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7OH tolerance

P

Psynaught

Bluelighter
Joined
Sep 12, 2023
Messages
408
I take 5 grams of Kratom 5-6 days a week. Rarely...maybe once every 10-12 days or so I will get high on real opioids.

I purchased some 7OH and took 40 mgs last night. One and a half Opia which were third party tested at 26 mgs per pill. I spaced half a tab every 45 minutes.

I felt good, but not really high. Is that a normal reaction or do I have a high tolerance?

Thanks!
 
Psynaught said:
I take 5 grams of Kratom 5-6 days a week. Rarely...maybe once every 10-12 days or so I will get high on real opioids.

I purchased some 7OH and took 40 mgs last night. One and a half Opia which were third party tested at 26 mgs per pill. I spaced half a tab every 45 minutes.

I felt good, but not really high. Is that a normal reaction or do I have a high tolerance?

Thanks!
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Have you taken 7oh before? I wouldn't imagine 5 gram of regular kratom would produce that much tolerance, but it will produce some for sure. But yeah man when I was taking 30g+ regular kratom powder per day then switched to 7oh just 15-30mg would put me fucking ass backwards. Honestly without previous 7oh tolerance, just 5-10mg can produce a profound buzz and sedation/nods.

Then again, once I develop some tolerance towards 7oh, 40mg wouldn't do shit for me.... but that's way later down the line of tolerance.

But if it was your first time taking it I find it unusual you didn't feel much. Opia is a good brand... but I haven't tried their "new" stuff that is supposedly post ban ready? IDK
 
Quasimoto said:
Have you taken 7oh before? I wouldn't imagine 5 gram of regular kratom would produce that much tolerance, but it will produce some for sure. But yeah man when I was taking 30g+ regular kratom powder per day then switched to 7oh just 15-30mg would put me fucking ass backwards. Honestly without previous 7oh tolerance, just 5-10mg can produce a profound buzz and sedation/nods.

Then again, once I develop some tolerance towards 7oh, 40mg wouldn't do shit for me.... but that's way later down the line of tolerance.

But if it was your first time taking it I find it unusual you didn't feel much. Opia is a good brand... but I haven't tried their "new" stuff that is supposedly post ban ready? IDK
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I have taken it a few times. Nearly 2 weeks ago I took one legit 30 mg Oxy and one Mexican blue Oxy (which of course is fent). I waited half an hour and took 13 mgs of Opia and a half hour later another 13 mgs.

I definitely got a nice high from that. Then a week or so ago I took 13 g of Opia and just felt slightly good, no more. It seems I have a high tolerance.

I bought some 80mg tabs. Going to wait at least a few more days and try one of those...a half and then 45 minutes later another half. My take on 7OH is it is as addictive as real Oxy.
 
rentedbythehour said:
I believe 7-oh is on it's way to becoming a schedule 1 drug in the US.
www.fda.gov

FDA Takes Steps to Restrict 7-OH Opioid Products Threatening American Consumers

FDA Takes Steps to Restrict 7-OH Opioid Products Threatening American Consumers
www.fda.gov www.fda.gov
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Oct. 1st, 2025 they pulled it off every shelve in smoke shops in my area of VA. Most shops still sell it out of black trash bags to their regulars. I get it cheaper per pack than it costs to order it. No one wants to have on the shelves the moment it turns schedule 1 and catch a charge. The smoke shops know the game it up. There will still be a great deal of 7-OH on the black market leftover to sell if when all this happens.
 
Them Witches said:
Oct. 1st, 2025 they pulled it off every shelve in smoke shops in my area of VA. Most shops still sell it out of black trash bags to their regulars. I get it cheaper per pack than it costs to order it. No one wants to have on the shelves the moment it turns schedule 1 and catch a charge. The smoke shops know the game it up. There will still be a great deal of 7-OH on the black market leftover to sell if when all this happens.
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I've never done it, really have no interest in it but I like to keep up to date on things. Plus I'm allergic to morphine so I never know how something like that will affect me so I just stay away. I just watched a podcast on YouTube where one of the guys was talking about 7oh. It's all new to me. Maybe I'll understand more once I finish watching it.
FL made it a schedule 1 drug in an emergency order in August. From my understanding the 7oh that you get from kratom leaves is minimal, around 2%. Most of what is sold today is synthetic or semisynthetic. I've seen that it's 3, 10, 25, 30, 48 times more potent than morphine. I guess that makes sense since it's not regulated and you never actually know what strength you're getting.
I also saw an article about several people that have OD'd on this. Just be careful.

LISTING OF DEPARTMENT OF PUBLIC HEALTH PRESS RELEASES

publichealth.lacounty.gov publichealth.lacounty.gov
 
rentedbythehour said:
I've never done it, really have no interest in it but I like to keep up to date on things. Plus I'm allergic to morphine so I never know how something like that will affect me so I just stay away. I just watched a podcast on YouTube where one of the guys was talking about 7oh. It's all new to me. Maybe I'll understand more once I finish watching it.
FL made it a schedule 1 drug in an emergency order in August. From my understanding the 7oh that you get from kratom leaves is minimal, around 2%. Most of what is sold today is synthetic or semisynthetic. I've seen that it's 3, 10, 25, 30, 48 times more potent than morphine. I guess that makes sense since it's not regulated and you never actually know what strength you're getting.
I also saw an article about several people that have OD'd on this. Just be careful.

LISTING OF DEPARTMENT OF PUBLIC HEALTH PRESS RELEASES

publichealth.lacounty.gov publichealth.lacounty.gov
Click to expand...
Opia only. Closest feeling to morphine, heroin, oxycodone. What is funny is I know people that are hooked on Fetty and they are flopping around the bed with RLS and struggling cuz their plug is not answering. Yet a 2-4 min drive to a smoke shop and they are selling it for decent prices and in singles. A 60mg Opia got my bro off Fetty Empty in 10 mins flat and he does smaller amounts of fetty but has been dependent for 4 years.

7-OH in large doses is too much for opioid naive people. Even for people that fart around with Roxi 30mg here and there but never create a dependency. 7-OH is just like a stronger opioid absolutely. If I haven't done it in 2 days a 240mg dose feel close the heroin with 1000mg gabapentin and Busbar. I have taken 720mg 7-OH doses so many times. I am disappointed in myself for wasting money on 7-OH b/c it gets out of hand quickly and a tolerance builds faster than any opioid/opiate I have ever done. It does bind to the mu receptors 10-14 times the affinity of morphine.

It is instant release that works PO faster than any opioid I have ever taken. I have seen people nodding off on 15mg the first time. not me... I 240mg dose pushes vibrations out of the body that is very floating, warm just like heroin in some ways. On a blind test, most people that have taken opioids before would not know. They would say damn that works fast well.

Pain management should absolutely Rx 7-OH in IR, ER, IR & ER combo, and IV forms of 7-OH. It really works on pain like Roxicodone and Methadone, Morphine.
 
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Serious question. What would be a safe starting dose for someone who is not an opioid user? Male, 160 lbs, drinks beer every day and uses meth smokes it. Has chronic back pain and with no insurance, not many options for treatment. I'm not asking for sourcing, just a safe starting dose since Narcan is a 911 call away.
 
Be aware that there have been multiple reports of a particularly nasty AWS associated with chronic use of 7-hydroxy mitragynine. I don't know why that should be, but I strongly recommend treating it with respect.

A few people have posted warnings.

Now I have no idea why this should be, but I hear bits and bobs about how mitragynine picrate (and item of commerce) is being oxidized so it IS a semi-synthetic compound. Preparative chromatography appears to be used to isolate the product BUT if mitragynine pseudoindoxyl is a side-product, it may be left in the final prduct (given it's potency). It does appear that the quality of the products on offer can vary quite a bit.
 
rentedbythehour said:
Serious question. What would be a safe starting dose for someone who is not an opioid user? Male, 160 lbs, drinks beer every day and uses meth smokes it. Has chronic back pain and with no insurance, not many options for treatment. I'm not asking for sourcing, just a safe starting dose since Narcan is a 911 call away.
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I'd say they'd be better off trying kratom leaf. It works for pain in my experience and has less negative risks, though of course it's still addictive. 7 oh gets way out of control, he probably won't be using it just for pain before long, and besides, pretty soon it won't be available anyhow, so not very practical to have a habit. But poly drug usage ( alcohol, meth) is kind of risky. There have been some ODs with kratom and it's products, but I think it's pretty much always associated with poly drug use, not alone.
 
chippermonk said:
I'd say they'd be better off trying kratom leaf. It works for pain in my experience and has less negative risks, though of course it's still addictive. 7 oh gets way out of control, he probably won't be using it just for pain before long, and besides, pretty soon it won't be available anyhow, so not very practical to have a habit. But poly drug usage ( alcohol, meth) is kind of risky. There have been some ODs with kratom and it's products, but I think it's pretty much always associated with poly drug use, not alone.
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Thanks for the input! I know nothing about it really so I thought I'd ask here for advice. I also know nothing about kratom so I guess the same question would need to be asked. I do know kratom comes in different types. Is there one strain that's better than another for pain control?
 
rentedbythehour said:
Thanks for the input! I know nothing about it really so I thought I'd ask here for advice. I also know nothing about kratom so I guess the same question would need to be asked. I do know kratom comes in different types. Is there one strain that's better than another for pain control?
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I think people like to say red strain is better for pain and sedation than white, with green in the middle, but I don't personally see a big difference, though I go with green. I don't really use it for pain, but I can tell it helps. I think it's good to start out at just a level teaspoon ( about 2.4 g) to see how it goes. But it doesn't last terribly long, so if he is trying to use it for all day pain relief, then pretty soon dosage will go up. I don't know how it interacts with meth. Myself, one beer is no biggie with it, but it doesn't feel to me like more alcohol would be so good.
By the way, I tried 7oh a few times without any opioid tolerance and found 2.5 mg to have what I'd consider a strong effect for a few hours ( maybe I'm a light weight though 😉) But if you read accounts from people who take it, it's common for tolerance to shoot up way high, way fast. It seems to me really hard to use for all-day pain relief without it getting out of hand. Unfortunately, that can happen with kratom powder, too, though.
I'm sorry to hear your friend has chronic back pain. I'd urge caution because we all know how opioids can take over. I hope he can find some relief in a safe way.
 
He's familiar with the way opioids can take over. He was given meds to help with pain after an accident and never told of all the things that could happen. He has been thru withdrawal. He is aware of the potential for abuse. He normally doesn't take anything for his back pain. I have to ask him to take ibuprofen when it's really bad. I usually look up meds that are in the works. There's one that looks promising for chronic pain. It was just submitted for release in Germany. The US is in stage 3 testing. It's a cannabinoid based med.
vertanical.com

VERTANICAL | A world free of chronic pain

We want to give a new lease of life to chronic pain patients all over the world. With the development of VER-01, we have reached our first significant milestone.
vertanical.com vertanical.com
 
rentedbythehour said:
He's familiar with the way opioids can take over. He was given meds to help with pain after an accident and never told of all the things that could happen. He has been thru withdrawal. He is aware of the potential for abuse. He normally doesn't take anything for his back pain. I have to ask him to take ibuprofen when it's really bad. I usually look up meds that are in the works. There's one that looks promising for chronic pain. It was just submitted for release in Germany. The US is in stage 3 testing. It's a cannabinoid based med.
vertanical.com

VERTANICAL | A world free of chronic pain

We want to give a new lease of life to chronic pain patients all over the world. With the development of VER-01, we have reached our first significant milestone.
vertanical.com vertanical.com
Click to expand...
Wow, that's some stoic willpower not to even take an ibuprofen! Myself, I very often find just plain Tylenol to help me quite a bit, better than ibuprofen, and Ibuprofen is hard on my stomach.
And for kratom, if you take it no more than a couple times a week, you can keep tolerance down. He could even try taking half a teaspoon, I can feel a mild effect from that. When I take it, I like it in the morning with my coffee because it's kind of stimulating. But 7 oh is difficult for any moderation imho
 
I developed this opinion on how opiates/opioids work on humans in pain verse not in pain. It shows why people not in pain that take them to get high quickly start to lose the feeling they were after. We all know this as tolerance and dependency obviously. What is happening in the brain is the mu receptors are being tickled without their door's being open for business. Of course they feel it but after a while the mu receptors are still closed for business in a way.

Someone in pain has their mu receptors doors open at all times. People in pain feel more from opiates/opioids as they transition from being on guard to relief. This transition increases the reward center aspect of it.

Does this make sense?
 
rentedbythehour said:
Thanks for that feedback. I'll talk to him about options and see what he thinks.
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Kind regards and in no way am I attempting to lecture you. I thought sharing this would be useful information to you relating to all things considered via the current thread. I am hoping and aiming for this to be educational for all readers. Quoting you came about b/c I want you to read this the most :

7-OH works great for pain. I do not understand why it is not being used in pain management. It would be good rotation opioid or added for breakthru pain because of how fast it works. It would be very useful in the ER throughout all of medicine practice. The sedation level is lower than a standard opioid and less concern of respiratory depression, apnea, hypoxia, and/or inducing adverse reactions concerning COPD patients.

I think and feel that Opia 7-OH 480mg at once is similar to 3-5qty Roxicodone 30mg's at once. There are obviously differences between the medicines but as far as dependency needs being addressed and actual delivery of the drug to the mu-receptors is about even. The Roxicodone would be more sedating overall but the 7-OH provides the decent to strong sedation to the opioid naive. For the seasoned opioid tolerant, not so much sedation but a feeling of "flighty warm energetic calm" mixed with pain relief & anxiety relief. Also for the seasoned opioid tolerant, 7-OH meets dependency needs quickly and in large doses tends to cover most of the day after getting off empty or another wards the 1st dosages of the day. Taking the "pro-drug" pseudoindoxyl increases the 7-OH's effects and adds to the sedation.

The best way to take 7-OH is on an empty stomach, a few Tums before hand, take a large dose, split all capsules in half or quarters, and with 12oz-20oz of water depending on the dose size.
 
@Them Witches - I would certainly like to see a proper instrumental analysis of products being sold AS -OHM because from what I hear, preparative chromatorgrpahy is the only way to obtain a pure product but if a side-product is active and can be isolated, would you throw it away or added to the wholesale material? I've heard someone HAS found a much safer route than the two offered by the original Japanese (?) researchers which makes use of KH2SO5 (Oxone)... but even with that, yield is around 65% at best.

What do we know about mitragynine pseudoindoxyl other than it having an extremely high (low) affinity for the MOR? Is there research that may be able to spot it in product?
 
Them Witches said:
I developed this opinion on how opiates/opioids work on humans in pain verse not in pain. It shows why people not in pain that take them to get high quickly start to lose the feeling they were after. We all know this as tolerance and dependency obviously. What is happening in the brain is the mu receptors are being tickled without their door's being open for business. Of course they feel it but after a while the mu receptors are still closed for business in a way.

Someone in pain has their mu receptors doors open at all times. People in pain feel more from opiates/opioids as they transition from being on guard to relief. This transition increases the reward center aspect of it.

Does this make sense?
Click to expand...
I'm very curious about this issue. I've been trying to figure the effects of deregulation of receptors and all that after taking opioids, how quickly it kicks in, at what minimum diseases etc. Because what I read says the brain tries to dampen down the effects of this abnormal rush of pain killing and mood improving effects by making changes in the brain. The result being "tolerance" and even OIH ( a very unpleasant sounding thing). For my own self, I wonder if it means even just low level occasional use can lead to more pain sensitivity and depression.
But in the case you are talking about, of people with really serious pain problems, it sounds like you think that because the pain is such a serious problem, the mind responds by letting opioids continue to work well? It makes sense that it could work that way, and I certainly don't have the experience or knowledge to judge myself. But I have read that opioids can really screw up your minds ability to naturally control pain and depression, which are very interlinked. Yet obviously no amount of your body's natural endorphins is going to a damn thing for a serious injury or serious chronic illness, so doing without opioids is not an option if the pain doesn't go away.
However, my belief is that are levels of pain that we can cope with through our native endogenous system. That's the case for me, I have pain and it sometimes causes me to suffer but I can handle it without opioids, it's just that I'd rather use the opioids to feel better. And they work great! Until they wear off. But meanwhile I kinda feel like my natural neurotransmitter system gets messed up and perhaps that low level intermittent chipping use is making things worse.
Anyhow, sorry for my long ramble and I'm not dismissing anyone's need for opioids, just my own. I think this whole issue is important though, regardless of the level at which people are using opioids.
It seems like you are saying that even though you take have been taking high doses for a long time that you still get good effects from them, that your need to increase doses has plateaued? I wonder if that applies to 7 oh and kraton as well, being as they are partial agonists and work a bit differently.
 
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