Opioids dxm HCL synthesis + ~400mg trip report (insufflated) "becoming cosmic water"

[MDMAdness]

What is a trip report doing in the Opioids > Basic Drug Discussion? Is there not a "trip report" area?



Dude literally posted a synth tek & gave a "trip report" while making claims about DXM & DXO.
If you don't call that "research" or having "knowledge" then I dunno what you would.
Dude literally said DXO being dysphoric was "common knowledge".

dxm is an opioid especially without dxo. its weird to see people argue that dxm isnt.disso
without dxo but than question why this is in opioids. dxm is in the same class as morphine
and heroin and from experience by itself its almost more like o dsmt if it were good and had
a mkre stoney kick to it. i wouldve posted this in dissocistives sub if there even was one ...

and as for the synth tek, i just extracted dxm freebase and added hcl on to it. i didnt even know
synths were banned until my friend reminded me but apparently people have gotten away with worse.
i read a PPX hcl "synth tek" like mine involving extracting ppx from benzedrex and adding hcl

 

[DeathIndustrial88]

yes it is subjective, and mcpp causes dysphoria. dxo has higher NMDA affinity but NMDA antagonism alone is dysphoric. ill get back to reading this whole comment later, rn im feeling depressed from a caffeine crash. thanks for the thought out reply.

anyway for me oral DXM has always made me dysphoric and this one felt nothing but relieving in low intranasal


doses.

I think both DXM & DXO can cause dysphoria in certain circumstances, in my opinion. As both can increase norepinephrine, which can lead to higher heart rate, flushing, anxiety (flight or fight response).

Have you ever tried DXM polisterex? It's much more mild than a normal DXM trip. But it has a very nice body-euphoria & glow to it. I personally love a nice Desylum trip with a good movie.
And DXM Hbr with some good music & a secluded spot to go crazy in. lol

There's a fun easy extraction for DXM polisterex... Just pour the Delsyum in a ziploc, fill the bottle with some water & shake it. Then pour it into the bag with the syrup.
And then squish it around a bit & hang that bag up. And in a day or so, all the DXM polisterex bubbles will sink the bottom & the water will sit on top. Then you poke a hole in the bag & drain the water & then let the orange/brown stuff in the bottom of the bag dry out & you now almost pure DXM polisterex, which you can cap (and I have snorted before myself, because I'm retarded lol). It's a fun experiment though if you don't wanna down a bunch of syrup.

Feel better man & have a great weekend!
Cheers!

 

[MDMAdness]

This is an article about Antipsychotic efficacy in treating DXM induced psychosis.

Skimming through it, I don't see where it says DXO is strictly responsible for dysphoria, but this section slightly hints at it -
"Similar to ketamine and phencyclidine (PCP), DXM primarily acts through N-methyl-D-aspartate (NMDA) receptors, leading to a risk of psychotic symptoms, such as hallucinations, dissociation, euphoria, agitations, and even coma [3,19]. Interestingly, DXM exhibits higher affinity as an NMDA receptor antagonist than ketamine in some cellular assay systems [20].
In addition, the active metabolite of DXM (i.e., dextrorphan) exerts a variety of physiological effects via several mechanisms besides NMDA. Dextrorphan (DEXO) is a multi-target compound that tackles, among others, sigma-1 receptors (Sig1-R) and serotonin transporters (SERT). Furthermore, by inhibiting noradrenaline reuptake and blocking alpha3-beta-4 nicotinic (nACh) receptors, DEXO may increase norepinephrine availability in the synaptic cleft [20,21]. However, the mechanism by which DXM’s receptor agonism and antagonism translate to a clinical effect is not well understood [22]. The whole view of possible consequences that may occur in the settings of DXM’s overuse is shown in Figure 1."

This says DXO targets Sigma 1 & Serotonin transporters. If it affects serotonin, it could cause either euphoria or dysphoria, depending on the person & their physiological make up.

It does say DXO may increase norepinephrine which could lead to discomfort/anxiety, which could make one dysphoric.

I also don't get how this is "common knowledge" when I've been a DXM user for over 20 years & have heard that DXO is an important component to the DXM experience.

https://www.sciencedirect.com/topics/medicine-and-dentistry/dextrorphan is an article saying it causes pcp-like dysphoria. just subjectively speaking it causes dysphoria and my test subject seems to agree, though he didnt ever try it the normal way, he didnt report the 3 day mania i seem to get. if u do some research i promise u u will find many who agree with me. i geuss u do technically have a point it can be better subjectively.

If anything, DXO is more stoning & mild than DXM. You can try this out for yourself by consuming DXM polisterex (Delysum). One of my favorite kinds of DXM. It's encased in edible plastic, which slows down the metabolism, allowing more DXO to form. But you must use a bigger dosage than you would DXM Hbr. I've had some amazing, calm peaceful trips on DXM Polisterex. And it lasts much longer, at least 12hrs.

Taking Delsyum (Polisterex) versus DXM Hbr (robotussin, etc..) are definitely two different experiences, because the slower metabolism of the polisterex leads to more DXO. But I've had some wonderful polisterex trips. I've also had some terrible DXM hbr trips.

ive snorted some dxm polistrex i got from watering down dxm. it felt like this did, matches the description too. ive drank delsym too. my first liver seemed to metabolize dxm differently because back in the day id drink yummy grape delsym and jam out to rare lil xan music on SoundCloud. post transplant dxm has always felt like shit, robotabs and delsym. dxo is more responsible for erectile dysfunction and the afterglow, dxm hcl IN is alot shorter lived so erectile dysfunction isnt a problem

There's this as well, showing DXO plays a role in the reinforcing effects of DXM. So if it were only dysphoric every single time, then nobody would bother using DXM, since DXO is it's main metabolite. I think dysphoria can come from both DXM & DXO & depending on many other factors going on in your body.

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"Conclusions: Taken together, these data show that DXM has some PCP-like effects in rats and monkeys, but that they are more reliably produced by its metabolite, DXO. Thus, high doses of DXM may have some PCP-like abuse potential in humans but this potential may be associated with, or enhanced by, metabolism of DXM to DXO."

From Wikipedia :

"The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist and much less active as a serotonin reuptake inhibitor, but retains DXM's activity as a norepinephrine reuptake inhibitor.<a href="https://en.wikipedia.org/wiki/Dextrorphan#cite_note-8"><span>[</span>8<span>]</span></a>It also has more affinity for the opioid receptors than dextromethorphan, significantly so at high doses."

According to this, DXM itself has norepinephrine reuptake propertioes just like DXO, so I don't think DXO having those properties would be the reason it's dysphoric, like I mentioned earlier.

Dextrorphan - Wikipedia

en.wikipedia.org

i despise opioids. i was given morphine in the hospital, dilaudid etc. they always make me itchy and dysphoric without a potentiator, tramadol on robotabs felt pretty bomb surprisingly though each feels bad on its own.

nmda antagonism by itself is depressing which is probably why olneys lesions correlates with cognitive dysphoria. theres a horse tranquilizer they use now thats known to cause dysphoria, i read about it on bluelight. let me find it...
ok i cant find it but i swear to God im not making this up, theres a simple NMDA antagonist and it causes dysphoria, and a bluelight page with people describing how by itself is dysphoric. i will be looking for it alot, but arylcyclohexylamines, dxm, memantine, and nitrous have always given me great euphoria. i think how it works is because it shuts down our DMN were far more sensitive to dopamine and other shit the way babies are, and as for nitrous i think the brain creates neuroplasticity and euphoria when lacking oxygen because it knows its living its final moments, creating beautiful near death experiences. everything online u hear about DMT being in the brain was rather not present in me in the time bc of muscimols gabaergic effects + the other shit thats in death caps, or its just a misunderstood concept entirely. id like to go much more in depth on this, HMU if you want.

If DXO is a more potent NMDA antagonist than DXM, it's reasonable to conclude that it can cause euphoria (and dysphoria), other-wise nobody would enjoy PCP or ketamine.

From your link about the antipsychotics - "Psychotic symptoms (i.e., hallucinations, euphoria, dissociation, agitations, and coma) are the main result of NMDA receptor blocking [3]."

So your own link says euphoria is a possible side effect of NMDA antagonism. And Wikipedia says DXO is a stronger NMDA antagonist than DXM. So this basically contradicts the whole idea that "DXO is responsible for all the dysphoria felt on a DXM trip".

causation is not correlation. Just because of the dxo being an NMDA antagonist which can cause euphoria, doesn't mean its inherintly better. i mean meth isnt an nmda antagonist, does that mean dxo is more euphoric?

So I haven't found anything that distinctly says DXO is responsible for dysphoria. If anything, I think DXM itself can cause either euphoria or dysphoria, depending on a multitude of pysiological factors.


I enjoy learning & researching pharmacology, so if people are going to take it personally whenever I ask them about whatever facts or information they're presenting, then that's on them.
Helpingout came in here & made the mood & tone of this post hostile, where I'm just trying to have an intellectual debate.

i mean, u did insult me/lotus for spelling errors when he wasnt looking at the keyboard. i definitely got a kick out of seeing how it caused a fight

 

[MDMAdness]

All above arguments aside

I can't find a source or report or anything about dxm her turning into dxo that "fucks you up more" sorry I'm just not getting the back up data for this

And if you got the info from the site that sells dxm hcl ( well then that explains that part )

i clearly misread this. theres a site that sells dxm hcl? and also may i add DPH and scopolamine can defo fuck u up more than dxm.

again causation =/= correlation. being more fucked up correlates with euphoria, it doesnt cause it

 

[MDMAdness]

I think both DXM & DXO can cause dysphoria in certain circumstances, in my opinion. As both can increase norepinephrine, which can lead to higher heart rate, flushing, anxiety (flight or fight response).

Have you ever tried DXM polisterex? It's much more mild than a normal DXM trip. But it has a very nice body-euphoria & glow to it. I personally love a nice Desylum trip with a good movie.
And DXM Hbr with some good music & a secluded spot to go crazy in. lol

There's a fun easy extraction for DXM polisterex... Just pour the Delsyum in a ziploc, fill the bottle with some water & shake it. Then pour it into the bag with the syrup.
And then squish it around a bit & hang that bag up. And in a day or so, all the DXM polisterex bubbles will sink the bottom & the water will sit on top. Then you poke a hole in the bag & drain the water & then let the orange/brown stuff in the bottle of the bag dry out & you now almost pure DXM polisterex, which you can cap (and I have snorted before myself, because I'm retarded lol). It's a fun experiment though if you don't wanna down a bunch of syrup.

Feel better man & have a great weekend!
Cheers!

yeah delsym already tastes pretty damn good though. i might mix some fatty acids and dxm hcl into some THC syrup to make some party oriented dxm cough syrup with dxm hitting the brain immediatley because of the lymphatic acids. be on the lookout for it!

 

[DeathIndustrial88]

https://www.sciencedirect.com/topics/medicine-and-dentistry/dextrorphan is an article saying it causes pcp-like dysphoria. just subjectively speaking it causes dysphoria and my test subject seems to agree, though he didnt ever try it the normal way, he didnt report the 3 day mania i seem to get. if u do some research i promise u u will find many who agree with me. i geuss u do technically have a point it can be better subjectively.


ive snorted some dxm polistrex i got from watering down dxm. it felt like this did, matches the description too. ive drank delsym too. my first liver seemed to metabolize dxm differently because back in the day id drink yummy grape delsym and jam out to rare lil xan music on SoundCloud. post transplant dxm has always felt like shit, robotabs and delsym. dxo is more responsible for erectile dysfunction and the afterglow, dxm hcl IN is alot shorter lived so erectile dysfunction isnt a problem


i despise opioids. i was given morphine in the hospital, dilaudid etc. they always make me itchy and dysphoric without a potentiator, tramadol on robotabs felt pretty bomb surprisingly though each feels bad on its own.

nmda antagonism by itself is depressing which is probably why olneys lesions correlates with cognitive dysphoria. theres a horse tranquilizer they use now thats known to cause dysphoria, i read about it on bluelight. let me find it...
ok i cant find it but i swear to God im not making this up, theres a simple NMDA antagonist and it causes dysphoria, and a bluelight page with people describing how by itself is dysphoric. i will be looking for it alot, but arylcyclohexylamines, dxm, memantine, and nitrous have always given me great euphoria. i think how it works is because it shuts down our DMN were far more sensitive to dopamine and other shit the way babies are, and as for nitrous i think the brain creates neuroplasticity and euphoria when lacking oxygen because it knows its living its final moments, creating beautiful near death experiences. everything online u hear about DMT being in the brain was rather not present in me in the time bc of muscimols gabaergic effects + the other shit thats in death caps, or its just a misunderstood concept entirely. id like to go much more in depth on this, HMU if you want.


causation is not correlation. Just because of the dxo being an NMDA antagonist which can cause euphoria, doesn't mean its inherintly better. i mean meth isnt an nmda antagonist, does that mean dxo is more euphoric?


i mean, u did insult me/lotus for spelling errors when he wasnt looking at the keyboard. i definitely got a kick out of seeing how it caused a fight

So you had a liver transplant? Interesting. Maybe the newer liver has different enzymes & things that might metabolize stuff differently for you now. Interesting to ponder though.

I didn't mean to be insulting, I was genuinely just shocked. lol Never seen "surrounded" spelled like that before & was more confused, because most modern computers & phones show a red line under a word if it' s not spelled right, so people can just proof-read & auto-correct anything in red. But I didn't call you any names or harp on you for it, just thought I'd call it out. If I'm mis-spelling anything significant, people can let me know, I don't mind. lol Tone is hard to read over the internet though, so I could see how one might of taken it the wrong way and for that apologize.

I actually love tramadol & opioids. Specifically tramadol & diacetylmorphine. I've been an opioid addict for almost 20 years now. Absolutely wonderful drugs for my depression. The itch is part of the high! Histamine release & all.

But even on tramadol & heroin, I'd have the one-off experiences where I'd feel like shit, get nauseous, dysphoric. But I'd say 95% of the time it was enjoyable, but that other 5%, it would some times make me feel pretty gross. I think this happens mostly with people who don't have tolerances. Opioids can feel rather boring & drab when you first start them but after a few days of using is when the euphoria & bliss really starts to shine.

Same happens with buprenorphine some days, even after taking it every day for over 8 years now. I'll have those one-off days where it'll just make me feel like shit. Actually buprenorphine makes me feel like shit quite often compared to the aforementioned two opioids.

The one & only DXO experience on Erowid is a negative one, full of side effects it sounds like - https://www.erowid.org/chemicals/dxm/dxm_info3.shtml

So you're probably not alone in having dysphoric/negative experiences with DXO unfortunately. There's a synth-tek in that link as well that might be of interest to you (most likely not, since it's for DXO).

I'll have to respond more to the rest when I'm more cognizant.

I've had some insane near death-like experiences on DXM & cannabis. I've also experience what I refer to as "Paranormal" type experiences & such on DXM. Like strange unexplainable things happening, even with sober witnesses around to see it. Psychedelics don't even have this property IMO. But something about DXM messes with the fabric of reality in some ways. And I use to use it a lot for ritual purposes & manifesting things. Causes a lot of synchronicities too (or maybe just delusions, but at least the delusions are fun & make life interesting lol). I think William White wrote about DXM's purported "paranormal" properties, if you haven't seen the William White DXM FAQ.

 

[MDMAdness]

So you had a liver transplant? Interesting. Maybe the newer liver has different enzymes & things that might metabolize stuff differently for you now. Interesting to ponder though.

I didn't mean to be insulting, I was genuinely just shocked. lol Never seen "surrounded" spelled like that before & was more confused, because most modern computers & phones show a red line under a word if it' s not spelled right, so people can just proof-read & auto-correct anything in red. But I didn't call you any names or harp on you for it, just thought I'd call it out. If I'm mis-spelling anything significant, people can let me know, I don't mind. lol Tone is hard to read over the internet though, so I could see how one might of taken it the wrong way and for that apologize.

I actually love tramadol & opioids. Specifically tramadol & diacetylmorphine. I've been an opioid addict for almost 20 years now. Absolutely wonderful drugs for my depression. The itch is part of the high! Histamine release & all.

But even on tramadol & heroin, I'd have the one-off experiences where I'd feel like shit, get nauseous, dysphoric. But I'd say 95% of the time it was enjoyable, but that other 5%, it would some times make me feel pretty gross. I think this happens mostly with people who don't have tolerances. Opioids can feel rather boring & drab when you first start them but after a few days of using is when the euphoria & bliss really starts to shine.

Same happens with buprenorphine some days, even after taking it every day for over 8 years now. I'll have those one-off days where it'll just make me feel like shit. Actually buprenorphine makes me feel like shit quite often compared to the aforementioned two opioids.

The one & only DXO experience on Erowid is a negative one, full of side effects it sounds like - https://www.erowid.org/chemicals/dxm/dxm_info3.shtml

So you're probably not alone in having dysphoric/negative experiences with DXO unfortunately. There's a synth-tek in that link as well that might be of interest to you (most likely not, since it's for DXO).

I'll have to respond more to the rest when I'm more cognizant.

I've had some insane near death-like experiences on DXM & cannabis. I've also experience what I refer to as "Paranormal" type experiences & such on DXM. Like strange unexplainable things happening, even with sober witnesses around to see it. Psychedelics don't even have this property IMO. But something about DXM messes with the fabric of reality in some ways. And I use to use it a lot for ritual purposes & manifesting things. Causes a lot of synchronicities too (or maybe just delusions, but at least the delusions are fun & make life interesting lol). I think William White wrote about DXM's purported "paranormal" properties, if you haven't seen the William White DXM FAQ.

im sure ill do dxo by itself. just to try it

 

[DeathIndustrial88]

im sure ill do dxo by itself. just to try it

Would be an interesting experience. You could rate the subjective euphoria/dysphoria of both DXM & DXO & see how they compare.

If you do, I'd definitely love to read that trip report!

 

[MDMAdness]

Would be an interesting experience. You could rate the subjective euphoria/dysphoria of both DXM & DXO & see how they compare.

If you do, I'd definitely love to read that trip report!

sorry dxo is too advanced for me i saw the process . ill stick to 2 step processes for now. r u dominosburritos?

 

[Coffeeshroom]

OP was suggesting DXO is dysphoric, not that it "fucks you up more".
And I just provided sources that say many of DXM's dissociative effects are caused by DXO. And this has been my understanding from the past 20 years of abusing the hell of DXM.

Both DXM & DXO are probably capable of causing dysphoria under certain conditions IN MY OPINION & from my own understanding of the research.

Hell, any drug can cause a dysphoric feeling for people at times, even heroin, morphine, MDMA, acid, etc.. etc..

Thank you

 

[DeathIndustrial88]

sorry dxo is too advanced for me i saw the process . ill stick to 2 step processes for now. r u dominosburritos?

I am not. Do you mean on here or?
Only have the one username on here.

 

[MDMAdness]

I am not. Do you mean on here or?
Only have the one username on here.

after i invited u to my discord server he joined

 

[DeathIndustrial88]

after i invited u to my discord server he joined

Aaah. Yeah I don't think I actually joined that day that you sent it.

I just tried to join it under my "DeathIndustrial" moniker right now. But honestly, I've had a few people invite me to discord servers, but once I'm in there, I honestly have no idea what I'm doing, suppose to be doing or what anything means. I also don't know where to go to see where people are talking or anything. So I honestly don't even know how it all works & have been avoiding discord servers all these years. lol

 

[MDMAdness]

Aaah. Yeah I don't think I actually joined that day that you sent it.

I just tried to join it under my "DeathIndustrial" moniker right now. But honestly, I've had a few people invite me to discord servers, but once I'm in there, I honestly have no idea what I'm doing, suppose to be doing or what anything means. I also don't know where to go to see where people are talking or anything. So I honestly don't even know how it all works & have been avoiding discord servers all these years. lol

my dxm brings all the boys to the car and their like its better than urs damn right its better than urs u can have some but i have to charge