🌟🌟 Social 🌟🌟 Rectify's molecular poetry thread

[Rectify]

LES_MISERABLES
1-phenyl-1-carboethoxy-3-diethylamino-1-azabutane

 

[Smyth2]

https://sci-hub.st/https://doi.org/10.1002/ardp.19803130206

In short - much like the original but a bit worse for many reasons e.g. hydrolysis of Si-O bond. Nothing serious, just a lot of little things like that.

I think the value of this paper is that it provides a lot more information on clofenciclan itself. It's essentially a non-rigid, achiral, synthetically simple bioisostere of cocaine. It's even active at around the same dose and even numbs the nose like cocaine. Sounds like it also stresses the heart just like cocaine ;-)

That or the p-Cl homologue of dimethocaine (chlorocaine). But the KEY to the latter is to know that the sulfate salt is water soluble while the hydrochloride salt is almost insoluble i.e. you cannot snort the hydrochloride salt of chlorocaine. The sulfate IS soluble - you can snort that.

I hate cocaine and I hated clofenciclan and 'chlorocaine' for precicely the same reasons.

I am not 'experienced' with any of the three having tried each just twice. First the numbing of the nose and that feeling that their is a drip in the back of one's throat. At the same time intense anxiety develops over a couple of minutes. Then the akathisia. Be it tapping your finger, bouncing your leg by applying pressure to the sole of the foot or just tearing a bus ticket into ever tinier squares, it's impossible to do NOTHING with one's body. Then it sort of levels off with what I ASSUME others like but to me is a fragile, plastic euphoria with a supression of happiness.

I reallty don't underatand quite what people like about it.

Chlorocaine pointed to procaine on the pubchem website. I tried inputting the structure of dimethocaine but substituted with a para-chloro but only retrieved 0 hits. If this compound were invented you would be the first person to have thought of this compound. Wait but you are saying you actually tried some already? I guess that's possible also.

Have you actually tried grey market clofenciclan? I've never seen it for sale either.

 

[Smyth2]

LES_MISERABLES
1-phenyl-1-carboethoxy-3-diethylamino-1-azabutane

Not sure what you are up to here but it looks most similar to Phenampromide.

 

[4DQSAR]

Chlorocaine pointed to procaine on the pubchem website. I tried inputting the structure of dimethocaine but substituted with a para-chloro but only retrieved 0 hits. If this compound were invented you would be the first person to have thought of this compound.

Well, in the end nitrocaine was chosen for dumb reasons but I had a sample of chlorocaine sulfate made and was unsurprised that it was subjectively identical to cocaine... well, slightly longer duration but essentially the same.

But you can overlay chlorocaine, chlofenciclan and para chlorococaine in their respective minimum-energy conformations.

-Aromatic ring (optionally meta and para substituted)
-Quaternary carbon (or bioisostere thereof)
-Oxygen bridge
-Methylene bridge whose role is to place the basic nitrogen in the appropriate spatial relationship to aromatic.
-Tertiary amine with lone-pair in appropriate orientation.

The ionic site is ignored because placing three moieties in specific spatial relationships to each other is obviously an order of magniture more complex and studies showed that things like fluorococaine will still reasonable active. The aromatic and nitrogen's N: are the most important bits.

It's simply researchers working out what the key moieties are and what their spatial relationships are. Once again public sources note the important of the aromatic but not of the oxygen bridge (bond angle).

I told you that 90% of the things made were bbandoned and because someone had ordered a huge supply of the nitrocaine precursor, we were stuck with that decision.

I don't like cocaine, I have no interest in producing a cocaine analogue, I'm merely pointing out that there are examples of non-rigid compounds that have the same activity. The p-Cl increases affinity which overcomes the lack of an ionic site and the fact that those synthetics aren't rigid. There are four key moieties but there are innumerable medicines that do not fulfil the entire criteria but importantly - WORK. Heuristics was applied.

BTW it's also worth overlaying amfonelic acid. That forgoes key moieties but being rigid, works. Nowhere neaely as potent as some of the WIN series but still quite complex so while I believe it did briefly turn up on the RC market, it disn't last long. BTPC likewise - it was used in fake MDMA tablets but again, disappeared. I would estimate due to the cost-per-dose. That's an example of heuristic not being applied. I can only guess there was an assumption that production costs would go down... and didn't.

I don't really name things, or rather, I simply apply names that are descriptive. No idea where clofenciclan got it's name. I would guess that it's descriptive but in German. Little project for you - figure out why the name clofenciclan was adopted.