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Health I’ve given up on psychedelics, although saving myself for mescaline

M1sterEd

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Joined
Apr 7, 2025
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Well hell, since mushrooms don’t work on me due to psych meds I’ve stopped trying to trip. It is frustrating having the means to escape reality but hindered by medication designed to prevent psychosis when that is the purpose behind tripping. Mushrooms don’t appeal to me, perhaps because I’ve never had any luck with mushrooms, while on the other hand I can see peyote to be useful. At least that is my hope.
 
Just to prevent you from being disappointed again, if your medication stopped shrooms from having an effect, it's almost guaranteed it will do the same for mescaline. If you need medication to prevent psychosis I would not recommend using psychedelics either way, but if your condition isn't severe, you can always weigh your options and maybe consult your doctor about going off them for the time being. If it's antipsychotics you're using it would probably only take a few days to a week for psychedelics to work again, antidepressants are a different case
 
Not sure peyote is the way forward - san pedro is a lot cheaper. And until you actually try to eat cactus snot I wouldnt get too excited. I spent a week preparing cactus only to take one sip, gag, say "Fuck this" and never got any furthur. I had to buy a red rubber enema hose and squirt it up my ass.
 
If it's antipsychotics you're using it would probably only take a few days to a week for psychedelics to work again, antidepressants are a different case
We really should have a sticky thread on drugs that would affect how a psychedelic works. This question comes up a lot.

MrEd (good name) I see you listed what you take and for what in the combination thread. I do notice sometimes that some people can trip on certain things while other can’t.
 
@M1sterEd

as a kid, aged 5 and 6 I had to wear a leg brace that included special shoes a metal frame covered in padded leather which went higher than my waist and covered my left leg.

I had to be strapped into this thing every day, although for a short time before my parents awoke I could hop on my right foot if I needed to do something.

Being strapped in (so I did not prevent healing of my leg and hip damaged in an accident) was normal for my younger self.

Eventually I learned how to walk without it after healing. I was so happy not to be strapped in, but I never quite got used to being "like" everyone else.
In a way, I am still strapped in to that brace so long ago.

I think that psych meds are a bit like that brace which I wore for a while, It straps you into a form that does not interfere with life's flow at a certain stage.

When you get past that stage, it is good not to be strapped in any more, but in memory, you will always be a bit strapped in.
 
I just wanted to say at the exact moment that I commented on Mr. Ed’s name, someone on TV said Mister Ed. Sort of an odd synchronicity. Gave me a little bit of a hope, for what I don’t know. Ha ha.

Carry on. If anyone wants to list any substances they think would inhibit a trip, start listing and maybe we’ll get a sticky going.
 
Not sure peyote is the way forward - san pedro is a lot cheaper. And until you actually try to eat cactus snot I wouldnt get too excited. I spent a week preparing cactus only to take one sip, gag, say "Fuck this" and never got any furthur. I had to buy a red rubber enema hose and squirt it up my ass.
Imagining what you did with that hose. Can i assume extraction is a pain in the ass.

As that was what i was planning, end up with nice crystal s [in my dream s]
But at least a reduction of cactus vs Mescaline. When im old and grow
San Pedro s instead of Geranium s. Tripping on 1 of the last legal Psychedelic s.
 
Not sure peyote is the way forward - san pedro is a lot cheaper. And until you actually try to eat cactus snot I wouldnt get too excited. I spent a week preparing cactus only to take one sip, gag, say "Fuck this" and never got any furthur. I had to buy a red rubber enema hose and squirt it up my ass.
I've had two failed attempts at san pedro simply because I could not stomach it.. fitting them into 1g pills and swallowing 35 of them was somehow the easiest way
 
Imagining what you did with that hose. Can i assume extraction is a pain in the ass.

As that was what i was planning, end up with nice crystal s [in my dream s]
But at least a reduction of cactus vs Mescaline. When im old and grow
San Pedro s instead of Geranium s. Tripping on 1 of the last legal Psychedelic s.

Its no joke even taking it rectally - first you have to really nip your bunghole tight for fear of anal leakage and hold it up there for 45 mins...but after 5 mins you get stomach cramps and beg God to help you. After 20 mins I finally screamed "No more" and ran to the toilet and shit it all out.

I could never get to crystals - the snot is just too thick and viscous to work with.
 
I've had two failed attempts at san pedro simply because I could not stomach it.. fitting them into 1g pills and swallowing 35 of them was somehow the easiest way

Tried capsuling dried cactus but my God - the nausea was dire. I once dropped some dry pedro into water and it balloons to ten times its original volume and all this awful black shit appears. Imagine that happening in your gut. I was dry heaving for about 3 hours.
 
I've had two failed attempts at san pedro simply because I could not stomach it.. fitting them into 1g pills and swallowing 35 of them was somehow the easiest way
Tried capsuling dried cactus but my God - the nausea was dire. I once dropped some dry pedro into water and it balloons to ten times its original volume and all this awful black shit appears. Imagine that happening in your gut. I was dry heaving for about 3 hours.
Synthetic mescaline is love. Synthetic mescaline is life.
 
You all know you can boil San Pedro tea down until it's thick, then spread it on a cookie sheet and dry it with a fan, right? Scrape the goo up and roll into little pill balls with some sugar, and you don't have to taste it. It's way less plant matter than encapsulated dry powdered cactus.

Will it still cause nausea? Absolutely. Pure mescaline causes nausea. But at least you dint have to drink bitter snot.

Please source your cactus domestically - I just learned that "sustainable" San Pedro is on track to be extinct in the wild in much of its native range due to commercial harvesting.

And OP, mescaline is gentle. If stronger psychedelics can't break through, I don't think it's likely to either.
 
Weird that psychedelic school chart didn’t mention lithium, since it supposedly causes seizures with psychedelics. Just something good for people to know who are on it. Much worse than your drugs just not working.
 
I have a friend who also take some medication which basically prevents him to enjoy mushrooms. But it also prevents most effects of mescaline for him.

Btw. extraction of mescaline is not that difficult at home, I am quite surprised that it's not more popular. Pure mescaline is quite accesible to almost anyone with some skills and access to cactus plant material.
 
I found it a bit boring in comparison to the cactus. It had a much weaker stimulatory feel and didn't last as long, it missed that 'dirtiness' that makes San Pedro so good
Fair enough. I've only ever tried synthetic so have no basis for comparison. Even in it's synthetic form though it's a magical molecule and transcendant when mixed with acid.

I wonder if an anti emetic like metoclopramide or zofran would be enough to inhibit the nausea from the cactus.
 
I have only had Peruvianus that I have had for many many years. Decades. 30 gr of skins, powdered I can get down without issue by tossing and washing. And get this, my last 5 cactus trips I first T&W 15 grams of kratom first. Then a half hour later T&W'd 30 grams of cactus powder. I usually have like 2 cream cheese bagels to nibble on. Something "bready" always helps the stomach settle. Then I would have a smoke an hour in and wham, magical day with no nausea.

I can get nausea too from a substance. Morning Glory seeds can do it to me. But never things like mushrooms or 2C-B. For some reason nausea is not a part of my tripping. Yet I have had friends that had to puke every time they did mushrooms.

Never had just mescaline. Just cactus and I love what it does.
 
Synthetic mescaline is love. Synthetic mescaline is life.

Yeah I bought some but I think it must have been allescalline or whatever a fake version is - really intense for the first 2 hours - like a strong dose of 2c-b - then the trip just completely stopped dead.
 
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