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  • BDD Moderators: Keif’ Richards

Opioids dxm HCL synthesis + ~400mg trip report (insufflated) "becoming cosmic water"

MDMAdness

Bluelighter
Joined
Sep 11, 2022
Messages
40
background: i have been thinking on making dxm HCL for a long time now. for those who

dont know, dxm HCL is what freebase dxm turns into in the stomach to help pass into

the BBB. dxm HBR, the most common version, breaks down more into DXO and is

responsible for the dysphoria . DXM hcl is the best of both worlds because it's freely

water soluble and has less of a dxo problem. so i bought myself 9 grams of freebase

in the form of robotablets, n heptane , a seperatory funnel, and hydrochloric acid.

edit: i thought it was common knowledge that dxo causes dysphoria but since it isnt heres a link:

the guy who wrote the trip report has never even had a bluelight or reddit account i dont think
and in order to give it a more natural vibe i intentionally left his typos in

to create my dxm hcl, what i did was:



put all the rohotablets in the funnel wirh n heptane and allowed to sit overnight. after

</=15 minutes, the crystals stopped leaving them, but i had to be sure


i strained through a cheesecloth into a pyrex measuring cup, and let it dry. there was a

combination of insoluble fibers and what looked like glass shards which were crystal

DXM.


i redissolved into hcl solution so that the dxm would turn into dxm HCL in the water

and the fibers sunk to the bottom, so i strained it through a coffee filter on to a plate

and dried it.


the final product after i scraped it up with a razor was a substance that looked like

sand, smelled mostly odorless but faintly a "bitter spicy" smell, and was pretty much

identical to how i remember DXM polistrex was after watering down delsym cough

syrup and extracting the dxm. i weighed it on the scale to have 2.6 grams, and after

insufflating ~40mg and having a pleasent antidepressant effect it was certified

clean dxm HCL in my syez 👍 (the burn was about as bad as DPT if anyone in this

thread has insufflated that)


fast forward to yesterday , my plug just came back from rehab. this guy can

hook me up with all the rarest shit but he dissappeared flr months. randomly i

stumbled upon him via a mutual friend , after his previous 1000 member telegram

chat was deleted. we were texting on signal and i mention my dxm. hes like yo

man lets link up, and ill trade half to a full gram of mescaline HCL along with a tab

and a half for it. i say bet, i was eager to hear a trip report on insufflating this substance,

given there's none on youtube or erowid or anywhere at the time of me writing this

post. i already gave half a gram away for my friend to take with him back to sun

valley ohio and write me his own trip report, only he threw it away, leaving me with

roughly 2 grams after taking a 40mg bump and my tremoring brain damaged hands.

i still wanted to save some to inject, so i put 600mg in a little dime baggie (keep

posted for an IV trip report with mescaline, lsd, MDMA) to keep and gave him the other

~1.4g.


now, i will copy and paste exactly what he sent me on signal about it:


Possibly one of my favorite substances out of trying 40+ rare substances and pychs

Becoming cosmic water

Snorted 330-500 mg

Over 4 1/2 -5 hours

5 or 6 redoses

At first it was a warm head rush, my nose, mouth, and most of my head went numb, it tasted sweet my nose swelled up and it was almost impossible to breath through it, a slight headache and manageable nausea came through, and before a noticeable high came through i started having pychadelic esc thoughts, "what a blessing it is to be cerounded by such wonderful people" no one was with me, just acknowledging the people in my life, the air became heavier, I became light and feeling like I was floating and I felt bigger than I was. There wasnt a any couch lock, but I felt that there was a horizontal and vertical axis running on all 4 sides of me, and each side was seperate yet pulling together, and yet, I was made out of some gas or liquid. I was all one element shaped into form, I didnt real real any separate parts of my body, or could identify separate sensations of my body. I didnt notice how high I really was till I would get up and walk around, I was a stick man that had to swing from right to left, and everything had a overlay of light colorful sparkle, the natural colors were deeper, and i felt as if everything was just a diffrent peace of me, it surprised me when I looked in the mirror and my eyes were huge. I e
Waddled back to my bed and continued my alien movie, I could see galaxys in his eyes, time moved slow. And I felt like I was a black and blue form with stars floating through it, and that I was one with the existence, a warm joy and peace had become me, I was at peace with everything, my window would make lightning shaped reflections when cars passed by that were beautiful, and time didnt seem to exist. I continued to do more and more, and would only ever realize how high I was when I got back up, the warmness and peace would incrementally increase. The last time I got up I felt something like the alien from the movie I was watching, once it ended i listened to ram das and Terrance McKenna and it seemed like they were talking directly to me. I could understand what they were saying to a much higher capacity, I would replay sentences over and over to truly find the meaning. When I would close my eyes, id see green pastures with happy people, the beach with family's playing, quaint castles with animals and people watching, and these sights would slowly and freely change and the transition would make sence. It took me about a hour at least to fall asleep witch is very unatural, the next morning I hesitantly got up and started on my day, I got much less sleep than I would typically get, yet after the first 30 minutes and coffee i felt much more well rested than typically when id get more sleep. The afterglow is still present, 14 hours after, I woke up still slightly high but extremely functional. The air is still heavy, im euphoric, im not bothered by time slowly moving, and I still feel that one form cosmic goo feeling that is my body.

FYI, dosent hurt to snort as bad as they say, and ive snorted very painful substances, and ive snorted around 13 substances, sometimes 10 grams a day, and never ever have i had so much fucking snot, immediately clogged and flushed my sinuses, had to blow loud enough to wake up the whole house regularly to clear my nose. But i feel its alot of much needed lymphatic fluid. I feel better and have being having lymphatic issued for 4 or 5 months un medicated.

Will re dose 400-600 tn.


i will be continuing to update with more trip reports. please comment for any and all

questions!
 
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"what a blessing it is to be cerounded by such wonderful people"
Did you seriously just spell "surrounded" as "cereounded" ? lol
How can some one with clearly some intelligence mess up a simple word like this?


dxm HBR, the most common version, breaks down more into DXO and is

responsible for the dysphoria
Do you have a source for this?

As far as I remember, DXM itself is mostly a weak SNRI & the DXO is what actually causes any dissociative effects. So by taking just strictly DXM, with no DXO conversion, you're mostly getting just an overdose of SNRI effects. I have heard that DXM itself does possess some psychedelic (not dissociative) properties without being converted to DXO, but I'd have to read up on it again. But it's always been generally considered that you want more of the DXO for a dissociative effect. I'm also pretty sure that no matter what form of DXM you take, it's still going to get metabolized into DXO to varying degrees. Unless you use enzyme inhibition or naturally lack the enzymes needed to metabolize DXM.

Maybe somebody else will come in with more info.

Your trip sounds like a standard good DXM trip. I've had all kinds of different DXM trips. Considering it has plateaus at different doses, which all cause their own effects and varies depending on your metabolism & the DXM/DXO ratios you get that day, DXM trips can be amazing, boring or downright scary. So every time I've tripped on DXM, I'm never sure what kind of trip I'm going to get. Some times I've had some really nasty, side-effect-ridden scary ones. And some times I'd have glowing, phenomenal ones.
 
Did you seriously just spell "surrounded" as "cereounded" ? lol
How can some one with clearly some intelligence mess up a simple word like this?
hes probably still high on dxm lol

Do you have a source for this?

As far as I remember, DXM itself is mostly a weak SNRI & the DXO is what actually causes any dissociative effects. So by taking just strictly DXM, with no DXO conversion, you're mostly getting just an overdose of SNRI effects. I have heard that DXM itself does possess some psychedelic (not dissociative) properties without being converted to DXO, but I'd have to read up on it again. But it's always been generally considered that you want more of the DXO for a dissociative effect. I'm also pretty sure that no matter what form of DXM you take, it's still going to get metabolized into DXO to varying degrees. Unless you use enzyme inhibition or naturally lack the enzymes needed to metabolize DXM.
he did snort 400mg and doesn't even have appeared tk reach the 3rd plateau. u can still achieve dissociation
on dxm with more dxm to make up for it. but i posted it with opioids as a prefix which i think is fair.

Maybe somebody else will come in with more info.
im pretty confident in my knowledge on dxm

Your trip sounds like a standard good DXM trip. I've had all kinds of different DXM trips. Considering it has plateaus at different doses, which all cause their own effects and varies depending on your metabolism & the DXM/DXO ratios you get that day, DXM trips can be amazing, boring or downright scary. So every time I've tripped on DXM, I'm never sure what kind of trip I'm going to get. Some times I've had some really nasty, side-effect-ridden scary ones. And some times I'd have glowing, phenomenal ones.
absolutley. i personally will be injecting it soon which i suspect will be the best dxm trip u can have
 
Oh how did I misspell such a simple word. I must clearly be an idiot.
"Surrounded" is a pretty fucking simple word. Or at least it should be to some one doing at-home drug synthesis.

If some one's gonna come on here & make statements like "DXO is responsible for dysphoria", not only do I wanna see sources, but I expect the person to know how to spell.
Besides, I acknowledged that OP clearly is intelligent & you're the one turning it into "I must clearly be an idiot", because YOU'RE the asshole. You also provided ZERO information to thread besides your bitching. You're no different than the image you're trying to project onto me, except at least I kept my responses on topic & you added nothing of value at all.
 
"Surrounded" is a pretty fucking simple word. Or at least it should be to some one doing at-home drug synthesis.

If some one's gonna come on here & make statements like "DXO is responsible for dysphoria", not only do I wanna see sources, but I expect the person to know how to spell.
Besides, I acknowledged that OP clearly is intelligent & you're the one turning it into "I must clearly be an idiot", because YOU'RE the asshole. You also provided ZERO information to thread besides your bitching. You're no different than the image you're trying to project onto me, except at least I kept my responses on topic & you added nothing of value at all.

Hahahahahahahhahahaha

I am the asshoooooooooooole!

You misspelled “want to” but you’re clearly of a certain intelligence so I won’t mention it.

All of life is a mirror,
By the way this is a trip report, I read the trip report.

That’s how you engage with the post, then I engaged with the commenters, I’m on topic.

You’re calling out information in a trip report as if it’s erroneous.

The dude just wrote his thoughts while he was recovering from drug use.

Typos and erroneous information are expected from individuals, when they are reporting their subjective experience.

He’s not speaking as a researcher or a person of immense knowledge on the subject.

Cut some slack.

Enjoy the trip report and don’t expect people to know every element of every truth, like how to spell surrounded or whether a metabolite of dxm is dysphoric or not. Lowering the expectations improves the experience.

OP, Go back to trip report college! You’re making people angry with your lack of perfection.
 
All above arguments aside

I can't find a source or report or anything about dxm her turning into dxo that "fucks you up more" sorry I'm just not getting the back up data for this

And if you got the info from the site that sells dxm hcl ( well then that explains that part )
 
All above arguments aside

I can't find a source or report or anything about dxm her turning into dxo that "fucks you up more" sorry I'm just not getting the back up data for this

And if you got the info from the site that sells dxm hcl ( well then that explains that part )
early in the post i mentioned that i made it and how.

and what does the 2nd paragraph mean?
 
Hahahahahahahhahahaha

I am the asshoooooooooooole!

You misspelled “want to” but you’re clearly of a certain intelligence so I won’t mention it.

All of life is a mirror,
By the way this is a trip report, I read the trip report.

That’s how you engage with the post, then I engaged with the commenters, I’m on topic.

You’re calling out information in a trip report as if it’s erroneous.

The dude just wrote his thoughts while he was recovering from drug use.

Typos and erroneous information are expected from individuals, when they are reporting their subjective experience.

He’s not speaking as a researcher or a person of immense knowledge on the subject.

Cut some slack.

Enjoy the trip report and don’t expect people to know every element of every truth, like how to spell surrounded or whether a metabolite of dxm is dysphoric or not. Lowering the expectations improves the experience.

OP, Go back to trip report college! You’re making people angry with your lack of perfection.
thanks for defending me i geuss this really cracked me up seeing people get so mad.
 
Personally I thought your extraction tek was pretty cool. Self designed or did you get it online? How’d you source hydrochloric acid?
 
Personally I thought your extraction tek was pretty cool. Self designed or did you get it online? How’d you source hydrochloric acid?
ebay . its self designed but i used n heptane which made me lose ~70% of it. next time i will use chloroform
because its freely soluble in it, and less than half an ml of 30% hcl solution per gram of crystal
dxm freebase is needed, knowing these 2 things wouldve saved me time and money. ill
send it to a full spectrum lab next time as well. dm me for my discord
 
You’re calling out information in a trip report as if it’s erroneous.
What is a trip report doing in the Opioids > Basic Drug Discussion? Is there not a "trip report" area?


He’s not speaking as a researcher or a person of immense knowledge on the subject.
Dude literally posted a synth tek & gave a "trip report" while making claims about DXM & DXO.
If you don't call that "research" or having "knowledge" then I dunno what you would.
Dude literally said DXO being dysphoric was "common knowledge".
 
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What is a trip report doing in the Opioids > Basic Drug Discussion? Is there not a "trip report" area?



Dude literally posted a synth tek & gave a "trip report" while making claims about DXM & DXO.
If you don't call that "research" or having "knowledge" then I dunno what you would.

Even OP isn't as upset about this as you are. Quit being upset on other people's behalf. OP is a grown & smart man, he clearly can handle the criticism.
Beautifyl
 
i did because its common knowledge but here https://www.mdpi.com/2227-9059/11/1/123
This is an article about Antipsychotic efficacy in treating DXM induced psychosis.

Skimming through it, I don't see where it says DXO is strictly responsible for dysphoria, but this section slightly hints at it -
"Similar to ketamine and phencyclidine (PCP), DXM primarily acts through N-methyl-D-aspartate (NMDA) receptors, leading to a risk of psychotic symptoms, such as hallucinations, dissociation, euphoria, agitations, and even coma [3,19]. Interestingly, DXM exhibits higher affinity as an NMDA receptor antagonist than ketamine in some cellular assay systems [20].
In addition, the active metabolite of DXM (i.e., dextrorphan) exerts a variety of physiological effects via several mechanisms besides NMDA. Dextrorphan (DEXO) is a multi-target compound that tackles, among others, sigma-1 receptors (Sig1-R) and serotonin transporters (SERT). Furthermore, by inhibiting noradrenaline reuptake and blocking alpha3-beta-4 nicotinic (nACh) receptors, DEXO may increase norepinephrine availability in the synaptic cleft [20,21]. However, the mechanism by which DXM’s receptor agonism and antagonism translate to a clinical effect is not well understood [22]. The whole view of possible consequences that may occur in the settings of DXM’s overuse is shown in Figure 1."


This says DXO targets Sigma 1 & Serotonin transporters. If it affects serotonin, it could cause either euphoria or dysphoria, depending on the person & their physiological make up.

It does say DXO may increase norepinephrine which could lead to discomfort/anxiety, which could make one dysphoric.

I also don't get how this is "common knowledge" when I've been a DXM user for over 20 years & have heard that DXO is an important component to the DXM experience.

If anything, DXO is more stoning & mild than DXM. You can try this out for yourself by consuming DXM polisterex (Delysum). One of my favorite kinds of DXM. It's encased in edible plastic, which slows down the metabolism, allowing more DXO to form. But you must use a bigger dosage than you would DXM Hbr. I've had some amazing, calm peaceful trips on DXM Polisterex. And it lasts much longer, at least 12hrs.

Taking Delsyum (Polisterex) versus DXM Hbr (robotussin, etc..) are definitely two different experiences, because the slower metabolism of the polisterex leads to more DXO. But I've had some wonderful polisterex trips. I've also had some terrible DXM hbr trips.

There's this as well, showing DXO plays a role in the reinforcing effects of DXM. So if it were only dysphoric every single time, then nobody would bother using DXM, since DXO is it's main metabolite. I think dysphoria can come from both DXM & DXO & depending on many other factors going on in your body.


"Conclusions: Taken together, these data show that DXM has some PCP-like effects in rats and monkeys, but that they are more reliably produced by its metabolite, DXO. Thus, high doses of DXM may have some PCP-like abuse potential in humans but this potential may be associated with, or enhanced by, metabolism of DXM to DXO."

From Wikipedia :

"The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist and much less active as a serotonin reuptake inhibitor, but retains DXM's activity as a norepinephrine reuptake inhibitor.<a href="https://en.wikipedia.org/wiki/Dextrorphan#cite_note-8"><span>[</span>8<span>]</span></a>It also has more affinity for the opioid receptors than dextromethorphan, significantly so at high doses."

According to this, DXM itself has norepinephrine reuptake propertioes just like DXO, so I don't think DXO having those properties would be the reason it's dysphoric, like I mentioned earlier.


If DXO is a more potent NMDA antagonist than DXM, it's reasonable to conclude that it can cause euphoria (and dysphoria), other-wise nobody would enjoy PCP or ketamine.

From your link about the antipsychotics - "Psychotic symptoms (i.e., hallucinations, euphoria, dissociation, agitations, and coma) are the main result of NMDA receptor blocking [3]."

So your own link says euphoria is a possible side effect of NMDA antagonism. And Wikipedia says DXO is a stronger NMDA antagonist than DXM. So this basically contradicts the whole idea that "DXO is responsible for all the dysphoria felt on a DXM trip".

So I haven't found anything that distinctly says DXO is responsible for dysphoria. If anything, I think DXM itself can cause either euphoria or dysphoria, depending on a multitude of pysiological factors.


I enjoy learning & researching pharmacology, so if people are going to take it personally whenever I ask them about whatever facts or information they're presenting, then that's on them.
Helpingout came in here & made the mood & tone of this post hostile, where I'm just trying to have an intellectual debate.
 
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All above arguments aside

I can't find a source or report or anything about dxm her turning into dxo that "fucks you up more" sorry I'm just not getting the back up data for this

And if you got the info from the site that sells dxm hcl ( well then that explains that part )
OP was suggesting DXO is dysphoric, not that it "fucks you up more".
And I just provided sources that say many of DXM's dissociative effects are caused by DXO. And this has been my understanding from the past 20 years of abusing the hell of DXM.

Both DXM & DXO are probably capable of causing dysphoria under certain conditions IN MY OPINION & from my own understanding of the research.

Hell, any drug can cause a dysphoric feeling for people at times, even heroin, morphine, MDMA, acid, etc.. etc..
 
Personally I thought your extraction tek was pretty cool. Self designed or did you get it online? How’d you source hydrochloric acid?
ebay . its self designed but i used n heptane which made me lose ~70% of it. next time i will use chloroform
because its freely soluble in it, and less than half an ml of 30% hcl solution per gram of crystal
dxm freebase is needed, knowing these 2 things wouldve saved me time and money. ill
send it to a full spectrum lab next time as well.
 
This is an article about Antipsychotic efficacy in treating DXM induced psychosis.

Skimming through it, I don't see where it says DXO is strictly responsible for dysphoria, but this section slightly hints at it -
"Similar to ketamine and phencyclidine (PCP), DXM primarily acts through N-methyl-D-aspartate (NMDA) receptors, leading to a risk of psychotic symptoms, such as hallucinations, dissociation, euphoria, agitations, and even coma [3,19]. Interestingly, DXM exhibits higher affinity as an NMDA receptor antagonist than ketamine in some cellular assay systems [20].
In addition, the active metabolite of DXM (i.e., dextrorphan) exerts a variety of physiological effects via several mechanisms besides NMDA. Dextrorphan (DEXO) is a multi-target compound that tackles, among others, sigma-1 receptors (Sig1-R) and serotonin transporters (SERT). Furthermore, by inhibiting noradrenaline reuptake and blocking alpha3-beta-4 nicotinic (nACh) receptors, DEXO may increase norepinephrine availability in the synaptic cleft [20,21]. However, the mechanism by which DXM’s receptor agonism and antagonism translate to a clinical effect is not well understood [22]. The whole view of possible consequences that may occur in the settings of DXM’s overuse is shown in Figure 1."


This says DXO targets Sigma 1 & Serotonin transporters. If it affects serotonin, it could cause either euphoria or dysphoria, depending on the person & their physiological make up.

It does say DXO may increase norepinephrine which could lead to discomfort/anxiety, which could make one dysphoric.

I also don't get how this is "common knowledge" when I've been a DXM user for over 20 years & have heard that DXO is an important component to the DXM experience.

If anything, DXO is more stoning & mild than DXM. You can try this out for yourself by consuming DXM polisterex (Delysum). One of my favorite kinds of DXM. It's encased in edible plastic, which slows down the metabolism, allowing more DXO to form. But you must use a bigger dosage than you would DXM Hbr. I've had some amazing, calm peaceful trips on DXM Polisterex. And it lasts much longer, at least 12hrs.

Taking Delsyum (Polisterex) versus DXM Hbr (robotussin, etc..) are definitely two different experiences, because the slower metabolism of the polisterex leads to more DXO. But I've had some wonderful polisterex trips. I've also had some terrible DXM hbr trips.

There's this as well, showing DXO plays a role in the reinforcing effects of DXM. So if it were only dysphoric every single time, then nobody would bother using DXM, since DXO is it's main metabolite. I think dysphoria can come from both DXM & DXO & depending on many other factors going on in your body.


"Conclusions: Taken together, these data show that DXM has some PCP-like effects in rats and monkeys, but that they are more reliably produced by its metabolite, DXO. Thus, high doses of DXM may have some PCP-like abuse potential in humans but this potential may be associated with, or enhanced by, metabolism of DXM to DXO."

From Wikipedia :

"The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist and much less active as a serotonin reuptake inhibitor, but retains DXM's activity as a norepinephrine reuptake inhibitor.<a href="https://en.wikipedia.org/wiki/Dextrorphan#cite_note-8"><span>[</span>8<span>]</span></a>It also has more affinity for the opioid receptors than dextromethorphan, significantly so at high doses."

According to this, DXM itself has norepinephrine reuptake propertioes just like DXO, so I don't think DXO having those properties would be the reason it's dysphoric, like I mentioned earlier.


If DXO is a more potent NMDA antagonist than DXM, it's reasonable to conclude that it can cause euphoria (and dysphoria), other-wise nobody would enjoy PCP or ketamine.

From your link about the antipsychotics - "Psychotic symptoms (i.e., hallucinations, euphoria, dissociation, agitations, and coma) are the main result of NMDA receptor blocking [3]."

So your own link says euphoria is a possible side effect of NMDA antagonism. And Wikipedia says DXO is a stronger NMDA antagonist than DXM. So this basically contradicts the whole idea that "DXO is responsible for all the dysphoria felt on a DXM trip".

So I haven't found anything that distinctly says DXO is responsible for dysphoria. If anything, I think DXM itself can cause either euphoria or dysphoria, depending on a multitude of pysiological factors.


I enjoy learning & researching pharmacology, so if people are going to take it personally whenever I ask them about whatever facts or information they're presenting, then that's on them.
Helpingout came in here & made the mood & tone of this post hostile, where I'm just trying to have an intellectual debate.
yes it is subjective, and mcpp causes dysphoria. dxo has higher NMDA affinity but NMDA antagonism alone is dysphoric. ill get back to reading this whole comment later, rn im feeling depressed from a caffeine crash. thanks for the thought out reply.

anyway for me oral DXM has always made me dysphoric and this one felt nothing but relieving in low intranasal


doses.
 
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