• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

What exactly happens to my brain when I go on and off gabapentin 1600mg a day?

Well, its a voltage gate calcium channel blocker (specifically at the alpha 2 delta subtype in the CNS,) so basically your brain is becoming more active then less active repeatedly which I would imagine results in greater levels of oxidative stress (aging) due to it struggling to maintain homeostasis plus there would be a greater number of neupsychiatric related cognitive issues as well especially if it is prescribed for such already.
 
ShulginsReincarnation said:
Well, its a voltage gate calcium channel blocker (specifically at the alpha 2 delta subtype in the CNS,) so basically your brain is becoming more active then less active repeatedly which I would imagine results in greater levels of oxidative stress (aging) due to it struggling to maintain homeostasis plus there would be a greater number of neupsychiatric related cognitive issues as well especially if it is prescribed for such already.
Click to expand...
I would like to know more about what a calcium-blocker is and does that sounds a little crazy
 
Omlovepeace said:
I would like to know more about what a calcium-blocker is and does that sounds a little crazy
Click to expand...
They can be used to treat cardiovascular conditions like arrhythmia or hypertension in the more traditional sense, but this one specifically works to block that receptor subtype in the CNS resulting in downstream effects on GABA and Glutamate. It reduces neuronal firing by reducing glutamatergic action (excitatory) in the brain and increasing gabaeric activity (inhibitory,) so it works to calm brain activity which in your case seems to calm the heart even though that is not necessarily the primary function of the drug.

It does sound crazy, but I assure you it isn't that crazy compared to the mechanisms of action of other psychiatric drugs such as ariprazole which honestly fascinates me to this day due to its relative complexities.
 
There is a guy I know who said he gets stimulant effects of gabapentin.

I'd like to make the effort to point out that gabapentins metabolite is expected to be Hexacyclonate. This is a central stimulant.
 
You must log in or register to reply here.
Top