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Opioids How MUCH Does Grapefruit Potentiate Opioids?

ChemicallyEnhanced

Bluelighter
Joined
Apr 29, 2018
Messages
11,183
Location
UK
I suppose "potentiate" is the wrong word as it actually increases the percentage of the Morphine that your body actually absorbs.

So, if oral Morphine normally has a bioavailability of ~30%....do we know how much of a difference grapefruit/juice makes? Like, is it a small change like changing the b/a to 40%? Or a big change like 80%?

Since rectal Morphine has a b/a of more like 60%, I'm wondering whether taking it orally with grapefruit or plugging it is better?
Has anyone done both?
 
Plugging will be stronger every time with Morphine, in my experience. You should just skip the rest of this and administer rectally and see for yourself.

I was a Heroing addict for ~15 years. I have used plenty of other drugs, Methadone included.

Ive done it all.

Protein Pump Inhibitors e.g. Cimetidine (Tagamet)

Grapefruit family of fruit. Grapefruit juice. Grapefruit extract. Drinking Grapefruit juice every day.

Cats Claw (common medicinal herb)

Ive been there and done it. Do not waste your valuable time and energy on what are generally, trivial pursuits. Totally, utterly, trivial.

Do we invest hours into research, paying money for the shit, sitting and waiting and wondering.

Let's say, and i think this is a longshot, you could get a 10% boost on your Morphine. I mean, will you actually feel the difference? Maybe, slightly. This is in the most ideal of circumstances.

When dependent on Opioids and wanting the "magic" back, the only way is by reducing your dosage. That's it.

We are Opioid addicts man, come on. We get a 10% boost on our Morphine and that just what, changes everything? No. We take the increase then turn around and ask for the next increase.

So now you eat a Grapefruit every morning for literally the rest of your life? Any increase, I dont care if it is double, triple... give it a few days of sedation followed by "well, this is now my life, exactly how it was before, except now I need to pick up grapefruits and Heroin to stay well.

Its a fun topic to muse about, but we are addicts. The solution is never in more drugs.

As an Opioid dependent person, you've probably got 5--7 days tops before you cant even feel the difference. Then you are just tolerant.

Opioids as recreational drugs are only for occasional usage. You can feel them again, but that feeling doesn't come back from getting more dope, it comes back from being less-saturated.

Example:

In America, Fentanyl created habits that are practically 10 times higher than they were with Heroin. 10 fucking times. Do they look happy to you?
 
I took it once with my normal oxy dose and I experiences respiratory depression. Its very effective, dont underestimate it. It inhibits enzymes responsible for the breakdown of the specific drug. The alkaloids in grapefruit are also pretty strong, sometimes it can increase the blood level of the by factor 1.5(according to a oxy leaflet I read).

However, it also only affects the drugs metabolized by the so called CYP3A4 enzyme systems. These include oxycodone or tramadol.

Hydromorphone, morphine on the other hand isnt affected because they are metabolized by glucuronidation.
 
Here I am researching the topic just to try and have my wife's alprazolam last her long enough until we can get back from out of state for her to get her new prescription.

This information can be useful for other people other than just addicts trying to get more euphoria out of their opoids.
 
I suppose "potentiate" is the wrong word as it actually increases the percentage of the Morphine that your body actually absorbs.

So, if oral Morphine normally has a bioavailability of ~30%....do we know how much of a difference grapefruit/juice makes? Like, is it a small change like changing the b/a to 40%? Or a big change like 80%?

Since rectal Morphine has a b/a of more like 60%, I'm wondering whether taking it orally with grapefruit or plugging it is better?
Has anyone done both?
Yes I tried potentiating w/ grapefruit juice, cimetidine, etc, but booty-bumping takes it to a whole nother level if (and only if) you give yourself an enema or two using an oral syringe (the same one you will dose the MSContin with) before dosing via the butt. Rectal administration exists in the same world as IV use. It gives way more euphoria and when the high is done you crash back to reality and need to do it again. Booty bumping is very demeaning as a daily habit and I strongly suggest keeping tolerance low by taking meds orally with no potentiators and not becoming a slave to morphine.
 
dont think it potentiates morphine because morphine doesent have to be metabolized by anything in the liver really its just morphine. However it does potentiate codeine and oxycodone by increasing the amount of morphine and oxymorphone codeine and oxy are metabolized into. It may work with other opiates if they use a similar route as well.

I have used white grapefruit juice (ruby red doesent work nearly as well) for trying to potentiate codeine and i dont think i noticed anything. I never tried it with oxy though
 
Yes I tried potentiating w/ grapefruit juice, cimetidine, etc, but booty-bumping takes it to a whole nother level if (and only if) you give yourself an enema or two using an oral syringe (the same one you will dose the MSContin with) before dosing via the butt. Rectal administration exists in the same world as IV use. It gives way more euphoria and when the high is done you crash back to reality and need to do it again. Booty bumping is very demeaning as a daily habit and I strongly suggest keeping tolerance low by taking meds orally with no potentiators and not becoming a slave to morphine.

Yeah, I definitely find plugging works best.
I don't need to do the enema thing, but I'm very regular [I poop like 4 times a day].

I've already been dependant on opioids for a very long time, but have been working on gradually tapering down to reduce my tolerance. The plugging is more for either the occasions I really want/need to get high, or if I'm running low and wanna make the pills stretch out as much as possible.
 
dont think it potentiates morphine because morphine doesent have to be metabolized by anything in the liver really its just morphine. However it does potentiate codeine and oxycodone by increasing the amount of morphine and oxymorphone codeine and oxy are metabolized into. It may work with other opiates if they use a similar route as well.

I have used white grapefruit juice (ruby red doesent work nearly as well) for trying to potentiate codeine and i dont think i noticed anything. I never tried it with oxy though

It's the opposite. Grapefruit DECREASES the absorption of pro-drugs like Codeine. It increases the b/a of Morphine from ~30% to ~60% by reducing the levels of the enzyme that breakdown or eliminate it or something. I'm not sure on the details, somebody else on here could definitely explain it a lot better than me.
 
It's the opposite. Grapefruit DECREASES the absorption of pro-drugs like Codeine. It increases the b/a of Morphine from ~30% to ~60% by reducing the levels of the enzyme that breakdown or eliminate it or something. I'm not sure on the details, somebody else on here could definitely explain it a lot better than me.

Weird but ive always read that white grapefruit juice potentiates codeine because it inhibits cyp 3a4. Oxycodoe i always thought went the same route. But i could be wrong
 
I don't need to do the enema thing, but I'm very regular [I poop like 4 times a day].
There should be a Bluelight award for most bowel movements per day.

I could always tell when it was gonna be a bangin' high when I could feel the mscontin liquid hitting the walls of my intestines

The plugging is more for either the occasions I really want/need to get high, or if I'm running low and wanna make the pills stretch out as much as possible.
I tried that trick too and learned that sometimes it backfires and the pill gets wasted.
 
Hi. Thanks in advance for any help! Any advice would be so much appreciated. My doc is sort of flexible. I’ve been on oxy for a long time and just in the last few years I’m really blowing through it and can’t stay on track, Then have way too little at the end of the month. Month over month, is wearing on me. Any advice???? I tried regular red grapefruit juice to no avail. Pls pls help. I get 6, 10mg per day and 2, 30 MS Contin. 8-9, 10mg would be perfect for OXY. The MS Contin really makes me super tired. I have thought about asking for hydromorphone ER, as insurance has said no the OxyContin. He may be willing to go to 4-5, 20mg’s per day vs the 10’s and the MS Contin. Any suggestions I will totally consider/incorporate.
 
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