Off-targets of arylcyclohexylamine dissociatives

[dopamimetic]

I am an experienced disso user. I know what the NMDA antagonism feels like. But that's not the whole picture by far - I find that some arylcyclohexylamine dissociatives must have some other prominent effect, and this is what I am after. I have just now dosed ~50mg of HXE and it's not dissociative at all, but fluffy, pro-cognitive, stimulating and awesome. I missed this so much when I was stuck with only DXM which is a cold dissociative disso without the feature I am looking for. Anybody having a clue? MXE hits the same target, ketamine is middle (long time since I had ket so my memory isn't that good).

 

[Allylbenzene]

For ketamine, (R)-ketamine is mainly a DRI whilst (S)-ketamine is primarily on the NMDA antagonist side of things. S-ket is the type used for veterinary purposes and the Spravato nasal spray.
Ketamine also has other effects inc estrogenic, sigma, D2, AMPA and opioid.

Have you ever tried Agmatine? See this post on it's effects.

 

[Skorpio]

Ketamine also has other effects inc estrogenic, sigma, D2, AMPA and opioid.

At reasonable concentrations?