RCs Avizafone aka Pro-Diazepam - ROA oral vs. intranasal

[baba_aller_babas]

Hey guys,

actually I wanted to ask in the specific Reddit sub-reddits, but since I am usually just a lurker there and to ask questions I need enough karma and with a freshly created account there aren't any...

Sooooo I am just gonna ask you guys!

Okay, following: I now got twice 1g of Avizafone (same batch). The first gram I just took completely orally in like 2 days with maybe even only minimal effects. So I tried it intranasally with the next gram. Put it on a spoon (tried it on a glass plate first but somehow it was really sticky). So I just take a little bit on a spoon and snort it and damn, suddenly it works very very well.

Does anybody else had experienced this? Maybe even with an explanation why? Yes I know that Avizafone was made for i.m. injections, but I really do not want to go down that path, neither with i.m. nor i.v. injections.

Thanks in advance and with best regards!

 

[pcplease]

it is freely soluble in water so IN bioavailability should be very high

 

[baba_aller_babas]

Thank you for your answer!

Yeah, I am a bit interested in chemistry, but by far no pro. I am more a CS guy haha.

At first I thought all pro-drugs need to be metabolized by the liver first for the appearance of the effects, but as it seems this isn't always the case.

The reason I found why this works out better is that the metabolisation/the hydrolysis happens through aminopeptidases. Which is why it works intranasally way better due to a way better access to blood vessels and mucous membranes.

 

[vision conquest]

So we are just like a consolation prize to your beloved reddit?
Well I could have given heaps of helpful advice regarding your question, but now I'm not giving you anything.
No just kidding man, I have no experience with this particular compound, so I can't help man.

Blue light rocks!

 

[baba_aller_babas]

No, I actually do not even like Reddit for the most part and wtf I am surely not in love with that site... Just some sub-reddits are fine and interesting.

And also I am lurking here very regularly. And also am lurking in the best drug forum from my country.

So there are three places where I lurk around...here, specific sub-reddits and the one from my country but which I do not want to disclose due to being able to know which country I mean. But if you look at my username you probably can guess where I am from anyway.

I just try to stay a lurker because if I have an account I will be here way too often and I know by experience that this definitely increases my consumption... Recently I read a thread on a sub-reddit, where someone wrote an answer about trying 2C-B purely and not as pressed pills...and I just wanted to give a harm reduction information about being very careful with the dosages because 15mg 2C-B is something totally different than e.g. 25mg 2C-B...which of course wasn't able for me to do...

Yeah, and thanks for the very heartly welcoming (which ofc was meant cynically, seems like mentioning Reddit triggered something in you)...therefore it seems like I am also not welcomed here too (gave me now an impression of being on Stack Overflow 2.0), so don't worry, I already deleted my account here too, but it takes 14 days for the completion of that.

Thank you anyway and wish you all the best (and this isn't meant cynically, since I always try to be as respectful as possible)...

Peace!

 

[Dextro .45]

it is freely soluble in water so IN bioavailability should be very high

Actually……Avizafone must be treated / reacted with a human enzyme (forgot the name) to produce a super saturated water soluable solution of Diazepam (Valium)

There is a medical journal on IN administration of Avizafone

Avizafone (Like Vyvanse) MUST enter the bloodstream were typsin (enzyme in red blood cells) cleave the prodrug molecule into Lysin and the API, being Diazepam (Valium) …..in Vyvanse case, it’s d-Amph

I have had over 3,000mg of quality Avizafone (Pro-Diazepam) oral sucks, sorry……SC in ok, but sucks also. For the intended results you should administer IM injection. It’s not as scary as it sounds ….the pharmacist will know which needed but usually a 1 ml …even 3ml, doesn’t matter….. it’s the needle itself 25 gauge X 1 inch

Avizafone 40-60mg = Valium 20-30mg (I take 60-80mg)

Mix light yellow sticky Avizafone powder into small glass vial, add 0.5ml hot water from needle to dissolve Avizafone, shake around abit, clean, clear, pale yellow water, draw up through syringe, no filter needed.

Pharmacists always say the shoulder muscle is the most effective site for IM …not centre but closer to your back slightly but still near middle of shoulder (specific muscle in shoulder located there)

Poke it in, and slowly slide the 1 inch needle into muscle…..push in solution….keep needle in 30 sec or so, remove slowly and place tissue + alcohol

Easy as pie, and you’re not wasting your precious molecule …..10-15min already onset is taking place


***NOTE- this is from medical journal below with c-max & T-max ***

Avizafone (Pro-Diazepam) 22.5 mg IM injection = Diazepam (Valium) 10mg oral tablet

Avizafone is a rapid acting- water soluble pro-drug prodrug designed for IM administration……Trypsin in red blood cells cleave to parent prodrug molecule into L-Lysine (amino acid) and the API (Diazepam) responsible for the drugs desired effects

T-Max(h) time to reach maximum concentration in bloodstream
Oral Diazepam 1.5h
IM Avizafone 0.5-0.7h

C-Max ( ng’mL-1) max concentration in bloodstream
Oral Diazepam 118
IM Avizafone 223

As a water soluble pro-drug, Avizafone rapidly crosses the BBB and reaches very high Max Concentration in CNS as compared to oral Diazepam tablets

God bless Avizafone lol…..need another gram already ….over few years maybe 4,000 - 6,000mg (average IM dose 60-90mg)

 

[notsmokeymcpot42088]

you Killin it today --- my only note is it should be called valhalium due to its military application lol

 

[pcplease]

our noses are so easy to bleed, is it much of a stretch to think that the mere agitation caused by sniffing a powder would be sufficient to help most/all of the avizafone cross the BBB? Obviously that is not the case for Vyvanse, but neither is IV/IM use of vyvanse AFAIK

 

[baba_aller_babas]

Actually……Avizafone must be treated / reacted with a human enzyme (forgot the name) to produce a super saturated water soluable solution of Diazepam (Valium)

There is a medical journal on IN administration of Avizafone

Avizafone (Like Vyvanse) MUST enter the bloodstream were typsin (enzyme in red blood cells) cleave the prodrug molecule into Lysin and the API, being Diazepam (Valium) …..in Vyvanse case, it’s d-Amph

I have had over 3,000mg of quality Avizafone (Pro-Diazepam) oral sucks, sorry……SC in ok, but sucks also. For the intended results you should administer IM injection. It’s not as scary as it sounds ….the pharmacist will know which needed but usually a 1 ml …even 3ml, doesn’t matter….. it’s the needle itself 25 gauge X 1 inch

Avizafone 40-60mg = Valium 20-30mg (I take 60-80mg)

Mix light yellow sticky Avizafone powder into small glass vial, add 0.5ml hot water from needle to dissolve Avizafone, shake around abit, clean, clear, pale yellow water, draw up through syringe, no filter needed.

Pharmacists always say the shoulder muscle is the most effective site for IM …not centre but closer to your back slightly but still near middle of shoulder (specific muscle in shoulder located there)

Poke it in, and slowly slide the 1 inch needle into muscle…..push in solution….keep needle in 30 sec or so, remove slowly and place tissue + alcohol

Easy as pie, and you’re not wasting your precious molecule …..10-15min already onset is taking place

T-Max(h)
Avizafone 0.6 - 0.7 h
Diazepam 1.5 h

C-Max don’t have info off top of head ….but Avizafone is Significantly more higher than oral Diazepam

As a water soluble pro-drug, Avizafone rapidly crosses the BBB and reaches very high Max Concentration in CNS as compared to oral Diazepam tablets

God bless Avizafone lol…..need another gram already ….over few years maybe 4,000 - 6,000mg (average IM dose 60-90mg)

Thank you very much for your answer! Love such answers

I think the enzyme where you forgot the name is aminopeptidase. I wrote it in a reply a bit upper than yours. As I said, I always thought pro-drugs need to be metabolized by the liver first. As it is for example with all those LSD derivates nowadays that act as pro-drugs for LSD.

And thank you for your IM tutorial. For me it's not actually something that I am scared of but more of a thing which I don't want to do due to not overstepping a specific point (of no return lol). Because if I will be able to do IM then IV isn't that far away anymore. I prefer a decreased bioavailability over the overstepping. And yes, for me intranasally works really well with Avizafone (but can't compare it to IM ofc since I won't do that and also can't compare it to Diazepam itself, since the last time I had Diazepam itself was a very long time ago). Orally was really a complete waste.

 

[baba_aller_babas]

Actually……Avizafone must be treated / reacted with a human enzyme (forgot the name) to produce a super saturated water soluable solution of Diazepam (Valium)

There is a medical journal on IN administration of Avizafone

Avizafone (Like Vyvanse) MUST enter the bloodstream were typsin (enzyme in red blood cells) cleave the prodrug molecule into Lysin and the API, being Diazepam (Valium) …..in Vyvanse case, it’s d-Amph

I have had over 3,000mg of quality Avizafone (Pro-Diazepam) oral sucks, sorry……SC in ok, but sucks also. For the intended results you should administer IM injection. It’s not as scary as it sounds ….the pharmacist will know which needed but usually a 1 ml …even 3ml, doesn’t matter….. it’s the needle itself 25 gauge X 1 inch

Avizafone 40-60mg = Valium 20-30mg (I take 60-80mg)

Mix light yellow sticky Avizafone powder into small glass vial, add 0.5ml hot water from needle to dissolve Avizafone, shake around abit, clean, clear, pale yellow water, draw up through syringe, no filter needed.

Pharmacists always say the shoulder muscle is the most effective site for IM …not centre but closer to your back slightly but still near middle of shoulder (specific muscle in shoulder located there)

Poke it in, and slowly slide the 1 inch needle into muscle…..push in solution….keep needle in 30 sec or so, remove slowly and place tissue + alcohol

Easy as pie, and you’re not wasting your precious molecule …..10-15min already onset is taking place


***NOTE- this is from medical journal below with c-max & T-max ***

Avizafone (Pro-Diazepam) 22.5 mg IM injection = Diazepam (Valium) 10mg oral tablet

Avizafone is a rapid acting- water soluble pro-drug prodrug designed for IM administration……Trypsin in red blood cells cleave to parent prodrug molecule into L-Lysine (amino acid) and the API (Diazepam) responsible for the drugs desired effects

T-Max(h) time to reach maximum concentration in bloodstream
Oral Diazepam 1.5h
IM Avizafone 0.5-0.7h

C-Max ( ng’mL-1) max concentration in bloodstream
Oral Diazepam 118
IM Avizafone 223

As a water soluble pro-drug, Avizafone rapidly crosses the BBB and reaches very high Max Concentration in CNS as compared to oral Diazepam tablets

God bless Avizafone lol…..need another gram already ….over few years maybe 4,000 - 6,000mg (average IM dose 60-90mg)

Okay...I got another question where you might know the answer to.

I just found out, that Rilmazafone also has to be metabolized by aminopeptidase. But somehow, Rilmazafone works/worked (haven't used it for around 2 years anymore, but recently Rilmazolam) as intended when I took it orally. So why does it work with this chemical substance when it does not with Avizafone for me? Could probably also be genetically right?

Best wishes!

 

[vision conquest]

No, I actually do not even like Reddit for the most part and wtf I am surely not in love with that site... Just some sub-reddits are fine and interesting.

And also I am lurking here very regularly. And also am lurking in the best drug forum from my country.

So there are three places where I lurk around...here, specific sub-reddits and the one from my country but which I do not want to disclose due to being able to know which country I mean. But if you look at my username you probably can guess where I am from anyway.

I just try to stay a lurker because if I have an account I will be here way too often and I know by experience that this definitely increases my consumption... Recently I read a thread on a sub-reddit, where someone wrote an answer about trying 2C-B purely and not as pressed pills...and I just wanted to give a harm reduction information about being very careful with the dosages because 15mg 2C-B is something totally different than e.g. 25mg 2C-B...which of course wasn't able for me to do...

Yeah, and thanks for the very heartly welcoming (which ofc was meant cynically, seems like mentioning Reddit triggered something in you)...therefore it seems like I am also not welcomed here too (gave me now an impression of being on Stack Overflow 2.0), so don't worry, I already deleted my account here too, but it takes 14 days for the completion of that.

Thank you anyway and wish you all the best (and this isn't meant cynically, since I always try to be as respectful as possible)...

Peace!

Well I thought where I said, "no just kidding man" would have made it prretty clear I was just mucking around, to be honest I can barely remember my post here so chances are pretty good I was toasted at the time.

I meant no offence at all man.

You are totally welcome here.