• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Harm Reduction Kava + SNRI combo

D

Deleted member 290563

Greenlighter
Joined
May 23, 2013
Messages
9,034
Location
Silicodone Valley
I didn’t see anything on this site but found some mixed reviews online for the combo of kava and SNRIs (ie duloxetine).

Kava has some MAOI activity. Seems like a bad combo on paper and a couple of negative reports on Reddit. Some alleged metabolic competition too between the two alleged on Reddit which could also cause problems.

Anyone tried this combo?
 
I've never tried with an SNRI but I'm fairly certain that I have with Mirtazapine. Mirtazapine has a different mechanism of action than SNRIs but from what I remember there was no interaction. I'd be more cautious with an SNRI though. Mirtazapine seems to be more forgiving in combinations than SNRIs and SSRIs. At the very least I'd either skip that days SNRI dose or lower significantly. However, I always think that its best to err on the side of caution and avoid the combo until you get more replies.
 
I really feel like I might do this because I’m desperate to get fucked up.

Someone talk me out of this. I keep telling myself if I just do a little bit it will boost my serotonin to a recreational level but not toxic level.
 
LucidSDreamr said:
I didn’t see anything on this site but found some mixed reviews online for the combo of kava and SNRIs (ie duloxetine).

Kava has some MAOI activity. Seems like a bad combo on paper and a couple of negative reports on Reddit. Some alleged metabolic competition too between the two alleged on Reddit which could also cause problems.

Anyone tried this combo?
Click to expand...
I believe I read that one of the main kavalactones had significant norepinephrine blocking pharmacology. May be related to these negative reviews.

Have you tried kava before?
 
LucidSDreamr said:
I really feel like I might do this because I’m desperate to get fucked up.

Someone talk me out of this. I keep telling myself if I just do a little bit it will boost my serotonin to a recreational level but not toxic level.
Click to expand...
Kava isn't a good drug to get fucked up on.

I've had some decent buzzes from it, but it's short lasting. 90 min later whatever buzz I had is gone and replaced with a headache and stomach ache. I've never had any good sedative high from it, but maybe due to cross tolerance from alcohol.

Every time I try to get high on it, I always end up with the side effects ruining the mild buzz it does provide. Kava always makes me feel like shit in the end for many hours afterwards. I've tried to make it work. I've spent a few hundred dollars on various products. I gave up on it.

Whatever high it does provide is nothing like a drug of abuse imo.
 
You must log in or register to reply here.
Top