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Stimulants Auvelity and stimulant drugs

777iLLucidDreamer777

777iLLucidDreamer777

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Joined
Aug 8, 2025
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I got prescribed Auvelity and recently Vyvanse. I'm an infrequent meth user and was wanting to start a discussion on the subjective and objective effects of DXM buproprion and different stimulants, getting down to the WHY of the pharmacology and maybe finding other ways to recreate this more effectively.

Its unique as fuck how it works, buproprion keeps DXM from quickly converting to DXO thus only partial ndma antagonism occurs initially if I'm correct. 20+ hours of that from one dose and you take it 2x a day. Both DXM and buproprion allegedly reduce neurotoxicity and in different ways potentiate stimulants while the buproprion blocks re-uptake of the norepinephrine and co.?

I've gotten high off Auvelity a number of times taking unsafe doses like 7+ pills over 3 hours and noticed significant sigma 1 and 5ht2a effects like full walls and ceiling flowing and a holographic net that i could interact with, haven't seen anything like it since i megadosed memantine years ago.


The point of the thread is finding a good combination of things that help replenish and protect the brain, I'm thinking buproprion, amantadine, memantine, and DXM (inhibited to stay DXM via buproprion, not turning into DXO) are the best as they regulate and modulate serotonin glutamate norepinephrine and dopamine receptors and levels to varying degrees. I've seen a list where people suggested different ndma antagonists and they said PCP wasn't worth it but I think it may be the best besides memantine and DXM in practicality for some people depending on personal neurochemistry. If low doses are taken to ensure dopaminergic drive and mania would that not cause a neuroplastic surge in the brain? The reason I'm proposing this is because I've noticed this after high doses of Auvelity or just plain DXM have been consumed.

This overpowering stim like drive that I think synergizes with stims but also is a sign of better neurotransmitter uptake in general occurs.


That's enough stim typing for now, I hope this thread grows and it's good to be back. Last time I made an account on here ironically I made a crazy psychotic post about mixing Adderall meth dxm and Klonopin against everyone's advice on here. I've grown a lot since then, and I miss the forum format. Discord and signal have made it easier to want the instant gratification of live chat lol. Have a great day
 
I wrote this in another post but it's relevant here.

Buproprion (wellbutrin) mainly increases noradrenaline (+weakly increases dopamine). Noradrenaline is part of the stress response (aka fight-or-flight) and is a factor in anxiety.
Meth strongly increases noradrenaline and dopamine. It's also an MAO inhibitor, dopamine D2 agonist and alpha-2 adrenergic agonist. (according to wiki)

NMDA antagonists:
Agmatine is otc and helps reduce withdrawals + repairs things via neurogenesis (inc BDNF). It shares similar properties to ketamine/amantadine/memantine.
Theanine should also help, it's pro-GABA, stops the stress response and helps repair things (neurogenesis). Best used in the evening.

As for the stimulant bit:
- Coffee - metabolic stimulant & boosts dopamine
- Theacrine - relaxed version of caffeine, boosts dopamine
- Hordenine - increases noradrenaline, direct dopamine D2 effects, weakly increases dopamine (more info)

That pretty much covers DXM, buproprion and meth but more sustainably.

A good plan would be to support your bodies core metabolic system, this post explains what it is and what it does.
It makes protective hormones and cellular energy (ATP). Vitamin B1 helps mitochondria turn glucose (sugar/carbs) into ATP.

image.png
 
Allylbenzene said:
I wrote this in another post but it's relevant here.

Buproprion (wellbutrin) mainly increases noradrenaline (+weakly increases dopamine). Noradrenaline is part of the stress response (aka fight-or-flight) and is a factor in anxiety.
Meth strongly increases noradrenaline and dopamine. It's also an MAO inhibitor, dopamine D2 agonist and alpha-2 adrenergic agonist. (according to wiki)

NMDA antagonists:
Agmatine is otc and helps reduce withdrawals + repairs things via neurogenesis (inc BDNF). It shares similar properties to ketamine/amantadine/memantine.
Theanine should also help, it's pro-GABA, stops the stress response and helps repair things (neurogenesis). Best used in the evening.

As for the stimulant bit:
- Coffee - metabolic stimulant & boosts dopamine
- Theacrine - relaxed version of caffeine, boosts dopamine
- Hordenine - increases noradrenaline, direct dopamine D2 effects, weakly increases dopamine (more info)

That pretty much covers DXM, buproprion and meth but more sustainably.

A good plan would be to support your bodies core metabolic system, this post explains what it is and what it does.
It makes protective hormones and cellular energy (ATP). Vitamin B1 helps mitochondria turn glucose (sugar/carbs) into ATP.

image.png
Click to expand...
I appreciate the response, it's very helpful to understand these mechanisms of action to potentially develop a well made combination of half-life timelines, pharmacological phenomena, and psychological benefits reduced to pros and cons.
 
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