Stimulants Dexamphetamine only lasting an hour and really inconsistent, any advice?

[sadmachine]

0 tolerance, only used 2-3 times in my life.

I dropped 10mg and for the first hour I felt all the typical benefits I was looking for but after that it's just swings and roundabouts. I took another 10mg one hour in when I felt it suddenly just falling off. One minute I want to talk everyone's heads off and listen deeply, the next I feel like a cold emotionless robot. One minute my libido skyrockets and I'm suddenly really horny for my partner, the next 0 libido. I suddenly feel angry/frustrated for 5 mins and then I don't. I never experienced this in my weekend warrior meth days (15 years ago) it was always heaven followed hell.

I had plans to get a lot of work done but now 2 hours and 20mg in I'm not getting the effects I'd hoped for. I wasn't really looking for the euphoric high I just wanted a boost to get things done and maybe express myself to my girlfriend and friends in ways that I normally would be too inhibited/unmotivated to.

I should also add I did eat quite a lot (3mg) of clonazepam yesterday, and 2mg the day before, so maybe that's diminishing it. My other theory is that for my purposes maybe only 5mg is what I need. I'm going to give Lisdexamfetamine a try in the coming weeks maybe that will provide me with something more to what i'm looking for. Another theory I have is that im overthinking it too much and having expectations, perhaps if I just forget/ignore that I took anything and go about my day as usual maybe I'll notice the effects more.

Any tips or tricks would be greatly appreciated, last time coffee just made the sides worse, nicotine kind of helps only if I constantly keep a zyn in or chain smoke. Overall it's very up and down, does anyone else experience this? Did I just get my doses/timing wrong perhaps?

 

[chippermonk]

I'm not any expert but I never cared much for dex. It never gave me much of a good feeling like with other stims. The one time I took a high dose, it was awful. Anxiety and jitters and no euphoria. Lisdex seemed a little more low key, consistent, long lasting, but it's basically just a slower delivery system for dex.
Personally, I like Ritalin better than dexies, but always at low doses for any of them if I'm actually trying to do anything productive. If you truly have no tolerance and just want to function better, try 2.5 mg of dex. But I suspect maybe you want a little euphoria to go with your work? Tricky managing that, at least in my experience.

 

[sadmachine]

But I suspect maybe you want a little euphoria to go with your work? Tricky managing that, at least in my experience.

Spot on. I'm telling myself "I just want the motivation and focus" but internally I'm aware that part of me is chasing that dragon. Provided I can stick to it (lol) I think the play here is to use them sparingly at 5mg with 1 or 2 boosters as needed, and then once in a blue moon drop 20-40mg at once when I'm on a night out/drinks and company type sitch.

 

[tryptakid]

0 tolerance, only used 2-3 times in my life.

I dropped 10mg and for the first hour I felt all the typical benefits I was looking for but after that it's just swings and roundabouts. I took another 10mg one hour in when I felt it suddenly just falling off. One minute I want to talk everyone's heads off and listen deeply, the next I feel like a cold emotionless robot. One minute my libido skyrockets and I'm suddenly really horny for my partner, the next 0 libido. I suddenly feel angry/frustrated for 5 mins and then I don't. I never experienced this in my weekend warrior meth days (15 years ago) it was always heaven followed hell.

I had plans to get a lot of work done but now 2 hours and 20mg in I'm not getting the effects I'd hoped for. I wasn't really looking for the euphoric high I just wanted a boost to get things done and maybe express myself to my girlfriend and friends in ways that I normally would be too inhibited/unmotivated to.

I should also add I did eat quite a lot (3mg) of clonazepam yesterday, and 2mg the day before, so maybe that's diminishing it. My other theory is that for my purposes maybe only 5mg is what I need. I'm going to give Lisdexamfetamine a try in the coming weeks maybe that will provide me with something more to what i'm looking for. Another theory I have is that im overthinking it too much and having expectations, perhaps if I just forget/ignore that I took anything and go about my day as usual maybe I'll notice the effects more.

Any tips or tricks would be greatly appreciated, last time coffee just made the sides worse, nicotine kind of helps only if I constantly keep a zyn in or chain smoke. Overall it's very up and down, does anyone else experience this? Did I just get my doses/timing wrong perhaps?

What other medications are you on regularly, and what other drugs are you using.

Dexamphetamine should be active (ir) 4-6 hours at least, 6-8 if you eat a low sugar/low acid diet (fats vs. sugars).

Other medications like welbutrin or effexor can also modulate the effects of amphetamine, as can supplements like NAC. Without knowing what else you're taking (aside from the benzo) it's hard to know what's going on.

 

[sadmachine]

What other medications are you on regularly, and what other drugs are you using.

Dexamphetamine should be active (ir) 4-6 hours at least, 6-8 if you eat a low sugar/low acid diet (fats vs. sugars).

Other medications like welbutrin or effexor can also modulate the effects of amphetamine, as can supplements like NAC. Without knowing what else you're taking (aside from the benzo) it's hard to know what's going on.

Cheers for your response tryptakid,

January to Feb: on and off binging oxycodone (40-80mg a day)

March until a week ago: mid-strength cannabis daily around 1-2g.

March to April: 10mg of an ssri (escitolopram). This made cannabis supremely enjoyable during, but has seemingly permanently changed how ket/oxy/clonazepam effects me, I seem to get much less positive effects and have a lot higher tolerance to all 3 than I ever had during the peak of my using, even after a break.

I haven't used Clonazepam in almost a year, but have used it daily for the past 4 days, never abused it/dosed high/built a tolerance but again since the SSRI it has a lot less anxiolytic & especially hypnotic effect.

Also a nicotine slave, pouches and those horrid vapes, no science here but Ive often suspected that constantly needing and stimulating the release of dopamine through nic might have something to do with my lacklustre drug experiences. (wishful thinking probably).

I've been weight training & tracking my diet for 3 months now, 150g protein daily, plenty of fruits/veg for the micronutrients and I occasionally take a dose of magnesium glycinate (200mg) to aid sleep. Overall in pretty good physical shape/health.

Not sure if this tells you anything, but I frequently found oxycodone (even in the early days) quite dysphoric/bit of anhedonia.

 

[tryptakid]

Weight training should occur in the evening when using stimulants fyi - nicotine has a funny relationship with stimulants. it boosts and it reaps. I've found my most effective amphetamine regimen is this:

5-10mg of instant release dexmethamphetamine combined with 10mg of xr dexamphetamine.
I skip the xr on weekends or days I'm not working. If I need a lot of focus, I increase the ratio of dexamphetamine to dexmethamphetamine.

Cheers for your response tryptakid,

January to Feb: on and off binging oxycodone (40-80mg a day)

March until a week ago: mid-strength cannabis daily around 1-2g.

March to April: 10mg of an ssri (escitolopram). This made cannabis supremely enjoyable during, but has seemingly permanently changed how ket/oxy/clonazepam effects me, I seem to get much less positive effects and have a lot higher tolerance to all 3 than I ever had during the peak of my using, even after a break.

I haven't used Clonazepam in almost a year, but have used it daily for the past 4 days, never abused it/dosed high/built a tolerance but again since the SSRI it has a lot less anxiolytic & especially hypnotic effect.

Also a nicotine slave, pouches and those horrid vapes, no science here but Ive often suspected that constantly needing and stimulating the release of dopamine through nic might have something to do with my lacklustre drug experiences. (wishful thinking probably).

I've been weight training & tracking my diet for 3 months now, 150g protein daily, plenty of fruits/veg for the micronutrients and I occasionally take a dose of magnesium glycinate (200mg) to aid sleep. Overall in pretty good physical shape/health.

Not sure if this tells you anything, but I frequently found oxycodone (even in the early days) quite dysphoric/bit of anhedonia.

 

[emkee_reinvented]

0 tolerance, only used 2-3 times in my life.

I dropped 10mg and for the first hour I felt all the typical benefits I was looking for but after that it's just swings and roundabouts. I took another 10mg one hour in when I felt it suddenly just falling off. One minute I want to talk everyone's heads off and listen deeply, the next I feel like a cold emotionless robot. One minute my libido skyrockets and I'm suddenly really horny for my partner, the next 0 libido. I suddenly feel angry/frustrated for 5 mins and then I don't. I never experienced this in my weekend warrior meth days (15 years ago) it was always heaven followed hell.

I had plans to get a lot of work done but now 2 hours and 20mg in I'm not getting the effects I'd hoped for. I wasn't really looking for the euphoric high I just wanted a boost to get things done and maybe express myself to my girlfriend and friends in ways that I normally would be too inhibited/unmotivated to.

I should also add I did eat quite a lot (3mg) of clonazepam yesterday, and 2mg the day before, so maybe that's diminishing it. My other theory is that for my purposes maybe only 5mg is what I need. I'm going to give Lisdexamfetamine a try in the coming weeks maybe that will provide me with something more to what i'm looking for. Another theory I have is that im overthinking it too much and having expectations, perhaps if I just forget/ignore that I took anything and go about my day as usual maybe I'll notice the effects more.

Any tips or tricks would be greatly appreciated, last time coffee just made the sides worse, nicotine kind of helps only if I constantly keep a zyn in or chain smoke. Overall it's very up and down, does anyone else experience this? Did I just get my doses/timing wrong perhaps?

Seem s almost like the description of MethylPhenidate [MPH] IR, to me.
My dr, psychiatrist. That did see the advantages of dextro-Amphetamine.
Took me a long search, endurance persistence and knowledge on the subject.

Like me vs MPH, which wasn t the right med for me effect & side wise.
Short duration anorexic/ tremor s/ raised heart rate/ the sweat s and re-bound s.
He started me on a lower dex does then you.
Not the equivalent of MPH right away.
Difference was obvious, is became relaxed instant. Again.

While i had tolerance due to MPH, he still started me on 5x5 mg.
Which id didn t feel, the 5x5x5 when noticment s of improvement in focus,
and taming hyperactivity. Occured.
The dose raised slowly to the optimum, att via 7.5x7.5x7.5 to 10x10x10.
Ended at 15x10x10, which i currently hardly take, most day s 15x10.

So total opposite, you could start over, that way i was put on and slowly.
Seek a dose that work s, without side effect s [only one s i had: dry mouth first few month s/ accidentally taking a double dose in the morning.
So 30mg, which is a to much 're-creative' i get the effect you describe above.

Minus the short duration, and falling of. Sound s as re-bound is associate with MPH.
Dextro-Amphetamine always been smooth up and down, despite if doudle dosed [orally accidentally doubled]. Get talkative, less functional, stimulatied and then realise i took the morning dose twice. You might need XR.

Or Lis-dextro-Amphetamine, so it sound s.
Maybe you are a fast metabolizer, maybe on a to high dose ?
Hope it helps 'sadmachine', eMKee took a long time getting it right.

Many dr,/ Psychiatrist passed the review all different opinion s on how to use.
And some knew nada. Hadn t a clue what patient s experience on the meds.

 

[pnillyg]

Curious if booster doses help with the comedown and if so is it possible to utilize without disrupting too much sleep?

 

[emkee_reinvented]

Curious if booster doses help with the comedown and if so is it possible to utilize without disrupting too much sleep?

At the end of my MPH period i was taking 5 mg at a time.
So apparently the bio-availability is high for my body.
But the Pharma-kinetic s of MPH are very irredic from person to person.
So i needed to dose another 5 mg, every 1.5/ 2 hour to try keep steady.

But not to heavy, trying to find the sweet spot base-line.
A spot only existing in my mind, not in reality.
It did had no effect on the re-bound. The most hated side effect imo.
Maybe you call that 'the comedown' ?, i just found it irritating mainly for other s.
Though its tiring being ANIMALISTIC WILD while coming down,
and effecting your rest, a fucked up medication.

Clockwise you could count on it, 2 hour maybe a bit more.
And i d go 'bezerk', like i had ADHD times 10.
So that still interrupted my sleeping pattern,
and was a burden for me as to other s this side effect,
UN_ACCEPTABLE, just like INSOMNIA due to the rebound.

 

[sadmachine]

I'm ready to give up on these. Today was

10:30 - 10mg
1:00 - 10mg
3:00 - 5mg
8:45 - 20mg


It's been over an hour since I took the 20mg (largest dose i've ever taken) and it didn't do a single thing. About 15 minutes after I took it my pupils dilated a little briefly and I felt a glimpse of energy but it was short lived. I don't even really have sides/anxiety let alone drive/motivation/focus. I'm not even uncomfortably stimmed out, just flat, no energy and irritable. Can't even hyperfixate on a good article and lose track of time.

I have had very few meals the past 3 days of this binge but ive had a 2mg clonazepam each night to sleep and slept fine. This is just a wild stab in the dark but maybe it's not stimulating any dopamine release because I haven't eaten enough food (is dopamine produced from food?) I ate a good sized lunch with plenty of pulled pork today and immediately after it it killed any stim effects and I got sleepy and relaxed. I've ate nothing else since. I've also had some diarrhoea this morning from yesterdays magnesium and overall gurgling/strange stomach sounds so perhaps not much is being absorbed.

I'm really frustrated as not only did I waste money but I made some sacrifices to get these in hopes that I could have a few days of getting some real solid work done and maybe have a few great chats with my partner and in the end it's mostly been a waste. I do think that especially today I was preoccupied with expectations when instead I should have just taken the pills and gone about my day as if I didn't. Instead I sat at the computer all day waiting, checking the clock to see how long it has been since the last dose.

Just occurred to me that i've only eaten 1 meal today (its 10pm now) and 1 yesterday, could the lack of food = no dopamine production for the dex to release?

 

[someguyontheinternet]

I'm ready to give up on these. Today was

10:30 - 10mg
1:00 - 10mg
3:00 - 5mg
8:45 - 20mg


It's been over an hour since I took the 20mg (largest dose i've ever taken) and it didn't do a single thing. About 15 minutes after I took it my pupils dilated a little briefly and I felt a glimpse of energy but it was short lived. I don't even really have sides/anxiety let alone drive/motivation/focus. I'm not even uncomfortably stimmed out, just flat, no energy and irritable. Can't even hyperfixate on a good article and lose track of time.

I have had very few meals the past 3 days of this binge but ive had a 2mg clonazepam each night to sleep and slept fine. This is just a wild stab in the dark but maybe it's not stimulating any dopamine release because I haven't eaten enough food (is dopamine produced from food?) I ate a good sized lunch with plenty of pulled pork today and immediately after it it killed any stim effects and I got sleepy and relaxed. I've ate nothing else since. I've also had some diarrhoea this morning from yesterdays magnesium and overall gurgling/strange stomach sounds so perhaps not much is being absorbed.

I'm really frustrated as not only did I waste money but I made some sacrifices to get these in hopes that I could have a few days of getting some real solid work done and maybe have a few great chats with my partner and in the end it's mostly been a waste. I do think that especially today I was preoccupied with expectations when instead I should have just taken the pills and gone about my day as if I didn't. Instead I sat at the computer all day waiting, checking the clock to see how long it has been since the last dose.

Just occurred to me that i've only eaten 1 meal today (its 10pm now) and 1 yesterday, could the lack of food = no dopamine production for the dex to release?

you are absolutely correct on your last statement!

this is the reason I'm always beating the drum of good diet as a baseline, our bodies need raw materials to do repairs and make neurotransmitters

amino acids from eating proteins, such as tyrosine, is used as the raw material to make both norepinephrine as well as dopamine

eating enough calories and protein throughout the day, and especially plenty before sleep, is vital for maintaining mood and energy

when we sleep our bodies use that rest time to regenerate and produce new transmitters

I had actually just popped into the thread to say something about food but it seems you beat me to it!

 

[sadmachine]

Thanks for your response someguyontheinternet

God do I feel like a fool.

Had a bowl of tortellini and some whey and instantly mood is improved. Now i'm just wondering had I eaten properly yesterday and today would I have not wasted all those pills

The worst part is i've been eating in a pretty strict calorific surplus and decently high protein (150g) for the past few months so my poor body must have been absolutely distraught trying to keep me functioning off ultra low cals the last few days. It was so disappointing taking a large dose and having no effect, especially considering I took time off work for this.

Reminded me of being in the club back in the day waiting for the e to kick in only to realise after hours of waiting you got sold a dud.

 

[someguyontheinternet]

Thanks for your response someguyontheinternet

God do I feel like a fool.

Had a bowl of tortellini and some whey and instantly mood is improved. Now i'm just wondering had I eaten properly yesterday and today would I have not wasted all those pills

I think we've all been there at some point, I sure have

 

[emkee_reinvented]

I think we've all been there at some point, I sure have

Sure have too, MPH should maybe mentioned its extremely anorexic.
Only mentioned dextro-Amphetamine having no such side effect s.
Only 1, in the beginning dry mouth, when i was on thatt i quickly regained lost weight.

What i don t get in the dosing schedule is that the lsat dose.
Seems to be the biggest 20 mg, why, isn t that asking for sleep disruption ?

 

[sadmachine]

What i don t get in the dosing schedule is that the lsat dose.
Seems to be the biggest 20 mg, why, isn t that asking for sleep disruption ?

I was frustrated that I wasn't getting any results so I thought if this doesn't do the trick, nothing will.

I have a 2mg klonopin and some magnesium on standby for bedtime so should be fine.

Tomorrow I'll return to work, gym and responsibilities and maybe in a week I'll experiment some more, maybe with a bit more emphasis on responsibility next time.

 

[Vanilla_Incense]

10:30 - 10mg
1:00 - 10mg
3:00 - 5mg
8:45 - 20mg

Sounds like the type of doses I would have taken to stay up all night studying at university (except I would have taken 20mg at the start). I've never found it to give a particularly good high (only really good for focus and staying awake) unless you take it way too far and do 80-100mg over the course of a night (although I wouldn't recommend as the come down is pretty harsh (especially if you've also been drinking ))

ps psychonaut wiki says 30mg+ is a high dose, so I'm not sure doing as much as I've said is the best idea from a harm reduction perspective

If you can't get the desired effect you could also experiment with different ROA. I've found it to be more potent when snorting it although with this ROA you should consider that I'm pretty sure they add something in it which makes it bad for your health to snort it (meant to help stop abuse but makes the consequences worse ). I forgot exactly what is added maybe someone else can remember

 

[sadmachine]

I saw an old post last night about a guy who water extracted the binders then evaporated and used to snort the remaining powder. I'm not sure if posting a thread asking how to do it would be harm reduction or not.

I have snorted them a few times and it was good but that much binder up my nose.... no thank you. Especially considering out of all that powder only 5mg is the active good stuff.

Snorting oxynorm capsule powders twice gave me a thunderclap level migraine with power vomiting. It was the single most painful experience of my life, like getting hit with a hammer every time I retched. Which never made any sense to me as the 60mg of oxy in my system surely should have been dulling my ability to feel pain.


15mg 2 hours ago made me irritable and non-talkative. Damn. Was hoping to have a great chat with the other half and text some friends.


EDIT: Avoiding hyperfixating on one thing for long periods and reminding myself to do something new every half hour/hour seems to have a tremendous effect in prolonging the positives and avoiding fluctuating moods. This may just be my personal chemistry but if you find this thread and can relate, worth trying.

Also anything that dumps your dopamine below baseload (post-ejaculation for men) or going without nicotine if you are dependant also seems to mess heavily with mood.

As for food you need to be proactive especially if you've had a day or 3 where you didn't eat enough. According to what I could find on the topic, it takes around 1-3hrs for the protein to be digested and broken down into the amino acid tyrosine and then anywhere from 30 mins-3 hours for that Tyrosine to cross the blood-brain barrier. Once its in the brain it'll be another couple hours before it's converted to l-dopa and finally dopamine. Not a fast process, looking at 3-6 hours in total. Stay on top for best results regardless of whether you're using them recreationally or using them therapeutically.