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Mental Health Coming off Invega/Xeplion (paliperidone) injections v. 10

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Trueart2 said:
You’re believing ChatGPT over medical studies and what your literal doctor said. This is exactly why I advised you to ignore using ChatGPT as a medical resource.

Read the medical study I linked, reading just the abstract and conclusion is enough to gain understanding.

Start taking SJW if you want Invega to get out your system quicker
Click to expand...
Actually ChatGPT is more educated about AP’s damage than 99.99% doctors i talked with, and it’s good for technical use but again don’t fall for it too emotional because when it capting that it start to give you answer you “need to hear” just to track your emotional profile, these data is shared with mossad, never forget that.
 
Trueart2 said:
Carbamazepine significantly reduced the plasma concentration of paliperidone. The plasma concentration of paliperidone at baseline and with coadministration of 200, 400, and 600 mg/d were 45.8 ± 11.7, 26.9 ± 13.7, 17.1 ± 8.2, and 15.9 ± 7.6 ng/mL, respectively. The concentration of paliperidone with carbamazepine coadministration at doses of 200, 400, and 600 mg/d were 55.7% ± 20.7%, 36.1% ± 12.2%, and 33.6% ± 10.4%, respectively, of baseline. This effect occurred even at the carbamazepine dose of 200 mg/d and reached a plateau at doses higher than 400 mg/d. However, carbamazepine coadministration exacerbated the psychotic symptoms in some patients.
Click to expand...
Someone have to make serious study and research about that, we cannot do shit like that from our own, we are the patient but we have to do the doctors and researcher’s work
 
I asked an update from the university hospital, they answered me like that:

Dear Mr ********

Thanks for your message.
Right now we are in the process to translate all your reports from Italian to German.
The first step is to understand what is the reason for your symptoms and suffering and afterwards we can give our advice how to treat them
We already discussed your case with the senior doctors but right now I can't tell you anything new

Kind regards
 
RisperdalConsta50mg said:
I asked an update from the university hospital, they answered me like that:

Dear Mr ********

Thanks for your message.
Right now we are in the process to translate all your reports from Italian to German.
The first step is to understand what is the reason for your symptoms and suffering and afterwards we can give our advice how to treat them
We already discussed your case with the senior doctors but right now I can't tell you anything new

Kind regards
Click to expand...
Is this good?
 
Trueart2 said:
You’re believing ChatGPT over medical studies and what your literal doctor said. This is exactly why I advised you to ignore using ChatGPT as a medical resource.

Read the medical study I linked, reading just the abstract and conclusion is enough to gain understanding.

Start taking SJW if you want Invega to get out your system quicker
Click to expand...
Yeah but that study is for oral paliperidone, not the injection.

What ChatGPT says makes sense. It may lower the levels of Invega in the blood, but it won’t accelerate the depot dissolving into the blood. So, who knows. Plus that drug comes with its own side effects as well.

I asked about St. John’s Wort. My doctor doesn’t think it would help much. Not much evidence that it will clear the drug. It affects liver enzymes and paliperidone is mostly excreted through the kidneys. But carbamazepine does affect the drug transporter (P-gp) which can accelerate clearance of the drug.

So in conclusion it may lower levels in the blood, but it won’t cause the depot to dissolve faster. Which means it will still take 18-24 months for full clearance if we are to trust the literature.
 
Trueart2 said:
Carbamazepine significantly reduced the plasma concentration of paliperidone. The plasma concentration of paliperidone at baseline and with coadministration of 200, 400, and 600 mg/d were 45.8 ± 11.7, 26.9 ± 13.7, 17.1 ± 8.2, and 15.9 ± 7.6 ng/mL, respectively. The concentration of paliperidone with carbamazepine coadministration at doses of 200, 400, and 600 mg/d were 55.7% ± 20.7%, 36.1% ± 12.2%, and 33.6% ± 10.4%, respectively, of baseline. This effect occurred even at the carbamazepine dose of 200 mg/d and reached a plateau at doses higher than 400 mg/d. However, carbamazepine coadministration exacerbated the psychotic symptoms in some patients.
Click to expand...
“Six schizophrenic patients initially received a 6-12 mg/d dose of paliperidone alone.”

This study is for the pill form only. I have looked for one with the injection and couldn’t find it.
 
rawbanana said:
Yeah but that study is for oral paliperidone, not the injection.

What ChatGPT says makes sense. It may lower the levels of Invega in the blood, but it won’t accelerate the depot dissolving into the blood. So, who knows. Plus that drug comes with its own side effects as well.

I asked about St. John’s Wort. My doctor doesn’t think it would help much. Not much evidence that it will clear the drug. It affects liver enzymes and paliperidone is mostly excreted through the kidneys. But carbamazepine does affect the drug transporter (P-gp) which can accelerate clearance of the drug.

So in conclusion it may lower levels in the blood, but it won’t cause the depot to dissolve faster. Which means it will still take 18-24 months for full clearance if we are to trust the literature.
Click to expand...
Ya Allah they robbed 2 years from us
 
RisperdalConsta50mg said:
If i will have effects past 24 months they will have some bullets in their body
Click to expand...
Like i think about this dude that after work time came out the psych ward and go to his car to go back home but suddently he got shot multiple time, i just want to hear his scream and look at his face while he is in agony about to die
 
RisperdalConsta50mg said:
Like i think about this dude that after work time came out the psych ward and go to his car to go back home but suddently he got shot multiple time, i just want to hear his scream and look at his face while he is in agony about to die
Click to expand...
But maybe i made a full recovery before 24 months, i hope for him, so he can live.
 
RisperdalConsta50mg said:
I asked an update from the university hospital, they answered me like that:

Dear Mr ********

Thanks for your message.
Right now we are in the process to translate all your reports from Italian to German.
The first step is to understand what is the reason for your symptoms and suffering and afterwards we can give our advice how to treat them
We already discussed your case with the senior doctors but right now I can't tell you anything new

Kind regards
Click to expand...
The reason is the injection you recieved,nothing else. That's what is causing it.you think they're going to give you dopamine agonists
 
rawbanana said:
Every time i smoke the high only lasts for 20-30 min. And it’s not the same feeling as before.
Click to expand...
It’s the same for me but with anhedonia added. I smoked 25 mins ago and the high is very strong. I hardly smoke so my tolerance is low. This will last around 90mins I reckon.
 
rawbanana said:
My psychiatrist from my AOT program just talked to me about a drug called carbamazepine that supposedly induces enzymes that break down invega in the blood and reduce blood levels.

Has anyone heard of this drug? I’m thinking of starting it tomorrow
Click to expand...

I took carbamazepine once it gave me a migraine for 2 weeks. These enzyme inducers are not really going to work for this imo
 
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