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BDD Moderators: Keif’ Richards
Opioids Switching to Morphine from Oxycodone (help me with dosage equivalency)
- Thread starter evo4ever
- Start date
What are you kidding? Oxy is 1.5x as strong as morphine. I was on both at the same time. They said I had a year to live.
How is your liver and how is your kidneys.
Oxycodone is much stronger and it is a killer.
Also, IR or ER?
Also, are you trying to quit opiods or just switch for pain?
If it is for pain, um, everbody is different but morphine is also processed through the liver; whereas the Oxy is the kidneys.
(If you have organ issues). pain stick with Oxy, unless somehow the morphine works better. I would not give up an Oxy script like that unless I wasn't in pain, or the doctor took it away.
Also, do you know how morphine reacts to your body. The bioavailability of morphine is as low as 20% and OXy is 80-90%.
So, what is your goal?
How is your liver and how is your kidneys.
Oxycodone is much stronger and it is a killer.
Also, IR or ER?
Also, are you trying to quit opiods or just switch for pain?
If it is for pain, um, everbody is different but morphine is also processed through the liver; whereas the Oxy is the kidneys.
(If you have organ issues). pain stick with Oxy, unless somehow the morphine works better. I would not give up an Oxy script like that unless I wasn't in pain, or the doctor took it away.
Also, do you know how morphine reacts to your body. The bioavailability of morphine is as low as 20% and OXy is 80-90%.
So, what is your goal?
Actually Morphine is easier on the liver than Oxycodone. Morphine has less metabolites and it's metabolized through a different pathway. I just want to see if I get better pain relief at the equivalent dose.
Excuse me it is excreted through the kidneys. you'll need 45 mg 4 times a day. If they try 90mg ER, forget it if it is twice a day ER
Oral morphine was less effective than Oxy in every way . ( that's me) Morphine is weaker. ( also that mood lift will be gone. Please don't say Morphine Sulfate ER.
If you were to switch to that, maybe it will help. Also I got a bridge for sale. I don't like the way NYC is headed.lol
What next codeine, then asprin. Careful what you wish for and what your expectations are. Remember oral morphine varies very much on the person.
As in, MORPHINE 20-40% bioavailability. Oxy 80-90%. OXY is 1.5 times as strong.
Just be sure you can switch back if they don't prescribe it by the kilo.
Oral morphine was less effective than Oxy in every way . ( that's me) Morphine is weaker. ( also that mood lift will be gone. Please don't say Morphine Sulfate ER.
If you were to switch to that, maybe it will help. Also I got a bridge for sale. I don't like the way NYC is headed.lol
What next codeine, then asprin. Careful what you wish for and what your expectations are. Remember oral morphine varies very much on the person.
As in, MORPHINE 20-40% bioavailability. Oxy 80-90%. OXY is 1.5 times as strong.
Just be sure you can switch back if they don't prescribe it by the kilo.
My fear, is that if a large of morphine doesn't work; that you might have trouble getting the Oxy script back.
I just don't want you stuck in pain and not be able to get pain relief. Much worse if you are physically dependent on opiods.
I just am scared, as a pain patient, that you could end up in pain and wd's. I just want you to be able get pain relief.
Yes, if both are taken via the oral route, Morphine is approximately 2/3 the strength of Oxycodone. In other words 1mg Morphine = 1.5mg Oxycodone.
Everyone will respond differently. I believe most people would say Oxycodone provides a greater degree of psychological relief, whereas Morphine is more physical, if that makes sense.
I dont think it will hurt to try. Just be sure you lnow you have a pathway back to Oxycodone should things not work out. Oxycodone has acquired a bad name and I can see that affecting its prescription.
Everyone will respond differently. I believe most people would say Oxycodone provides a greater degree of psychological relief, whereas Morphine is more physical, if that makes sense.
I dont think it will hurt to try. Just be sure you lnow you have a pathway back to Oxycodone should things not work out. Oxycodone has acquired a bad name and I can see that affecting its prescription.
That last paragraph summed it up extremely well. If someone is in pain at this time in history( I believe he is in America) it could mean lots of unnecessary pain because of both sides of the political isle.( ha, I am blaming both major parties). Opiod panic, when just before the fentanyl crisis really began?
I saw the numbers, those retards in government, many are lawyers. Ambulance chasers like that ass wipe who got caught cheating on his wife
Getting 120 mgs a day of Oxy is not too common. State and Federal laws. The doctors are scared. How do I know this, I know a few doctors personally. Also you hear things.
Especially while waiting at a mom and pop type pharmacy.lol
I can only get a fraction of that Oxy script by state guidelines. I am fine with that. If the shit I went through( my own fault
). Happened a decade earlier, I would have ended up onThe morphine did help the pain. The Oxycodone gives me energy and a mood lift , along with pain relief. I was on both at the same time. Yes the morphine works but it is has more some issues with low and in some people much higher bioavailibility( mis ?, don't care). Although, there are some people who hate Oxycodone and would actually want hydrocodone instead?
Do they even manufacture or have hydrocodone without any liver killing Tylenol ( acetaminophen or in other places paracetamol). ugh.
It is shocking what the government in some states will do. My state has the most liberal weed laws in the country.
Opiods are different.
The Detroit area was devastated during the 70' s heroin epidemic. It was really bad, in Detroit in the 70's.
Then crack: I believe crack saved the day.
It made Detroit so bad( besides being the murder capital later on) (I believe Dade county Florida, aka Miami, was per capita worse). It was either the mayor of police chief on the news: He basically said, If you don't live, work or have important business here, stay out. It is too dangerous. Now, it is turning back to nature as more and more people leave( flee)
Cocaine cowboys: Cubans and Columbian drug dealers all out killing each other and their families. The Cartels are considered at the top of the brutality level; in the case of, for- profit criminal organizations.
Sorry to drone on. Just bored,sorry.
nope 1mg of Oxycodone =1.5mg of morphine.
10mg of Oxy= 15mgs of morphine
you said 1 mg of morphine= 1.5mg of Oxy, ah no. Backwards; I had this discussion with my doctor.
You agree Oxy is 1.5 times as strong so if 1 mg of Oxy is 1.5 times as strong.
1mg x1.5 = 1.5 aka in other correct words, 1mg of Oxycodone= 1.5mg of morphine.
Hey, you had somethings to say about me, so.... I get it, you are tired and overworked.
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Morphine actually works better for me then oxy for severe pain. I also find oxy pretty useless for nerve pain
That is because of differences in people.
Oxy is great for many and good for some, but there are those who get the same feeling or deadening off, of pain and that extra mood lift. Morphine is cold and doesn't work as well for me. I want real relief. I'll take the stronger stuff. I was on morphine for 6 plus years. I still take Oxy for pain. I would take laying in hospital bed with IV Dilaudid and Ativan( lorazepam) over either.
They also would sometimes give me something else also, I think a very weak and very low dose of a barbiturate, is there one that would be weak enough that they would give to a person with severe alcohol wd's. I think it began with the letter P. No not pentobarbital, I wasn't executed.lol
But that has nothing to do with the substance, but how an individual reacts.
Some people hate it. Some are instantly addicted. Me, long time, low dose user, ( legit script). Some people don't get the euphoric feeling. I am not addicted. I sometimes forget to take it, till there is pain. I only see opiods as pain relievers; now that extra mood lift, is just an added bonus. Some people are just prone to opiods. I was prone to alcohol.
For me it takes away the physical pain and strangely makes eating easier. I messed up my liver and pancreas but that was me being a drunk for 2+ decades. ugh.
Your neglecting the fact that I'm not from the US, I live in the UK, so I'm not subject to the same BS as you guys when it comes to prescribing opioids. I'll most probably be able to go back to the Oxycodone if the Morphine doesn't work.
I could also try Hydromorphone instead of Morphine. How does oral Hydromorphone compare to oral Oxycodone?
So would you try Hydromorphone instead of Morphine given the choice?
Yes but; like I can get that easily.lol
Besides dilauded has a horrible bioavailibility. Oral Dilaudid sucks.
But, definitely better than morphine, if I had a chance at a script, I would switch if it was the ones without Tylenol. ( liver issues)
But, that ain't likely. I have already tried, but my doctor said no. I am not a criminal and I ain't about to risk dying in an American Federal Prison, so your way is out of the question.
Yes, but everybody is different. Some get high off of one pill and suddenly they are an opiod fiend. I was like that with booze, not opiods. They are a tool, to ease pain.
Besides dilauded has a horrible bioavailibility. Oral Dilaudid sucks.
But, definitely better than morphine, if I had a chance at a script, I would switch if it was the ones without Tylenol. ( liver issues)
But, that ain't likely. I have already tried, but my doctor said no. I am not a criminal and I ain't about to risk dying in an American Federal Prison, so your way is out of the question.
Yes, but everybody is different. Some get high off of one pill and suddenly they are an opiod fiend. I was like that with booze, not opiods. They are a tool, to ease pain.
It seems Oxycodone is the best "Oral Opioid", I presume you agree? IMHO I agree with you. But my CYP450 enzymes in my liver which metabolize Oxycodone are already taking a beating because of the other meds I'm on, this is why I want to try a different Opioid which doesn't go down the CYP450 metabolic route so I can give my liver some relief. Morphine and Hydromorphone get metabolized by the UGT2B7 enzymatic pathway which would give my liver an easier life, understand the logic?
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@evo4ever I know your case might be special, but I´ve never understood Oxycodone to be actually harmful to the liver in any way. I understand your logic, but I am nost totally sure that it is sound. This is something I would need to read up on, but that is my current opinion on the subject.
You are correct though. If we are going by your theory, Morphine does not undergo significant metabolism in the liver so it would give your enzymes less to do.
I suggest trying everything available to you if you can. Why not? Everyone responds differently to different drugs. You might find something that just really ¨works¨ for you. There should be no harm in experienting provided the dose conversions are correct.
You are correct though. If we are going by your theory, Morphine does not undergo significant metabolism in the liver so it would give your enzymes less to do.
I suggest trying everything available to you if you can. Why not? Everyone responds differently to different drugs. You might find something that just really ¨works¨ for you. There should be no harm in experienting provided the dose conversions are correct.
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My other meds are:
Pregabalin
Mirtazapine
Atorvastatin
Hyoscine HBr
My liver enzymes are raised and I think the main culprit is the statin, maybe I could lower the statin dose?
Generation *DMT*
Ex-Bluelighter
..and *fentanyl*?....
Fentanyl is mainly metabolized by CYP3A4 in the liver into norfentanyl which is inactive, does that help with your question?