Biggest one, alchohol. Have only had one semi-good time drunk, but my body physically cannot handle it whatsoever, as in a single beer will have me throw up the entire day afterwards. I think it’s the multiple meds I take for my chronic illness that are causing this reaction, but idk.
That and my eating disorder hating the idea of a drug with calories. Even now that I wouldn’t consider myself anorexic anymore, I just hate consuming disgusting tasting drinks when I can do benzos and become just as stupid and reckless.
Another big one is cocaine. Impulsively bought a gram once because I was bored, but no matter how many damn lines I snorted, I never got the ‘confident, need to talk’ feeling and the rush was very disappointing compared to synthetic cathinones that are 5x cheaper. Also hated the sensory experience of the numbness it causes. Ended up giving what was left of the gram to a friend, so hey, at least something positive came out of whatever that situation was.
Might be my adhd, because I do get that confidence and motivation boost from speed, as well as wanting to talk (such as this long ass ramble right now lol

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Feel lucky to dislike the expensive drugs haha