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  • NSADD Moderators: tryptakid

Emergence of Medetomidine in the NYC Drug Supply (Carfentanil as well)

tryptakid

Sr. Moderator: DP&MC, NSADD, CEPS
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Hey all, I wanted to mention a developing issue with a novel xylazine like drug 'medetomidine' in a few drug markets. I've heard of Philly and Chicago in addition to NYC where this appears to be competing with xylazine as an additive in the street dope market.

From the linked release:

Medetomidine is a non-opioid anesthetic that is FDA-approved for veterinary use. It is similar to xylazine,but is more potent and causes longer-lasting effects. At this time, medetomidine cannot be differentiated from dexmedetomidine (Precedex)—a sedative which is FDA-approved for human use—through secondary laboratory testing. As medetomidine/dexmedetomidine are not opioids, naloxone cannot reverse the effects of these substances. However, since medetomidine/dexmedetomidine have most often been found with fentanyl and other potent opioids, it is important to use naloxone even in the case of a suspected medetomidine/dexmedetomidine-involved overdose. Individuals may still be sedated after naloxone reversal of opioid-induced respiratory depression. For this reason, it is important to administer rescue breathing, place individuals in a rescue position to protect their airways, and continue to monitor their breathing with a pulse oximeter. Call emergency services to facilitate access to further monitoring and administration of supplemental oxygen.

Clinical Information on Medetomidine/Dexmedetomidine:

• Similar to xylazine, medetomidine is a synthetic alpha-2 adrenoreceptor agonist sedative used in veterinary medicine. Medetomidine is used for sedation, analgesia, muscle relaxation and anxiolysis (i.e., anti-anxiety).

• The effects of medetomidine intoxication may include: extreme sedation, slower than usual heart rate (reportedly as low as 40 beats per minute), low blood pressure, and central nervous system depression. Someone experiencing medetomidine intoxication may be unresponsive to verbal commands or physical stimuli even though they may still be breathing.

• Medetomidine is not an opioid, so the effects of medetomidine cannot be reversed with the administration of naloxone.

• Since medetomidine has most often been found with fentanyl and other opioids, naloxone should be administered in all suspected overdoses involving medetomidine. Rescue breathing or supplemental oxygen should be administered in cases of stopped or irregular breathing.

Just wanted to pass along as this came up in one of our team meetings this week. My thinking is that this continues to be a way for suppliers/manufacturers to attempt to differentiate the qualities of 'dope' (of which all can produce nearly pure fentanyl/fentalogues) so the use of admixtures to increase potency as a way to stand out as opposed to competitors is a viable option. Of course, this leads to the potential for undesirable side effects such as xylazine wounds (no graphic photos contained in this link) and complications in withdrawal management.

According to this health alert from the city of Philadelphia it is currently unknown whether medetomidine causes the wounds that xylazine is know for.

Just wanted to pass along.
 
Im so sorry that you have this fuckin problem. I dont know where are we gonna finish with this shit in the streets. Fucking stupid bastards gangs!
 
My heart goes out to the nod squad in the US. Here in Australia all we have is crappy high purity Heroin HCL.
 
does medetobicmide also rat your asshole out to your eyeballs like xylzine? seems structurally related at least. fuck America, aren't even the best at drugs anymore... just at dying from them because they are that fucking shitty. if we had good drugs people we get to a satisfactory high and not die as much taking more and more garbage chasing a high that they can't get close to with shit gear
 
Medetomidine and dexmedetomidine (less harmful enantiomer) are widely used in human and veterinary medicine as sedatives. They are more targeted than Xylazine and have less side effects. However, they are not meant for chronic use. Clonidine, which binds the same receptor, doesn’t cause flesh rotting, but does have a pretty dangerous withdrawal symptoms. Why do manufacturers feel the need to put this stuff into narcotics? fentanyl is cheap and doesn’t need to be cut with alpha 2 agonists. It’s like they are deliberately trying to harm people, which doesn’t make sense for the long term sustainability of their business model. I don’t use dope, but I wax nostalgic for the days of heroin.
 
Clonidine, which binds the same receptor, doesn’t cause flesh rotting, but does have a pretty dangerous withdrawal symptoms.
I know about this all too well. I have been on Clonidine for 25 years. I have had a few episodes of withdrawal and they like opioids meet Benzo withdrawals.
 
I don’t use dope, but I wax nostalgic for the days of heroin.

At this point I just wax nostalgic for the days of fent-only dope.

I can honestly say that I would use fentanyl if it wasn’t for xylazine. Xylazine was my redline where I stuck with methadone after that

So yes, these retsrd traffickers lacing it with xylazine are losing money.
 
There are many ways to destabilize a country. Poisoning the drug supply is a fantastic way to way do it.
It sure is - you get to harm the people with the most vulnerability to blame. You chemically extract the undesirable elements of society and create a believable narrative to assign blame in the process. "Those junkies did it to themselves".
 
It sure is - you get to harm the people with the most vulnerability to blame. You chemically extract the undesirable elements of society and create a believable narrative to assign blame in the process. "Those junkies did it to themselves".
Nailed it.
Bye bye you filthy heathens.
 
There are many ways to destabilize a country. Poisoning the drug supply is a fantastic way to way do it.

I feel like making it fent only would kill more people and also cause more people to use the door because it would be a better high

If they are trying to kill drug userers and homeless on purpose I feel like xylazine is counter productive.

Like I said….i quit dope specifically because of xylazine. If they didn’t put that shit in I would’ve spent another 100k by now on dope.
 
You’re acting like the people doing this shit don’t have any clue as to what they’re doing. They do.

Why sell just fent when you can put poison in it that makes peoples skin rot off making them unbearable for most people to look at?

As if nodding off in public wasn’t bad enough. Now people are rotting from the inside out. Takes a certain type of person to give a single fuck about an addict as it is, let alone one that literally looks like a walking zombie.

Sometimes multiple naloxone kits are needed for a fent OD. They’ve found a way around that as well - Put other poisons in the fent that naloxone won’t do shit for.
You still give it, but then you have to do mouth to mouth until help arrives. When/if it arrives. Assuming there’s even going to be someone there thats willing, or capable, of administering mouth to mouth and chest compressions to the person/people (possibly with open wounds on their faces) who have OD.

You can absolutely still get proper heroin.
 
You can absolutely still get proper heroin.
It’s def still around idk why people say it’s extinct it’s just not out on the corners like 16 years ago.

I got a buddy in a certain well known city in south Jers that gets it on a regular basis same stamp errrry time.

I’m on 2mg of subs a day anyway so I don’t want any parts but there ain’t no “doesn’t exist” in the dope/drug/illegal trades game lol. Money talks that’s all imma say.
 
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It’s def still around idk why people say it’s extinct it’s just not out on the corners like 16 years ago.

I got a buddy in a certain well known city in south Jers that gets it on a regular basis same stamp errrry time.

I’m on 2mg of subs a day anyway so I don’t want any parts but there ain’t no “doesn’t exist” lol. Money talks that’s all imma say.

For once we agree

People pay eight bills for a short zip of 24g
You just need the connection. And that is fucking hard to come by.
People in bars like cocaine and have friends. Use your connects to trade up.

Best fucking heroin on earth though

A fucking beautiful rich red brown fine powder. Formed little beads if you breathed on it. Smell was like strange flowers. The spice melange. I’m pretty sure that shit was locally grown lol

I also got a single gram of some off white powder. Pretty sure it was the good one. Number four or some shit. Got it off some nazzies.

Most of the time tho I’d get some nice hard rock kinda stuff that dissolved beautifully. There was never any sediment.

I had some really great connects jeez

Too bad heroin fucking stole my short term memory. And my money. And my sex drive. And my physical health. And my ability to be honest either literally anyone. And my self confidence. But I have all that willingly. The short term memory was the dealbreaker.

Get out and meet people
 
For once we agree

Too bad heroin fucking stole my short term memory. And my money. And my sex drive. And my physical health. And my ability to be honest either literally anyone. And my self confidence. But I have all that willingly. The short term memory was the dealbreaker.

Get out and meet people
Right lol, I’m glad you put that last part as a disclaimer after you started waxin poetic about it 😂


What’s good gotta come to an end eventuallly maybe I’ll reacquaint one day but sure as shit not now things are goin too good

For some people maybe it’s a blessing in disguise that they can’t get their hands on it honestly you never had to worry about your flesh rotting off lol but the newer generation shouldn’t be lulled into a false sense of security that shit’ll still fuck your year up. might just wish you never found it in the first place



Tranq/Xylazine is nothing new either they been doing it on the islands (puerto Rico and the DR) for decades. Having it in the US is new but as a cut itself, nah. This is again some weird internet phenomenon where they get their facts mixed up because they just read articles instead of actually being on the streets lolz. I know people involved in that supply chain from my old neighborhood and believe me they’re all aware. They like the tranq because they claim it’s a better high that’s what’s selling simple as that. Offer them regular H they laugh they wouldn’t even be able to afford to stay well on that

Damn I miss the old roll call threads with stamp reviews and shit. This place used to be so much better and just more alive with normal people but that’s a different discussion 😂
 
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Right lol, I’m glad you put that last part as a disclaimer after you started waxin poetic about it 😂


What’s good gotta come to an end eventuallly maybe I’ll reacquaint one day but sure as shit not now things are goin too good

For some people maybe it’s a blessing in disguise that they can’t get their hands on it honestly you never had to worry about your flesh rotting off lol but the newer generation shouldn’t be lulled into a false sense of security that shit’ll still fuck your year up. might just wish you never found it in the first place



Tranq/Xylazine is nothing new either they been doing it on the islands (puerto Rico and the DR) for decades. Having it in the US is new but as a cut itself, nah. This is again some weird internet phenomenon where they get their facts mixed up because they just read articles instead of actually being on the streets lolz. I know people involved in that supply chain from my old neighborhood and believe me they’re all aware. They like the tranq because they claim it’s a better high that’s what’s selling simple as that. Offer them regular H they laugh they wouldn’t even be able to afford to stay well on that

Damn I miss the old roll call threads with stamp reviews and shit. This place used to be so much better and just more alive with normal people but that’s a different discussion 😂
I haven't done dope since 2008. The only opioid (aside from kratom) I've used since then was hydrocodone after getting a nasty cough when I had covid. It was so liberating to be able to appropriately use tussionex with my doctor and my wife aware that I was taking it and for what purpose.

Earlier this year I obtain some live poppies and have been growing them and recently harvested some pods to make opium tea with. It's the only recreational use I'll probably invite at this point. I say this all to say that we can find ways to recover and improve and eventually develop new relationships with substances if we do the work we need to do to change.

Heroin is a no no (maybe when I'm old and want to fade away after a life well lived I will reconsider this).
 
Right lol, I’m glad you put that last part as a disclaimer after you started waxin poetic about it 😂


What’s good gotta come to an end eventuallly maybe I’ll reacquaint one day but sure as shit not now things are goin too good

For some people maybe it’s a blessing in disguise that they can’t get their hands on it honestly you never had to worry about your flesh rotting off lol but the newer generation shouldn’t be lulled into a false sense of security that shit’ll still fuck your year up. might just wish you never found it in the first place



Tranq/Xylazine is nothing new either they been doing it on the islands (puerto Rico and the DR) for decades. Having it in the US is new but as a cut itself, nah. This is again some weird internet phenomenon where they get their facts mixed up because they just read articles instead of actually being on the streets lolz. I know people involved in that supply chain from my old neighborhood and believe me they’re all aware. They like the tranq because they claim it’s a better high that’s what’s selling simple as that. Offer them regular H they laugh they wouldn’t even be able to afford to stay well on that

Damn I miss the old roll call threads with stamp reviews and shit. This place used to be so much better and just more alive with normal people but that’s a different discussion 😂

I’ll give you that. I’m not a normal person. I really struggle with affinity towards anyone besides my dead.

That said I don’t think people who try to conserve a culture which is so clearly not beneficial to so many citizens of the nation to which the culture being conserved belongs.

I mean imagine being a black person in the south and people are tearing down the slave owner statues of old and then a whole nation of the most moronic people you’ve ever met in your life start public discussion about why the heroes of a former failed state built on racial stratification as traitors to the great nation to which we belong start fucking marching around with tiki torches, and wearing masks and beating people up calling themselves proud for doing a very unamerican thing, showing up at protests where the only armed individuals are you and your cohort and then murdering people and crying foul that you were being attacked when you brought an automatic weapon to a parade where people hold signs and express discontent, and then when people start cracking windows like fucking super soldiers and start inciting people to riot we don’t call foul and say this is a very different type of protest than the one these people arrived to participate in, you don’t call foul on foreign agents of governments actively seeking to destroy our nation both conservative and democrat, the foul is called on the protestors themselves connecting the voice of the opposition to these instigating actors who could very well have not been connected to the protests at all and could have just been attempting to incite a riot.

And the reason you and I can’t see each other as normal people is because you’ll take these same events.

The tiki torch terror squad
Proud boy violent attacks
The murderer Kyle rittenhouse
Foreign nation sleeper cells

And you’ll call them

Good people
Good people
Good person
Ally

And you’ll think nothing of it at all.

Because to you, a normal person, any normal person could discern the same things that you believe about these events based on the evidence.

But on my side of normal, it’s much the same, except me and my people do not agree that the same things can be discerned based on the evidence. Instead we debate the facts and arrive at a consensus.

You guys just tell a story that you want to believe.

George Floyd was murdered by a boot on his neck for seven minutes cutting off his air supply. Not fetanyl fingers. And counterfeit money isn’t punished by public execution in the America I love.

Kyle rittenhouse murdered people by gunning them down in the street. He showed up with a gun for no reason than to be in the position to use a gun. If I hold the point of a knife to the left of your neck and then say hey to your left ear and you turn towards the sound and impale yourself on my knife. Is it your fault that you died because you technically killed yourself. And technically Kyle rittenhouse was afraid of violence so he brought his gun and then with his gun he brought the violence he was afraid of. Because he’s a coward. Like someone holding that knife to your neck and tapping you on the shoulder so the official record will say that you killed yourself by walking into my knife.
It’s legal for me to stand with a knife isn’t it.
It’s legal to bring a weapon to a protest.
It’s legal to feel afraid of people you knew you were afraid of, hence your gun, and then to gun them down because you felt afraid.

The tiki torch people were not good people. There are no good people among Neo Nazis or white nationalists or christofascists.
Controlling the behavior of others is unamerican.

The proud boys are a terror squad and they’re funded by the people who like to see democrat / anti trump protesters get beat up.

Foreign nations helped get Trump elected by making your wack ass viewpoints and narratives about current events receive widespread support among the uneducated to whom these viewpoints and narratives provided explanations of events that they felt better about than the truth of these events. You’d rather turn on your countrymen than admit you’ve been conned by Putin xi and Trump.

But you’re also a normal person and I understand how much pressure you and yours are holding against each other by insisting that everyone live think and vote the same way.

You’re getting the change you desire. All the civil rights and personal freedoms that women voters helped make possible by creating a voting bloc with educated men has been swept under the rug by your tide of ignorant political action.

But you’ll disagree.

A great new age is coming where ivermectin cures cancer!
Because we believe
Where prayer is in school and religion defines politics!
Because we believe!
Where Russia and China are allies and Canada and Mexico are enemies!
Because we believe.

You guys are the most head in the sand people on the planet.

But you formed a voting bloc. A miraculous one. The most uneducated men our society has ever seen vote, with everyone who makes over a million dollars and all the idiots in between.

It’s your nation, get in front of that tv screen and lie to it.
 
I offer my comment as an olive branch. I’m showing that our disagreements on things cannot be married because we see the same evidence and arrive at polar conclusions. Our worldviews have no overlap.

Except that we both like seeing forums with pictures of heron.

So I know you’re going to report me as is tradition after our every interaction but I do wish you well and I hope that our nation is in the triumph you think it is.

It’s do unfortunate that the triumph of your nation means the subjugation of mine.

And we belong to the same nation

SAD!
 
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