
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