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Tryptamines The Small & Handy 4-Pro-DMT Thread

I finally tried this once last year, it had a different color enhancement effect which I thought was interesting. Usually shrooms and 4-ho or aco-dmt have the same colors but pro had a darker contrast. Like deeper blues and reds. Browns.
 
Is rectal application effective? Do you need less than when taking it orally?
What about intranasally?
 
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CavernsoftheMind said:
4-PrO-DMT & 4-PrO-MET don't fall under the german NPS law & are available.

Is rectal application effective? Do you need less than when taking it orally?
What about intranasally?
Click to expand...
4-PrO-DMT is an ester of psilocin and thus covered by BtmG, just fyi.
 
@BorbOrB these binding studies are done in vitro, away from the presence of enzymes. The counter-claim is that in the human body, the enzymatic breakdown of these drugs happens so fast that these prodrugs are not hitting the receptors directly or at a meaningful rate, they are quickly being broken down into 4-HO-DMT (psilocin) and it is that molecule that's overwhelmingly what's being tripped upon.

However, a lot of people claim subjective differences between these drugs so it could be that the enzymatic activity is slow enough to feel the prodrug directly, or maybe there are some other factors that we don't know about.

I'm agnostic on this matter. I should say that I find 4-AcO-DMT to be quite different from mushrooms, but I don't know if it's because of the pharmacodynamics being different in psilocybin vs 4-AcO breakdown, or because of poorly studied molecules in mushrooms that have an entourage effect with psilocin, or if the 4-AcO-DMT really is a mix of being a pro-drug and a drug-drug.
 
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