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🌟🌟 Social 🌟🌟 Rectify's molecular poetry thread

My god! that's a whole heap of fluorines! Does someone offer the precursor or would you have to DAST your own precustor?
 
There is a way to search to see if a chemical is commercially available or not.
 
Inspired by Smyth2,

1-(4-fluoro-3-trifluoromethylphenyl)-2-methylaminopropane.png


THE_SMITHS
1-(4-fluoro-3-trifluoromethylphenyl)-2-methylaminopropane
 
You seem to prefer your methamphetamines over regular benzedrine for some reason.
 
Mate - I don't touch stimulants beyond caffeine. I'm quite capable of being anxious without chemicals. In fact, I don't consume anything not prescribed and I don't even like HAVING to take those.

I also find the chemistry sort of dull. Once you have seen a few clandestine labs, you quickly decide that no, you don't want to put ANYTHING made that way into your body.

I like opioid chemistry BECAUSE nobody has been able to find a set of rules. It's a genuine unknown where an independant researcher can genuinely improve upon that which is known. But I don't go anywhere NEAR breaking the law, ever.
 
This is just analogs anyway you need the original Bruce Horrom patent i cited above.
pubchem.ncbi.nlm.nih.gov

1-[4-Fluoro-3-(trifluoromethyl)phenyl]propan-2-amine

1-[4-Fluoro-3-(trifluoromethyl)phenyl]propan-2-amine | C10H11F4N | CID 79020960 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
pubchem.ncbi.nlm.nih.gov

1-[3-Fluoro-4-(trifluoromethyl)phenyl]propan-2-amine

1-[3-Fluoro-4-(trifluoromethyl)phenyl]propan-2-amine | C10H11F4N | CID 103694471 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
but the compound you called Snoopy (i called it Triflutamine or Trifluorex) looks a most interesting compound to study.
 
I found a new drug called IDDC that looks interesting:

Eckard Weber, John Keana, & Peter Barmettler, WO1990012575 (Oregon State Board of Higher Education, Oregon State).
Gee KR, Barmettler P, Rhodes MR, McBurney RN, Reddy NL, Hu LY, Cotter RE, Hamilton PN, Weber E, Keana JF. 10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands. J Med Chem. 1993 Jul 9;36(14):1938-46. doi: 10.1021/jm00066a002. PMID: 8101572.

It shares the same precursor that is used to make Diphenidine, namely 1,2-diphenylethylamine.
 
Well, isophenidine was the much better product. Bu as stated, the IDIOTS in the lab bought something like 1000l of piperidine so we VERY keen that dipenidine analogues were the way.

They EVEN had the cheek to say 'oh, we can't make the N-isopropyl because of the low BP of the amine'. So I sent a RT route with quantitative yields and methanol as solvent... and they STILL tried to tell the boss they couldn't make it...

Funny - the boss sacked them quite soon afterwards. If I take a man's dollar, I work to make the man money. The labrats were only interested in their own cut. Understandable - But don't take a banana to a knife-fight if you intend to argue facile syntheses.

I ASSUME these compounds to be more potent - but I can make isophendine for about £400/Kg - see also 'very facile indeed'.
 
This agent is worth taking a look at:
BRN 2382808
11-Dimethylamino-9,10-dihydro-9,10-ethanoanthracene
[4053-11-6]

DE1291743 idem Herbert Schroter & Daniel A Prins, US3519718 (1970 to Novartis Corp).
Boissier JR, Ratouis R, Dumont C, Taliani L, Forest J. Synthesis and pharmacological properties of new 9,10-dihydro-9,10-ethanoanthracene derivatives. J Med Chem. 1967 Jan;10(1):86-91. doi: 10.1021/jm00313a018. PMID: 4382229.
Herbert Schroter & Daniel A Prins, US3422104 (1969 to Novartis Corp).
 
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4DQSAR said:
Mate - I don't touch stimulants beyond caffeine. I'm quite capable of being anxious without chemicals. In fact, I don't consume anything not prescribed and I don't even like HAVING to take those.

I also find the chemistry sort of dull. Once you have seen a few clandestine labs, you quickly decide that no, you don't want to put ANYTHING made that way into your body.

I like opioid chemistry BECAUSE nobody has been able to find a set of rules. It's a genuine unknown where an independant researcher can genuinely improve upon that which is known. But I don't go anywhere NEAR breaking the law, ever.
Click to expand...
I think the opioids are likely that way because the natural ligands are polypeptides rather than small molecule transmitters

Likely other receptors that respond to endogenous polypeptides are similar
 
Here's another good one (also made from anthracene):

[1] Rajagopalan, P. (August 1984). "Synthetic CNS agents. 1. (.+-.)-1,2,3,4,4a,5,10,10a-Octahydro-5,10[1',2']-benzenobenz[g]isoquinoline hydrochloride. A new, highly potent, potential antidepressant". Journal of Medicinal Chemistry. 27 (8): 946–947. doi:10.1021/jm00374a002.
[2] Rajagopalan, P. (22 January 1985). "ChemInform Abstract: SYNTHETIC CNS AGENTS. 1. (.+-.)-1,2,3,4,4A,5,10,10A-OCTAHYDRO-5,10(1′,2′)-BENZENOBENZ(G)ISOQUINOLINE HYDROCHLORIDE. A NEW, HIGHLY POTENT, POTENTIAL ANTIDEPRESSANT". Chemischer Informationsdienst. 16 (3). doi:10.1002/chin.198503229.
[3] Parthasarathi Rajagopalan, US4351836 (1982 to Bristol Myers Squibb Pharma Co).
[4] Zhang Hui, CN101696187 (2011 to Xuzhou College of Industrial Technology).
 
1-phenyl-1-methylamino-2-methylaminopropane.png


KERMIT_THE_FROG
1-phenyl-1-methylamino-2-methylaminopropane

Probably not active, I Guess.
 
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