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Lysergamides LSD manufacturing

S

scabbard

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Apr 2, 2024
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141
How is LSD accurately dosed onto blotter paper, so that each tab is uniformly coated and gets the same amount as all other tabs?
 
The real answer is that it is incredibly hard, and even commercially produced tabs (i.e. 1-acylated pro-drugs) have considerable spread in dosage despite all the best efforts to get a uniform product.
 
Do they take an entire sheet and dunk it in the LSD solution, or is it pipetted onto each tab individually?
 
Personally have never worked with commercial quaintly so don't know about multi-channel pipettes and automation. The blotters I have worked with were a solute measured out in sufficient solvent to cover the bottom of an A4 size tray. Let the blotter take it up, then hung up to dry in a dark room. Nothing special at all, no fancy equipment other than the lab balance and some ethyl alcohol.
 
when I made my salvinorin papers (like salvia blotter from extract for smoking not ingesting), I spread out the cigarette papers flat over top of an open web of fine thread that I wrapped around a large rectangular tray.
then I carefully used an eyedropper with a measured amount for each paper (later to be cut to 1/8 x 1/4 inch pipe size doses).
The fluid was acetone which evaporated quickly, and since the paper was suspended over the tray - no contact with that surface, no material was lost on the soaking tray surface. A tiny amount may have gone into the threads.
using this method I was able to get a very regular distribution.
the material has to be very flat so that fluid does not run, and the contact below has to be minimal so the drug is not lost on the tray.
If I were to do it again, I would use a second mesh of threads over top to prevent the cigarette paper from curling which did cause a few tiny pools of irregular concentration, but the evaporation seemed to even out anyway.
 
Find out exactly how much liquid your blotter can absorb, mix solution to the appropriate strength, dunk until fully saturated and allow to air dry.

I'm kind of assuming here -i've never tried laying my own blotter- but that seems like the most sensible way to do it.
 
I would think that if you dunked an entire sheet of paper in the solution it would not only be really hard to tell what the absorption density would be (i.e. how much solution would saturate into each 5mmx5mm piece of the paper, though I guess you could weigh your solvent pool before and after dunking to see how much the paper absorbed) but the distribution would also be uneven, especially if you were to hang it vertically (I'd think it would tend to pool at the bottom of the sheet). Using a quick evaporating solvent like acetone would help to mitigate that.

It's interesting, it just popped into my mind the other day and it got me thinking about how it's done on a large scale.

After the solvent dries, I would think the solute (the LSD, or whatever else you're dissolving) would be in a crystalline form - what would keep it immersed in the paper, as opposed to forming crystals that could just fall off when you picked it up? I guess the LSD quantities would be so tiny, but I would still think that it would be in a solid form after the solvent evaporated which would make it susceptible to simply falling off of the paper when it was handled or moved.
 
scabbard said:
I would think that if you dunked an entire sheet of paper in the solution it would not only be really hard to tell what the absorption density would be (i.e. how much solution would saturate into each 5mmx5mm piece of the paper, though I guess you could weigh your solvent pool before and after dunking to see how much the paper absorbed) but the distribution would also be uneven, especially if you were to hang it vertically (I'd think it would tend to pool at the bottom of the sheet). Using a quick evaporating solvent like acetone would help to mitigate that.

It's interesting, it just popped into my mind the other day and it got me thinking about how it's done on a large scale.

After the solvent dries, I would think the solute (the LSD, or whatever else you're dissolving) would be in a crystalline form - what would keep it immersed in the paper, as opposed to forming crystals that could just fall off when you picked it up? I guess the LSD quantities would be so tiny, but I would still think that it would be in a solid form after the solvent evaporated which would make it susceptible to simply falling off of the paper when it was handled or moved.
Click to expand...
The LSD is absorbed into the fibers of the paper and trapped when it dries so most of the dose is inside the paper not on the surface. Blotter paper is designed to be absorbent. It wouldn't be hard to work out exactly how much liquid blotter paper can absorb cmxcm until fully saturated by trial and error (assuming absorbency isn't stated by the manufacturer of the blotter paper, it probably is in most cases) and then you can just vary the concentration of the solution accordingly. I think a mix of distilled water and ethanol is typically used as the carrier. I know LSD is stable in ethanol, not sure about acetone.

Some vendors lay it by individually laying drops square by square, or a single drop on the corners between 4 squares, but that's an inefficient way of doing it which leaves a lot of room for human error. Can't imagine anyone handling crystal would want to do it that way.
 
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There's an underlying issue that as the solvent evaporates unevenly it will set up diffusion gradients within the blotter substrate that will lead to eventual concentration variations between the centre and the edges. It is, after all, essentially a crude liquid chromatogram. Rapid drying would probably help reduce this issue - so perhaps best to use a solvent with a high vapor pressure and dry under vacuum conditions.
 
idle_curiosity said:
There's an underlying issue that as the solvent evaporates unevenly it will set up diffusion gradients within the blotter substrate that will lead to eventual concentration variations between the centre and the edges. It is, after all, essentially a crude liquid chromatogram. Rapid drying would probably help reduce this issue - so perhaps best to use a solvent with a high vapor pressure and dry under vacuum conditions.
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the more water to alcohol ratio..... generally means a slower, yet more even distribution of the moelcule in the paper, assuming its not over saturated. I


ME depending on how paper is laid, its either the center is hotter, or the edges.... and this is due to where people throw the concentrated LSD onto to the dry paper and spread it out. Or, they spread it out on the paper in quadrants and lets the saturation bleed into each other.

Alot of times people will measure exact amount of liquid the blotter can contain, and then give it just a little bit of extra solvent, and continually card the liquid that seeps back into the paper.... generally means each blotter is equally saturated but the edges of those pages...... muahahha

Ive seen it done enough ways, I know each works, but.... which is best ,,, i dont know
 
It's known that for sheets dunked and hung out to dry much like old school black and white photography in a darkroom the strongest hits are the bottom corners since thats where the liquid drips from most frequently so ask your provider for corners if possible
 
i think i got the above on one of the bottom of a ten strip and it looked kind of like how paper looks when it gets wet... it was very very strong for the two tabs i took. i've taken 4 tabs around 100ugs that weren't as powerful... was different sheets of acid from different people, but if your paper looks darker around the edges i think it might mean it's stronger at least if it's on white tabs... i see people post pics of the same discoloration on reddit.

edit: i'm googling and it says this could be because of degradation... really doubt it was what was going on with my tabs...

more reading: "White LSD blotter paper looking wet might be due to the paper being freshly soaked in an LSD solution or it might have been exposed to moisture during storage. "
 
I've lain blotter before for a handful of compounds, the real killer is the ones that aren't easily soluble in anything that evaps well, think benzodiazepines. Putting etizolam on paper truly beat my ass compared to putting MDMB-4en-PINACA on paper for example, as the spice was ethanol soluble which evapped quickly, the tiz was barely soluble in shit. Having not used a level when laying sheets, trying to "drip-drop" (apply to each tab with a pipette), and trying to spray sheets have all been absolute fucking nightmares. the only reliable thing to do was to use one sheet of blotter as an inert test, to figure out just how much ethanol it could absorb, then set it in to that amount of ethanol infused with (amount of tabs * dose per tab), make sure the pan perfectly fits your sheet(s), and then let it sit and dry without hanging it, as that creates a gradient of hotspots towards the bottom.
 
Viraldrome said:
This guy built a machine to drop 25 1000 mic pipette drops at one time and each big square was cut 4 ways. Still a whopping 250 per dose, but that used to be normal in the 60s

thereader.mitpress.mit.edu

For Brilliant Color: Packaging the First LSD Blotter

Eric Ghost's cleverly disguised LSD packaging mirrored the 1960s counterculture's psychedelic vision.
thereader.mitpress.mit.edu thereader.mitpress.mit.edu
Click to expand...

Seems like a crazy device for what "should be" pretty straight forward
 
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