First LSD Trip 320ug? – Bad Experience Mixed with Mirtazapine (Possible Serotonin Syndrome?)

[keftaboyzKoln]

** Trigger Warning: Dangerous drug interaction, fainting, panic, near-serotonin syndrome**


Hey everyone,

Yesterday I tried LSD for the very first time, and it turned into the scariest drug experience of my life.

I was with my friend J, who had done LSD before (250µg and supposedly 500µg). We both decided to dose at 20:00. By 20:30 we dropped the blotter, and only 15 minutes later (20:45) the visuals started rushing in. While they were coming up, I even tried to make a pizza, but things quickly spiraled.

By 21:30 the trip was overwhelming: insane visuals, paranoia, and total reality distortion. It felt like my ego was dissolving and the world was collapsing. These were **the most intense, insane visuals I’ve ever had in my life**—and instead of enjoying them, they terrified me.

By 22:30 I was desperate to stop. I remembered reading that mirtazapine (15mg) could end a bad trip. Without thinking clearly, I took one—and so did my friend.

At 22:50, the visuals suddenly dropped. Then my friend told me he felt like he was about to faint. As I tried to help him, I felt the exact same thing: my body shutting down, vision fading, heart pounding out of my chest. For a moment, I was convinced this was it—I was going to collapse and maybe not wake up.

The feeling came in waves. Every time I thought about fainting, it got worse, like my brain could trigger the blackout. I was dripping sweat, barely holding myself together, and I truly considered calling an ambulance. I was terrified we had given ourselves serotonin syndrome—or that our bodies just couldn’t handle the mix.

By some miracle, by 00:00 we were stable again. We sat down and watched Scooby Doo while riding out the comedown. For a moment, it almost felt safe. But then at 02:00, it hit me again—I nearly fainted one more time. My friend stayed awake watching me until 04:30 when we finally sleep

When I woke up at 16:00, I felt normal again. Ate some pasta, went outside, like nothing happened. But looking back—it was one of the most dangerous situations I’ve ever put myself in.

**My conclusions:**

* Never, ever mix LSD with antidepressants like mirtazapine. It can be deadly.
* The dose (320µg) was way too much, way stronger than what my friend had remembered.
* At the peak, I genuinely thought I was going to die, or lose my mind forever.
* The visuals were beautiful but terrifying—the most insane trip I’ll probably ever have.

For now, I’m done with psychedelics. I know many people love them, but after last night, I don’t want to risk that again.
We think it probably was other drug instead LSD what u all think?

Stay safe out there.

 

[iom]

I doubt you had serotonin syndrome. Your blood pressure may have been rather low, but it's hard to say.

No one really knows what drug you actually took, but what you describe is definitely consistent with LSD at 320 ug. Unfortunately, LSD doses are often misrepresented and inflated such that a supposedly "320 ug" dose might be less than half that, and then when you get the real deal you find yourself totally unprepared. With appropriate preparation, a 320 ug dose is not necessarily too high, but it is extremely powerful. Even 200 ug is enough for most people to have very strong experiences.

 

[onetwocatpoo]

I have to agree that iom is right here. This just sounds like quite a strong trip for you. Many of us have been there. I agree dosage is likely incorrect. They often say it's more than it is.

However even if it were quite a bit less it can be pretty strong. Tabs from a former well known supplier (recently retired) who was known for their accuracy when dosing would have stuff that'd cause strong effects for some at a total around 200ug.

Obviously we weren't there but it doesn't seem like serotonin syndrome. I'd mixed an SSRI with lucy a fair bit back in the day and this sounds like just a strong trip.

I hope this helps to put you at ease.

 

[keftaboyzKoln]

I have to agree that iom is right here. This just sounds like quite a strong trip for you. Many of us have been there. I agree dosage is likely incorrect. They often say it's more than it is.

However even if it were quite a bit less it can be pretty strong. Tabs from a former well known supplier (recently retired) who was known for their accuracy when dosing would have stuff that'd cause strong effects for some at a total around 200ug.

Obviously we weren't there but it doesn't seem like serotonin syndrome. I'd mixed an SSRI with lucy a fair bit back in the day and this sounds like just a strong trip.

I hope this helps to put you at ease.

Thanks for taking the time to read It and answer.
Yes probably it was that.
I gotta say I'm not a LSD type of guy, I need stimulant to enjoy.
So I got scared, I had 2cb 18mg before but this was other level.

 

[keftaboyzKoln]

I doubt you had serotonin syndrome. Your blood pressure may have been rather low, but it's hard to say.

No one really knows what drug you actually took, but what you describe is definitely consistent with LSD at 320 ug. Unfortunately, LSD doses are often misrepresented and inflated such that a supposedly "320 ug" dose might be less than half that, and then when you get the real deal you find yourself totally unprepared. With appropriate preparation, a 320 ug dose is not necessarily too high, but it is extremely powerful. Even 200 ug is enough for most people to have very strong experiences.

Thanks for taking the time to read It and answer.
Probably it was that

 

[ageingpartyfiend]

can only repeat what's been said

if you take lsd again , do proper research on what not to mix it with, and test your drugs prior to consuming - also pay ereal attention to set and setting

It's a notoriously underdosed drug, also usually claimed to be stronger than it is. This has led to many, many people believing they have ingested say 200ug previously and had a light, very manageble trip (which was maybe 80-100ug, 100ug can still be damn strong in the right environment). Then, when said person has a genuine 200ug dose all hell breaks lose.

The amount of trip reports I've read when people have taken 500ug and 3 hours into that are chatting away on their computer aahaha, hell no! 3 hours into a genuine 500ug you are not typing, in fact you have no idea what a computer even IS (or even what YOU are come to that....if 'you' even exist anymore that is!

320ug is a huge dose, even for very experienced users and when taken in close-to-perfect scenarios. I had genuine ego-death states last time I took 'real' 200ug dose. If you want to try again then next time set your environment up properly, take a genuine 100ug trip with tested lsd and things will be very different.

You'd only had 2 swimming lessons and you jumped in the deep end without armbands when there was no lifeguard on duty - lesson learned, and hopefully your story could stop someone else making the same mistake

EDIT - looking at your timeline again I'm now even wondering if it even was lsd, or if the Mirtaz affected it hugely (I'm unaware of their synergy).

For a genuine 250ug lsd hit I'd expect the following kinda timeline if set/setting were good (ie I felt in good spirits and my environment was conducive to 'letting go') - I'll use your drop time as base

20.30 - drop the acid
21.15 - feel the first stirrings
22.00 - starting to trip properly, coming up strong
22.30 - 02.30 Peaking, potential ego-death, very intense
02.30 - 5.30 Still heavily tripping but aware of yourself more and deeply reflective, sometimes lighthearted/giggly
5.30-8.30 slow descent to something close to baseline but still exploring and very enjoyable
sleep by 9.30-10.30 after plenty cannabis (doesn't sit well with some that, but I love plenty cannabis at end of trip)

 

[iom]

EDIT - looking at your timeline again I'm now even wondering if it even was lsd, or if the Mirtaz affected it hugely (I'm unaware of their synergy).

The Mirtaz almost certainly did affect things as it blocks 5-HT2A receptors. It probably didn't kill the trip entirely because the (assumed) LSD dose was so high, and the combo may have caused some other side-effects.

 

[Burkett]

Mirtazapine numbs your brain out like crazy. LSD lights it up. They both affect serotonin receptors so they're both at direct odds. That must have felt like shit. I really hate mirtazapine and it should be prescribed with extreme caution. Just put a bit of powder on your tongue and you'll stop feeling your tongue. That's what it does to your brain.

 

[emkee_reinvented]

Next time post before taking, 100 mcg to get a feel/ especially with low body mass,
male or female matters too. 125 / 150 little difference the visuals start.
See no reason to take 200 and i am seasoned and old man, it never got better.
You took a heroic dose.

Mirtazepine should on paper block LSD. But the dose LSD Was Bizarre˙

 

[4DQSAR]

Mitrazipine essentially stops LSD acting. I found out after consuming a dozen blotters and feeling almost nothing. But I don't think there is a dangerous interaction.