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  • BDD Moderators: Keif’ Richards | negrogesic

Alcohol Why is Alcohol more popular as a drug as opposed to benzos like Xanax?

Definitely, the stimulating effect only occurs at low-moderate doses and goes away after a few hours. Once it is gone, you’ll just end up going straight to sick and drowsy town if you continue to drink. I remember hearing a while back that the explanation for this had to do with downstream effects of alcohol in stimulatory neurotransmitter systems like dopamine and norepinephrine which later subside as the depressant gabaergic effects completely take hold. I also find it really depends on set and setting. If you’re in an energizing environment with a somewhat decent mood/attitude, and energetic music, it is much more likely to be stimulating at first. If you’re instead moody or drinking alone and not listening to anything that amps you up, then you’re more likely to just go straight to sedation. I also think tolerance is likely a major factor. I drink less than 15-20 times a year, so it usually is quite fun when I do it. This seems to not be the case as much with more regular drinkers.

Alcohol makes me want nicotine even though I’ve never picked up a real nicotine habit (narrowly dodged that by having a body with heightened inflammatory responses to fucking everything). I haven’t done much coke while drinking, it supposedly is quite enjoyable and makes both substances better. I have done amphetamines with booze plenty which is fun, but I don’t have a strong association between those two drugs. I also generally get decent euphoria from amphetamines and almost no euphoria from coke (done great quality fish scale and smoked crack a few times too, it does give me good body tingles with music though). Coke is short lasting, expensive, and has bad quality control, especially in my region. Also the people around me who had/did coke were often annoying, impulsive, and selfish when on it (and most cokeheads I knew were douchebags before ever touching the stuff lol) so i didn’t hang around them much when they hit the slopes. This isn’t saying all coke users suck (most people I know who use it do so sparingly and are pleasant to be around when they do a few lines), just that in order to be around people who had access to good product at all, you would often also be forced to spend time around a decent amount of completely insufferable cokeheads. I will still do some when its around (which is uncommon for me), but I don’t feel inclined to actually seek it out and buy any myself anymore. I know cocaethylene is produced when the substances are combined and it’s generally quite euphoric and bring out the best in both substances, so i would like to give it a proper try or 2 though with good blow (was unremarkable when done with mediocre coke).
Yeah I mean its not great. On wallet or on your health. I don't really do stimulants anymore other than coffee, my addictions right now are just prescribed (buprenorphine and diazepam) and coffee and vaping ( though I've got the nicotine level so low you could practically call it not even there anymore - though I continue to vape - more of a physical habit at this point).

Anyway still having lots of experiences with amphetamines and coke, if I was forced to do one it would be powder coke. Just because I do get a nice feeling and I can rely on it being short. At one time in my life I would have picked meth. And amphetamines (either meth or European) have a habit of making me go kinda crazy, though meth seems highly more likely to have this effect. Coke doesn't really do that. Though I acknowledge coke is worse on the heart, as far as I understand anyway.
 
It does, but the positive (sought) effects of alcohol (ethanol) are primarily the a1 and a5 subunits of the GABA receptor.

Drugs that closely mimic ethanol are known and molecular probes were able to pinpoint the activity of said drugs.

Why hasn't it become huge? Because it would still be a synthetic psychoactive compound. Not a food, not alcohol (ethanol) but also unsuited to being classed as a medicine since it isn't curing or treating a recognized illness.

There is no precedent for how such a drug could be marketed. What licencing laws would be appropriate? Who would be responsible for taxation? Who for control of distribution and of production? Then, if a user IS harmed, who is responsible?

If you intend to entirely supplant the most popular drug on the planet, you need it to be a global product. That would take immense resources.

The 'under the radar' route would be to get the drug introduced as an investigational treatment for alcoholism. That way, a large body of case studied using people who have conveniently signed-away the right to sue would then provide a body of work comparing how much safer the alcohol alternative is. Then pay the politician of your choosing to ask why alcohol is legal, the alternative illegal? That's the LONG game but by far the cheaper (but not cheap)
GABA-A is 99.5% of Alcohol effects It more like Ambien/Muscimol than a dirty drug. GABA-A a1 agonism also what GABA deliriants affect which Is why Ambien & Muscimol have drunk phases at low/mid doses and why Xanax dosen't.

The issue here Is 90% of the ones who demand a Alcohol alt are just wanting CNS depressent effects & many cases refuse to admit they don't get true drunk/delirious effects. Muscimol Is the only one that would keep Alcohol users happy since It lasts 8+ hours with the same drunk effects at low/mid doses(4 ~ 8g AM shrooms). They don't want to admit they love the NMDA antagonism from High GABA-A levels directly blocking It and try out Ketamine or DXM.
 
This is one of stupidest questions ever asked on here, and that is saying a lot.
 
GABA-A is 99.5% of Alcohol effects It more like Ambien/Muscimol than a dirty drug. GABA-A a1 agonism also what GABA deliriants affect which Is why Ambien & Muscimol have drunk phases at low/mid doses and why Xanax dosen't.

The issue here Is 90% of the ones who demand a Alcohol alt are just wanting CNS depressent effects & many cases refuse to admit they don't get true drunk/delirious effects. Muscimol Is the only one that would keep Alcohol users happy since It lasts 8+ hours with the same drunk effects at low/mid doses(4 ~ 8g AM shrooms). They don't want to admit they love the NMDA antagonism from High GABA-A levels directly blocking It and try out Ketamine or DXM.

Well, I've not tried muscimol but I have tried both alcohol and pyeyzolam. Pyeyzolam doesn't work in quite the same way as alcohol as instead of actually acting as a bioisostere of alcohol, it acts as a PAM at the a5 subunit.

But there was also a selective a1 ligand and that turned out to produce most of the negative effects of alcohol.

It's important to note that the EC50 of ethanol differs between subunits so the precise effect can change in character a great deal depending on the dose.

It's not as if ethanol is unique. Almost all of the short-chain alcohols produce similar effects, it's just that ethanol is simple to produce and for whatever reason(s) is socially acceptable.
 
Well, I've not tried muscimol but I have tried both alcohol and pyeyzolam. Pyeyzolam doesn't work in quite the same way as alcohol as instead of actually acting as a bioisostere of alcohol, it acts as a PAM at the a5 subunit.

But there was also a selective a1 ligand and that turned out to produce most of the negative effects of alcohol.

It's important to note that the EC50 of ethanol differs between subunits so the precise effect can change in character a great deal depending on the dose.

It's not as if ethanol is unique. Almost all of the short-chain alcohols produce similar effects, it's just that ethanol is simple to produce and for whatever reason(s) is socially acceptable.
It the fact that ethanol seems to be more like a GABA-A agonist than a PAM. Because Xanx & Z-drugs only take a month to get addicted while for ethanol It up to 10 years of heavy use even then they have check If actual alcoholism. GABA displacement a thing where Muscimol Is what the brain uses allowing in theory no true tolerance & addiction, It seems like ethanol does the same but It depends on how others Liver/brain behave.

I think Muscimol Is weirder because It might be the only Deliriant that isn't a toxin at high doses and lacks the body load of Datura/DPH while producing mania tier euphoria.
 
Z-drugs are a1 selective and there is quite a large body of literature demonstrating that the a1 subunit is largely responsible for the dependence liability of benzodiazepines.


I do appreciate that the term 'positive' and 'negative' are subjective, but what everyone found was that they felt happy, relaxed and slightly wobbly BUT no amnesia, mood lability or hypnotic effects. Obvious no hangover and no damage associated with alcohol and it's metabolites.

There are indeed a number of papers and patents mostly issued by Milwaukee Institute for Drug Discovery lead by Dr. James T. Cook (really) who undertook the elucidation of the various subreceptor types. They were able to find many a5 selective compounds and the point was to understand and circumvent the addictive nature of existing benzodiazepines.

All we did with pyeyzolam was to produce a compound that didn't undergo metabolism but rather is excreted unchanged - because 3 hydroxylation is a common metabolic pathway for many benzodiazepines and they tended to have increased a1 activity.
 
Z-drugs are a1 selective and there is quite a large body of literature demonstrating that the a1 subunit is largely responsible for the dependence liability of benzodiazepines.


I do appreciate that the term 'positive' and 'negative' are subjective, but what everyone found was that they felt happy, relaxed and slightly wobbly BUT no amnesia, mood lability or hypnotic effects. Obvious no hangover and no damage associated with alcohol and it's metabolites.

There are indeed a number of papers and patents mostly issued by Milwaukee Institute for Drug Discovery lead by Dr. James T. Cook (really) who undertook the elucidation of the various subreceptor types. They were able to find many a5 selective compounds and the point was to understand and circumvent the addictive nature of existing benzodiazepines.

All we did with pyeyzolam was to produce a compound that didn't undergo metabolism but rather is excreted unchanged - because 3 hydroxylation is a common metabolic pathway for many benzodiazepines and they tended to have increased a1 activity.
Z-drugs/Benzos are GABA-A PAM's, They seem to behave more like a SRI but are far more destructive since the brain will run out GABA causing issues. They seem to be very unselective subunit agonism since people say Ambien trip switches from Shroom style to Datura style to Disso style without any warning. Alcohol & Muscimol do this but not in a grindcore sense, It more like all 3 styles at once with some fading in/out. Just like how high dose MDMA binges for 4 days make It hard to LSD because there too little serotonin.
 
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