RCs Avizafone aka Pro-Diazepam - ROA oral vs. intranasal

[baba_aller_babas]

Hey guys,

actually I wanted to ask in the specific Reddit sub-reddits, but since I am usually just a lurker there and to ask questions I need enough karma and with a freshly created account there aren't any...

Sooooo I am just gonna ask you guys!

Okay, following: I now got twice 1g of Avizafone (same batch). The first gram I just took completely orally in like 2 days with maybe even only minimal effects. So I tried it intranasally with the next gram. Put it on a spoon (tried it on a glass plate first but somehow it was really sticky). So I just take a little bit on a spoon and snort it and damn, suddenly it works very very well.

Does anybody else had experienced this? Maybe even with an explanation why? Yes I know that Avizafone was made for i.m. injections, but I really do not want to go down that path, neither with i.m. nor i.v. injections.

Thanks in advance and with best regards!

 

[pcplease]

it is freely soluble in water so IN bioavailability should be very high

 

[baba_aller_babas]

Thank you for your answer!

Yeah, I am a bit interested in chemistry, but by far no pro. I am more a CS guy haha.

At first I thought all pro-drugs need to be metabolized by the liver first for the appearance of the effects, but as it seems this isn't always the case.

The reason I found why this works out better is that the metabolisation/the hydrolysis happens through aminopeptidases. Which is why it works intranasally way better due to a way better access to blood vessels and mucous membranes.

 

[vision conquest]

So we are just like a consolation prize to your beloved reddit?
Well I could have given heaps of helpful advice regarding your question, but now I'm not giving you anything.
No just kidding man, I have no experience with this particular compound, so I can't help man.

Blue light rocks!

 

[baba_aller_babas]

No, I actually do not even like Reddit for the most part and wtf I am surely not in love with that site... Just some sub-reddits are fine and interesting.

And also I am lurking here very regularly. And also am lurking in the best drug forum from my country.

So there are three places where I lurk around...here, specific sub-reddits and the one from my country but which I do not want to disclose due to being able to know which country I mean. But if you look at my username you probably can guess where I am from anyway.

I just try to stay a lurker because if I have an account I will be here way too often and I know by experience that this definitely increases my consumption... Recently I read a thread on a sub-reddit, where someone wrote an answer about trying 2C-B purely and not as pressed pills...and I just wanted to give a harm reduction information about being very careful with the dosages because 15mg 2C-B is something totally different than e.g. 25mg 2C-B...which of course wasn't able for me to do...

Yeah, and thanks for the very heartly welcoming (which ofc was meant cynically, seems like mentioning Reddit triggered something in you)...therefore it seems like I am also not welcomed here too (gave me now an impression of being on Stack Overflow 2.0), so don't worry, I already deleted my account here too, but it takes 14 days for the completion of that.

Thank you anyway and wish you all the best (and this isn't meant cynically, since I always try to be as respectful as possible)...

Peace!

 

[Dextro .45]

it is freely soluble in water so IN bioavailability should be very high

Actually……Avizafone must be treated / reacted with a human enzyme (forgot the name) to produce a super saturated water soluable solution of Diazepam (Valium)

There is a medical journal on IN administration of Avizafone

Avizafone (Like Vyvanse) MUST enter the bloodstream were typsin (enzyme in red blood cells) cleave the prodrug molecule into Lysin and the API, being Diazepam (Valium) …..in Vyvanse case, it’s d-Amph

I have had over 3,000mg of quality Avizafone (Pro-Diazepam) oral sucks, sorry……SC in ok, but sucks also. For the intended results you should administer IM injection. It’s not as scary as it sounds ….the pharmacist will know which needed but usually a 1 ml …even 3ml, doesn’t matter….. it’s the needle itself 25 gauge X 1 inch

Avizafone 40-60mg = Valium 20-30mg (I take 60-80mg)

Mix light yellow sticky Avizafone powder into small glass vial, add 0.5ml hot water from needle to dissolve Avizafone, shake around abit, clean, clear, pale yellow water, draw up through syringe, no filter needed.

Pharmacists always say the shoulder muscle is the most effective site for IM …not centre but closer to your back slightly but still near middle of shoulder (specific muscle in shoulder located there)

Poke it in, and slowly slide the 1 inch needle into muscle…..push in solution….keep needle in 30 sec or so, remove slowly and place tissue + alcohol

Easy as pie, and you’re not wasting your precious molecule …..10-15min already onset is taking place


***NOTE- this is from medical journal below with c-max & T-max ***

Avizafone (Pro-Diazepam) 22.5 mg IM injection = Diazepam (Valium) 10mg oral tablet

Avizafone is a rapid acting- water soluble pro-drug prodrug designed for IM administration……Trypsin in red blood cells cleave to parent prodrug molecule into L-Lysine (amino acid) and the API (Diazepam) responsible for the drugs desired effects

T-Max(h) time to reach maximum concentration in bloodstream
Oral Diazepam 1.5h
IM Avizafone 0.5-0.7h

C-Max ( ng’mL-1) max concentration in bloodstream
Oral Diazepam 118
IM Avizafone 223

As a water soluble pro-drug, Avizafone rapidly crosses the BBB and reaches very high Max Concentration in CNS as compared to oral Diazepam tablets

God bless Avizafone lol…..need another gram already ….over few years maybe 4,000 - 6,000mg (average IM dose 60-90mg)

 

[notsmokeymcpot42088]

you Killin it today --- my only note is it should be called valhalium due to its military application lol

 

[pcplease]

our noses are so easy to bleed, is it much of a stretch to think that the mere agitation caused by sniffing a powder would be sufficient to help most/all of the avizafone cross the BBB? Obviously that is not the case for Vyvanse, but neither is IV/IM use of vyvanse AFAIK

 

[baba_aller_babas]

Actually……Avizafone must be treated / reacted with a human enzyme (forgot the name) to produce a super saturated water soluable solution of Diazepam (Valium)

There is a medical journal on IN administration of Avizafone

Avizafone (Like Vyvanse) MUST enter the bloodstream were typsin (enzyme in red blood cells) cleave the prodrug molecule into Lysin and the API, being Diazepam (Valium) …..in Vyvanse case, it’s d-Amph

I have had over 3,000mg of quality Avizafone (Pro-Diazepam) oral sucks, sorry……SC in ok, but sucks also. For the intended results you should administer IM injection. It’s not as scary as it sounds ….the pharmacist will know which needed but usually a 1 ml …even 3ml, doesn’t matter….. it’s the needle itself 25 gauge X 1 inch

Avizafone 40-60mg = Valium 20-30mg (I take 60-80mg)

Mix light yellow sticky Avizafone powder into small glass vial, add 0.5ml hot water from needle to dissolve Avizafone, shake around abit, clean, clear, pale yellow water, draw up through syringe, no filter needed.

Pharmacists always say the shoulder muscle is the most effective site for IM …not centre but closer to your back slightly but still near middle of shoulder (specific muscle in shoulder located there)

Poke it in, and slowly slide the 1 inch needle into muscle…..push in solution….keep needle in 30 sec or so, remove slowly and place tissue + alcohol

Easy as pie, and you’re not wasting your precious molecule …..10-15min already onset is taking place

T-Max(h)
Avizafone 0.6 - 0.7 h
Diazepam 1.5 h

C-Max don’t have info off top of head ….but Avizafone is Significantly more higher than oral Diazepam

As a water soluble pro-drug, Avizafone rapidly crosses the BBB and reaches very high Max Concentration in CNS as compared to oral Diazepam tablets

God bless Avizafone lol…..need another gram already ….over few years maybe 4,000 - 6,000mg (average IM dose 60-90mg)

Thank you very much for your answer! Love such answers

I think the enzyme where you forgot the name is aminopeptidase. I wrote it in a reply a bit upper than yours. As I said, I always thought pro-drugs need to be metabolized by the liver first. As it is for example with all those LSD derivates nowadays that act as pro-drugs for LSD.

And thank you for your IM tutorial. For me it's not actually something that I am scared of but more of a thing which I don't want to do due to not overstepping a specific point (of no return lol). Because if I will be able to do IM then IV isn't that far away anymore. I prefer a decreased bioavailability over the overstepping. And yes, for me intranasally works really well with Avizafone (but can't compare it to IM ofc since I won't do that and also can't compare it to Diazepam itself, since the last time I had Diazepam itself was a very long time ago). Orally was really a complete waste.

 

[baba_aller_babas]

Actually……Avizafone must be treated / reacted with a human enzyme (forgot the name) to produce a super saturated water soluable solution of Diazepam (Valium)

There is a medical journal on IN administration of Avizafone

Avizafone (Like Vyvanse) MUST enter the bloodstream were typsin (enzyme in red blood cells) cleave the prodrug molecule into Lysin and the API, being Diazepam (Valium) …..in Vyvanse case, it’s d-Amph

I have had over 3,000mg of quality Avizafone (Pro-Diazepam) oral sucks, sorry……SC in ok, but sucks also. For the intended results you should administer IM injection. It’s not as scary as it sounds ….the pharmacist will know which needed but usually a 1 ml …even 3ml, doesn’t matter….. it’s the needle itself 25 gauge X 1 inch

Avizafone 40-60mg = Valium 20-30mg (I take 60-80mg)

Mix light yellow sticky Avizafone powder into small glass vial, add 0.5ml hot water from needle to dissolve Avizafone, shake around abit, clean, clear, pale yellow water, draw up through syringe, no filter needed.

Pharmacists always say the shoulder muscle is the most effective site for IM …not centre but closer to your back slightly but still near middle of shoulder (specific muscle in shoulder located there)

Poke it in, and slowly slide the 1 inch needle into muscle…..push in solution….keep needle in 30 sec or so, remove slowly and place tissue + alcohol

Easy as pie, and you’re not wasting your precious molecule …..10-15min already onset is taking place


***NOTE- this is from medical journal below with c-max & T-max ***

Avizafone (Pro-Diazepam) 22.5 mg IM injection = Diazepam (Valium) 10mg oral tablet

Avizafone is a rapid acting- water soluble pro-drug prodrug designed for IM administration……Trypsin in red blood cells cleave to parent prodrug molecule into L-Lysine (amino acid) and the API (Diazepam) responsible for the drugs desired effects

T-Max(h) time to reach maximum concentration in bloodstream
Oral Diazepam 1.5h
IM Avizafone 0.5-0.7h

C-Max ( ng’mL-1) max concentration in bloodstream
Oral Diazepam 118
IM Avizafone 223

As a water soluble pro-drug, Avizafone rapidly crosses the BBB and reaches very high Max Concentration in CNS as compared to oral Diazepam tablets

God bless Avizafone lol…..need another gram already ….over few years maybe 4,000 - 6,000mg (average IM dose 60-90mg)

Okay...I got another question where you might know the answer to.

I just found out, that Rilmazafone also has to be metabolized by aminopeptidase. But somehow, Rilmazafone works/worked (haven't used it for around 2 years anymore, but recently Rilmazolam) as intended when I took it orally. So why does it work with this chemical substance when it does not with Avizafone for me? Could probably also be genetically right?

Best wishes!

 

[vision conquest]

No, I actually do not even like Reddit for the most part and wtf I am surely not in love with that site... Just some sub-reddits are fine and interesting.

And also I am lurking here very regularly. And also am lurking in the best drug forum from my country.

So there are three places where I lurk around...here, specific sub-reddits and the one from my country but which I do not want to disclose due to being able to know which country I mean. But if you look at my username you probably can guess where I am from anyway.

I just try to stay a lurker because if I have an account I will be here way too often and I know by experience that this definitely increases my consumption... Recently I read a thread on a sub-reddit, where someone wrote an answer about trying 2C-B purely and not as pressed pills...and I just wanted to give a harm reduction information about being very careful with the dosages because 15mg 2C-B is something totally different than e.g. 25mg 2C-B...which of course wasn't able for me to do...

Yeah, and thanks for the very heartly welcoming (which ofc was meant cynically, seems like mentioning Reddit triggered something in you)...therefore it seems like I am also not welcomed here too (gave me now an impression of being on Stack Overflow 2.0), so don't worry, I already deleted my account here too, but it takes 14 days for the completion of that.

Thank you anyway and wish you all the best (and this isn't meant cynically, since I always try to be as respectful as possible)...

Peace!

Well I thought where I said, "no just kidding man" would have made it prretty clear I was just mucking around, to be honest I can barely remember my post here so chances are pretty good I was toasted at the time.

I meant no offence at all man.

You are totally welcome here.

 

[baba_aller_babas]

Well I thought where I said, "no just kidding man" would have made it prretty clear I was just mucking around, to be honest I can barely remember my post here so chances are pretty good I was toasted at the time.

I meant no offence at all man.

You are totally welcome here.

All good dude and thank you for welcoming me here!

Yeah, I read the "just kidding", but it was about the first two phrases being so long and then the short "just kidding". If it would have been like this for example: "So we are just like a consolation prize to your beloved reddit? Nah just kidding man"...then it would have been way easier to view it as a joke imo.

And thank you for clarifying (again, because yeah I knew you were joking) that it wasn't meant as an offence, how I said, all good. I was probably smashed too at that time lmao. It was somewhere in the night where we wrote that.

Best wishes

 

[vision conquest]

All good dude and thank you for welcoming me here!

Yeah, I read the "just kidding", but it was about the first two phrases being so long and then the short "just kidding". If it would have been like this for example: "So we are just like a consolation prize to your beloved reddit? Nah just kidding man"...then it would have been way easier to view it as a joke imo.

And thank you for clarifying (again, because yeah I knew you were joking) that it wasn't meant as an offence, how I said, all good. I was probably smashed too at that time lmao. It was somewhere in the night where we wrote that.

Best wishes

Fair point man...sometimes it's hard to accurately capture the mood ofwhat is being said in a post, also being smashed when writing doesn't make it easier.

Anyway, glad we got it all sorted out.

Best wishes back at you man and I hope you decide to stick around.

 

[baba_aller_babas]

Fair point man...sometimes it's hard to accurately capture the mood ofwhat is being said in a post, also being smashed when writing doesn't make it easier.

Anyway, glad we got it all sorted out.

Best wishes back at you man and I hope you decide to stick around.

I am also glad, that we sorted this out

Always better to be on good terms! And oh btw, it was at least night for me but somehow I thought of Brisbane being in the UK instead of Australia lol, therefore I said it was night for us when we wrote that lol.

Yeah, I already looked up to reverse the account deletion but didn't find any way, maybe it's done automatically by login in again, maybe I need to contact the support, idk. If it happens I probably will just create a new account!

 

[Dextro .45]

Thank you very much for your answer! Love such answers

I think the enzyme where you forgot the name is aminopeptidase. I wrote it in a reply a bit upper than yours. As I said, I always thought pro-drugs need to be metabolized by the liver first. As it is for example with all those LSD derivates nowadays that act as pro-drugs for LSD.

And thank you for your IM tutorial. For me it's not actually something that I am scared of but more of a thing which I don't want to do due to not overstepping a specific point (of no return lol). Because if I will be able to do IM then IV isn't that far away anymore. I prefer a decreased bioavailability over the overstepping. And yes, for me intranasally works really well with Avizafone (but can't compare it to IM ofc since I won't do that and also can't compare it to Diazepam itself, since the last time I had Diazepam itself was a very long time ago). Orally was really a complete waste.

Also of note…..for a healthy man 200lbs / 6” on an empty stomach……Diazepam 10mg tablet isn’t always a sufficient dose…..even benzodiazepine naive patients

As a tolerant individual, I myself would take
Diazepam 30-40mg oral tablets
Alprazolam 1mg oral tablet
Pregabalin 300mg oral capsule
Clonidine 0.1mg (half a scored tablet)

This would rapidly eradicate any anxiety, nervousness, stress, worry, panic attacks, etc dead in their tracks in 45min on a fasted state

Pregabalin (Lyrica) has 90% oral bioavailability…..BUT …..on an empty stomach 45min - 1h reaches peak serum levels in bloodstream……after a large meal……4 HOURS to reach C-Max …..Massive discrepancy in onset of action

 

[Dextro .45]

Hence, why Avizafone (Pro-Diazepam) is so appealing and useful in medical settings. It’s being marketed to hospitals where hostile & violent/aggressive patients have assaulted and attacked hospital staff.

Waiting 45min to sedate patient is unacceptable

IM injection of Avizafone and in 10-15min the subject just melts into a state of significant sedation……most likely in a carefully designed IM cocktail. I would select personally for IM injection

Avizafone 60-70mg (35mg Valium) water soluble rapid acting Diazepam
Ketamine HCL- unknown exact mg dose, but IM ROA is 5min (slightly same as Avizafone)
Possibly an anti-psychotic medication like Thorazine etc

Held down by several large men, a fat IM shot in the shoulder and this spun Meth tweaked out nut bar would be a drooling invalid softly mumbling to themselves lol

Ketamine is an AMAZING rapid acting anesthesia (disassociate anesthetic) unable to move, but Super Safe. Doesn’t affect patients heart rate or breathing ……just in a deep “K-Hole” unable to move ha ha ha ……add a rapid acting pro-drug to Valium, and that’s a wrap son

….take it ease lol

 

[notsmokeymcpot42088]

^Sounds like 'drug abuse' -- really just the thorazine. And I know it is needed for some but just feels obsolete and inhumane in general.

Don't really love ketamine for 'restraint' purposes either -- I'm not real experienced with it - Feels like a recipe for a real bad trip. (Which hopefully the person did something to merit).

In general I am against --- "Non consensual" drug use lol

 

[Dextro .45]

Ya well the nurse with a broken jaw and PTSD from a 20 second beating before help comes and tackled dude to the ground. I drove her to Ketamine clinic at previous job for PTSD and also used for treatment resistant depression and pain, neurological pain, and as an anesthesia med

A tweaked out Meth head experiencing psychosis is a Significant handful ….and Extremely dangerous

Id slam a 22 gauge 1inch needle / 5ml syringe loaded with 100mg of Avizafone and 300mg of Ketamine into his shoulder, thigh, necks, where ever I could …….both compounds are VERY rapid acting 3-5min and are VERY potent …..dude would be drooling on the floor after an intense struggle, blows & blocks, grappling on the floor trying to get control of this super charged tweaked out Superman…….until, Woooooooow, spinning, legs turning into jelly, balance off, leaning against the wall bleeding until he falls like a sack of potatoes fully anesthetized in a Deep K-Hole mixed with extremely high levels of Valium in his bloodstream

Hospital staff safety paramount……Meth head……minor injuries…..all drugs safe, breathing and heart rate un affected by Ketamine……Diazepam muscle relaxant and anxiolytic.

I personally woke up 4 hours after a fat 100mg IM shot in the shoulder …….within 20min I was out……timer I set was over 4 hours when came to

 

[notsmokeymcpot42088]

in some cases it is certainly needed as mentioned.

See the difference is you had control over dose setting duration and everything else.

In general leaves plenty of room for the guy on pcp or meth attacking the staff.