Dissociatives The Big & Dandy DMXE (3-me-2′-oxo-PCE, deoxymethoxetamine) Thread

[4DQSAR]

Has anyone obtained GC-MS/NMR instrumentation data for this compound? I ask because the tilmetamine wasn't tilmetamine and the OP on the topic admitted that Chinese chemists were not aversed to making something cheaper or simpler if they thought they could get away with it.

I remain confident that the 2-chloro-5-methoxy homologue of K/MXE (it overlays both) will prove to be the best - but I am informed the production cost is high. Maybe so, but if it's activity is high, that need not be an issue.

 

[Esperighanto]

Has anyone obtained GC-MS/NMR instrumentation data for this compound? I ask because the tilmetamine wasn't tilmetamine and the OP on the topic admitted that Chinese chemists were not aversed to making something cheaper or simpler if they thought they could get away with it.

I remain confident that the 2-chloro-5-methoxy homologue of K/MXE (it overlays both) will prove to be the best - but I am informed the production cost is high. Maybe so, but if it's activity is high, that need not be an issue.

The precursor (2-chloro-5-methoxybenzene) should be easy as hell to acquire, Reimer-Tiemanning mequinol allegedly can lead to an ~80% yield on this reaction. Even after cleaning it up and pulling 50% total post re-x, that's still 40% conversion of one of the most difficult to acquire precursors for ket production. That's probably why patents and the sort are grabbing that compound imo. 2-Chlorobenzene is a bitch to make, it involves going through steps involving 2-Nitrobenzene from what I've seen and anybody working at scale is going to want to avoid this like the plague imo.

 

[4DQSAR]

The precursor (2-chloro-5-methoxybenzene) should be easy as hell to acquire, Reimer-Tiemanning mequinol allegedly can lead to an ~80% yield on this reaction. Even after cleaning it up and pulling 50% total post re-x, that's still 40% conversion of one of the most difficult to acquire precursors for ket production. That's probably why patents and the sort are grabbing that compound imo. 2-Chlorobenzene is a bitch to make, it involves going through steps involving 2-Nitrobenzene from what I've seen and anybody working at scale is going to want to avoid this like the plague imo.

Yeah, I think you touched on this before and I provided the GB patent number.

The fact that the -Cl and the -OCH3 moieties are on the opposite sides of the benzene ring may suggest that K and MXE bind in slightly different ways. So it's quite possible that the presence of both will increase affinity. If I were still in a position to have a sample of ANY compound made, that would be at the top of my list.

 

[Liminality]

I've got 1g coming today, will update when I try it. I LOVED MXE in 2013, so I was quite keen when this became available domestically, even at an inflated price, I had to at least try it.
Thanks to all the commenters.

Edit:
Ketamine tolerance from a month ago, I.M but disso tolerance is hard to gauge.
I'm on Sertraline 100mg

All DMXE reports

Allergy test <5mg IN - Recommended for all unknowns.

T+0: 20mg rectal
T+20 min: 40mg rectal
Wasn't feeling much, but slight warmth from T0 dose.

T+45 min: A bit of a wonk reminiscent of MXE.
A Good sign of my old love.
Slightly mxe-like

T+3hrs: 60mg rectal
Hard to do verification captcha
Warmth was there with classic vision effects alA Ket/MXE so I knew it was working. Colours were much more vivid.

T+6hrs
Tapering off stimulation/visual effects

The warmth and stimulation were there. Not much of a trip. Some euphoria. But the lack of psychedelia could be due to me using BDO earlier in the day.
Anxiolysis and anti depressant effects working well. See how long it lasts.

Will trial again soon

Has anyone combined this with suboxone yet? I'm on 12mg of Suboxone a day. I've mixed buprenorphine with plenty of dissos; 3-cl-pcp, 3-fl-pcp,mxpr, fxe, etc. I just always get paranoid when mixing it with a new disso. I know respiratory depression issues are rare with dissociatives, but I imagine any respiratory issues would be more of an issue with a close MXE analogue than with Pcp analogues

I'm on Buvidal, 64mg bolus S.C. No issues with DMXE. (Once month stable levels from bolus released slowly)
Equates to about 16mg Suboxone if I vaguely recall.


Oh and special thanks to SuperPsych for the combinations post. Very useful!


And yes, CMXE would be very interesting.
Any data or research sources for that?
Explain info on CMXE


I don't want to have a running trip report in the mega but I might post to trip reports if I find a good psychedelic experience. Considering combining with LSD once more acquainted.

I'll be sure to post again on how my 1g goes in some format.

Edit 2: Well I couldn't sleep. It's now 5am and my last dose was at 10.30pm I believe. I did however write a very insightful essay (683 words) on my own health and situation with drug use, and future focus.

 

[4DQSAR]

I've only tried ketamine and MXE a handful of times, but for me at least, MXE was the much better product. The fact that dozens of other homologues have turned up and each one seems worse than the last does suggest that cost is considered more important than subjective activity.

Ketamine is produced on a massive scale which is why it's still the only common arylcyclohexylamine.

Why CMXE hasn't turned up is cost. If I were still in the RC business I would at least have a sample made. Because if it turns out to be 2-3x more potent than MXE, as long as consumesr know, you could sell 250mg of it for the same price as a gram of K since they would yield the same number of doses.

Of course there are other compounds. Ones that aren't arylcyclohexylamines. Diphenidine was only ever meant to be a prototype. We discovered some much better analogues but due to some poor business decisions (like buying 1000Kg of piperidine!), we were stuck making N-piperidine varients.

 

[Liminality]

Very annoying feeling like you need to pee but you can't/don't. Sitting down helps but DMXE is as bad as ket for this.

I I.M'd 60mg today with a micron filter.
Warm fuzzy

Well, it wasn't a very pleasant hole experience. A bit of mania, a blood nose from snorting yesterday in the heat. Hard to control it so blood all over my room / carpet now to clean.
Apart from that kinda ruining it. It lacked the magic for sure of MXE.

But lower doses (20-60mg rectal) for stimulation/socialising were quite good. Not over talkative just relaxed and on point enough.

Might have to wait until further away from my morning BDO usage. Or my 4 week break from it.

Maybe again in 2 weeks at low doses rectally. Cause I wasn't sure about that. But definitely not up the nose again even if the effects were alright / easy to use.

No problems with serotonin syndrome from 100mg Sertraline and bupe.

Oh and it says my bupe is equivalent to 8-10mg bupe daily. No naloxone for quite a while for me for good behaviour.



But bi-weekly pharmacy visits for Subutex were a pain. Buvidal monthly much easier I just thought it was a higher dose.

Anyway that's my review of it for now, until 2 weeks again.

Stay safe everyone.

 

[4DQSAR]

Very annoying feeling like you need to pee but you can't/don't. Sitting down helps but DMXE is as bad as ket for this.

Yep. It's agony.

That's something that has always concerned me about RC manufacturers bringing compounds that haven't even undergone animal testing to market. Nobody really knows what the potential risks are.

I've mentioned this before but I took the time to read through 114 patents assigned to Parke-Davis on the arylcyclohexylamine class of compound. Over 100 patents and the ONLY ring-substituents they covered were the chloro and alkoxy (methoxy, ethoxy, isopropoxy). One of the MOST important things a patent is intended to do is to prevnt other manufacturers from making what are termed 'me too' drugs. There are entire research teams who try to find active compounds that avoid and patent conflict.

So why didn't Parke-Davis patent ketamine homologues with other (pseudo)halogens? Why do all 114 patents only cover -Cl, -OCH3, -OCH2CH3 and O-CH(CH3)2 as ring-substituents? They did try different aromatics hence tiletamine and they did try various different N-substitutions (hence 114 patents).

But WHY did they ignore all the other (pseudo)halogens?

They certainly did test many of them in animal models. Now a weakness of drug studies is that none of them have to be made public. In a few cases this has resulded in disasters but if Parke-Davis with all of it's resources decided not to even patent the fluoro, bromo, alkyl and indeed any other ring-substitutions, I would be asking 'why', because they are in the position of knowing while we are not.

Don't forget, esketamine is an NMDA antagonis, arketamine is a DRI. So the racemate possesses both activities. It's compounds that retain that balance but which are more potent that Parke-Davis were searching for.

1 — Postimages

postimg.cc

Novel cyclohexanone compounds and process means for the production thereof
Publication Number: GB-1202834-A
Priority Date: 1968-05-08

Example 1 is CMXE

People have asked 'well, if CMXE is better than ketamine, why hasn't it replaced ketamine?'. Well, I could ask the same question about MXE. The reason is simple. Ketamine was a revolutionay new medicine able to relieve the most severe pain and be able to produce surgical anasthesia in a safer manner than existing agents. So while research continued, the management of Parke-Davis spent billions on having ketamine tested and introduced into medicine on a global scale. CMXE was only discovered 6 years later and since ketamine had no competition, why introduce something else?

BTW the way Parke-Davis (as US company) only took out a GB patent is interesting. My theory is that they didn't want competitors to be aware of the improved drug. I guess it meant that IF another company discovered a better medicine than ketamine, Parke-Daivs could quicky swap research to CMXE.

Arylcyclohexylamine Derivatives: Pharmacokinetic, Pharmacodynamic, Clinical and Forensic Aspects

Since the 2000s, an increasing number of new psychoactive substances (NPS) have appeared on the drug market. Arylcyclohexylamine (ACH) compounds such as ketamine, phencyclidine and eticyclidine derivatives are of particular concern, given their rapidly increasing use and the absence of detailed...

www.mdpi.com

Reading the above makes me wonder if the other halogens were rejected by Parke-Davis because they produce potentially toxic metabolites. With any ned medicine, one doen't just have to test the toxicity of the drug itself but also it's metabolites. We now know ketamine can damage the bladders. I have no idea if Parke-Davis regonigized this issue and if so, did they try various (pseudo)halogens to find the least toxic? It's all just a guess, but Parke-Davis not patenting 2-fluoro norketamine seems odd. We see it turn up as a 'me too' drug, but we don't know why Parke-Davis seeminly discared it.

 

[Liminality]

Ah great, thanks for that. It is very close to MXE, just with a chlorine and something going on with the CH3 group, not sure. (I'm a physicist who never did chemistry past 1st year.)
Physics was enough for me, nanotechnology, etc. Tokyo nanotech expo was amazing!
That Chloromethoxetamine (CMXE) would be VERY interesting!

Got an update. 85mg Rectal provided lots of stimulated dissociation.
Had a 30 minute shower as it came on. Very relaxed.
Little trouble with motor control.
Lasted about 5 hours.
Etizolam 2mg after that.
Very nice.

Going to try 135mg Rectal next time as the dosage seems a bit higher. (75-80%) of MXE doses from reading this thread

 

[Hammerbund]

I wonder how much is the dose for a DMXE-Hole...
from what I've read so far: it seems to be quite far over 100mg nasally and orally, maybe even +150mg and rectal maybe around 120mg. Can anyone confirm this? Thank you!

Because of the lower dosage rectally I'm interested to try this, even if I've never done this ROA before. Which fluid do you choose to mix it in the syringe? Thanks for any advice.

I'm quite experienced with older (RC)-Dissociatives, but I was clean several years and am now back to try those novel dissos, so my tolerance is quite low.

 

[Img_9999]

I fairly recently tried this one, wasn't super impressed but it was also a lowish dose, 20 mg oral. Found it surprisingly clear headed at that dose. Definitelly weaker than MXE and also lacking some of the warmth and "magic" MXE had, but I can see it really shining in combination with a low dose of psychedelic or even just some weed. It's also shorter lasting than I expected, after three hours I was already approaching baseline. Felt a bit of a manic afterglow, during and after the comedown, but not the next morning. Another time, at 10 mg snorted it provided functional stimulation. I need to experiment further when I find the time.

 

[CavernsoftheMind]

I fairly recently tried this one, wasn't super impressed but it was also a lowish dose, 20 mg oral. Found it surprisingly clear headed at that dose. Definitelly weaker than MXE and also lacking some of the warmth and "magic" MXE had, but I can see it really shining in combination with a low dose of psychedelic or even just some weed. It's also shorter lasting than I expected, after three hours I was already approaching baseline. Felt a bit of a manic afterglow, during and after the comedown, but not the next morning. Another time, at 10 mg snorted it provided functional stimulation. I need to experiment further when I find the time.

30mg nasally should provide the magic you're looking for

 

[CavernsoftheMind]

We tried the black 40mg 3D-MXE pellets yesterday. Took a half orally first, which produced a light effect after ~45min.
1h after ingestion we took the other half.

The dose is nice for social settings / being in public. It's not too intense, but very comfortable.

Later, when we got home, we started snorting DMXE lines & got quite deep in, close to holing.
At first we were still clear headed enough to read a wikipedia article about 9/11 & had interesting discussions, which were still rational.

Then we watched The Beatles' movie "Magical Mystery Tour" (which fits with dissociatives well).
After that we layed down & went deeper.
I just love listening to music on dissos.

The last line was at 5 AM, we fell asleep at 9 & woke up at 4 PM.
We were still pretty dissociated after waking up, for at least 3h.

Back to baseline maybe 14-16h after the last line.

 

[rockett_the_emo]

your dmxe is fake or sumthing. Deffo 100mgs would eject even an heavy disso tolerant out of the troposphere

Definitely doesnt send a heavy disso user outbof the troposphere. Dmxe is like k lite. Which means its mxe ultra lite. I went through 5 grams in 2 days and i had 8hr of sleep in between. Started off with 30mg and then by bump number 3 my tolerance was at the level of i needed 150mg line to get to the same place the first 30mg bump did. I can also go through 7g of k in 6 hours at work and still drive home no problem. Dmxe is the disso for people that dont do dissos regularly but want to feel like theyvare doing something more potent than k. Which if i cook the k myself only mxe has been stronger out of the analogs ive tried. Dmxe was like a walk in the park where k is like being thrown into the psychological blender, and then mxe is like being thrown in the psychological super toilet from fairly odd parents. Dmxe just wasnt anywhere close to the euphoria or warmth of mxe, plus mxe only needing 100mg to hole where as i never once holed on dmxe even with the 300mg line i did. I do a 300mg line of k and im even starting to mentally hole but can still walk around. But that is why i am a moose and everyone that likes dmxe is a miniature pony. They cant even be a full sized horse

 

[Esperighanto]

Definitely doesnt send a heavy disso user outbof the troposphere. Dmxe is like k lite. Which means its mxe ultra lite. I went through 5 grams in 2 days and i had 8hr of sleep in between. Started off with 30mg and then by bump number 3 my tolerance was at the level of i needed 150mg line to get to the same place the first 30mg bump did. I can also go through 7g of k in 6 hours at work and still drive home no problem. Dmxe is the disso for people that dont do dissos regularly but want to feel like theyvare doing something more potent than k. Which if i cook the k myself only mxe has been stronger out of the analogs ive tried. Dmxe was like a walk in the park where k is like being thrown into the psychological blender, and then mxe is like being thrown in the psychological super toilet from fairly odd parents. Dmxe just wasnt anywhere close to the euphoria or warmth of mxe, plus mxe only needing 100mg to hole where as i never once holed on dmxe even with the 300mg line i did. I do a 300mg line of k and im even starting to mentally hole but can still walk around. But that is why i am a moose and everyone that likes dmxe is a miniature pony. They cant even be a full sized horse

Jesus christ I just noticed this over a week after it was posted, but I need to say it here for future readers, never absolutely ever consider it wise to drive under the influence of any hallucinogens, dissociatives included.

Also dude, if 5 grams of any arylcyclohexylamine in two days, even those known to be the weakest such as 2-Bromodeschloroketamine, has no effect? Maybe the problem is something pertaining to your enodgenous neurochemistry, or uh, based on this:

I do a 300mg line of k and im even starting to mentally hole but can still walk around. But that is why i am a moose and everyone that likes dmxe is a miniature pony. They cant even be a full sized horse

My suspicions are that your problems lie more with some sort of intersection between arylcyclohexylamine tolerance and an ego complex best handled by legitimate mental health counselors or therapists or something. I've never once had a thought along the lines of like, comparing myself to other humans are varying mammals in this manner, idk it's just very strange and it makes me question your accounts of this substance a lot. I've never even used DMXE, I'm just responding based on what I've seen you comment here.

 

[Vastness]

I do a 300mg line of k and im even starting to mentally hole but can still walk around. But that is why i am a moose and everyone that likes dmxe is a miniature pony. They cant even be a full sized horse

Lol, yeah that's just a wild thing to say.

From memory I think DMXE and K are actually pretty similar in potency, I think I've posted about my experiences with DMXE before with exact dosages although I can't be bothered to look that up right now.

DMXE is it's own thing and quite qualitatively different to the "hole space" of ketamine and the close ketamine analogues, IMO (deschloro-, 2-flourodeschloro-... maybe others but they're the closest I think). It's actually more "holey" in my experience than MXE itself, personally I prefer it, I'm not saying it's more "potent" and it's been a long time since I've done enough MXE to enter an "M-hole" but from memory the experience was more profoundly alien than ketamine in a way that personally I just didn't really like, I think it's a bit too stimulating, perhaps? DMXE is too but it's easier to enter "Hole Space", so to speak.... IIRC... maybe not necessarily dosage-wise but just... it's friendlier, a smoother ride in? All that said I've done a lot less MXE than I have ketamine, it's possible that M-holes are something of an acquired taste which I could learn to like and appreciate in the same way I appreciate K holes.

Oh wait! I just got the joke... ketamine is a "horse tranquilizer", ughhhhh yeah OK dude this would actually be funny I'll give you that, if you hadn't said it in the same post as talking about driving after doing 7g of ketamine at work, hopefully your job isn't anything that important. Tbh at this level of tolerance you don't really have any idea or business commenting on the qualitative nuances of any other dissociatives because that massive tolerance has just smoothed out the parts of your brain which would be able to notice and appreciate any of them. It's nothing to be proud of, you're not a moose, you're a horse like all the rest of us dissoheads, but you're looking more and more like a frazzled newborn foal and all the other horses are worried about you.

 

[Esperighanto]

Oh wait! I just got the joke... ketamine is a "horse tranquilizer"

This shit went clean over my head, I'm glad somebody coherently pointed this out. I just know that the last time I saw a moose I popped one of my in-car backup stimulants, I was driving out in rural northern/central Maine returning from a wedding years ago, heading back down to the coast. Saw a baby moose, and knowing the season, its parent(s)/sibling(s) were likely nearby. It's tough to articulate that a fully grown moose, standing in a normal room with 8' ceilings is going to have to angle its ears down to fit underneath the ceiling, hitting even a moderate sized one in a car tends to kill all in the vehicle, crush the car like a soda can and the moose often walks off from the scene.

all the other horses are worried about you.

I've long wondered what leads people to feel like they need to egoistically prove themselves via weird arbitrary metrics on anonymized forums centered not around competitive dosing, but harm reduction. I'm saying this too as possibly Bluelight's worst offender of popping on to speak about experiences eating a quarter sheet of acid after a bump of meth and all that classic foolery I get up to, but the reason I do shit like that is that I'm exploring the somewhat purposeless fringes of the actually useful span of the psychedelic experience in doing so. Knocking yourself out with 30 tabs of acid in a gel cap leads to a state of intense and profound understanding of whatever you have on your mind, sure, but it's so profoundly difficult to integrate, it's closer to a DMT breakthrough than it is a more useful, lower dose LSD experience in my personal opinion.