Its more Euphoric, like GHB or ...
When in WD from Alcohol Benzo s dont actually work as cover.
They prevent seizures and take away one symptom GABA-a rebound.
Other seizure control, they don t do anything but make you sleep through it.
Ime. Greta for THC cessation Diazepam though.
One thing scientific i can add.
They discovered true evolution, gene selection.
Most but not all humans have a genetic mutation that made it able,
to eat more fermenting fruit. We share this with some other species.
Fruitflies, several primates oa Bonobo s.
Theory behind it the advantage of eating large amount of fermenting fruit.
A advantage for evolution then. And the culprit for addiction now.
In Asia there are many lacking this mutation,
and they get quickly drunk and sick after.
Btw so do many animals.
To them Alcohol is actually poisonous in large amounts.
Mechanism of action in humans, fruitflies ? Bonobos/ Chimps/ Orang Oetangs:
Steps
Binding of the coenzyme NAD+
- Binding of the alcohol substrate by coordination to zinc(II) ion
- Deprotonation of His-51
- Deprotonation of nicotinamide ribose
- Deprotonation of Thr-48
- Deprotonation of the alcohol
- Hydride transfer from the alkoxide ion to NAD+, leading to NADH and a zinc-bound aldehyde or ketone
- Release of aldehyde.
See no evidence about other species dying after consuming a fermented Apple.
But assume they could consume less, as the miss the mutation.