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Coming off Invega/Xeplion (paliperidone) injections v11

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jrturp said:
I first felt it lifting when my baby smiling would make me smile and I could feel laughter again. A more subtle sign was finding it easier to get engrossed in a TV show. I feel similarly to you where I’m still flat-ish, just not as flat as I used to be.

Yes, I feel like Vyvanse and Adderall still aren’t working as well as they did pre-injections. Medication definitely helps with focus but isn’t as effective as it used to be. There’s no mood lift for me either. No heart rate changes though.

You’re about a month ahead of me. When did you resume ADHD medication and has there been any change in effectiveness since then?

I suspect sleeping 10 hours a night is a sign I’m not recovered, as I used to sleep 6-7 hours a night pre-injections. Have you experienced any sleep changes?
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I would suggest that the ADHD medication is not able to work as it normally would and while it is said the medications cancel each other out overall Invega is a much more powerful drug & works on far more parts of the brain than the stimulant.
Additionally antipsychotics also make ADHD symptoms worse.
I had sleep issues from Invega, It made me completely exhausted while also worsening preexisting insomnia, I spent months mainly in bed but unable to rest.

Source: The dopamine dilemma - https://pmc.ncbi.nlm.nih.gov/articles/PMC2898838/
"So where is the dilemma? According to mainstream psychiatry basic research and psychopharmacology, stimulant and antipsychotic medications have opposing mechanisms of action. Stimulants are thought to work by increasing dopamine (DA) levels between neurons, and antipsychotics work by blocking their effects at dopamine receptors. Concurrent stimulant-antipsychotic use has been rationalized by suggesting that they likely interact with different receptor subtypes and do so in different pathways of the brain. In reality, while the main therapeutic sites of stimulants and antipsychotics are different, they both interact at the same receptors sub-types and do so in the same parts of the brain. Examination of DA pathways has revealed that stimulants have significant activation at both the limbic system and the cortex. Antipsychotics have their strongest effects in the limbic system, but they have also have effects on the cortex.

Research on receptor subtypes has shown that the therapeutic effects of stimulants are strongest at D1 receptors, but they also have significant action at D2. The therapeutic effects of antipsychotics come from D2 antagonism, but these medications are actually unselective antagonists, being able to bind to all five receptor types. Going beyond theoretical implications, research has shown that stimulants and antipsychotics actually do block the effects of each other."
 
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jrturp said:
Yes. Akathisia and some energy improvements were the only things I noticed until month 5. Month 5 is when the anhedonia started getting better for me. Cognition has improved too, mainly from being back on my ADHD medication. I’m now at month 6.
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Most people say it takes 6 Months for the anhedonia to lift. I hope mine will also be like that.
 
invegaloner said:
I started taking my meds almost right out of the hospital when I was still on invega. I felt a difference immediately but not much. I don’t think I noticed the heart rate changes until a month or so ago? When I was in the hospital I was on risperidone and I had to sleep right after taking my meds and I slept for most of my time in the hospital. Now I sleep for 7-9 hours a night.
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Is your sleep the same as before?
 
Trueart2 said:
Post more often @lostsoulowen
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Lol sure but there isn't much to talk about.
Personally i wake up, meet friends and smoke weed and vape.
I'm also researching solution for this horrible drug, i found the strongest way to get rid of this medicine.
I'm really good at using ai i used to program full stack with ai on serious coding projects.
He said Rifampin is even stronger then carbamazepine and could really reduce invega blood level.
I'm trying to get doctors here to prescribe me that but if i fail i might try in other countries.
 
RisperdalConsta50mg said:
Last week, when I was admitted to the hospital against my will, I appealed for compulsory hospitalization. Today was the hearing and I won the appeal. I can leave here whenever I want, even now.

That one doctor from psych ward stayed at my side and blamed the other psychiatrysts who did that forced stay against my will and she said he used nonsense and false things to justify the forced stay over me.

I will keep staying here in the psych ward because that doctor i meet here it’s on my side and he want to push for a PET and to find out what happened to my brain and what we can do to restore the damage.

Even the judge today was surprised about how “non-crazy” I’am and he cannot understeand why i was forced into a stay against my will..
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They mess with the wrong person, they fucked with that one who it’s better to not fuck with.

I was just chilling, smoking weed, training on the gym, playing videogames and following geopolitics.

They started this fucking war out of nowhere, i had no choice but to fight, and now i’am fighting do protect myself from them and to find out what they did to my brain and how to heal the damage.

I’am proud of what I become, but I had not choice, they started this war and I had to protect myself.
 
jrturp said:
You had a window, don’t discount that.
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Things have progressively got worse for me since then, libido and sexual.function close to permanently dead, sleep disturbances gone to 3 to 4 times a night, energy levels dropped significantly. I dont know what i should take things getting worse after 6 months as a sign of?
 
  • The statement "Psychiatry is a narcissism machine" is a well-known quote attributed to the fictional character Ryan Howard from the TV show The Office.
    This phrase generally reflects criticisms and observations regarding potential issues within the field and practice of psychiatry, particularly concerning the power dynamics and personality traits of some practitioners.
    Key perspectives and points related to this sentiment include:
    • Unequal Power Dynamics: Critics of the field often point to an inherent power imbalance between the doctor and patient, where the subjective nature of diagnosis leaves significant room for the psychiatrist's personal opinions and interpretations, which can feel dismissive to a patient's lived experience.
    • Practitioner Arrogance: Some anecdotal accounts and articles suggest that certain psychiatrists may exhibit grandiose behaviors, believing in their own infallibility or possessing a special insight that no one else has. This perceived arrogance or bias can lead to poor patient outcomes, as doctors may be dismissive of patient input or concerns about side effects.
 
Guys I think a lot of our problems may be tied to us taking St Johns Wort. It's not the best source, but most AI says it is a bad idea. I think I get insomnia from taking it. I have been experimenting with cycling it on and off and I think I have insomnia again by taking it. I may have linked it at some point, but a European poison control clinic did recommend 900mg to deal with invega (maybe someone here can link it), but I think me sleeping more hours would help me recover faster than taking the drug.
 
I think we are just struggling to find the solution but dont forget the fact we never comeback to ourselves again and thats sad
 
moerez said:
I think we are just struggling to find the solution but dont forget the fact we never comeback to ourselves again and thats sad
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You will get back to normal eventually once you stop the shots. It feels like you won’t, but it’s just the ugliness of the drugs half life. Last shot I was on took 7 months to recover from. You feel really weird for a while but it will go away.
 
washingtonbound said:
You will get back to normal eventually once you stop the shots. It feels like you won’t, but it’s just the ugliness of the drugs half life. Last shot I was on took 7 months to recover from. You feel really weird for a while but it will go away.
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But there is many people still struggling after 7 months im on 3months mark and feel no difference
 
washingtonbound said:
You will get back to normal eventually once you stop the shots. It feels like you won’t, but it’s just the ugliness of the drugs half life. Last shot I was on took 7 months to recover from. You feel really weird for a while but it will go away.
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I’am feeling wired 17 months after my last shots…?!
 
washingtonbound said:
You will get back to normal eventually once you stop the shots. It feels like you won’t, but it’s just the ugliness of the drugs half life. Last shot I was on took 7 months to recover from. You feel really weird for a while but it will go away.
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how many doses did you take?
 
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