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Need Help Definitive List of Comfort Meds for Opiate Detox/ log of fent detox.

IMHO the most effective way to lower relapse rates is to improve core metabolic function. Coffee is the worlds most popular choice for this (see here why).
Strong metabolic function implies the body makes plenty of it's own dopamine, GABA, agmatine, endocannabinoids, protective hormones (eg progesterone) and even opioids.
So I’d imagine a healthy dose of caffeine along with rigorous exercise and a clean diet would all serve to increase metabolic function. Along with the supplements you mentioned?

I wonder why caffeine is so poo pooed during the paws phase then? Everybody says to stay away from it, but that’s the only thing that gets me moving in post acute.

And just to reiterate, in case I didn’t actually say this yet, all the supplements you mentioned I plan on taking as soon as possible for the end of this detox, all the way for several months after ….hoping it will help with PAWS and just living healthy in general.
 
I dont do it myself! From a doctor of course but either way i hear you. The IM is much easier and doesn’t feel as crazy cause that NAD is no joke… also dude should i try this patch out? I’m tired of dosing the oxy 3 x daily but also dont wanna get on bupe without a solid taper plan… sorry if im being. Annoying im just super isolated right now and need somebody to talk to
 
NAD will no doubt help with this big time. Also can I ask what protocol you’re doing for your comfort meds right now?
my
I dont do it myself! From a doctor of course but either way i hear you. The IM is much easier and doesn’t feel as crazy cause that NAD is no joke… also dude should i try this patch out? I’m tired of dosing the oxy 3 x daily but also dont wanna get on bupe without a solid taper plan… sorry if im being. Annoying im just super isolated right now and need somebody to talk to
Almost all of us are isolated man, who has a whole group of addicts and friends SUPPORTING their detoxes? We're on here to get the support, info, and guidance.

For me, IM is all good bc I've been pinning test for 10 years lol. And a slower rate of Absorbtion for something that's "no joke" sounds safer to me.

Also- what patch are you talking about? A bupe patch? Personally, after I experienced precipitated WD I was scared of bupe for life. Thats why I waited till day 6 of this detox to take only 2mg. (2/1.5/1/.5) taper. TBH- this detox hasn't been terrible bc of the meds and supps I've had. I was lazy AF, no energy, diarrhea, and no appetite, but I didn't have all the other classic symptoms... ESPECIALLY the mental ones... those feelings of emptiness when it gets dark, when you hear other people going about their lives while you're in bed with the world still going. I had none of that. THANK GOD.

Point is, ill layout exactly what I took which produced this better result. And if it wasnt for a couple nights of no sleep and RLS, i wouldn't have even added the bupe that late in the game. (I also was using a long acting form of fent, so I still have the fear that this may be drawn out longer then normal). So, if you can sack it up a little (which was my plan), I could have pushed through and not included the bupe at all! But I'm with you- bupe is scary, and doctors push it for long-term maintenance. I dont want that, and I dont think you do either. So, IMO, wait 3-4 days, rely on your meds and just lay in bed like a zombie, then write out a sub taper and STICK TO IT. Be conservative. my taper is extremely conservative, but a standard inpatient detox sup taper is typically (8/6/4/4/2/2)... and I beg them to bring me down to 1mg, bc why not?

Depending on your current substance intake, maybe opt for something like (4/2/2/1/1). Sure, it lengthens things a bit, but it does soften the blow. But im not a doctor, so thats just an idea.

my list of prescriptions for comfort meds:
-.1mg clonidine (30ct + 1 refill)
---I take one pill per dose
-25mg hydroxyzine (30ct + 1 refill)---I take one pill per dose
-5mg Valium (42 count)---- I take 1 OR 1.5 pills per dose
-4mg Tizanidine (21 count + refill)----I take 1/2 pill per dose (knocks me out too much)
-4mg zofran (12 count + 1 refill)----Havnet needed it, thank god.
-8mg subutex (10 count)---I broke one pill up for the small taper I described above.

Other Meds/Supplements I acquired on my Own:
-1mg Klonopin (15 pills)---I take one AM and one PM
-Imodium- (used as needed. Which was a lot)... buy a big bottle. The Vitamin C can make diarrhea worse.
-Sodium Ascorbate (taken in 2g doses)---I mix with Gatorlyte and drink every ~2 hours.
-Black Seed Oil (200mg pill @ 5% extract strength)---I took one AM and PM, but have ramped up to 4 split throughout the day
-Passionflower Extract (375mg pill at 4:1 extract strength)---I took one AM and PM but have ramped up to 2 am and 2pm
-Agmatine Sulfate (1g dose)--- taken 2-3 times a day
-L-Tyrosine (500mg pill)---I take 2 upon waking, and 2 in the mid afternoon)
-Multivitamin---Taken with morning meal and night meal
-Good Ole Weed (one hit in the morning for appetite, several hits at night to help sleep).

I take the OTC Supps first in the AM with my first dose of Vitamin C (sodium Ascorbate). 20 Mins later, I take my med doses. I take that cocktail of Rx meds 3 times a day... morning, afternoon, and slightly before bed. I dose the OTC supplements throughout the day as I see fit.
*I absolutely feel the vitamin C was the key player here in this detox being easier. I'm sure its a combo of everything, but there's nearly overwhelming evidence out there that it works!

Also worth noting that as of day 5 or so, I started halving my Rx meds, since I didn't feel the symptoms that they are there to counteract. I also felt that they were sapping my energy more then the detox itself. And I think I was correct. But these are PRN, so take them when needed, just not closer then ~5 hours apart, bc they are DEF CNS depressants. And obv be careful with the benzos. I saved a lot of my valium (I would have enjoyed taking larger doses then a measly 5mg)... but I wanted to make sure I had a good 5-10 pills to wean off of after all of this. I also knew my doc wasn't going to write me another script for them.

Lastly, @Allylbenzene has contributed a mountain-full of extra info here and has suggested and explained several other supplements that I WISH I could have. If I had the money atm, they'd be on the list above. So, Read his posts, because you could end up having it easier then me with some of his suggestions! I plan on still getting much of his suggestions next week, and using them through PAWS. I want to end the RX meds as soon as I see fit. I expect that ill need them in smaller doses for a day or two after my sub taper, as such goes.
 
36y/o… been through the classic opiate path. Oxy->dope->fent. I’ve successfully completed 4 in patient detox’s and one at home detox. I’ve had clean periods of over a year a few times.

But I’ve been using fent in south Florida for 4 years straight. Granted, I don’t just go balls out and do as much as I can (like I used to)… I stick to a regiment of 4 bags a day to stay well. The type of fent I have I barely feel, but it keeps me well for close to 24 hours. This scares me as I know the detox will likely be more drawn out. Last time using this same fent, I waited 72 hours before Suboxone and STILL went into precips.

SO- my plan is to do a “cold turkey” detox meaning NO subs. I’ve done it before with a standard protocol of comfort meds and I just pushed on. I did it. I can do it again, and this time, I’m further along in life and have SO MUCH more to gain from kicking. I’m ready to live my life.

MY QUESTION IS: (and I’m sure threads exist but I can’t find them)… what would we say is the list of standard comfort meds to get from my doctor? Last time I went in, told him the deal and he literally asked me what I wanted. If I remember correctly it was:

-Clonidine (hot cold flashes, rls, helps with physical discomfort)
-hydroxyzine (antihistamine for yawning, sneezing, and has some anti anxiety action… allegedly)
-Valium (anti anxiety, helps sleep, muscle relaxing)
-Muscle Relaxer (I prefer bacofen, but anything would help
-ondasteron (stops nausea)

I did it with these. Below I’ll list some others that I’ve tried, don’t feel strongly that they are as helpful, but I’d like to hear anyone’s opinion on them:

-pregbalin/gabapentin (never did much for me)
-REAL SLEEP AID (like ambient… not some off label old school anti depressants. Those just don’t do it for me)
-cbd/weed (cbd may have helped before, but weed didn’t actually help much other then giving me a mental break. And maybe appetite stimulating)

And lastly, other supps that I can get otc that may help:
-Delta Sleep Inducing Peptide (helps sleep)
-NAD+ (has some promising initial research to overall recovery post acute, and in lowering acute withdrawal)
-SODIUM ASCORBATE (at high doses, there are LOTS of people saying this was “the” godsend. I’m willing to try it)
-passionflower extract (helps with mood/depression)
-L-Tyrosie/DLPA- (dopamine precursors. This seems like it make be more helpful for PAWS… anyone use during scute?)
-loperamide (obviously helpful)


Anyone with ANY INPUT here is greatly appreciated. I’m aiming to start detox in about 10 days. I work from home during the week, and can take off from my weekend job. I’m in the process of getting my ex gf back, so I have to just do this. Life gets SO good SO quick when you throw all this BS out!!!

Anything I missed? Whether it’s the top catagory- prescribed “must haves”? Any random things that helped them?

Like I said this ain’t my first rodeo, but I’m convinced I can make it manageable with the right meds. And my mindset to quit is stronger than it ever was. To me, clonidine is king. If I had to pick one med, that would be it.
Hello there. Just wondering how you are gettin along with your detox. I just read this post and realized I’m too late. Your top list is “the bomb” by the way
 
So I took my final dose (1 bag Fent) this morning at 8am. It’s pretty long acting. From past experience I’ll probably not feel bad until around 18 hours. So, expecting to wake up tomorrow morning (24hours) and the fun should start. I got a home detox kit from my doctor:

-.1mg clonidine (30ct + 1 refill)
-25mg hydroxyzine (30ct + 1 refill)
-5mg Valium (42 count)
-4mg Tizanidine (21 count + refill)
-4mg zofran (12 count + 1 refill)
-8mg subutex (10 count)

I also have 15 1mg Klonopin (I got this to supplement the Valium since that 5mg dose won’t do much for me. I’ve been taking small doses of pressed stocks for the last two months. I only take a quarter stick but it’s def some incredibly strong type of research benzo. So I’ve done a good job of fucking up my benzo tolerance. But I’ve also gone cold turkey off if a few times here or there and it wasn’t too bad, luckily my dose has been small.

OTC wise I have;
-Tylenol, ibuprofen, tylenol
-immodum
-plenty of sodium ascorbate (enough to dose 25g for months)
-black seed oil (200mg equivalent to 5g of the active ingredient)
-passionflower extract.

I’m pretty well dosed on the comfort meds. I know the combo of clonidine, hydroxyzine, tizanidine and Valium needs to be respected for its ability To lower blood pressure abs knock me out, but I also know what I can handle. And I don’t mind getting some small naps to pass the time if anything. Any input on dosing would be appreciated. I could have sworn I was always given 50mg hydroxyzine. And the 4mg dose of tizanidine seems light, but I could be wrong

One benefit to doing it at home is being able to dose as needed. In patient I have to wait 8 hours to take my clonidine -which sucks bc that’s most helpful to me. Granted I’ll still try to wait as long as possible.

Does anyone have experience with passionflower extract or black seed oil? In terms of dosing, amount and frequency.

I’m not hoping for much from the otc side, but I’ll be honest… some of the reviews of vitamin C mega dosing and black seed oil are really exciting.

Mentally im ready. Ready to not be broke. Ready to put all my work into living my life. I’ve gotten clean before in detox and at home from longer and much heavier habits. I know it will suck. But I’ve never wanted to move on with life more. It’s always been more of a”running away from the pain of active addiction”. Sure that’s here now, but I’m just so ready to live. I’ve been fortunate to have a good job, and have gotten a nice apt and set myself up even while addicted- bc I’ve been just using a strict “minimum dosing” protocol to stay well. Havnt been trying (or able) to get high. So enough is enough.
Hi there. Your hydroxyzine is about 25 mg short for what you’re doing. Make sure you have tons of Imodium. As for the mega vit c..that is called an Ascorbic Acid flush and alone it’s not pretty, let alone in the middle of a detox. I would reconsider that one. I actually use Sublinox (zolpliderm) and it’s amazing. What a smooth sleep. Need a script though. Good luck buddy and be careful with everything. We are rooting for you…seriously. God Bless🙏🙏
 
Darling.. I’ve gone weeks without showering in the past. I understand.

You need to summon every bit of energy and fire you have in your fucking body and you need to love yourself and fight. I know the intense pain.

You will do this
Amazing reply. And pixies is completely spot on. Don’t worry about the shower (I know what you mean), no one going to or wanting to smell you or even care. They care about you buddy. Loads of love and hugs💕🥰🫂🫂
 
I dont do it myself! From a doctor of course but either way i hear you. The IM is much easier and doesn’t feel as crazy cause that NAD is no joke… also dude should i try this patch out? I’m tired of dosing the oxy 3 x daily but also dont wanna get on bupe without a solid taper plan… sorry if im being. Annoying im just super isolated right now and need somebody to talk to
The Butrans patch is amazing on pain. Just slap on and go. Don’t even think of pain till day 5, but you can wear them for 7.
 
Hydroxyzine is related to diphenhydramine, which has been getting bad press for years and there have been some recent negative articles about it (keyword: dementia). It's weak sauce anyway. You're better off with the strychnine. 🤪

"Strychnine is one of my favorite medicinal substances. From the moment I obtained authorization to purchase and use strychnine, I immediately did so."

Dr. Henryk Różański. [Ancient and Modern Medicine. Strychnine – Strychninum and Strychnos in Medicine]. Dec 31 2010 [blog entry] [translated from Polish]
Years ago everything caused cancer. Now everything causes Early Onset Dementia. It’s all the politicians in bed with big Pharma talking like this.
 
So I’d imagine a healthy dose of caffeine along with rigorous exercise and a clean diet would all serve to increase metabolic function. Along with the supplements you mentioned?
Over-excercising is also a thing. Having to much caffeine or over-excercising BOTH trigger a stress response.
The point is not to excercise till the point of fatigue. The stress response = cortisol which is a catabolic hormone = reduced muscle gains.

50mg caffeine with a meal/carbs several times per day is easier on the body than 200mg of caffeine in one go.

I wonder why caffeine is so poo pooed during the paws phase then? Everybody says to stay away from it, but that’s the only thing that gets me moving in post acute.
It's probably because people don't realise it's a powerful metabolic enhancer and so needs proper support (mainly lots of glucose/carbs) to work properly.
If everyone had read this then they would understand how to use coffee in a sustainable way that maximises it's invaluable theraputic benefits.

Coffee is a potent metabolic stimulator and must be viewed as such. The caffeine in coffee is powerful and can act like thyroid to increase your metabolic rate and the oxidation of sugar, making it a health-protective food.
Coffee also has supportive nutrients in the form of B vitamins and magnesium...

These characteristics make coffee a useful tool in your health toolbox provided that you’re taking the right steps to maximize effectiveness.

Symptoms to expect when you do coffee right are calmness, focus, motivation, warmth, and stable energy. Coffee done wrong leads to anxiety, shakiness, sweating, feeling wired, inability to focus, and sometimes cold extremities. Truthfully there is no right or wrong because whether you react well or not, the situation serves as a learning tool if you’re knowledgeable and aware enough to assess and correct the symptoms.

Since the goal is to support metabolic (thyroid) function, it makes sense to avoid anti-thyroid substances. The most popular is probably fluoride.
Fluoride is used to slow an overactive thyroid.
It can also slow a normal thyroid to "below-normal".
A dose of 2 to 5 mg of fluoride per day was typically found to be effective for suppressing an overactive thyroid.
https://thyroidpharmacist.com/articles/fluoride-and-your-thyroid/
Fluoride, however, is known to be an anti-thyroid agent and has been used to treat hyper-thyroidism
https://jamanetwork.com/journals/jama/article-abstract/660219



Here's another tool to help with opioid cessation/WD: Curcumin
Several recent publications suggest that long-term treatment with curcumin is effective in attenuating opioid tolerance and dependence...

https://pmc.ncbi.nlm.nih.gov/articles/PMC4352596/
The results of this study demonstrate that curcumin attenuates morphine dependence in rats through an inhibitory effect on neuroinflammation and a decrease in the expression of μ-opioid receptors in the prefrontal cortex.

https://www.sciencedirect.com/science/article/abs/pii/S0143417922000932
Curcumin also attenuates opioid-induced tolerance, dependence, and morphine withdrawal syndrome

https://www.sciencedirect.com/science/article/pii/S0944711318304781

Also the herbs Cats claw and Corydalis have been mentioned on other posts.
The active in Cats claw is Rhynchophylline. It's an NMDA antagonist (like agmatine) and possibly also an 5-HT2A agonist. Cat's claw could be useful as an anti-depressant.
The active in Corydalis is tetrahydropalmatine. It has anti-dopmine effects which isn't necessarily ideal when the goal is to boost dopamine and overcome WD.
 
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Hi there. Your hydroxyzine is about 25 mg short for what you’re doing. Make sure you have tons of Imodium. As for the mega vit c..that is called an Ascorbic Acid flush and alone it’s not pretty, let alone in the middle of a detox. I would reconsider that one. I actually use Sublinox (zolpliderm) and it’s amazing. What a smooth sleep. Need a script though. Good luck buddy and be careful with everything. We are rooting for you…seriously. God Bless🙏🙏
I know about the hydroxyzine, I was always given 50mg tabs, but these are 25mg with a refill, and that's a med I could call my doc to get more for if I needed. which I don't think I will (after a refill). I also haven't been getting much sneezing/watery eyes/yawning, so my lower dose hasn't been much of an issue.

I've been taking like 3 imodium every two hours all week. Bowel movements are starting to improve. (day 7)

I specifically avoided Ascorbic Acid because of how rough it is on the gut. I opted for Sodium Ascorbate which was a godsend. I realized I was dosing a little too aggressively at first, so cut down to exactly 2g every 2 hours or so. This has also improved the "gut".

I appreciate the input as always. Going to leave a general update in the post after this. but I will say, I definitely feel that I'm past the worst of it. been feeling about 10% better each day the last 3 days.
 
Over-excercising is also a thing. Having to much caffeine or over-excercising BOTH trigger a stress response.
The point is not to excercise till the point of fatigue. The stress response = cortisol which is a catabolic hormone = reduced muscle gains.

50mg caffeine with a meal/carbs several times per day is easier on the body than 200mg of caffeine in one go.


It's probably because people don't realise it's a powerful metabolic enhancer and so needs proper support (mainly lots of glucose/carbs) to work properly.
If everyone had read this then they would understand how to use coffee in a sustainable way that maximises it's invaluable theraputic benefits.



Since the goal is to support metabolic (thyroid) function, it makes sense to avoid anti-thyroid substances. The most popular is probably fluoride.
Fluoride is used to slow an overactive thyroid.
It can also slow a normal thyroid to "below-normal".





Here's another tool to help with opioid cessation/WD: Curcumin




Also the herbs Cats claw and Corydalis have been mentioned on other posts.
The active in Cats claw is Rhynchophylline. It's an NMDA antagonist (like agmatine) and possibly also an 5-HT2A agonist. Cat's claw could be useful as an anti-depressant.
The active in Corydalis is tetrahydropalmatine. It has anti-dopmine effects which isn't necessarily ideal when the goal is to boost dopamine and overcome WD.
In terms of exercise, I'm not too concerned with over doing it. Bodybuilding has been my main hobby for most of my life, and I already know this next week will start with walks, and super light blood-flow educing movements, just to get some light pump, and encourage appetite. I'm talking using pin loaded machines and doing sets of 15-20 NOT to failure. I will build this up over time of course. I'm also lucky that I've only lost 2-3lbs this detox. My typical weight loss in past detoxes is 15-20lbs. (which brings on a whole other world of anxiety for someone whos obsessed with getting "bigger").

I also take supps like HMB which is a "super charged L-Leucine" (the most anti-catabolic EAA).... so I take this upon waking, between meals, and immediately after a workout. I think that has helped prevent some of my weight loss. And on a completely separate note- anyone into working out should strongly consider HMB. its cheap, and its the only supp I take other then creatine and PWO. And I've tried every supp in the last 20 years. And almost every anabolic as well lol. Point is, I agree with you in being very cognizant of how I start to get moving. I want healthy movement, not cortisol inducing stress movement.


I've really taken an interest into your info on caffeine- and how to use it properly both for my detox and life. It all makes perfect sense. I had already been waiting to take my first dose of caffeine till after breakfast, but even with mini doses throughout the day, making sure my Blood Glucose is slightly raised definitely helps.

As for Curcumin and the other herbs you mentioned, I have to look into them more. My shopping list for Tuesday night is already getting pretty big. (L-Theanine, L-Phenylalanine... etc)

And thank you again. This thread is as much yours as it is mine lol. I really hope it sticks around because it could provide the motivation for some ppl to finally make the jump and kick it. My experience was not hell. I was prepared for hell.
 
General Update: 174 hours after last dose. (on day 7 currently)

I took 1.5mg sub yesterday divided into 1mg in the late morning, and .5mg at around 8pm. Today, I took .5-1mg (hard to tell) at around 10am. I'm planning on taking maybe .25mg before bed, and then .25 tomorrow around noon and thats it.

As for my meds, Ive cut back from 3-4 doses a day to essentially a noon dose, and a pre-bed "ko dose". The doses of each med have been cut in half or more. I only took .5mg klonopin last night and this morning. I will take .25mg tonight, and .25mg tomorrow and thats it for the klonopin. I have about 12 mg valium left. I take 3 a day, so tomorrow will start 2, and then just halving the dose (2.5mg) twice a day, then once. Seems like a soft enough landing considering benzoes were never the issue here.

Each day my periods of energy are increasing. 1 hour day 4, 2 hours day 5, ... 5-6 hours today... I'm improving. Granted, after each energy bout I still need to lay down and recharge.

I've also made a point to reach out to some friends who deserved my honesty but didnt get it, and let them know what I'm going through. IDK where this came from, but likely the desire to live well, and possibly sitting in near psychosis for the first 3-4 days staring at the wall contemplating life. Anyway, sharing whats gonig on feels good. And getting honest with the people in your life that deserve it is inherently good. And for me, they seem to really respect it. So, that's that.

Today, Sunday I will continue to take it easy. The weather is also shit rn. But tomorrow (day 8) I'm going to really try to ramp up the time I spend on work and start taking some short walks. If im up to it.
 
Quick update, I’m going to bed early tonight. Going to take “about” .25mg bupe, and my lowered doses of rx meds. Tomorrow at 8am starts day 8. Feeling better, I for the most part was semi active (inside the house) today, followed by small bouts of the sapped energy.

Hoping by Tuesday (day 10) I can be done with the meds and just continue on with my pro-dopamine and pro-gaba supps to dive into PAWS head on.

Oh yea, and secure a sleep med in the next day or two. I’ve been knocking myself out with meds and weed and that’s just not the move after acute WD.
 
I’ve been knocking myself out with meds and weed and that’s just not the move after acute WD.
If you can get some CBG flower/extracts (zero THC). CBG blocks adrenaline and boosts GABA in the same way as agmatine and clonidine.
The cannabis terpene oils support detox/WD too btw, the best sedative ones are probably linalool, myrcene, caryophyllene, humulene. You can get them from regular essential oils, or buy them as pure isolates which are popular now thanks to the popularity of cannabis terpenes. If using essential oils, only use theraputic grade steam-distilled ones.

Caryophyllene for supporting drug cessation/detox:
A growing body of research indicates that β-caryophyllene, a constituent present in a large number of plants, possesses significant therapeutic properties against CNS disorders, including alcohol and psychostimulant use disorders. These findings suggest that caryophyllene may have certain therapeutic effects against opioid use disorders with fewer unwanted side-effects by itself.
https://pubmed.ncbi.nlm.nih.gov/38631564/
Caryophyllene has been shown to boost the painkilling effect of morphine...making possible the reduction of the dose of the drug and, consequently, decreasing its side effects.
https://www.mdpi.com/2076-3417/9/24/5420
Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear whether β-caryophyllene, a CB2 receptor agonist, has therapeutic effects on methamphetamine abuse and dependence.
...
Together, the present findings suggest that caryophyllene might be a promising therapeutic candidate for the treatment of methamphetamine use disorder.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.722476/full

Linalool:
This study indicated that linalool has a significant effect on morphine tolerance and dependence. This effect may be mediated partially through the inhibition of NMDA receptors.
https://pubmed.ncbi.nlm.nih.gov/22318903/
Finally, the activation of opioidergic and cholinergic systems appears to play a crucial role in (-)-linalool-induced antinociception
https://pubmed.ncbi.nlm.nih.gov/12535857/

Myrcene:
It has a significant analgesic effect, which is blocked by the action of naloxone, an opioid antagonist, suggesting a mechanism of action through the opioid receptor.
However, myrcene's lack of affinity for opioid receptors points to alpha 2-adrenoceptor–stimulated release of endogenous opiates.
In contrast to morphine, no tolerance was observed after repeated dosing in rats. At very high doses, myrcene in mice was a sedative comparable to phenobarbital
https://www.sciencedirect.com/topics/neuroscience/myrcene

Pinene:
Pinene exhibited significant curable effects on capsaicin-induced pulpal nociception and inflammation mainly via pharmacological interfacing with GABA-A and μ-opioid receptors.
https://pubmed.ncbi.nlm.nih.gov/30152861/

Clove (eugenol):
Clove facilitates the de-addiction of opiates.
The study of clove as a potential analgesic and a supportive agent in combating opioid addiction...
...
With its long history in traditional medicine and its potent biological properties, clove may provide an effective alternative for individuals dependent on opioids for pain relief.
https://www.wisdomlib.org/science/journal/world-journal-of-pharmaceutical-research/d/doc1371443.html

Menthol:
These results indicate that (-)-menthol is endowed with analgesic properties mediated through a selective activation of kappa-opioid receptors.
Menthol acts as a positive allosteric modulator of recombinant GABA-A receptors.
...
Other potential cellular targets for menthol within the CNS include voltage-gated sodium and calcium channels, 5-HT3 receptors, nicotinic ACh receptors, glycine receptors and GABA-A receptors.
In the case of GABA-A receptors, menthol acts as a potent positive allosteric modulator of recombinant human GABA-A receptors

Vanilla:
Furthermore, this antinociceptive effect of vanillin may be mediated by alpha2-adrenergic and opioid receptors...
https://pubmed.ncbi.nlm.nih.gov/20091280/
As described above, vanillin may bind to the vanilloid receptor in the same manner as eugenol and thus produce an analgesic effect and a muscle relaxation effect.
https://www.sciencedirect.com/science/article/pii/S075333221930616X
Vanillin's antidepressant activity could be due to the agonistic action at α2 adrenergic or opioid receptors or due to the antioxidant property.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3660925/

Creatine:
Supplemental creatine has been promoted for its positive health effects and is best known for its use by athletes to increase muscle mass. Creatine supplementation has protective effects on the brain in models of neuronal damage and also alters mood state and cognitive performance.
...
Recent work shows that creatine supplementation has the ability to function in a manner similar to antidepressant drugs and can offset negative consequences of stress. These observations are important in relation to addictive behaviors as addiction is influenced by psychological factors such as psychosocial stress and depression.
https://pubmed.ncbi.nlm.nih.gov/21399936/


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God job mister @NY2soFlo!! Youve past the worst I think. Thats incredible for me as I told you. Youre beating the beast and thanks to @Allylbenzene for all thread answers that give us so much valuable info. That is pure gold!

I want to ask you if you dont mind @Allylbenzene of what can help me to get off 250mg intranasal ket daily dose. I think its more a psycological game but it might be some things that could help me. I want to kick my amp sulphate same daily dose too so ill be happy with any input and very gratefull.

Keep pushing trough mister @NY2soFlo !!!

Peace and love!!
 
One thing I forgot is to be carefull with essential oils via oral admistration. These compounds are really powerfull and some of them can be poisoning you with a few drops via oral administration. This info is taken from a very good aromatherapyst of my country with many many years of experience with essential oils. Correct me if Im wrong @Allylbenzene.

What are the plants(essential oils) from we can take these compounds you listed on the answer above??

Many thank in advance!!
 
If you can get some CBG flower/extracts (zero THC). CBG blocks adrenaline and boosts GABA in the same way as agmatine and clonidine.
The cannabis terpene oils support detox/WD too btw, the best sedative ones are probably linalool, myrcene, caryophyllene, humulene. You can get them from regular essential oils, or buy them as pure isolates which are popular now thanks to the popularity of cannabis terpenes. If using essential oils, only use theraputic grade steam-distilled ones.

Caryophyllene for supporting drug cessation/detox:




Linalool:



Myrcene:


Pinene:


Clove (eugenol):


Vanilla:




Creatine:



zfdoevf.png


So the CBG and the terpenes are two different things here right? Getting a good quality CBG tincture would not necessarily contain some/all of the terpenes you mentioned above?
Myrcene:
It has a significant analgesic effect, which is blocked by the action of naloxone, an opioid antagonist, suggesting a mechanism of action through the opioid receptor.
However, myrcene's lack of affinity for opioid receptors points to alpha 2-adrenoceptor–stimulated release of endogenous opiates.
In contrast to morphine, no tolerance was observed after repeated dosing in rats. At very high doses, myrcene in mice was a sedative comparable to phenobarbital
Now that is interesting stuff. To be blocked by naloxone then yes, it's either attaching at the Mu receptor, or has some other function that releases endogenous "opiates" that would also hence be blocked by naloxone. Good thing I'm not using naloxone lol. Id guess that Buperenorphine has a stronger binding affinity then this, and would also produce a similar affect. Regardless, my last dose of bupe was an hour ago. .25mg lol.
 
God job mister @NY2soFlo!! Youve past the worst I think. Thats incredible for me as I told you. Youre beating the beast and thanks to @Allylbenzene for all thread answers that give us so much valuable info. That is pure gold!

I want to ask you if you dont mind @Allylbenzene of what can help me to get off 250mg intranasal ket daily dose. I think its more a psycological game but it might be some things that could help me. I want to kick my amp sulphate same daily dose too so ill be happy with any input and very gratefull.

Keep pushing trough mister @NY2soFlo !!!

Peace and love!!
Yo couldnt have said it better. I appreciate the support, I do think im in my final days of Acute WD here.... and theres no question @Allylbenzene is the MVP of this thread. I plan to put a final post up- a sort of "cliff notes" for anyone who just wants the TDLR version. It will include my meds, otc, dosing, and a lot of the extra tools @Allylbenzene has mentioned.... some of which I've been able to acquire, some of which I have yet to.
 
So the CBG and the terpenes are two different things here right?
Yes, cannabis makes cannabinoids (eg THC, CBD, CBG) and terpenoids (eg pinene, limonene, myrcene, linalool).
Most plants make terpenoids...peppermint = menthol / pine = pinene / hop = humulene / myrrh = curzerene (opioid) etc.

Getting a good quality CBG tincture would not necessarily contain some/all of the terpenes you mentioned above?
Yes, look for a high % CBG extract and look for the terpenes seperately (via theraputic grade steam-distilled essential oils):
  • Menthol (peppermint, mint sweets)
  • Pinene (pine, less in lemon)
  • Limonene (lemon)
  • Linalool (97% in ho-wood oil)
  • Eugenol (clove, or make a clove tea...)
  • etc...
Remember don't use the oils if they are undiluted.

Myrcene
Now that is interesting stuff. To be blocked by naloxone then yes, it's either attaching at the Mu receptor, or has some other function that releases endogenous "opiates" that would also hence be blocked by naloxone. Good thing I'm not using naloxone lol. Id guess that Buperenorphine has a stronger binding affinity then this, and would also produce a similar affect.
Myrcene is pretty KO, high myrcene strains = couchlock.
Nature designed myrcene so it has several synergistic effects. It releases endogenous opioids AND prevents opioid tolerance AND enhances opioid pain relief.
Myrcene, a terpene in Lavender oil, may be the main source of its sedative-hypnotic properties.
https://pubmed.ncbi.nlm.nih.gov/39338324/

Here's another angle on the opioid detox...
TRPV1 activation prevents opioid tolerance formation and enhances opioid pain relief.
Using TRPV1 is a potential strategy to improve the therapeutic profile of opioids.
https://www.pnas.org/doi/pdf/10.1073/pnas.1717005114
TRPV1 activators:
  • citronellol (main constituent of rose oil)
  • geraniol (main constituent of 'thyme geraniol' and palmarosa oils)
  • ginger (shogaols, gingerols, paradols, zingerone)
  • myrcene (thyme oil, ylang-ylang oil)
  • CBG
  • camphor
  • menthol
  • garlic pungent compounds (allyl isothiacyanate, allicin, diallyl disulfide)
 
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This is all really interesting stuff. I used to grow my own bud but that was in the early years of significant research into different cannabinoids and terpenes and all. For now, I think a simple CBG oil would probably help.

I'm also at the point where my acute WD seems to be ending. Today is day 8. So, almost everything I'm looking into now is to prepare to hopefully blast through PAWS. So, I'm assuming most of the OTCs, Herbs, Etc that are helpful in detox are also helpful in PAWS. I obviously don't need my Rx meds after then next day or two.

I hate to ask, since you've provided so much info and even repeated it several times, but for PAWS, what would you recommend my stack to be? Keep in mind, the dopamine deficiency, lack of energy and sleep are what really gets me. Mood and GABAergic things dont seem to be as much of an issue. So, based on what you've said, and what I've remembered, this is looking to be my PAWS supp stack:

-L-Phenylalanine (for pure dopamine production)
-Mucana Puriens (?) thoughts here? Is this wasteful to stack on something that's already a precursor to L-Dopa?
-L- Theanine... to be used with small caffeine amounts.
-Passionflower Extract
-BSO
-Clove Oil
-Agmatine 500g as needed.
-Creatine 7.5 grams daily, 10g on workout days.

*These are based on the supps I remember you saying that are more dopamine producing.

Also, would some form of the Vitamin c megadosing be beneficial during PAWS?
 
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