Hi everybody,
I am a clandestine chemist and during 10 years I've made plenty of new drugs : first we discussed about the molecule with neuropharmacologist, then I made it, then I tested them on myself until low/medium dose before destroying them in permanganic acid. I've never sold anything, just single test to see the activities and the effects like shulgin did. My goal was the release a PiHKAL-like book with all the molecules beyond phenethylamines and tryptamines including from PCP-like to opioids. but I decided to never publish it because of... RC Companies ! 5 years ago I stopped doing this kind of research on psychoactive but still doing clandesting chemistry to make new anti-cancers synthesis pathway or making new human pheromones.
I hate the RC compagnies because of the complete lack of proffessionnalism not because of the buisness of selling drugs. Did you remember the website "HCl Research" based in Germany how proffessional they were ? They were discrete and shipped only good molecules probably made in germany. But after this time when the new drug "mephedrone" arrived on the market everything broke up into pieces and the full market went completely bullshit. The chinese lab were competing togheter and made impure product at the lowest price possible and send kilograms to hundred of new website (mainly UK-based), then the clubber bought from there and resold the mephedrone at the local parties. Neither the maker nor the website reseller nor the clubbers have any knowledge in chemistry or basic pharmacology, they just want their little bags of drugs. And the chinese knew that and started doing absolute shit.
They sold very impure products ( a batch of 4-MeO-PCP was analyzed and contained 40% cyanide) claiming its 99.9999% just because they know the product will finished on the street and will be never analyzed by the customers. When a drug is banned they made analogue without asking the neuropharmacologist or doctor about eventual toxicity and started selling neurotoxic mephedrone analogues. For exemple they sold a synthetic cannabinoid that will be cleaved to naphtylamine by the liver and any person who has little knowledge in toxicity knows its one of the most potent carcinogen. But they didn't care, they sold "not for human consumption" anyway, the cancers are not their problems.
But at the times there was still a red line to not cross : selling deadly opioids. After a few years the red line was finally crossed and they directly sold fentanyl analogues by kilogram directly to the mafia leading to the well known fentanyl crisis you have seen in the media...
About 10 years ago I was discussing with a russian chemist about making the benzofurane analogue of MDMA. Now they are known as 5-APB and 6-APB but back then I called them "furamphetamines". He want to make the 5-isomer with the oxygen in para but me I prefer to let the oxygen in meta because of PMA toxicity. So we bet who was right. One day he wrote me he won the bet because the molecule is finished and has MDMA activity without the need for N-methylation, he also told me its even better than MDMA. But me , I finished my molecule and test it and YEEEES it is active and MDMA-like ! So I published the molecular structure on my blog along with the bioassays and commentaries.
A few month later I found a website selling what ? Yes, 5-APB AND 6-APB under the fancy name "benzo fury", ours furamphetamines !!I don't try to let beleive I invented the molecule, no because they were already patented, but I was the first to try and explain the activity. So based on our research the companies ordered kilograms to chinese labs and started making huge amount of money with no respect to the molecules. I ordered a sample and analyzed it and it was only 85%, the rest is other isomer and unreatced products... From now I immediatly removed the blog and did not published anything anymore but I kept doing research.
I made and tested a lot of new rings : benzimidazole, benzisoxazoles, and so on. And I find a new ring with MDMA-like qualities but never plublished anything. And guess what ? Today I find the ring on.... Wikipedia ! And with plenty of other rings ! Apparently there are new neuropharmacologist that made new analogues, tested them and published in 2024. I haven't read the pubs yet, but it is question of time for the RC companies to read it and ordering kilograms of new molecules.... I bet its that will happened in 2025.
I thought researchers in universities stop publishing after Ralf Heim discovered bomamines (NBOMes)and RC companies spread them all across the world and killed thousands of people of overdoses due to the unsafty profiles of N-BOMe. By the way, with the help of a friends who works with IA neurologic software, I made new N-alkylated 2C-X with the activity starting at 25 ug ! Way more potent than LSD ! But if I publish the structure it will be completely legal in all the world because not based on N-Benzyl mioety and RC compagnies will sold them again and killing a lot more of people...
Now I am fed up with how the RC market has turned and how the product are sold. It can be easy to start a new website selling controlled molecules analyzed by GC/MS or NMR and selling to intelligent people but no ... money talks....
And who knows what happened to the website "blacklight.in" for advanced drug discussion ???
Thank you for reading,
Dr.Methyl
I am a clandestine chemist and during 10 years I've made plenty of new drugs : first we discussed about the molecule with neuropharmacologist, then I made it, then I tested them on myself until low/medium dose before destroying them in permanganic acid. I've never sold anything, just single test to see the activities and the effects like shulgin did. My goal was the release a PiHKAL-like book with all the molecules beyond phenethylamines and tryptamines including from PCP-like to opioids. but I decided to never publish it because of... RC Companies ! 5 years ago I stopped doing this kind of research on psychoactive but still doing clandesting chemistry to make new anti-cancers synthesis pathway or making new human pheromones.
I hate the RC compagnies because of the complete lack of proffessionnalism not because of the buisness of selling drugs. Did you remember the website "HCl Research" based in Germany how proffessional they were ? They were discrete and shipped only good molecules probably made in germany. But after this time when the new drug "mephedrone" arrived on the market everything broke up into pieces and the full market went completely bullshit. The chinese lab were competing togheter and made impure product at the lowest price possible and send kilograms to hundred of new website (mainly UK-based), then the clubber bought from there and resold the mephedrone at the local parties. Neither the maker nor the website reseller nor the clubbers have any knowledge in chemistry or basic pharmacology, they just want their little bags of drugs. And the chinese knew that and started doing absolute shit.
They sold very impure products ( a batch of 4-MeO-PCP was analyzed and contained 40% cyanide) claiming its 99.9999% just because they know the product will finished on the street and will be never analyzed by the customers. When a drug is banned they made analogue without asking the neuropharmacologist or doctor about eventual toxicity and started selling neurotoxic mephedrone analogues. For exemple they sold a synthetic cannabinoid that will be cleaved to naphtylamine by the liver and any person who has little knowledge in toxicity knows its one of the most potent carcinogen. But they didn't care, they sold "not for human consumption" anyway, the cancers are not their problems.
But at the times there was still a red line to not cross : selling deadly opioids. After a few years the red line was finally crossed and they directly sold fentanyl analogues by kilogram directly to the mafia leading to the well known fentanyl crisis you have seen in the media...
About 10 years ago I was discussing with a russian chemist about making the benzofurane analogue of MDMA. Now they are known as 5-APB and 6-APB but back then I called them "furamphetamines". He want to make the 5-isomer with the oxygen in para but me I prefer to let the oxygen in meta because of PMA toxicity. So we bet who was right. One day he wrote me he won the bet because the molecule is finished and has MDMA activity without the need for N-methylation, he also told me its even better than MDMA. But me , I finished my molecule and test it and YEEEES it is active and MDMA-like ! So I published the molecular structure on my blog along with the bioassays and commentaries.
A few month later I found a website selling what ? Yes, 5-APB AND 6-APB under the fancy name "benzo fury", ours furamphetamines !!I don't try to let beleive I invented the molecule, no because they were already patented, but I was the first to try and explain the activity. So based on our research the companies ordered kilograms to chinese labs and started making huge amount of money with no respect to the molecules. I ordered a sample and analyzed it and it was only 85%, the rest is other isomer and unreatced products... From now I immediatly removed the blog and did not published anything anymore but I kept doing research.
I made and tested a lot of new rings : benzimidazole, benzisoxazoles, and so on. And I find a new ring with MDMA-like qualities but never plublished anything. And guess what ? Today I find the ring on.... Wikipedia ! And with plenty of other rings ! Apparently there are new neuropharmacologist that made new analogues, tested them and published in 2024. I haven't read the pubs yet, but it is question of time for the RC companies to read it and ordering kilograms of new molecules.... I bet its that will happened in 2025.
I thought researchers in universities stop publishing after Ralf Heim discovered bomamines (NBOMes)and RC companies spread them all across the world and killed thousands of people of overdoses due to the unsafty profiles of N-BOMe. By the way, with the help of a friends who works with IA neurologic software, I made new N-alkylated 2C-X with the activity starting at 25 ug ! Way more potent than LSD ! But if I publish the structure it will be completely legal in all the world because not based on N-Benzyl mioety and RC compagnies will sold them again and killing a lot more of people...
Now I am fed up with how the RC market has turned and how the product are sold. It can be easy to start a new website selling controlled molecules analyzed by GC/MS or NMR and selling to intelligent people but no ... money talks....
And who knows what happened to the website "blacklight.in" for advanced drug discussion ???
Thank you for reading,
Dr.Methyl
